Putative RNA-binding protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

RNA-binding protein, putative

Species:

Leishmania braziliensis

UniProt:

A4HHE7_LEIBR

TriTrypDb:

LbrM.29.1440 , LBRM2903_290020700

Length:

619

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	1
GO:0005737	cytoplasm	2	1
GO:0005815	microtubule organizing center	2	1
GO:0032991	protein-containing complex	1	1
GO:0036064	ciliary basal body	3	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1
GO:1990904	ribonucleoprotein complex	2	1

Expansion

Sequence features

A4HHE7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HHE7

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	7
GO:0003723	RNA binding	4	7
GO:0005488	binding	1	7
GO:0097159	organic cyclic compound binding	2	7
GO:1901363	heterocyclic compound binding	2	7
GO:0003729	mRNA binding	5	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	199	203	PF00656	0.592
CLV_C14_Caspase3-7	590	594	PF00656	0.531
CLV_NRD_NRD_1	156	158	PF00675	0.622
CLV_NRD_NRD_1	159	161	PF00675	0.554
CLV_NRD_NRD_1	261	263	PF00675	0.631
CLV_NRD_NRD_1	71	73	PF00675	0.419
CLV_NRD_NRD_1	84	86	PF00675	0.265
CLV_PCSK_KEX2_1	144	146	PF00082	0.673
CLV_PCSK_KEX2_1	156	158	PF00082	0.582
CLV_PCSK_KEX2_1	84	86	PF00082	0.238
CLV_PCSK_PC1ET2_1	144	146	PF00082	0.673
CLV_PCSK_SKI1_1	160	164	PF00082	0.504
CLV_PCSK_SKI1_1	177	181	PF00082	0.372
CLV_PCSK_SKI1_1	84	88	PF00082	0.372
DEG_Nend_Nbox_1	1	3	PF02207	0.668
DEG_SCF_FBW7_1	302	308	PF00400	0.554
DOC_CKS1_1	25	30	PF01111	0.768
DOC_CKS1_1	302	307	PF01111	0.807
DOC_MAPK_gen_1	156	164	PF00069	0.583
DOC_MAPK_gen_1	61	71	PF00069	0.633
DOC_PP1_RVXF_1	212	219	PF00149	0.552
DOC_PP2B_LxvP_1	11	14	PF13499	0.523
DOC_PP2B_LxvP_1	386	389	PF13499	0.541
DOC_USP7_MATH_1	239	243	PF00917	0.609
DOC_USP7_MATH_1	387	391	PF00917	0.575
DOC_USP7_MATH_1	421	425	PF00917	0.751
DOC_USP7_MATH_1	495	499	PF00917	0.557
DOC_USP7_MATH_1	6	10	PF00917	0.780
DOC_WW_Pin1_4	147	152	PF00397	0.667
DOC_WW_Pin1_4	16	21	PF00397	0.664
DOC_WW_Pin1_4	24	29	PF00397	0.499
DOC_WW_Pin1_4	272	277	PF00397	0.560
DOC_WW_Pin1_4	293	298	PF00397	0.808
DOC_WW_Pin1_4	301	306	PF00397	0.675
DOC_WW_Pin1_4	308	313	PF00397	0.556
DOC_WW_Pin1_4	320	325	PF00397	0.469
DOC_WW_Pin1_4	329	334	PF00397	0.714
DOC_WW_Pin1_4	352	357	PF00397	0.738
DOC_WW_Pin1_4	419	424	PF00397	0.643
DOC_WW_Pin1_4	46	51	PF00397	0.734
DOC_WW_Pin1_4	463	468	PF00397	0.706
DOC_WW_Pin1_4	519	524	PF00397	0.756
DOC_WW_Pin1_4	542	547	PF00397	0.748
DOC_WW_Pin1_4	556	561	PF00397	0.634
DOC_WW_Pin1_4	9	14	PF00397	0.755
LIG_14-3-3_CanoR_1	208	216	PF00244	0.619
LIG_Actin_WH2_2	164	179	PF00022	0.619
LIG_APCC_ABBA_1	189	194	PF00400	0.619
LIG_APCC_ABBA_1	218	223	PF00400	0.619
LIG_BIR_III_4	440	444	PF00653	0.713
LIG_BRCT_BRCA1_1	322	326	PF00533	0.697
LIG_BRCT_BRCA1_1	449	453	PF00533	0.663
LIG_FHA_1	108	114	PF00498	0.619
LIG_FHA_1	297	303	PF00498	0.808
LIG_FHA_1	330	336	PF00498	0.558
LIG_FHA_1	353	359	PF00498	0.790
LIG_FHA_1	366	372	PF00498	0.443
LIG_FHA_1	429	435	PF00498	0.788
LIG_FHA_1	483	489	PF00498	0.814
LIG_FHA_2	115	121	PF00498	0.619
LIG_FHA_2	197	203	PF00498	0.523
LIG_FHA_2	77	83	PF00498	0.546
LIG_LIR_Apic_2	132	137	PF02991	0.619
LIG_LIR_Gen_1	368	376	PF02991	0.648
LIG_LIR_Gen_1	52	60	PF02991	0.653
LIG_LIR_Gen_1	95	103	PF02991	0.619
LIG_LIR_Nem_3	110	115	PF02991	0.555
LIG_LIR_Nem_3	181	186	PF02991	0.549
LIG_LIR_Nem_3	368	373	PF02991	0.742
LIG_LIR_Nem_3	456	460	PF02991	0.633
LIG_LIR_Nem_3	52	56	PF02991	0.679
LIG_MLH1_MIPbox_1	322	326	PF16413	0.542
LIG_Pex14_2	515	519	PF04695	0.539
LIG_PTAP_UEV_1	388	393	PF05743	0.530
LIG_PTAP_UEV_1	422	427	PF05743	0.528
LIG_PTB_Apo_2	212	219	PF02174	0.619
LIG_SH2_CRK	134	138	PF00017	0.589
LIG_SH2_CRK	429	433	PF00017	0.791
LIG_SH2_CRK	90	94	PF00017	0.619
LIG_SH2_NCK_1	417	421	PF00017	0.801
LIG_SH2_NCK_1	53	57	PF00017	0.716
LIG_SH2_NCK_1	570	574	PF00017	0.526
LIG_SH2_PTP2	370	373	PF00017	0.738
LIG_SH2_SRC	370	373	PF00017	0.738
LIG_SH2_SRC	395	398	PF00017	0.671
LIG_SH2_STAP1	417	421	PF00017	0.801
LIG_SH2_STAP1	460	464	PF00017	0.549
LIG_SH2_STAP1	53	57	PF00017	0.716
LIG_SH2_STAP1	588	592	PF00017	0.534
LIG_SH2_STAT5	103	106	PF00017	0.438
LIG_SH2_STAT5	2	5	PF00017	0.773
LIG_SH2_STAT5	370	373	PF00017	0.688
LIG_SH2_STAT5	395	398	PF00017	0.659
LIG_SH2_STAT5	417	420	PF00017	0.549
LIG_SH2_STAT5	457	460	PF00017	0.544
LIG_SH3_2	276	281	PF14604	0.575
LIG_SH3_3	273	279	PF00018	0.564
LIG_SH3_3	306	312	PF00018	0.552
LIG_SH3_3	330	336	PF00018	0.690
LIG_SH3_3	386	392	PF00018	0.704
LIG_SH3_3	420	426	PF00018	0.626
LIG_SH3_3	429	435	PF00018	0.592
LIG_SH3_3	449	455	PF00018	0.450
LIG_SH3_3	464	470	PF00018	0.626
LIG_SH3_3	535	541	PF00018	0.638
LIG_SH3_3	57	63	PF00018	0.711
LIG_SH3_4	469	476	PF00018	0.562
LIG_SUMO_SIM_par_1	167	172	PF11976	0.619
LIG_SUMO_SIM_par_1	298	304	PF11976	0.560
LIG_TRAF2_1	117	120	PF00917	0.438
LIG_TYR_ITSM	366	373	PF00017	0.741
LIG_WRC_WIRS_1	34	39	PF05994	0.534
LIG_WRC_WIRS_1	93	98	PF05994	0.619
LIG_WW_1	50	53	PF00397	0.747
LIG_WW_3	278	282	PF00397	0.576
MOD_CDC14_SPxK_1	466	469	PF00782	0.555
MOD_CDK_SPK_2	272	277	PF00069	0.560
MOD_CDK_SPxK_1	24	30	PF00069	0.768
MOD_CDK_SPxK_1	463	469	PF00069	0.553
MOD_CK1_1	107	113	PF00069	0.619
MOD_CK1_1	187	193	PF00069	0.591
MOD_CK1_1	203	209	PF00069	0.424
MOD_CK1_1	296	302	PF00069	0.726
MOD_CK1_1	308	314	PF00069	0.661
MOD_CK1_1	320	326	PF00069	0.788
MOD_CK1_1	33	39	PF00069	0.654
MOD_CK1_1	334	340	PF00069	0.621
MOD_CK1_1	348	354	PF00069	0.787
MOD_CK1_1	374	380	PF00069	0.692
MOD_CK1_1	456	462	PF00069	0.678
MOD_CK1_1	49	55	PF00069	0.625
MOD_CK1_1	517	523	PF00069	0.653
MOD_CK1_1	608	614	PF00069	0.575
MOD_CK1_1	76	82	PF00069	0.619
MOD_CK1_1	9	15	PF00069	0.785
MOD_CK2_1	113	119	PF00069	0.610
MOD_CK2_1	608	614	PF00069	0.532
MOD_GlcNHglycan	122	125	PF01048	0.284
MOD_GlcNHglycan	268	272	PF01048	0.667
MOD_GlcNHglycan	289	292	PF01048	0.717
MOD_GlcNHglycan	337	340	PF01048	0.761
MOD_GlcNHglycan	347	350	PF01048	0.648
MOD_GlcNHglycan	389	392	PF01048	0.727
MOD_GlcNHglycan	398	401	PF01048	0.636
MOD_GlcNHglycan	423	426	PF01048	0.527
MOD_GlcNHglycan	46	49	PF01048	0.784
MOD_GlcNHglycan	490	493	PF01048	0.812
MOD_GlcNHglycan	516	519	PF01048	0.669
MOD_GlcNHglycan	526	529	PF01048	0.617
MOD_GlcNHglycan	589	592	PF01048	0.555
MOD_GlcNHglycan	75	78	PF01048	0.420
MOD_GSK3_1	178	185	PF00069	0.555
MOD_GSK3_1	192	199	PF00069	0.580
MOD_GSK3_1	200	207	PF00069	0.561
MOD_GSK3_1	267	274	PF00069	0.744
MOD_GSK3_1	287	294	PF00069	0.552
MOD_GSK3_1	296	303	PF00069	0.691
MOD_GSK3_1	304	311	PF00069	0.738
MOD_GSK3_1	313	320	PF00069	0.533
MOD_GSK3_1	331	338	PF00069	0.709
MOD_GSK3_1	343	350	PF00069	0.710
MOD_GSK3_1	361	368	PF00069	0.570
MOD_GSK3_1	40	47	PF00069	0.766
MOD_GSK3_1	415	422	PF00069	0.653
MOD_GSK3_1	459	466	PF00069	0.742
MOD_GSK3_1	5	12	PF00069	0.524
MOD_GSK3_1	579	586	PF00069	0.618
MOD_GSK3_1	604	611	PF00069	0.534
MOD_N-GLC_1	187	192	PF02516	0.355
MOD_N-GLC_1	203	208	PF02516	0.404
MOD_N-GLC_1	272	277	PF02516	0.768
MOD_N-GLC_1	39	44	PF02516	0.660
MOD_N-GLC_1	503	508	PF02516	0.798
MOD_N-GLC_2	236	238	PF02516	0.620
MOD_NEK2_1	169	174	PF00069	0.598
MOD_NEK2_1	234	239	PF00069	0.639
MOD_NEK2_1	266	271	PF00069	0.677
MOD_NEK2_1	317	322	PF00069	0.728
MOD_NEK2_1	345	350	PF00069	0.801
MOD_NEK2_1	488	493	PF00069	0.561
MOD_NEK2_1	524	529	PF00069	0.728
MOD_NEK2_1	595	600	PF00069	0.537
MOD_NEK2_1	605	610	PF00069	0.496
MOD_NEK2_2	583	588	PF00069	0.535
MOD_OFUCOSY	238	243	PF10250	0.612
MOD_PIKK_1	208	214	PF00454	0.619
MOD_PIKK_1	482	488	PF00454	0.575
MOD_PIKK_1	62	68	PF00454	0.636
MOD_PK_1	136	142	PF00069	0.681
MOD_PK_1	182	188	PF00069	0.619
MOD_PKA_2	113	119	PF00069	0.619
MOD_PKA_2	200	206	PF00069	0.438
MOD_Plk_1	187	193	PF00069	0.555
MOD_Plk_1	204	210	PF00069	0.418
MOD_Plk_1	30	36	PF00069	0.781
MOD_Plk_4	229	235	PF00069	0.476
MOD_Plk_4	30	36	PF00069	0.587
MOD_Plk_4	305	311	PF00069	0.550
MOD_Plk_4	412	418	PF00069	0.577
MOD_Plk_4	534	540	PF00069	0.780
MOD_Plk_4	596	602	PF00069	0.686
MOD_Plk_4	89	95	PF00069	0.569
MOD_ProDKin_1	147	153	PF00069	0.666
MOD_ProDKin_1	16	22	PF00069	0.655
MOD_ProDKin_1	24	30	PF00069	0.501
MOD_ProDKin_1	272	278	PF00069	0.560
MOD_ProDKin_1	293	299	PF00069	0.808
MOD_ProDKin_1	301	307	PF00069	0.675
MOD_ProDKin_1	308	314	PF00069	0.556
MOD_ProDKin_1	320	326	PF00069	0.472
MOD_ProDKin_1	329	335	PF00069	0.716
MOD_ProDKin_1	352	358	PF00069	0.737
MOD_ProDKin_1	419	425	PF00069	0.642
MOD_ProDKin_1	46	52	PF00069	0.727
MOD_ProDKin_1	463	469	PF00069	0.710
MOD_ProDKin_1	519	525	PF00069	0.757
MOD_ProDKin_1	542	548	PF00069	0.752
MOD_ProDKin_1	556	562	PF00069	0.637
MOD_ProDKin_1	9	15	PF00069	0.759
MOD_SUMO_for_1	143	146	PF00179	0.651
MOD_SUMO_rev_2	54	63	PF00179	0.688
TRG_DiLeu_BaLyEn_6	205	210	PF01217	0.438
TRG_DiLeu_BaLyEn_6	520	525	PF01217	0.517
TRG_ENDOCYTIC_2	370	373	PF00928	0.747
TRG_ENDOCYTIC_2	429	432	PF00928	0.791
TRG_ENDOCYTIC_2	53	56	PF00928	0.726
TRG_ENDOCYTIC_2	90	93	PF00928	0.558
TRG_ER_diArg_1	83	85	PF00400	0.438
TRG_NLS_Bipartite_1	144	161	PF00514	0.612
TRG_NLS_MonoExtC_3	156	161	PF00514	0.577
TRG_NLS_MonoExtN_4	156	161	PF00514	0.577
TRG_Pf-PMV_PEXEL_1	174	178	PF00026	0.419
TRG_Pf-PMV_PEXEL_1	208	212	PF00026	0.238
TRG_Pf-PMV_PEXEL_1	84	89	PF00026	0.419

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I1Q0	Leptomonas seymouri	24%	100%
A0A3Q8IF58	Leishmania donovani	71%	97%
A4I4J0	Leishmania infantum	71%	97%
E9ADZ3	Leishmania major	71%	100%
E9ALT8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	71%	97%