Putative RNA binding protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

RNA binding protein, putative

Species:

Leishmania braziliensis

UniProt:

A4HHF3_LEIBR

TriTrypDb:

LbrM.29.1500 , LBRM2903_290021300

Length:

648

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HHF3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HHF3

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	6
GO:0003723	RNA binding	4	6
GO:0005488	binding	1	6
GO:0097159	organic cyclic compound binding	2	6
GO:1901363	heterocyclic compound binding	2	6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	118	120	PF00675	0.833
CLV_NRD_NRD_1	200	202	PF00675	0.246
CLV_NRD_NRD_1	222	224	PF00675	0.644
CLV_NRD_NRD_1	232	234	PF00675	0.454
CLV_NRD_NRD_1	351	353	PF00675	0.678
CLV_PCSK_KEX2_1	200	202	PF00082	0.241
CLV_PCSK_KEX2_1	222	224	PF00082	0.644
CLV_PCSK_KEX2_1	350	352	PF00082	0.657
CLV_PCSK_PC1ET2_1	350	352	PF00082	0.505
CLV_PCSK_SKI1_1	201	205	PF00082	0.241
CLV_PCSK_SKI1_1	235	239	PF00082	0.540
CLV_PCSK_SKI1_1	264	268	PF00082	0.377
DEG_ODPH_VHL_1	521	534	PF01847	0.525
DEG_SPOP_SBC_1	364	368	PF00917	0.579
DEG_SPOP_SBC_1	608	612	PF00917	0.541
DOC_MAPK_gen_1	200	211	PF00069	0.441
DOC_MAPK_gen_1	233	241	PF00069	0.541
DOC_MAPK_MEF2A_6	233	241	PF00069	0.541
DOC_MAPK_NFAT4_5	234	242	PF00069	0.532
DOC_PP1_RVXF_1	280	287	PF00149	0.577
DOC_PP2B_LxvP_1	34	37	PF13499	0.783
DOC_PP2B_LxvP_1	418	421	PF13499	0.708
DOC_PP2B_LxvP_1	521	524	PF13499	0.531
DOC_PP2B_LxvP_1	532	535	PF13499	0.661
DOC_USP7_MATH_1	12	16	PF00917	0.541
DOC_USP7_MATH_1	221	225	PF00917	0.674
DOC_USP7_MATH_1	29	33	PF00917	0.791
DOC_USP7_MATH_1	307	311	PF00917	0.576
DOC_USP7_MATH_1	448	452	PF00917	0.629
DOC_USP7_MATH_1	505	509	PF00917	0.597
DOC_USP7_MATH_1	591	595	PF00917	0.581
DOC_USP7_UBL2_3	234	238	PF12436	0.560
DOC_WW_Pin1_4	20	25	PF00397	0.757
DOC_WW_Pin1_4	270	275	PF00397	0.577
DOC_WW_Pin1_4	32	37	PF00397	0.589
DOC_WW_Pin1_4	367	372	PF00397	0.753
DOC_WW_Pin1_4	382	387	PF00397	0.509
DOC_WW_Pin1_4	416	421	PF00397	0.710
DOC_WW_Pin1_4	461	466	PF00397	0.569
DOC_WW_Pin1_4	58	63	PF00397	0.684
DOC_WW_Pin1_4	609	614	PF00397	0.621
DOC_WW_Pin1_4	624	629	PF00397	0.615
DOC_WW_Pin1_4	66	71	PF00397	0.640
LIG_14-3-3_CanoR_1	125	134	PF00244	0.663
LIG_14-3-3_CanoR_1	200	204	PF00244	0.595
LIG_14-3-3_CanoR_1	214	219	PF00244	0.601
LIG_14-3-3_CanoR_1	222	229	PF00244	0.574
LIG_14-3-3_CanoR_1	264	269	PF00244	0.577
LIG_14-3-3_CanoR_1	3	12	PF00244	0.721
LIG_14-3-3_CanoR_1	363	373	PF00244	0.671
LIG_14-3-3_CanoR_1	378	386	PF00244	0.476
LIG_14-3-3_CanoR_1	574	580	PF00244	0.565
LIG_14-3-3_CanoR_1	96	100	PF00244	0.690
LIG_Actin_WH2_2	339	356	PF00022	0.484
LIG_APCC_ABBA_1	266	271	PF00400	0.577
LIG_APCC_ABBA_1	286	291	PF00400	0.400
LIG_BIR_II_1	1	5	PF00653	0.522
LIG_BRCT_BRCA1_1	144	148	PF00533	0.539
LIG_BRCT_BRCA1_1	387	391	PF00533	0.514
LIG_deltaCOP1_diTrp_1	490	500	PF00928	0.523
LIG_FHA_1	186	192	PF00498	0.577
LIG_FHA_1	270	276	PF00498	0.577
LIG_FHA_1	404	410	PF00498	0.519
LIG_FHA_1	462	468	PF00498	0.567
LIG_FHA_1	541	547	PF00498	0.655
LIG_FHA_2	133	139	PF00498	0.611
LIG_FHA_2	247	253	PF00498	0.577
LIG_FHA_2	364	370	PF00498	0.602
LIG_FHA_2	556	562	PF00498	0.547
LIG_IBAR_NPY_1	637	639	PF08397	0.700
LIG_LIR_Gen_1	188	197	PF02991	0.577
LIG_LIR_Gen_1	496	505	PF02991	0.610
LIG_LIR_Nem_3	254	260	PF02991	0.592
LIG_LIR_Nem_3	410	415	PF02991	0.596
LIG_LIR_Nem_3	491	497	PF02991	0.542
LIG_LIR_Nem_3	526	532	PF02991	0.528
LIG_LIR_Nem_3	643	647	PF02991	0.664
LIG_PTB_Apo_2	638	645	PF02174	0.500
LIG_SH2_CRK	260	264	PF00017	0.556
LIG_SH2_CRK	415	419	PF00017	0.527
LIG_SH2_CRK	551	555	PF00017	0.701
LIG_SH2_GRB2like	639	642	PF00017	0.510
LIG_SH2_STAT5	289	292	PF00017	0.577
LIG_SH2_STAT5	639	642	PF00017	0.700
LIG_SH3_3	425	431	PF00018	0.664
LIG_SH3_3	542	548	PF00018	0.693
LIG_SH3_3	557	563	PF00018	0.500
LIG_SH3_3	625	631	PF00018	0.603
LIG_TRAF2_1	136	139	PF00917	0.570
LIG_TRAF2_1	38	41	PF00917	0.584
MOD_CDK_SPK_2	624	629	PF00069	0.659
MOD_CDK_SPxxK_3	32	39	PF00069	0.549
MOD_CDK_SPxxK_3	367	374	PF00069	0.745
MOD_CDK_SPxxK_3	382	389	PF00069	0.511
MOD_CDK_SPxxK_3	66	73	PF00069	0.561
MOD_CK1_1	185	191	PF00069	0.598
MOD_CK1_1	32	38	PF00069	0.604
MOD_CK1_1	379	385	PF00069	0.679
MOD_CK1_1	393	399	PF00069	0.569
MOD_CK1_1	508	514	PF00069	0.522
MOD_CK1_1	56	62	PF00069	0.576
MOD_CK1_1	589	595	PF00069	0.519
MOD_CK1_1	616	622	PF00069	0.593
MOD_CK1_1	627	633	PF00069	0.545
MOD_CK1_1	7	13	PF00069	0.736
MOD_CK1_1	82	88	PF00069	0.728
MOD_CK1_1	90	96	PF00069	0.679
MOD_CK2_1	132	138	PF00069	0.615
MOD_CK2_1	154	160	PF00069	0.556
MOD_CK2_1	192	198	PF00069	0.577
MOD_CK2_1	363	369	PF00069	0.607
MOD_CK2_1	555	561	PF00069	0.545
MOD_DYRK1A_RPxSP_1	20	24	PF00069	0.556
MOD_GlcNHglycan	173	176	PF01048	0.377
MOD_GlcNHglycan	29	32	PF01048	0.782
MOD_GlcNHglycan	347	350	PF01048	0.483
MOD_GlcNHglycan	378	381	PF01048	0.728
MOD_GlcNHglycan	499	503	PF01048	0.589
MOD_GlcNHglycan	511	514	PF01048	0.519
MOD_GlcNHglycan	594	597	PF01048	0.630
MOD_GlcNHglycan	618	621	PF01048	0.583
MOD_GSK3_1	120	127	PF00069	0.752
MOD_GSK3_1	167	174	PF00069	0.580
MOD_GSK3_1	210	217	PF00069	0.597
MOD_GSK3_1	3	10	PF00069	0.720
MOD_GSK3_1	359	366	PF00069	0.654
MOD_GSK3_1	403	410	PF00069	0.668
MOD_GSK3_1	489	496	PF00069	0.712
MOD_GSK3_1	505	512	PF00069	0.627
MOD_GSK3_1	53	60	PF00069	0.654
MOD_GSK3_1	570	577	PF00069	0.640
MOD_GSK3_1	609	616	PF00069	0.553
MOD_GSK3_1	79	86	PF00069	0.670
MOD_GSK3_1	90	97	PF00069	0.725
MOD_N-GLC_1	342	347	PF02516	0.471
MOD_N-GLC_1	41	46	PF02516	0.593
MOD_N-GLC_1	56	61	PF02516	0.681
MOD_N-GLC_1	640	645	PF02516	0.500
MOD_N-GLC_1	90	95	PF02516	0.727
MOD_N-GLC_2	381	383	PF02516	0.520
MOD_NEK2_1	142	147	PF00069	0.607
MOD_NEK2_1	246	251	PF00069	0.602
MOD_NEK2_1	342	347	PF00069	0.467
MOD_NEK2_1	353	358	PF00069	0.528
MOD_NEK2_1	4	9	PF00069	0.742
MOD_NEK2_1	509	514	PF00069	0.691
MOD_NEK2_1	516	521	PF00069	0.532
MOD_NEK2_1	586	591	PF00069	0.695
MOD_NEK2_2	199	204	PF00069	0.441
MOD_NEK2_2	307	312	PF00069	0.393
MOD_NEK2_2	505	510	PF00069	0.592
MOD_PIKK_1	154	160	PF00454	0.556
MOD_PIKK_1	489	495	PF00454	0.706
MOD_PIKK_1	516	522	PF00454	0.692
MOD_PIKK_1	535	541	PF00454	0.588
MOD_PK_1	214	220	PF00069	0.648
MOD_PKA_2	121	127	PF00069	0.632
MOD_PKA_2	191	197	PF00069	0.614
MOD_PKA_2	199	205	PF00069	0.545
MOD_PKA_2	221	227	PF00069	0.659
MOD_PKA_2	353	359	PF00069	0.719
MOD_PKA_2	364	370	PF00069	0.629
MOD_PKA_2	95	101	PF00069	0.730
MOD_PKB_1	101	109	PF00069	0.588
MOD_PKB_1	352	360	PF00069	0.533
MOD_PKB_1	363	371	PF00069	0.541
MOD_Plk_1	276	282	PF00069	0.441
MOD_Plk_1	342	348	PF00069	0.468
MOD_Plk_1	396	402	PF00069	0.699
MOD_Plk_1	407	413	PF00069	0.587
MOD_Plk_1	489	495	PF00069	0.560
MOD_Plk_1	555	561	PF00069	0.502
MOD_Plk_1	640	646	PF00069	0.500
MOD_Plk_4	167	173	PF00069	0.592
MOD_Plk_4	276	282	PF00069	0.441
MOD_Plk_4	29	35	PF00069	0.742
MOD_Plk_4	407	413	PF00069	0.574
MOD_Plk_4	448	454	PF00069	0.519
MOD_Plk_4	493	499	PF00069	0.715
MOD_Plk_4	505	511	PF00069	0.559
MOD_Plk_4	640	646	PF00069	0.709
MOD_ProDKin_1	20	26	PF00069	0.756
MOD_ProDKin_1	270	276	PF00069	0.577
MOD_ProDKin_1	32	38	PF00069	0.591
MOD_ProDKin_1	367	373	PF00069	0.745
MOD_ProDKin_1	382	388	PF00069	0.509
MOD_ProDKin_1	416	422	PF00069	0.713
MOD_ProDKin_1	461	467	PF00069	0.571
MOD_ProDKin_1	58	64	PF00069	0.684
MOD_ProDKin_1	609	615	PF00069	0.623
MOD_ProDKin_1	624	630	PF00069	0.612
MOD_ProDKin_1	66	72	PF00069	0.638
TRG_DiLeu_BaLyEn_6	279	284	PF01217	0.577
TRG_ENDOCYTIC_2	260	263	PF00928	0.556
TRG_ENDOCYTIC_2	415	418	PF00928	0.717
TRG_ENDOCYTIC_2	551	554	PF00928	0.513
TRG_ER_diArg_1	110	113	PF00400	0.582
TRG_ER_diArg_1	351	354	PF00400	0.698
TRG_NES_CRM1_1	278	292	PF08389	0.577
TRG_NLS_Bipartite_1	222	237	PF00514	0.618
TRG_NLS_MonoExtC_3	349	354	PF00514	0.502
TRG_NLS_MonoExtN_4	118	123	PF00514	0.775

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3Q8IIS4	Leishmania donovani	63%	98%
A4I4J6	Leishmania infantum	63%	98%
E9ADZ5	Leishmania major	63%	100%
E9ALT6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	62%	97%