Aurora kinase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Aurora kinase

Gene product:

serine/threonine-protein kinase, putative

Species:

Leishmania braziliensis

UniProt:

A4HHE4_LEIBR

TriTrypDb:

LbrM.29.1410 , LBRM2903_290020600

Length:

589

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 4
Forrest at al. (procyclic)	no	yes: 4
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 15

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 12

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 23
NetGPI	no	yes: 0, no: 23

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	3
GO:0005737	cytoplasm	2	3
GO:0043226	organelle	2	3
GO:0043227	membrane-bounded organelle	3	3
GO:0043229	intracellular organelle	3	3
GO:0043231	intracellular membrane-bounded organelle	4	3
GO:0110165	cellular anatomical entity	1	4
GO:0016020	membrane	2	1

Expansion

Sequence features

A4HHE4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HHE4

Function

Biological processes
Term	Name	Level	Count
GO:0006468	protein phosphorylation	5	24
GO:0006793	phosphorus metabolic process	3	24
GO:0006796	phosphate-containing compound metabolic process	4	24
GO:0006807	nitrogen compound metabolic process	2	24
GO:0008152	metabolic process	1	24
GO:0009987	cellular process	1	24
GO:0016310	phosphorylation	5	24
GO:0019538	protein metabolic process	3	24
GO:0036211	protein modification process	4	24
GO:0043170	macromolecule metabolic process	3	24
GO:0043412	macromolecule modification	4	24
GO:0044237	cellular metabolic process	2	24
GO:0044238	primary metabolic process	2	24
GO:0071704	organic substance metabolic process	2	24
GO:1901564	organonitrogen compound metabolic process	3	24
GO:0007165	signal transduction	2	3
GO:0018105	peptidyl-serine phosphorylation	6	2
GO:0018193	peptidyl-amino acid modification	5	2
GO:0018209	peptidyl-serine modification	6	2
GO:0035556	intracellular signal transduction	3	3
GO:0046777	protein autophosphorylation	6	2
GO:0050789	regulation of biological process	2	3
GO:0050794	regulation of cellular process	3	3
GO:0065007	biological regulation	1	3
GO:0000075	cell cycle checkpoint signaling	4	1
GO:0000077	DNA damage checkpoint signaling	5	1
GO:0006950	response to stress	2	1
GO:0006974	DNA damage response	4	1
GO:0007093	mitotic cell cycle checkpoint signaling	4	1
GO:0007346	regulation of mitotic cell cycle	5	1
GO:0010564	regulation of cell cycle process	5	1
GO:0010948	negative regulation of cell cycle process	6	1
GO:0022402	cell cycle process	2	1
GO:0031570	DNA integrity checkpoint signaling	5	1
GO:0033554	cellular response to stress	3	1
GO:0042770	signal transduction in response to DNA damage	4	1
GO:0044773	mitotic DNA damage checkpoint signaling	6	1
GO:0044774	mitotic DNA integrity checkpoint signaling	5	1
GO:0045786	negative regulation of cell cycle	5	1
GO:0045930	negative regulation of mitotic cell cycle	6	1
GO:0048519	negative regulation of biological process	3	1
GO:0048523	negative regulation of cellular process	4	1
GO:0050896	response to stimulus	1	1
GO:0051716	cellular response to stimulus	2	1
GO:0051726	regulation of cell cycle	4	1
GO:1901987	regulation of cell cycle phase transition	6	1
GO:1901988	negative regulation of cell cycle phase transition	7	1
GO:1903047	mitotic cell cycle process	3	1

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	24
GO:0003824	catalytic activity	1	24
GO:0004672	protein kinase activity	3	24
GO:0004674	protein serine/threonine kinase activity	4	19
GO:0005488	binding	1	24
GO:0005524	ATP binding	5	24
GO:0016301	kinase activity	4	24
GO:0016740	transferase activity	2	24
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	24
GO:0016773	phosphotransferase activity, alcohol group as acceptor	4	24
GO:0017076	purine nucleotide binding	4	24
GO:0030554	adenyl nucleotide binding	5	24
GO:0032553	ribonucleotide binding	3	24
GO:0032555	purine ribonucleotide binding	4	24
GO:0032559	adenyl ribonucleotide binding	5	24
GO:0035639	purine ribonucleoside triphosphate binding	4	24
GO:0036094	small molecule binding	2	24
GO:0043167	ion binding	2	24
GO:0043168	anion binding	3	24
GO:0097159	organic cyclic compound binding	2	24
GO:0097367	carbohydrate derivative binding	2	24
GO:0106310	protein serine kinase activity	4	5
GO:0140096	catalytic activity, acting on a protein	2	24
GO:1901265	nucleoside phosphate binding	3	24
GO:1901363	heterocyclic compound binding	2	24
GO:0004683	calmodulin-dependent protein kinase activity	5	2
GO:0005515	protein binding	2	2
GO:0005516	calmodulin binding	3	2
GO:0009931	calcium-dependent protein serine/threonine kinase activity	5	2
GO:0010857	calcium-dependent protein kinase activity	4	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	430	434	PF00656	0.272
CLV_NRD_NRD_1	263	265	PF00675	0.293
CLV_NRD_NRD_1	35	37	PF00675	0.538
CLV_NRD_NRD_1	430	432	PF00675	0.215
CLV_NRD_NRD_1	456	458	PF00675	0.251
CLV_NRD_NRD_1	525	527	PF00675	0.215
CLV_NRD_NRD_1	586	588	PF00675	0.450
CLV_PCSK_KEX2_1	263	265	PF00082	0.289
CLV_PCSK_KEX2_1	35	37	PF00082	0.538
CLV_PCSK_KEX2_1	456	458	PF00082	0.251
CLV_PCSK_KEX2_1	525	527	PF00082	0.215
CLV_PCSK_KEX2_1	85	87	PF00082	0.604
CLV_PCSK_PC1ET2_1	85	87	PF00082	0.577
CLV_PCSK_SKI1_1	25	29	PF00082	0.518
CLV_PCSK_SKI1_1	386	390	PF00082	0.459
CLV_PCSK_SKI1_1	56	60	PF00082	0.512
DEG_SPOP_SBC_1	6	10	PF00917	0.523
DOC_CKS1_1	329	334	PF01111	0.314
DOC_CYCLIN_yCln2_LP_2	545	551	PF00134	0.244
DOC_MAPK_gen_1	315	325	PF00069	0.275
DOC_MAPK_gen_1	386	395	PF00069	0.461
DOC_PP1_RVXF_1	295	301	PF00149	0.244
DOC_PP4_FxxP_1	329	332	PF00568	0.244
DOC_USP7_MATH_1	129	133	PF00917	0.492
DOC_USP7_MATH_1	170	174	PF00917	0.544
DOC_USP7_MATH_1	205	209	PF00917	0.484
DOC_USP7_MATH_1	227	231	PF00917	0.515
DOC_USP7_MATH_1	244	248	PF00917	0.557
DOC_USP7_MATH_1	4	8	PF00917	0.544
DOC_USP7_MATH_1	415	419	PF00917	0.256
DOC_USP7_MATH_1	539	543	PF00917	0.222
DOC_USP7_MATH_1	54	58	PF00917	0.540
DOC_USP7_MATH_1	571	575	PF00917	0.222
DOC_USP7_MATH_2	44	50	PF00917	0.523
DOC_USP7_UBL2_3	584	588	PF12436	0.413
DOC_WW_Pin1_4	156	161	PF00397	0.525
DOC_WW_Pin1_4	19	24	PF00397	0.539
DOC_WW_Pin1_4	190	195	PF00397	0.539
DOC_WW_Pin1_4	238	243	PF00397	0.489
DOC_WW_Pin1_4	328	333	PF00397	0.314
DOC_WW_Pin1_4	464	469	PF00397	0.382
DOC_WW_Pin1_4	7	12	PF00397	0.529
DOC_WW_Pin1_4	91	96	PF00397	0.586
LIG_14-3-3_CanoR_1	135	141	PF00244	0.521
LIG_14-3-3_CanoR_1	172	182	PF00244	0.532
LIG_14-3-3_CanoR_1	218	224	PF00244	0.590
LIG_14-3-3_CanoR_1	324	329	PF00244	0.284
LIG_14-3-3_CanoR_1	456	460	PF00244	0.303
LIG_14-3-3_CanoR_1	570	580	PF00244	0.266
LIG_14-3-3_CterR_2	587	589	PF00244	0.469
LIG_Actin_WH2_2	245	260	PF00022	0.413
LIG_BIR_II_1	1	5	PF00653	0.531
LIG_BIR_III_4	396	400	PF00653	0.254
LIG_BRCT_BRCA1_1	283	287	PF00533	0.213
LIG_CtBP_PxDLS_1	200	204	PF00389	0.473
LIG_CtBP_PxDLS_1	515	519	PF00389	0.244
LIG_FHA_1	109	115	PF00498	0.504
LIG_FHA_1	229	235	PF00498	0.489
LIG_FHA_1	366	372	PF00498	0.244
LIG_FHA_2	184	190	PF00498	0.502
LIG_FHA_2	425	431	PF00498	0.282
LIG_FHA_2	441	447	PF00498	0.244
LIG_FHA_2	542	548	PF00498	0.231
LIG_FHA_2	570	576	PF00498	0.267
LIG_LIR_Apic_2	125	131	PF02991	0.481
LIG_LIR_Apic_2	212	217	PF02991	0.476
LIG_LIR_Apic_2	327	332	PF02991	0.244
LIG_LIR_Apic_2	405	411	PF02991	0.234
LIG_LIR_Apic_2	462	468	PF02991	0.514
LIG_LIR_Gen_1	270	279	PF02991	0.305
LIG_LIR_Nem_3	132	137	PF02991	0.516
LIG_LIR_Nem_3	270	276	PF02991	0.309
LIG_LIR_Nem_3	284	290	PF02991	0.203
LIG_MAD2	218	226	PF02301	0.501
LIG_REV1ctd_RIR_1	285	295	PF16727	0.210
LIG_SH2_CRK	214	218	PF00017	0.491
LIG_SH2_CRK	273	277	PF00017	0.317
LIG_SH2_NCK_1	273	277	PF00017	0.244
LIG_SH2_STAP1	326	330	PF00017	0.244
LIG_SH2_STAP1	367	371	PF00017	0.244
LIG_SH2_STAT5	328	331	PF00017	0.316
LIG_SH2_STAT5	341	344	PF00017	0.361
LIG_SH2_STAT5	367	370	PF00017	0.244
LIG_SH2_STAT5	465	468	PF00017	0.377
LIG_SH2_STAT5	500	503	PF00017	0.321
LIG_SH3_1	36	42	PF00018	0.527
LIG_SH3_1	525	531	PF00018	0.210
LIG_SH3_3	154	160	PF00018	0.540
LIG_SH3_3	195	201	PF00018	0.533
LIG_SH3_3	36	42	PF00018	0.531
LIG_SH3_3	409	415	PF00018	0.248
LIG_SH3_3	525	531	PF00018	0.210
LIG_SH3_3	76	82	PF00018	0.524
LIG_SUMO_SIM_par_1	118	127	PF11976	0.490
LIG_SUMO_SIM_par_1	230	238	PF11976	0.488
LIG_SUMO_SIM_par_1	274	280	PF11976	0.244
LIG_SUMO_SIM_par_1	547	552	PF11976	0.242
LIG_TRAF2_1	44	47	PF00917	0.523
LIG_UBA3_1	286	291	PF00899	0.215
LIG_UBA3_1	558	565	PF00899	0.288
LIG_WRC_WIRS_1	137	142	PF05994	0.480
LIG_WW_1	497	500	PF00397	0.244
MOD_CDC14_SPxK_1	22	25	PF00782	0.534
MOD_CDC14_SPxK_1	94	97	PF00782	0.539
MOD_CDK_SPK_2	156	161	PF00069	0.518
MOD_CDK_SPxK_1	19	25	PF00069	0.540
MOD_CDK_SPxK_1	91	97	PF00069	0.537
MOD_CK1_1	100	106	PF00069	0.538
MOD_CK1_1	121	127	PF00069	0.538
MOD_CK1_1	133	139	PF00069	0.522
MOD_CK1_1	15	21	PF00069	0.534
MOD_CK1_1	159	165	PF00069	0.538
MOD_CK1_1	173	179	PF00069	0.560
MOD_CK1_1	192	198	PF00069	0.494
MOD_CK1_1	209	215	PF00069	0.514
MOD_CK1_1	228	234	PF00069	0.484
MOD_CK1_1	274	280	PF00069	0.255
MOD_CK1_1	343	349	PF00069	0.246
MOD_CK1_1	365	371	PF00069	0.256
MOD_CK1_1	418	424	PF00069	0.237
MOD_CK1_1	477	483	PF00069	0.244
MOD_CK1_1	521	527	PF00069	0.229
MOD_CK1_1	533	539	PF00069	0.272
MOD_CK1_1	57	63	PF00069	0.544
MOD_CK1_1	7	13	PF00069	0.531
MOD_CK2_1	104	110	PF00069	0.507
MOD_CK2_1	440	446	PF00069	0.215
MOD_CK2_1	541	547	PF00069	0.231
MOD_CK2_1	569	575	PF00069	0.344
MOD_Cter_Amidation	454	457	PF01082	0.244
MOD_GlcNHglycan	100	103	PF01048	0.552
MOD_GlcNHglycan	106	109	PF01048	0.556
MOD_GlcNHglycan	115	118	PF01048	0.511
MOD_GlcNHglycan	164	167	PF01048	0.551
MOD_GlcNHglycan	203	206	PF01048	0.498
MOD_GlcNHglycan	211	214	PF01048	0.516
MOD_GlcNHglycan	227	230	PF01048	0.498
MOD_GlcNHglycan	283	286	PF01048	0.282
MOD_GlcNHglycan	342	345	PF01048	0.247
MOD_GlcNHglycan	418	421	PF01048	0.261
MOD_GlcNHglycan	471	474	PF01048	0.336
MOD_GlcNHglycan	476	479	PF01048	0.288
MOD_GlcNHglycan	518	521	PF01048	0.222
MOD_GlcNHglycan	532	535	PF01048	0.257
MOD_GlcNHglycan	551	554	PF01048	0.348
MOD_GSK3_1	104	111	PF00069	0.556
MOD_GSK3_1	118	125	PF00069	0.513
MOD_GSK3_1	12	19	PF00069	0.542
MOD_GSK3_1	129	136	PF00069	0.497
MOD_GSK3_1	164	171	PF00069	0.591
MOD_GSK3_1	172	179	PF00069	0.583
MOD_GSK3_1	199	206	PF00069	0.518
MOD_GSK3_1	234	241	PF00069	0.509
MOD_GSK3_1	277	284	PF00069	0.245
MOD_GSK3_1	324	331	PF00069	0.248
MOD_GSK3_1	442	449	PF00069	0.295
MOD_GSK3_1	455	462	PF00069	0.491
MOD_GSK3_1	477	484	PF00069	0.244
MOD_GSK3_1	500	507	PF00069	0.252
MOD_GSK3_1	535	542	PF00069	0.243
MOD_GSK3_1	571	578	PF00069	0.300
MOD_GSK3_1	96	103	PF00069	0.578
MOD_N-GLC_1	162	167	PF02516	0.531
MOD_N-GLC_1	183	188	PF02516	0.503
MOD_N-GLC_1	516	521	PF02516	0.277
MOD_NEK2_1	12	17	PF00069	0.548
MOD_NEK2_1	120	125	PF00069	0.537
MOD_NEK2_1	182	187	PF00069	0.520
MOD_NEK2_1	203	208	PF00069	0.566
MOD_NEK2_1	313	318	PF00069	0.346
MOD_NEK2_1	406	411	PF00069	0.310
MOD_NEK2_1	518	523	PF00069	0.302
MOD_NEK2_2	54	59	PF00069	0.508
MOD_NEK2_2	541	546	PF00069	0.210
MOD_PIKK_1	59	65	PF00454	0.543
MOD_PKA_2	281	287	PF00069	0.319
MOD_PKA_2	357	363	PF00069	0.244
MOD_PKA_2	365	371	PF00069	0.210
MOD_PKA_2	455	461	PF00069	0.263
MOD_PKA_2	569	575	PF00069	0.408
MOD_PKA_2	96	102	PF00069	0.541
MOD_Plk_1	293	299	PF00069	0.276
MOD_Plk_1	46	52	PF00069	0.523
MOD_Plk_1	539	545	PF00069	0.280
MOD_Plk_1	54	60	PF00069	0.503
MOD_Plk_4	206	212	PF00069	0.541
MOD_Plk_4	271	277	PF00069	0.290
MOD_Plk_4	324	330	PF00069	0.268
MOD_Plk_4	343	349	PF00069	0.245
MOD_Plk_4	554	560	PF00069	0.316
MOD_ProDKin_1	156	162	PF00069	0.524
MOD_ProDKin_1	19	25	PF00069	0.540
MOD_ProDKin_1	190	196	PF00069	0.541
MOD_ProDKin_1	238	244	PF00069	0.489
MOD_ProDKin_1	328	334	PF00069	0.314
MOD_ProDKin_1	464	470	PF00069	0.382
MOD_ProDKin_1	7	13	PF00069	0.539
MOD_ProDKin_1	91	97	PF00069	0.587
MOD_SUMO_for_1	388	391	PF00179	0.466
TRG_DiLeu_BaLyEn_6	115	120	PF01217	0.516
TRG_DiLeu_BaLyEn_6	28	33	PF01217	0.511
TRG_DiLeu_BaLyEn_6	8	13	PF01217	0.534
TRG_ENDOCYTIC_2	273	276	PF00928	0.337
TRG_ENDOCYTIC_2	326	329	PF00928	0.319
TRG_ER_diArg_1	153	156	PF00400	0.525
TRG_ER_diArg_1	262	264	PF00400	0.293
TRG_ER_diArg_1	295	298	PF00400	0.306
TRG_ER_diArg_1	35	37	PF00400	0.582
TRG_ER_diArg_1	40	43	PF00400	0.576
TRG_Pf-PMV_PEXEL_1	301	306	PF00026	0.277
TRG_Pf-PMV_PEXEL_1	386	391	PF00026	0.317

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3Q8INQ4	Leishmania donovani	27%	100%
A0A3S5H5G0	Leishmania donovani	27%	100%
A0A3S7WY10	Leishmania donovani	27%	100%
A0A3S7X2F1	Leishmania donovani	74%	100%
A4H459	Leishmania braziliensis	27%	100%
A4HA97	Leishmania braziliensis	25%	100%
A4HCD7	Leishmania braziliensis	27%	100%
A4HD79	Leishmania braziliensis	28%	100%
A4HED7	Leishmania braziliensis	28%	100%
A4HHQ5	Leishmania braziliensis	24%	100%
A4HSE2	Leishmania infantum	27%	100%
A4I1T4	Leishmania infantum	27%	100%
E9ADZ1	Leishmania major	74%	100%
E9AET0	Leishmania major	27%	100%
E9AH34	Leishmania infantum	27%	100%
E9AHI7	Leishmania infantum	74%	100%
E9AKB7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	26%	100%
E9ALU0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	72%	100%
E9AWL2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	27%	100%
E9AXW8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	26%	100%
Q4QAV8	Leishmania major	27%	100%
Q4QJJ0	Leishmania major	26%	100%