Putative RNA binding protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

RNA binding protein, putative

Species:

Leishmania braziliensis

UniProt:

A4HHE9_LEIBR

TriTrypDb:

LbrM.29.1460 , LBRM2903_290021600

Length:

784

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Cellular components
Term	Name	Level	Count
GO:0032991	protein-containing complex	1	1
GO:1990904	ribonucleoprotein complex	2	1

Expansion

Sequence features

A4HHE9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HHE9

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	6
GO:0003723	RNA binding	4	6
GO:0005488	binding	1	6
GO:0097159	organic cyclic compound binding	2	6
GO:1901363	heterocyclic compound binding	2	6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	339	343	PF00656	0.510
CLV_C14_Caspase3-7	498	502	PF00656	0.539
CLV_C14_Caspase3-7	532	536	PF00656	0.534
CLV_NRD_NRD_1	322	324	PF00675	0.634
CLV_NRD_NRD_1	437	439	PF00675	0.805
CLV_NRD_NRD_1	485	487	PF00675	0.590
CLV_NRD_NRD_1	663	665	PF00675	0.650
CLV_PCSK_FUR_1	483	487	PF00082	0.565
CLV_PCSK_KEX2_1	322	324	PF00082	0.634
CLV_PCSK_KEX2_1	437	439	PF00082	0.805
CLV_PCSK_KEX2_1	485	487	PF00082	0.590
CLV_PCSK_KEX2_1	663	665	PF00082	0.650
CLV_PCSK_SKI1_1	129	133	PF00082	0.363
CLV_PCSK_SKI1_1	151	155	PF00082	0.424
CLV_PCSK_SKI1_1	157	161	PF00082	0.475
CLV_PCSK_SKI1_1	437	441	PF00082	0.523
CLV_PCSK_SKI1_1	485	489	PF00082	0.563
CLV_PCSK_SKI1_1	99	103	PF00082	0.405
DEG_APCC_DBOX_1	160	168	PF00400	0.404
DEG_ODPH_VHL_1	434	447	PF01847	0.533
DEG_SCF_FBW7_1	393	400	PF00400	0.518
DEG_SCF_FBW7_1	559	566	PF00400	0.541
DEG_SCF_FBW7_2	563	570	PF00400	0.550
DEG_SPOP_SBC_1	446	450	PF00917	0.553
DEG_SPOP_SBC_1	677	681	PF00917	0.527
DOC_CKS1_1	168	173	PF01111	0.579
DOC_CKS1_1	458	463	PF01111	0.688
DOC_CKS1_1	564	569	PF01111	0.684
DOC_CYCLIN_yCln2_LP_2	488	491	PF00134	0.547
DOC_MAPK_DCC_7	485	495	PF00069	0.711
DOC_MAPK_gen_1	155	164	PF00069	0.599
DOC_MAPK_gen_1	724	731	PF00069	0.542
DOC_MAPK_MEF2A_6	486	495	PF00069	0.575
DOC_PP2B_LxvP_1	488	491	PF13499	0.547
DOC_PP4_FxxP_1	250	253	PF00568	0.535
DOC_USP7_MATH_1	216	220	PF00917	0.333
DOC_USP7_MATH_1	24	28	PF00917	0.785
DOC_USP7_MATH_1	262	266	PF00917	0.730
DOC_USP7_MATH_1	267	271	PF00917	0.587
DOC_USP7_MATH_1	299	303	PF00917	0.550
DOC_USP7_MATH_1	349	353	PF00917	0.670
DOC_USP7_MATH_1	441	445	PF00917	0.561
DOC_USP7_MATH_1	462	466	PF00917	0.530
DOC_USP7_MATH_1	497	501	PF00917	0.697
DOC_USP7_MATH_1	512	516	PF00917	0.542
DOC_USP7_MATH_1	548	552	PF00917	0.555
DOC_USP7_MATH_1	616	620	PF00917	0.641
DOC_USP7_MATH_1	626	630	PF00917	0.636
DOC_USP7_MATH_1	639	643	PF00917	0.512
DOC_USP7_MATH_1	94	98	PF00917	0.545
DOC_WW_Pin1_4	167	172	PF00397	0.588
DOC_WW_Pin1_4	20	25	PF00397	0.695
DOC_WW_Pin1_4	249	254	PF00397	0.643
DOC_WW_Pin1_4	263	268	PF00397	0.547
DOC_WW_Pin1_4	295	300	PF00397	0.502
DOC_WW_Pin1_4	353	358	PF00397	0.663
DOC_WW_Pin1_4	393	398	PF00397	0.559
DOC_WW_Pin1_4	415	420	PF00397	0.643
DOC_WW_Pin1_4	43	48	PF00397	0.532
DOC_WW_Pin1_4	457	462	PF00397	0.599
DOC_WW_Pin1_4	469	474	PF00397	0.584
DOC_WW_Pin1_4	508	513	PF00397	0.672
DOC_WW_Pin1_4	533	538	PF00397	0.631
DOC_WW_Pin1_4	559	564	PF00397	0.568
DOC_WW_Pin1_4	622	627	PF00397	0.542
DOC_WW_Pin1_4	702	707	PF00397	0.548
DOC_WW_Pin1_4	719	724	PF00397	0.608
DOC_WW_Pin1_4	747	752	PF00397	0.568
DOC_WW_Pin1_4	776	781	PF00397	0.671
LIG_14-3-3_CanoR_1	124	132	PF00244	0.473
LIG_14-3-3_CanoR_1	163	168	PF00244	0.591
LIG_14-3-3_CanoR_1	322	331	PF00244	0.478
LIG_14-3-3_CanoR_1	391	397	PF00244	0.637
LIG_14-3-3_CanoR_1	504	513	PF00244	0.554
LIG_14-3-3_CanoR_1	544	553	PF00244	0.557
LIG_14-3-3_CanoR_1	557	562	PF00244	0.507
LIG_14-3-3_CanoR_1	667	677	PF00244	0.530
LIG_14-3-3_CanoR_1	724	732	PF00244	0.537
LIG_APCC_ABBA_1	227	232	PF00400	0.501
LIG_BRCT_BRCA1_1	464	468	PF00533	0.542
LIG_FHA_1	140	146	PF00498	0.546
LIG_FHA_1	221	227	PF00498	0.335
LIG_FHA_1	3	9	PF00498	0.679
LIG_FHA_1	33	39	PF00498	0.684
LIG_FHA_1	394	400	PF00498	0.536
LIG_FHA_1	448	454	PF00498	0.577
LIG_FHA_1	508	514	PF00498	0.556
LIG_FHA_1	564	570	PF00498	0.651
LIG_FHA_1	87	93	PF00498	0.374
LIG_FHA_2	107	113	PF00498	0.546
LIG_FHA_2	136	142	PF00498	0.460
LIG_FHA_2	208	214	PF00498	0.500
LIG_FHA_2	240	246	PF00498	0.581
LIG_FHA_2	255	261	PF00498	0.791
LIG_FHA_2	278	284	PF00498	0.472
LIG_FHA_2	296	302	PF00498	0.567
LIG_FHA_2	337	343	PF00498	0.510
LIG_FHA_2	473	479	PF00498	0.555
LIG_FHA_2	496	502	PF00498	0.540
LIG_IBAR_NPY_1	764	766	PF08397	0.672
LIG_LIR_Apic_2	671	677	PF02991	0.538
LIG_LIR_Gen_1	117	126	PF02991	0.611
LIG_LIR_Gen_1	141	150	PF02991	0.546
LIG_LIR_Gen_1	232	241	PF02991	0.468
LIG_LIR_Gen_1	429	439	PF02991	0.529
LIG_LIR_Gen_1	465	473	PF02991	0.549
LIG_LIR_Gen_1	71	80	PF02991	0.513
LIG_LIR_Nem_3	109	113	PF02991	0.467
LIG_LIR_Nem_3	117	122	PF02991	0.522
LIG_LIR_Nem_3	141	147	PF02991	0.546
LIG_LIR_Nem_3	219	224	PF02991	0.485
LIG_LIR_Nem_3	232	237	PF02991	0.464
LIG_LIR_Nem_3	429	434	PF02991	0.536
LIG_LIR_Nem_3	558	564	PF02991	0.646
LIG_LIR_Nem_3	602	608	PF02991	0.671
LIG_LIR_Nem_3	71	76	PF02991	0.636
LIG_MYND_1	685	689	PF01753	0.644
LIG_PCNA_yPIPBox_3	211	220	PF02747	0.340
LIG_Pex14_2	217	221	PF04695	0.477
LIG_PTB_Apo_2	228	235	PF02174	0.387
LIG_PTB_Apo_2	760	767	PF02174	0.691
LIG_PTB_Phospho_1	228	234	PF10480	0.380
LIG_PTB_Phospho_1	760	766	PF10480	0.695
LIG_REV1ctd_RIR_1	157	167	PF16727	0.521
LIG_SH2_CRK	234	238	PF00017	0.534
LIG_SH2_CRK	331	335	PF00017	0.501
LIG_SH2_CRK	556	560	PF00017	0.618
LIG_SH2_CRK	561	565	PF00017	0.637
LIG_SH2_CRK	777	781	PF00017	0.513
LIG_SH2_NCK_1	331	335	PF00017	0.501
LIG_SH2_NCK_1	350	354	PF00017	0.626
LIG_SH2_NCK_1	520	524	PF00017	0.532
LIG_SH2_SRC	634	637	PF00017	0.522
LIG_SH2_SRC	674	677	PF00017	0.542
LIG_SH2_STAP1	350	354	PF00017	0.626
LIG_SH2_STAP1	766	770	PF00017	0.677
LIG_SH2_STAT3	389	392	PF00017	0.559
LIG_SH2_STAT3	412	415	PF00017	0.683
LIG_SH2_STAT3	577	580	PF00017	0.538
LIG_SH2_STAT3	693	696	PF00017	0.549
LIG_SH2_STAT5	561	564	PF00017	0.674
LIG_SH3_3	165	171	PF00018	0.608
LIG_SH3_3	18	24	PF00018	0.536
LIG_SH3_3	235	241	PF00018	0.628
LIG_SH3_3	417	423	PF00018	0.662
LIG_SH3_3	455	461	PF00018	0.697
LIG_SH3_3	484	490	PF00018	0.619
LIG_SH3_3	531	537	PF00018	0.555
LIG_SH3_3	561	567	PF00018	0.650
LIG_SH3_3	58	64	PF00018	0.490
LIG_SH3_3	620	626	PF00018	0.593
LIG_SH3_3	726	732	PF00018	0.692
LIG_SUMO_SIM_anti_2	223	228	PF11976	0.334
LIG_SUMO_SIM_par_1	222	228	PF11976	0.327
LIG_SUMO_SIM_par_1	88	93	PF11976	0.380
LIG_TRAF2_1	242	245	PF00917	0.532
LIG_TRAF2_1	475	478	PF00917	0.560
LIG_TYR_ITIM	559	564	PF00017	0.537
LIG_WRC_WIRS_1	278	283	PF05994	0.467
LIG_WW_1	517	520	PF00397	0.524
MOD_CDK_SPK_2	719	724	PF00069	0.535
MOD_CDK_SPxxK_3	719	726	PF00069	0.599
MOD_CK1_1	139	145	PF00069	0.546
MOD_CK1_1	166	172	PF00069	0.610
MOD_CK1_1	207	213	PF00069	0.366
MOD_CK1_1	225	231	PF00069	0.459
MOD_CK1_1	251	257	PF00069	0.691
MOD_CK1_1	27	33	PF00069	0.671
MOD_CK1_1	336	342	PF00069	0.578
MOD_CK1_1	348	354	PF00069	0.756
MOD_CK1_1	422	428	PF00069	0.706
MOD_CK1_1	46	52	PF00069	0.711
MOD_CK1_1	469	475	PF00069	0.639
MOD_CK1_1	508	514	PF00069	0.650
MOD_CK1_1	529	535	PF00069	0.551
MOD_CK1_1	54	60	PF00069	0.637
MOD_CK1_1	546	552	PF00069	0.672
MOD_CK1_1	627	633	PF00069	0.682
MOD_CK1_1	716	722	PF00069	0.614
MOD_CK1_1	746	752	PF00069	0.626
MOD_CK2_1	135	141	PF00069	0.460
MOD_CK2_1	239	245	PF00069	0.667
MOD_CK2_1	249	255	PF00069	0.752
MOD_CK2_1	262	268	PF00069	0.635
MOD_CK2_1	277	283	PF00069	0.351
MOD_CK2_1	472	478	PF00069	0.553
MOD_CK2_1	78	84	PF00069	0.597
MOD_GlcNHglycan	126	129	PF01048	0.346
MOD_GlcNHglycan	29	32	PF01048	0.690
MOD_GlcNHglycan	314	319	PF01048	0.478
MOD_GlcNHglycan	325	328	PF01048	0.534
MOD_GlcNHglycan	347	350	PF01048	0.650
MOD_GlcNHglycan	351	354	PF01048	0.596
MOD_GlcNHglycan	39	42	PF01048	0.577
MOD_GlcNHglycan	399	402	PF01048	0.686
MOD_GlcNHglycan	415	418	PF01048	0.559
MOD_GlcNHglycan	424	427	PF01048	0.735
MOD_GlcNHglycan	548	551	PF01048	0.711
MOD_GlcNHglycan	55	59	PF01048	0.756
MOD_GlcNHglycan	610	613	PF01048	0.546
MOD_GlcNHglycan	626	629	PF01048	0.625
MOD_GlcNHglycan	66	69	PF01048	0.498
MOD_GlcNHglycan	680	683	PF01048	0.618
MOD_GlcNHglycan	726	729	PF01048	0.703
MOD_GlcNHglycan	743	746	PF01048	0.533
MOD_GlcNHglycan	755	758	PF01048	0.597
MOD_GSK3_1	135	142	PF00069	0.434
MOD_GSK3_1	163	170	PF00069	0.589
MOD_GSK3_1	2	9	PF00069	0.545
MOD_GSK3_1	20	27	PF00069	0.666
MOD_GSK3_1	216	223	PF00069	0.406
MOD_GSK3_1	263	270	PF00069	0.606
MOD_GSK3_1	295	302	PF00069	0.554
MOD_GSK3_1	345	352	PF00069	0.658
MOD_GSK3_1	37	44	PF00069	0.662
MOD_GSK3_1	393	400	PF00069	0.640
MOD_GSK3_1	411	418	PF00069	0.561
MOD_GSK3_1	422	429	PF00069	0.585
MOD_GSK3_1	441	448	PF00069	0.631
MOD_GSK3_1	462	469	PF00069	0.699
MOD_GSK3_1	491	498	PF00069	0.702
MOD_GSK3_1	503	510	PF00069	0.594
MOD_GSK3_1	525	532	PF00069	0.533
MOD_GSK3_1	544	551	PF00069	0.546
MOD_GSK3_1	555	562	PF00069	0.669
MOD_GSK3_1	622	629	PF00069	0.698
MOD_GSK3_1	743	750	PF00069	0.615
MOD_LATS_1	542	548	PF00433	0.562
MOD_N-GLC_1	230	235	PF02516	0.485
MOD_N-GLC_1	295	300	PF02516	0.505
MOD_N-GLC_1	594	599	PF02516	0.525
MOD_N-GLC_1	6	11	PF02516	0.547
MOD_NEK2_1	248	253	PF00069	0.535
MOD_NEK2_1	411	416	PF00069	0.663
MOD_NEK2_1	447	452	PF00069	0.557
MOD_NEK2_1	466	471	PF00069	0.659
MOD_NEK2_1	503	508	PF00069	0.560
MOD_NEK2_1	525	530	PF00069	0.514
MOD_NEK2_1	53	58	PF00069	0.604
MOD_NEK2_1	678	683	PF00069	0.529
MOD_NEK2_2	755	760	PF00069	0.583
MOD_PIKK_1	175	181	PF00454	0.521
MOD_PIKK_1	207	213	PF00454	0.510
MOD_PIKK_1	368	374	PF00454	0.684
MOD_PIKK_1	411	417	PF00454	0.784
MOD_PIKK_1	472	478	PF00454	0.553
MOD_PIKK_1	743	749	PF00454	0.653
MOD_PKA_2	336	342	PF00069	0.535
MOD_PKA_2	503	509	PF00069	0.560
MOD_PKA_2	543	549	PF00069	0.563
MOD_PKA_2	668	674	PF00069	0.532
MOD_PKB_1	161	169	PF00069	0.572
MOD_Plk_1	230	236	PF00069	0.534
MOD_Plk_1	368	374	PF00069	0.527
MOD_Plk_1	406	412	PF00069	0.530
MOD_Plk_1	594	600	PF00069	0.584
MOD_Plk_1	6	12	PF00069	0.549
MOD_Plk_4	222	228	PF00069	0.327
MOD_Plk_4	271	277	PF00069	0.518
MOD_Plk_4	454	460	PF00069	0.681
MOD_Plk_4	462	468	PF00069	0.638
MOD_Plk_4	529	535	PF00069	0.524
MOD_ProDKin_1	167	173	PF00069	0.580
MOD_ProDKin_1	20	26	PF00069	0.695
MOD_ProDKin_1	249	255	PF00069	0.644
MOD_ProDKin_1	263	269	PF00069	0.539
MOD_ProDKin_1	295	301	PF00069	0.512
MOD_ProDKin_1	353	359	PF00069	0.664
MOD_ProDKin_1	393	399	PF00069	0.562
MOD_ProDKin_1	415	421	PF00069	0.644
MOD_ProDKin_1	43	49	PF00069	0.531
MOD_ProDKin_1	457	463	PF00069	0.599
MOD_ProDKin_1	469	475	PF00069	0.586
MOD_ProDKin_1	508	514	PF00069	0.670
MOD_ProDKin_1	533	539	PF00069	0.634
MOD_ProDKin_1	559	565	PF00069	0.570
MOD_ProDKin_1	622	628	PF00069	0.541
MOD_ProDKin_1	702	708	PF00069	0.550
MOD_ProDKin_1	719	725	PF00069	0.609
MOD_ProDKin_1	747	753	PF00069	0.571
MOD_ProDKin_1	776	782	PF00069	0.671
MOD_SUMO_rev_2	207	217	PF00179	0.344
TRG_ENDOCYTIC_2	234	237	PF00928	0.466
TRG_ENDOCYTIC_2	556	559	PF00928	0.622
TRG_ENDOCYTIC_2	561	564	PF00928	0.635
TRG_ER_diArg_1	154	157	PF00400	0.546
TRG_ER_diArg_1	160	163	PF00400	0.444
TRG_ER_diArg_1	322	324	PF00400	0.477
TRG_ER_diArg_1	436	438	PF00400	0.674
TRG_ER_diArg_1	483	486	PF00400	0.659
TRG_ER_diArg_1	663	665	PF00400	0.650

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3Q8IEF2	Leishmania donovani	64%	100%
A4I4J9	Leishmania infantum	64%	100%
E9ADZ8	Leishmania major	63%	98%
E9ALT3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	63%	100%