Putative RNA binding protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

LYAR-type C2HC zinc finger, putative

Species:

Leishmania braziliensis

UniProt:

A4HHF0_LEIBR

TriTrypDb:

LbrM.29.1470 , LBRM2903_290021700

Length:

322

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	7
GO:0043226	organelle	2	8
GO:0043227	membrane-bounded organelle	3	7
GO:0043229	intracellular organelle	3	8
GO:0043231	intracellular membrane-bounded organelle	4	7
GO:0110165	cellular anatomical entity	1	8
GO:0005730	nucleolus	5	1
GO:0043228	non-membrane-bounded organelle	3	1
GO:0043232	intracellular non-membrane-bounded organelle	4	1

Expansion

Sequence features

A4HHF0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HHF0

Function

Biological processes
Term	Name	Level	Count
GO:0000122	negative regulation of transcription by RNA polymerase II	8	1
GO:0006139	nucleobase-containing compound metabolic process	3	1
GO:0006355	regulation of DNA-templated transcription	6	1
GO:0006357	regulation of transcription by RNA polymerase II	7	1
GO:0006364	rRNA processing	8	1
GO:0006396	RNA processing	6	1
GO:0006725	cellular aromatic compound metabolic process	3	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0009889	regulation of biosynthetic process	4	1
GO:0009890	negative regulation of biosynthetic process	5	1
GO:0009892	negative regulation of metabolic process	4	1
GO:0009987	cellular process	1	1
GO:0010468	regulation of gene expression	5	1
GO:0010556	regulation of macromolecule biosynthetic process	5	1
GO:0010558	negative regulation of macromolecule biosynthetic process	6	1
GO:0010605	negative regulation of macromolecule metabolic process	5	1
GO:0016070	RNA metabolic process	5	1
GO:0016072	rRNA metabolic process	7	1
GO:0019219	regulation of nucleobase-containing compound metabolic process	5	1
GO:0019222	regulation of metabolic process	3	1
GO:0031323	regulation of cellular metabolic process	4	1
GO:0031324	negative regulation of cellular metabolic process	5	1
GO:0031326	regulation of cellular biosynthetic process	5	1
GO:0031327	negative regulation of cellular biosynthetic process	6	1
GO:0034470	ncRNA processing	7	1
GO:0034641	cellular nitrogen compound metabolic process	3	1
GO:0034660	ncRNA metabolic process	6	1
GO:0043170	macromolecule metabolic process	3	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0045892	negative regulation of DNA-templated transcription	7	1
GO:0045934	negative regulation of nucleobase-containing compound metabolic process	6	1
GO:0046483	heterocycle metabolic process	3	1
GO:0048519	negative regulation of biological process	3	1
GO:0048523	negative regulation of cellular process	4	1
GO:0050789	regulation of biological process	2	1
GO:0050794	regulation of cellular process	3	1
GO:0051171	regulation of nitrogen compound metabolic process	4	1
GO:0051172	negative regulation of nitrogen compound metabolic process	5	1
GO:0051252	regulation of RNA metabolic process	5	1
GO:0051253	negative regulation of RNA metabolic process	6	1
GO:0060255	regulation of macromolecule metabolic process	4	1
GO:0065007	biological regulation	1	1
GO:0071704	organic substance metabolic process	2	1
GO:0080090	regulation of primary metabolic process	4	1
GO:0090304	nucleic acid metabolic process	4	1
GO:1901360	organic cyclic compound metabolic process	3	1
GO:1902679	negative regulation of RNA biosynthetic process	7	1
GO:1903506	regulation of nucleic acid-templated transcription	7	1
GO:1903507	negative regulation of nucleic acid-templated transcription	8	1
GO:2001141	regulation of RNA biosynthetic process	6	1

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	8
GO:0003677	DNA binding	4	8
GO:0005488	binding	1	9
GO:0043167	ion binding	2	8
GO:0043169	cation binding	3	8
GO:0046872	metal ion binding	4	8
GO:0097159	organic cyclic compound binding	2	8
GO:1901363	heterocyclic compound binding	2	8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	107	109	PF00675	0.606
CLV_NRD_NRD_1	135	137	PF00675	0.636
CLV_PCSK_KEX2_1	107	109	PF00082	0.555
CLV_PCSK_KEX2_1	292	294	PF00082	0.514
CLV_PCSK_PC1ET2_1	292	294	PF00082	0.514
CLV_PCSK_SKI1_1	156	160	PF00082	0.723
CLV_PCSK_SKI1_1	168	172	PF00082	0.645
CLV_PCSK_SKI1_1	289	293	PF00082	0.501
DEG_SCF_TRCP1_1	271	276	PF00400	0.400
DOC_MAPK_gen_1	136	145	PF00069	0.676
DOC_MAPK_MEF2A_6	136	145	PF00069	0.697
DOC_PP2B_LxvP_1	237	240	PF13499	0.578
DOC_USP7_MATH_1	116	120	PF00917	0.662
DOC_USP7_MATH_1	128	132	PF00917	0.587
DOC_USP7_MATH_1	141	145	PF00917	0.530
DOC_USP7_MATH_1	172	176	PF00917	0.607
DOC_USP7_MATH_1	305	309	PF00917	0.467
DOC_USP7_UBL2_3	280	284	PF12436	0.612
DOC_USP7_UBL2_3	292	296	PF12436	0.387
DOC_USP7_UBL2_3	56	60	PF12436	0.500
DOC_WW_Pin1_4	176	181	PF00397	0.677
DOC_WW_Pin1_4	192	197	PF00397	0.704
DOC_WW_Pin1_4	232	237	PF00397	0.650
LIG_14-3-3_CanoR_1	140	146	PF00244	0.575
LIG_14-3-3_CanoR_1	241	245	PF00244	0.599
LIG_14-3-3_CanoR_1	293	299	PF00244	0.505
LIG_14-3-3_CanoR_1	70	78	PF00244	0.591
LIG_FHA_1	233	239	PF00498	0.634
LIG_FHA_1	277	283	PF00498	0.529
LIG_FHA_2	255	261	PF00498	0.515
LIG_FHA_2	29	35	PF00498	0.366
LIG_FHA_2	50	56	PF00498	0.308
LIG_LIR_Gen_1	28	38	PF02991	0.334
LIG_LIR_Nem_3	28	33	PF02991	0.334
LIG_MAD2	70	78	PF02301	0.516
LIG_MYND_1	236	240	PF01753	0.629
LIG_SH2_STAP1	290	294	PF00017	0.440
LIG_SH2_STAT5	8	11	PF00017	0.464
LIG_SH3_3	10	16	PF00018	0.390
LIG_SH3_3	159	165	PF00018	0.703
LIG_SH3_3	186	192	PF00018	0.663
LIG_SH3_3	224	230	PF00018	0.806
LIG_SH3_4	15	22	PF00018	0.437
LIG_TRAF2_1	257	260	PF00917	0.519
LIG_TRAF2_1	52	55	PF00917	0.389
LIG_WRC_WIRS_1	1	6	PF05994	0.348
LIG_WRC_WIRS_1	250	255	PF05994	0.495
MOD_CDK_SPxxK_3	176	183	PF00069	0.549
MOD_CK1_1	144	150	PF00069	0.569
MOD_CK1_1	272	278	PF00069	0.551
MOD_CK1_1	315	321	PF00069	0.410
MOD_CK1_1	49	55	PF00069	0.337
MOD_CK1_1	66	72	PF00069	0.552
MOD_CK2_1	254	260	PF00069	0.506
MOD_CK2_1	49	55	PF00069	0.367
MOD_CK2_1	92	98	PF00069	0.551
MOD_GlcNHglycan	118	121	PF01048	0.695
MOD_GlcNHglycan	130	133	PF01048	0.775
MOD_GlcNHglycan	174	177	PF01048	0.660
MOD_GlcNHglycan	271	274	PF01048	0.549
MOD_GlcNHglycan	307	310	PF01048	0.502
MOD_GlcNHglycan	73	76	PF01048	0.647
MOD_GSK3_1	116	123	PF00069	0.593
MOD_GSK3_1	141	148	PF00069	0.696
MOD_GSK3_1	172	179	PF00069	0.637
MOD_GSK3_1	269	276	PF00069	0.572
MOD_GSK3_1	315	322	PF00069	0.539
MOD_GSK3_1	45	52	PF00069	0.339
MOD_GSK3_1	93	100	PF00069	0.665
MOD_N-GLC_1	269	274	PF02516	0.383
MOD_N-GLC_1	66	71	PF02516	0.523
MOD_N-GLC_2	23	25	PF02516	0.389
MOD_N-GLC_2	7	9	PF02516	0.458
MOD_NEK2_1	269	274	PF00069	0.507
MOD_NEK2_2	130	135	PF00069	0.556
MOD_NEK2_2	273	278	PF00069	0.484
MOD_OFUCOSY	25	32	PF10250	0.420
MOD_PKA_1	204	210	PF00069	0.716
MOD_PKA_2	240	246	PF00069	0.600
MOD_Plk_1	150	156	PF00069	0.588
MOD_Plk_2-3	97	103	PF00069	0.664
MOD_Plk_4	130	136	PF00069	0.596
MOD_Plk_4	249	255	PF00069	0.497
MOD_ProDKin_1	176	182	PF00069	0.677
MOD_ProDKin_1	192	198	PF00069	0.709
MOD_ProDKin_1	232	238	PF00069	0.650
TRG_DiLeu_BaEn_3	259	265	PF01217	0.503
TRG_DiLeu_LyEn_5	233	238	PF01217	0.520
TRG_NLS_Bipartite_1	155	172	PF00514	0.535
TRG_NLS_MonoCore_2	13	18	PF00514	0.379
TRG_NLS_MonoExtN_4	165	172	PF00514	0.621
TRG_Pf-PMV_PEXEL_1	284	288	PF00026	0.488

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PGN4	Leptomonas seymouri	53%	100%
A0A3Q8IRD2	Leishmania donovani	70%	100%
A4HHF1	Leishmania braziliensis	99%	100%
A4I4K0	Leishmania infantum	71%	100%
C9ZL83	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	36%	100%
E9ADZ9	Leishmania major	72%	98%
E9ALT2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	70%	100%