Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HHE8_LEIBR

TriTrypDb:

LbrM.29.1450 , LBRM2903_290021500

Length:

621

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	1
GO:0005829	cytosol	2	1
GO:0030684	preribosome	3	1
GO:0030688	preribosome, small subunit precursor	4	1
GO:0032991	protein-containing complex	1	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1
GO:1990904	ribonucleoprotein complex	2	1

Expansion

Sequence features

A4HHE8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HHE8

Function

Biological processes
Term	Name	Level	Count
GO:0009987	cellular process	1	8
GO:0022613	ribonucleoprotein complex biogenesis	4	8
GO:0042274	ribosomal small subunit biogenesis	5	8
GO:0044085	cellular component biogenesis	3	8
GO:0071840	cellular component organization or biogenesis	2	8
GO:0000054	ribosomal subunit export from nucleus	3	1
GO:0000056	ribosomal small subunit export from nucleus	4	1
GO:0006810	transport	3	1
GO:0006913	nucleocytoplasmic transport	5	1
GO:0031503	protein-containing complex localization	2	1
GO:0033750	ribosome localization	3	1
GO:0046907	intracellular transport	3	1
GO:0051168	nuclear export	6	1
GO:0051169	nuclear transport	4	1
GO:0051179	localization	1	1
GO:0051234	establishment of localization	2	1
GO:0051640	organelle localization	2	1
GO:0051641	cellular localization	2	1
GO:0051649	establishment of localization in cell	3	1
GO:0051656	establishment of organelle localization	3	1

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	20	24	PF00656	0.625
CLV_C14_Caspase3-7	69	73	PF00656	0.500
CLV_NRD_NRD_1	223	225	PF00675	0.598
CLV_NRD_NRD_1	230	232	PF00675	0.635
CLV_NRD_NRD_1	373	375	PF00675	0.516
CLV_NRD_NRD_1	458	460	PF00675	0.544
CLV_NRD_NRD_1	484	486	PF00675	0.543
CLV_NRD_NRD_1	56	58	PF00675	0.685
CLV_NRD_NRD_1	563	565	PF00675	0.627
CLV_NRD_NRD_1	575	577	PF00675	0.433
CLV_NRD_NRD_1	586	588	PF00675	0.441
CLV_NRD_NRD_1	606	608	PF00675	0.331
CLV_NRD_NRD_1	615	617	PF00675	0.510
CLV_PCSK_FUR_1	228	232	PF00082	0.622
CLV_PCSK_FUR_1	584	588	PF00082	0.538
CLV_PCSK_KEX2_1	222	224	PF00082	0.559
CLV_PCSK_KEX2_1	228	230	PF00082	0.605
CLV_PCSK_KEX2_1	373	375	PF00082	0.526
CLV_PCSK_KEX2_1	484	486	PF00082	0.543
CLV_PCSK_KEX2_1	56	58	PF00082	0.633
CLV_PCSK_KEX2_1	563	565	PF00082	0.579
CLV_PCSK_KEX2_1	575	577	PF00082	0.433
CLV_PCSK_KEX2_1	586	588	PF00082	0.441
CLV_PCSK_KEX2_1	606	608	PF00082	0.331
CLV_PCSK_KEX2_1	615	617	PF00082	0.502
CLV_PCSK_PC7_1	224	230	PF00082	0.582
CLV_PCSK_SKI1_1	10	14	PF00082	0.466
CLV_PCSK_SKI1_1	208	212	PF00082	0.523
CLV_PCSK_SKI1_1	231	235	PF00082	0.478
CLV_PCSK_SKI1_1	299	303	PF00082	0.531
CLV_PCSK_SKI1_1	397	401	PF00082	0.524
CLV_PCSK_SKI1_1	459	463	PF00082	0.635
CLV_PCSK_SKI1_1	535	539	PF00082	0.694
CLV_PCSK_SKI1_1	587	591	PF00082	0.476
CLV_PCSK_SKI1_1	607	611	PF00082	0.328
DEG_SCF_TRCP1_1	540	546	PF00400	0.535
DEG_SPOP_SBC_1	390	394	PF00917	0.519
DEG_SPOP_SBC_1	508	512	PF00917	0.630
DOC_PP1_RVXF_1	614	621	PF00149	0.583
DOC_PP2B_LxvP_1	400	403	PF13499	0.519
DOC_PP4_FxxP_1	123	126	PF00568	0.522
DOC_USP7_MATH_1	124	128	PF00917	0.597
DOC_USP7_MATH_1	340	344	PF00917	0.563
DOC_USP7_MATH_1	381	385	PF00917	0.411
DOC_USP7_MATH_1	390	394	PF00917	0.580
DOC_USP7_MATH_1	489	493	PF00917	0.551
DOC_USP7_MATH_1	508	512	PF00917	0.663
DOC_USP7_UBL2_3	526	530	PF12436	0.643
DOC_USP7_UBL2_3	565	569	PF12436	0.534
DOC_USP7_UBL2_3	590	594	PF12436	0.464
DOC_USP7_UBL2_3	6	10	PF12436	0.534
DOC_WW_Pin1_4	104	109	PF00397	0.774
DOC_WW_Pin1_4	122	127	PF00397	0.764
LIG_14-3-3_CanoR_1	41	49	PF00244	0.479
LIG_14-3-3_CanoR_1	453	461	PF00244	0.613
LIG_14-3-3_CanoR_1	587	597	PF00244	0.523
LIG_14-3-3_CanoR_1	606	613	PF00244	0.523
LIG_14-3-3_CanoR_1	615	619	PF00244	0.564
LIG_BIR_III_4	23	27	PF00653	0.636
LIG_BIR_III_4	344	348	PF00653	0.599
LIG_Clathr_ClatBox_1	418	422	PF01394	0.633
LIG_deltaCOP1_diTrp_1	191	196	PF00928	0.496
LIG_deltaCOP1_diTrp_1	89	99	PF00928	0.688
LIG_EVH1_1	400	404	PF00568	0.516
LIG_FHA_1	349	355	PF00498	0.517
LIG_FHA_1	367	373	PF00498	0.526
LIG_FHA_1	453	459	PF00498	0.472
LIG_FHA_1	608	614	PF00498	0.437
LIG_FHA_1	7	13	PF00498	0.478
LIG_FHA_2	209	215	PF00498	0.514
LIG_FHA_2	300	306	PF00498	0.623
LIG_FHA_2	472	478	PF00498	0.679
LIG_FHA_2	566	572	PF00498	0.469
LIG_FHA_2	594	600	PF00498	0.534
LIG_LIR_Apic_2	120	126	PF02991	0.521
LIG_LIR_Apic_2	440	446	PF02991	0.467
LIG_LIR_Gen_1	265	275	PF02991	0.459
LIG_LIR_Nem_3	13	17	PF02991	0.472
LIG_LIR_Nem_3	194	199	PF02991	0.626
LIG_LIR_Nem_3	204	210	PF02991	0.532
LIG_LIR_Nem_3	265	271	PF02991	0.371
LIG_LIR_Nem_3	437	442	PF02991	0.398
LIG_LIR_Nem_3	596	600	PF02991	0.518
LIG_Pex14_2	361	365	PF04695	0.458
LIG_RPA_C_Fungi	219	231	PF08784	0.576
LIG_SH2_CRK	14	18	PF00017	0.512
LIG_SH2_CRK	443	447	PF00017	0.535
LIG_SH2_GRB2like	442	445	PF00017	0.472
LIG_SH2_NCK_1	443	447	PF00017	0.535
LIG_SH2_NCK_1	62	66	PF00017	0.586
LIG_SH2_STAP1	439	443	PF00017	0.399
LIG_SH2_STAP1	62	66	PF00017	0.586
LIG_SH2_STAP1	83	87	PF00017	0.572
LIG_SH2_STAT3	442	445	PF00017	0.472
LIG_SH2_STAT5	285	288	PF00017	0.511
LIG_SH2_STAT5	300	303	PF00017	0.551
LIG_SH2_STAT5	333	336	PF00017	0.522
LIG_SH2_STAT5	62	65	PF00017	0.445
LIG_SH3_3	398	404	PF00018	0.611
LIG_SH3_4	6	13	PF00018	0.532
LIG_SUMO_SIM_anti_2	416	422	PF11976	0.597
LIG_TRAF2_1	211	214	PF00917	0.405
LIG_TRAF2_1	303	306	PF00917	0.448
LIG_TRAF2_1	404	407	PF00917	0.682
LIG_TRAF2_1	411	414	PF00917	0.648
LIG_TRAF2_1	568	571	PF00917	0.477
LIG_TRAF2_1	77	80	PF00917	0.654
LIG_TRFH_1	14	18	PF08558	0.512
LIG_TYR_ITIM	12	17	PF00017	0.504
LIG_UBA3_1	327	332	PF00899	0.546
LIG_UBA3_1	418	426	PF00899	0.606
MOD_CK1_1	395	401	PF00069	0.558
MOD_CK1_1	437	443	PF00069	0.469
MOD_CK1_1	492	498	PF00069	0.737
MOD_CK1_1	543	549	PF00069	0.666
MOD_CK1_1	608	614	PF00069	0.522
MOD_CK2_1	208	214	PF00069	0.522
MOD_CK2_1	234	240	PF00069	0.541
MOD_CK2_1	299	305	PF00069	0.530
MOD_CK2_1	32	38	PF00069	0.513
MOD_CK2_1	464	470	PF00069	0.720
MOD_CK2_1	471	477	PF00069	0.693
MOD_CK2_1	499	505	PF00069	0.536
MOD_CK2_1	538	544	PF00069	0.691
MOD_CK2_1	565	571	PF00069	0.475
MOD_CK2_1	593	599	PF00069	0.536
MOD_CMANNOS	193	196	PF00535	0.500
MOD_GlcNHglycan	126	129	PF01048	0.630
MOD_GlcNHglycan	148	152	PF01048	0.556
MOD_GlcNHglycan	236	239	PF01048	0.565
MOD_GlcNHglycan	383	386	PF01048	0.432
MOD_GlcNHglycan	436	439	PF01048	0.492
MOD_GlcNHglycan	44	47	PF01048	0.762
MOD_GlcNHglycan	491	494	PF01048	0.742
MOD_GlcNHglycan	511	514	PF01048	0.695
MOD_GlcNHglycan	517	520	PF01048	0.663
MOD_GlcNHglycan	523	526	PF01048	0.648
MOD_GlcNHglycan	540	543	PF01048	0.799
MOD_GlcNHglycan	590	593	PF01048	0.525
MOD_GlcNHglycan	607	610	PF01048	0.516
MOD_GSK3_1	124	131	PF00069	0.634
MOD_GSK3_1	143	150	PF00069	0.616
MOD_GSK3_1	180	187	PF00069	0.562
MOD_GSK3_1	391	398	PF00069	0.642
MOD_GSK3_1	434	441	PF00069	0.476
MOD_GSK3_1	488	495	PF00069	0.650
MOD_GSK3_1	496	503	PF00069	0.716
MOD_GSK3_1	509	516	PF00069	0.652
MOD_GSK3_1	517	524	PF00069	0.638
MOD_GSK3_1	536	543	PF00069	0.716
MOD_GSK3_1	6	13	PF00069	0.482
MOD_LATS_1	533	539	PF00433	0.540
MOD_NEK2_1	243	248	PF00069	0.672
MOD_NEK2_1	256	261	PF00069	0.474
MOD_NEK2_1	307	312	PF00069	0.568
MOD_NEK2_1	464	469	PF00069	0.519
MOD_NEK2_1	558	563	PF00069	0.436
MOD_NEK2_1	593	598	PF00069	0.538
MOD_NEK2_1	605	610	PF00069	0.415
MOD_NEK2_2	614	619	PF00069	0.507
MOD_PIKK_1	143	149	PF00454	0.544
MOD_PIKK_1	257	263	PF00454	0.534
MOD_PIKK_1	608	614	PF00454	0.522
MOD_PKA_1	223	229	PF00069	0.576
MOD_PKA_1	526	532	PF00069	0.605
MOD_PKA_2	223	229	PF00069	0.576
MOD_PKA_2	452	458	PF00069	0.587
MOD_PKA_2	480	486	PF00069	0.574
MOD_PKA_2	605	611	PF00069	0.571
MOD_PKA_2	614	620	PF00069	0.523
MOD_PKB_1	229	237	PF00069	0.467
MOD_Plk_1	395	401	PF00069	0.525
MOD_Plk_1	570	576	PF00069	0.474
MOD_Plk_2-3	283	289	PF00069	0.517
MOD_Plk_2-3	540	546	PF00069	0.535
MOD_Plk_2-3	599	605	PF00069	0.530
MOD_Plk_4	349	355	PF00069	0.525
MOD_Plk_4	438	444	PF00069	0.472
MOD_Plk_4	492	498	PF00069	0.744
MOD_Plk_4	517	523	PF00069	0.677
MOD_ProDKin_1	104	110	PF00069	0.775
MOD_ProDKin_1	122	128	PF00069	0.765
MOD_SUMO_rev_2	154	163	PF00179	0.607
MOD_SUMO_rev_2	416	425	PF00179	0.609
MOD_SUMO_rev_2	539	549	PF00179	0.566
MOD_SUMO_rev_2	566	574	PF00179	0.476
MOD_SUMO_rev_2	98	108	PF00179	0.693
TRG_DiLeu_BaEn_1	205	210	PF01217	0.536
TRG_DiLeu_BaEn_1	414	419	PF01217	0.633
TRG_DiLeu_LyEn_5	205	210	PF01217	0.536
TRG_ENDOCYTIC_2	14	17	PF00928	0.527
TRG_ENDOCYTIC_2	597	600	PF00928	0.455
TRG_ER_diArg_1	222	224	PF00400	0.559
TRG_ER_diArg_1	228	231	PF00400	0.607
TRG_ER_diArg_1	372	374	PF00400	0.530
TRG_ER_diArg_1	377	380	PF00400	0.506
TRG_ER_diArg_1	484	486	PF00400	0.529
TRG_ER_diArg_1	562	564	PF00400	0.630
TRG_ER_diArg_1	574	576	PF00400	0.458
TRG_ER_diArg_1	605	607	PF00400	0.544
TRG_NLS_MonoCore_2	4	9	PF00514	0.531
TRG_NLS_MonoExtC_3	458	463	PF00514	0.474
TRG_NLS_MonoExtN_4	2	9	PF00514	0.498
TRG_Pf-PMV_PEXEL_1	208	212	PF00026	0.523
TRG_Pf-PMV_PEXEL_1	262	267	PF00026	0.479
TRG_Pf-PMV_PEXEL_1	535	540	PF00026	0.543

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I2D0	Leptomonas seymouri	48%	88%
A0A3Q8IHA2	Leishmania donovani	67%	96%
A4I4J8	Leishmania infantum	67%	96%
E9ADZ7	Leishmania major	67%	100%
E9ALT4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	67%	94%
V5BH77	Trypanosoma cruzi	38%	100%