Putative RNA binding protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

LYAR-type C2HC zinc finger, putative

Species:

Leishmania braziliensis

UniProt:

A4HHF1_LEIBR

TriTrypDb:

LbrM.29.1480 , LBRM2903_290021700

Length:

287

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	7
GO:0043226	organelle	2	8
GO:0043227	membrane-bounded organelle	3	7
GO:0043229	intracellular organelle	3	8
GO:0043231	intracellular membrane-bounded organelle	4	7
GO:0110165	cellular anatomical entity	1	8
GO:0005730	nucleolus	5	1
GO:0043228	non-membrane-bounded organelle	3	1
GO:0043232	intracellular non-membrane-bounded organelle	4	1

Expansion

Sequence features

A4HHF1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HHF1

Function

Biological processes
Term	Name	Level	Count
GO:0000122	negative regulation of transcription by RNA polymerase II	8	1
GO:0006139	nucleobase-containing compound metabolic process	3	1
GO:0006355	regulation of DNA-templated transcription	6	1
GO:0006357	regulation of transcription by RNA polymerase II	7	1
GO:0006364	rRNA processing	8	1
GO:0006396	RNA processing	6	1
GO:0006725	cellular aromatic compound metabolic process	3	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0009889	regulation of biosynthetic process	4	1
GO:0009890	negative regulation of biosynthetic process	5	1
GO:0009892	negative regulation of metabolic process	4	1
GO:0009987	cellular process	1	1
GO:0010468	regulation of gene expression	5	1
GO:0010556	regulation of macromolecule biosynthetic process	5	1
GO:0010558	negative regulation of macromolecule biosynthetic process	6	1
GO:0010605	negative regulation of macromolecule metabolic process	5	1
GO:0016070	RNA metabolic process	5	1
GO:0016072	rRNA metabolic process	7	1
GO:0019219	regulation of nucleobase-containing compound metabolic process	5	1
GO:0019222	regulation of metabolic process	3	1
GO:0031323	regulation of cellular metabolic process	4	1
GO:0031324	negative regulation of cellular metabolic process	5	1
GO:0031326	regulation of cellular biosynthetic process	5	1
GO:0031327	negative regulation of cellular biosynthetic process	6	1
GO:0034470	ncRNA processing	7	1
GO:0034641	cellular nitrogen compound metabolic process	3	1
GO:0034660	ncRNA metabolic process	6	1
GO:0043170	macromolecule metabolic process	3	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0045892	negative regulation of DNA-templated transcription	7	1
GO:0045934	negative regulation of nucleobase-containing compound metabolic process	6	1
GO:0046483	heterocycle metabolic process	3	1
GO:0048519	negative regulation of biological process	3	1
GO:0048523	negative regulation of cellular process	4	1
GO:0050789	regulation of biological process	2	1
GO:0050794	regulation of cellular process	3	1
GO:0051171	regulation of nitrogen compound metabolic process	4	1
GO:0051172	negative regulation of nitrogen compound metabolic process	5	1
GO:0051252	regulation of RNA metabolic process	5	1
GO:0051253	negative regulation of RNA metabolic process	6	1
GO:0060255	regulation of macromolecule metabolic process	4	1
GO:0065007	biological regulation	1	1
GO:0071704	organic substance metabolic process	2	1
GO:0080090	regulation of primary metabolic process	4	1
GO:0090304	nucleic acid metabolic process	4	1
GO:1901360	organic cyclic compound metabolic process	3	1
GO:1902679	negative regulation of RNA biosynthetic process	7	1
GO:1903506	regulation of nucleic acid-templated transcription	7	1
GO:1903507	negative regulation of nucleic acid-templated transcription	8	1
GO:2001141	regulation of RNA biosynthetic process	6	1

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	9
GO:0043167	ion binding	2	8
GO:0043169	cation binding	3	8
GO:0046872	metal ion binding	4	8
GO:0003676	nucleic acid binding	3	7
GO:0003677	DNA binding	4	7
GO:0097159	organic cyclic compound binding	2	7
GO:1901363	heterocyclic compound binding	2	7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	100	102	PF00675	0.663
CLV_NRD_NRD_1	72	74	PF00675	0.634
CLV_PCSK_KEX2_1	257	259	PF00082	0.518
CLV_PCSK_KEX2_1	72	74	PF00082	0.584
CLV_PCSK_PC1ET2_1	257	259	PF00082	0.536
CLV_PCSK_SKI1_1	121	125	PF00082	0.743
CLV_PCSK_SKI1_1	133	137	PF00082	0.672
CLV_PCSK_SKI1_1	254	258	PF00082	0.617
DEG_Nend_UBRbox_1	1	4	PF02207	0.210
DEG_SCF_TRCP1_1	236	241	PF00400	0.429
DOC_MAPK_gen_1	101	110	PF00069	0.703
DOC_MAPK_MEF2A_6	101	110	PF00069	0.807
DOC_PP2B_LxvP_1	202	205	PF13499	0.604
DOC_USP7_MATH_1	106	110	PF00917	0.550
DOC_USP7_MATH_1	137	141	PF00917	0.620
DOC_USP7_MATH_1	270	274	PF00917	0.537
DOC_USP7_MATH_1	81	85	PF00917	0.699
DOC_USP7_MATH_1	93	97	PF00917	0.641
DOC_USP7_UBL2_3	21	25	PF12436	0.559
DOC_USP7_UBL2_3	245	249	PF12436	0.594
DOC_USP7_UBL2_3	257	261	PF12436	0.456
DOC_WW_Pin1_4	141	146	PF00397	0.667
DOC_WW_Pin1_4	157	162	PF00397	0.705
DOC_WW_Pin1_4	197	202	PF00397	0.664
LIG_14-3-3_CanoR_1	105	111	PF00244	0.627
LIG_14-3-3_CanoR_1	206	210	PF00244	0.639
LIG_14-3-3_CanoR_1	258	264	PF00244	0.533
LIG_14-3-3_CanoR_1	35	43	PF00244	0.637
LIG_FHA_1	198	204	PF00498	0.651
LIG_FHA_1	242	248	PF00498	0.631
LIG_FHA_2	15	21	PF00498	0.345
LIG_FHA_2	220	226	PF00498	0.617
LIG_MAD2	35	43	PF02301	0.567
LIG_MYND_1	201	205	PF01753	0.650
LIG_SH2_STAP1	255	259	PF00017	0.466
LIG_SH3_3	124	130	PF00018	0.771
LIG_SH3_3	151	157	PF00018	0.610
LIG_SH3_3	189	195	PF00018	0.799
LIG_TRAF2_1	17	20	PF00917	0.507
LIG_TRAF2_1	222	225	PF00917	0.638
LIG_WRC_WIRS_1	215	220	PF05994	0.538
MOD_CDK_SPxxK_3	141	148	PF00069	0.569
MOD_CK1_1	109	115	PF00069	0.587
MOD_CK1_1	14	20	PF00069	0.345
MOD_CK1_1	237	243	PF00069	0.558
MOD_CK1_1	280	286	PF00069	0.433
MOD_CK1_1	31	37	PF00069	0.601
MOD_CK2_1	14	20	PF00069	0.404
MOD_CK2_1	219	225	PF00069	0.543
MOD_CK2_1	57	63	PF00069	0.614
MOD_GlcNHglycan	139	142	PF01048	0.684
MOD_GlcNHglycan	236	239	PF01048	0.614
MOD_GlcNHglycan	272	275	PF01048	0.550
MOD_GlcNHglycan	38	41	PF01048	0.629
MOD_GlcNHglycan	83	86	PF01048	0.721
MOD_GlcNHglycan	95	98	PF01048	0.700
MOD_GSK3_1	10	17	PF00069	0.345
MOD_GSK3_1	106	113	PF00069	0.648
MOD_GSK3_1	137	144	PF00069	0.628
MOD_GSK3_1	234	241	PF00069	0.558
MOD_GSK3_1	280	287	PF00069	0.478
MOD_GSK3_1	58	65	PF00069	0.646
MOD_GSK3_1	81	88	PF00069	0.639
MOD_N-GLC_1	234	239	PF02516	0.414
MOD_N-GLC_1	31	36	PF02516	0.568
MOD_NEK2_1	234	239	PF00069	0.606
MOD_NEK2_2	238	243	PF00069	0.511
MOD_NEK2_2	95	100	PF00069	0.588
MOD_PKA_1	169	175	PF00069	0.832
MOD_PKA_2	205	211	PF00069	0.638
MOD_Plk_1	115	121	PF00069	0.620
MOD_Plk_2-3	62	68	PF00069	0.778
MOD_Plk_4	214	220	PF00069	0.540
MOD_Plk_4	95	101	PF00069	0.588
MOD_ProDKin_1	141	147	PF00069	0.665
MOD_ProDKin_1	157	163	PF00069	0.709
MOD_ProDKin_1	197	203	PF00069	0.664
TRG_DiLeu_BaEn_3	224	230	PF01217	0.617
TRG_DiLeu_LyEn_5	198	203	PF01217	0.536
TRG_NLS_Bipartite_1	120	137	PF00514	0.564
TRG_NLS_MonoExtN_4	130	137	PF00514	0.651
TRG_Pf-PMV_PEXEL_1	249	253	PF00026	0.513

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PGN4	Leptomonas seymouri	50%	97%
A0A3Q8IRD2	Leishmania donovani	66%	91%
A4HHF0	Leishmania braziliensis	99%	100%
A4I4K0	Leishmania infantum	67%	91%
C9ZL83	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	33%	96%
E9ADZ9	Leishmania major	69%	100%
E9ALT2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	66%	91%