Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HHE6_LEIBR

TriTrypDb:

LbrM.29.1430 , LBRM2903_290020300

Length:

217

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HHE6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HHE6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	52	54	PF00675	0.325
CLV_NRD_NRD_1	65	67	PF00675	0.447
CLV_PCSK_KEX2_1	52	54	PF00082	0.325
CLV_PCSK_KEX2_1	64	66	PF00082	0.435
CLV_PCSK_PC7_1	61	67	PF00082	0.368
CLV_PCSK_SKI1_1	26	30	PF00082	0.390
CLV_PCSK_SKI1_1	52	56	PF00082	0.342
CLV_PCSK_SKI1_1	66	70	PF00082	0.436
DEG_APCC_DBOX_1	65	73	PF00400	0.381
DEG_APCC_DBOX_1	89	97	PF00400	0.416
DOC_MAPK_gen_1	52	59	PF00069	0.360
DOC_PP4_FxxP_1	176	179	PF00568	0.315
DOC_USP7_MATH_1	209	213	PF00917	0.578
DOC_USP7_MATH_1	81	85	PF00917	0.382
DOC_WW_Pin1_4	175	180	PF00397	0.364
LIG_14-3-3_CanoR_1	155	164	PF00244	0.317
LIG_14-3-3_CanoR_1	198	203	PF00244	0.514
LIG_14-3-3_CanoR_1	52	59	PF00244	0.360
LIG_Clathr_ClatBox_1	28	32	PF01394	0.587
LIG_deltaCOP1_diTrp_1	24	29	PF00928	0.360
LIG_FHA_1	178	184	PF00498	0.536
LIG_FHA_1	37	43	PF00498	0.321
LIG_FHA_2	199	205	PF00498	0.567
LIG_FHA_2	73	79	PF00498	0.356
LIG_FHA_2	81	87	PF00498	0.398
LIG_LIR_Gen_1	146	156	PF02991	0.324
LIG_LIR_Gen_1	158	169	PF02991	0.344
LIG_LIR_Gen_1	186	196	PF02991	0.392
LIG_LIR_Gen_1	30	40	PF02991	0.384
LIG_LIR_Nem_3	146	151	PF02991	0.329
LIG_LIR_Nem_3	158	164	PF02991	0.326
LIG_LIR_Nem_3	186	191	PF02991	0.405
LIG_LIR_Nem_3	24	28	PF02991	0.354
LIG_LIR_Nem_3	37	43	PF02991	0.293
LIG_NRBOX	68	74	PF00104	0.424
LIG_Pex14_1	25	29	PF04695	0.337
LIG_Pex14_2	129	133	PF04695	0.324
LIG_Rb_pABgroove_1	71	79	PF01858	0.415
LIG_SH2_CRK	148	152	PF00017	0.332
LIG_SH2_NCK_1	188	192	PF00017	0.401
LIG_SH2_SRC	193	196	PF00017	0.462
LIG_SH2_STAP1	188	192	PF00017	0.424
LIG_SH2_STAP1	193	197	PF00017	0.399
LIG_SH2_STAT5	105	108	PF00017	0.338
LIG_SH2_STAT5	148	151	PF00017	0.331
LIG_SH2_STAT5	153	156	PF00017	0.314
LIG_SH2_STAT5	43	46	PF00017	0.304
LIG_SH2_STAT5	99	102	PF00017	0.356
LIG_SH3_3	176	182	PF00018	0.402
LIG_TRAF2_1	165	168	PF00917	0.457
LIG_TRAF2_1	201	204	PF00917	0.633
LIG_TYR_ITIM	191	196	PF00017	0.431
LIG_TYR_ITSM	144	151	PF00017	0.325
MOD_CK1_1	186	192	PF00069	0.528
MOD_CK1_1	208	214	PF00069	0.767
MOD_CK2_1	18	24	PF00069	0.369
MOD_CK2_1	198	204	PF00069	0.536
MOD_GlcNHglycan	12	15	PF01048	0.346
MOD_GlcNHglycan	207	210	PF01048	0.519
MOD_GlcNHglycan	211	214	PF01048	0.529
MOD_GSK3_1	205	212	PF00069	0.542
MOD_GSK3_1	48	55	PF00069	0.324
MOD_GSK3_1	6	13	PF00069	0.378
MOD_NEK2_1	183	188	PF00069	0.426
MOD_NEK2_1	36	41	PF00069	0.338
MOD_NEK2_1	72	77	PF00069	0.383
MOD_PIKK_1	183	189	PF00454	0.314
MOD_PK_1	53	59	PF00069	0.364
MOD_PKA_1	52	58	PF00069	0.355
MOD_PKA_2	52	58	PF00069	0.355
MOD_Plk_1	36	42	PF00069	0.332
MOD_Plk_4	146	152	PF00069	0.465
MOD_Plk_4	36	42	PF00069	0.358
MOD_Plk_4	72	78	PF00069	0.354
MOD_ProDKin_1	175	181	PF00069	0.364
MOD_SUMO_rev_2	203	208	PF00179	0.473
MOD_SUMO_rev_2	21	28	PF00179	0.371
TRG_DiLeu_BaLyEn_6	179	184	PF01217	0.398
TRG_ENDOCYTIC_2	147	150	PF00928	0.338
TRG_ENDOCYTIC_2	153	156	PF00928	0.303
TRG_ENDOCYTIC_2	188	191	PF00928	0.404
TRG_ENDOCYTIC_2	193	196	PF00928	0.379
TRG_ENDOCYTIC_2	33	36	PF00928	0.448
TRG_ER_diArg_1	64	66	PF00400	0.424

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A1X0NZU1	Trypanosomatidae	81%	68%
A0A3Q8IEE3	Leishmania donovani	94%	73%
A0A3R7KGQ0	Trypanosoma rangeli	83%	67%
A4HHE1	Leishmania braziliensis	100%	100%
A4I4I7	Leishmania infantum	94%	73%
C9ZL74	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	83%	68%
E9ADY8	Leishmania major	97%	100%
E9ALU3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	73%
V5BRA3	Trypanosoma cruzi	81%	67%