DNA-directed RNA polymerase III subunit RPC6

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

RNA polymerase Rpc34 subunit, putative

Species:

Leishmania braziliensis

UniProt:

A4HHE3_LEIBR

TriTrypDb:

LbrM.29.1400 , LBRM2903_290020500

Length:

447

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0000428	DNA-directed RNA polymerase complex	4	11
GO:0005666	RNA polymerase III complex	4	11
GO:0030880	RNA polymerase complex	3	11
GO:0032991	protein-containing complex	1	11
GO:0055029	nuclear DNA-directed RNA polymerase complex	3	11
GO:0061695	transferase complex, transferring phosphorus-containing groups	4	11
GO:0140513	nuclear protein-containing complex	2	11
GO:0140535	intracellular protein-containing complex	2	11
GO:1902494	catalytic complex	2	11
GO:1990234	transferase complex	3	11

Expansion

Sequence features

A4HHE3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HHE3

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	11
GO:0006351	DNA-templated transcription	7	11
GO:0006383	transcription by RNA polymerase III	8	11
GO:0006725	cellular aromatic compound metabolic process	3	11
GO:0006807	nitrogen compound metabolic process	2	11
GO:0008152	metabolic process	1	11
GO:0009058	biosynthetic process	2	11
GO:0009059	macromolecule biosynthetic process	4	11
GO:0009987	cellular process	1	11
GO:0016070	RNA metabolic process	5	11
GO:0018130	heterocycle biosynthetic process	4	11
GO:0019438	aromatic compound biosynthetic process	4	11
GO:0032774	RNA biosynthetic process	5	11
GO:0034641	cellular nitrogen compound metabolic process	3	11
GO:0034654	nucleobase-containing compound biosynthetic process	4	11
GO:0043170	macromolecule metabolic process	3	11
GO:0044237	cellular metabolic process	2	11
GO:0044238	primary metabolic process	2	11
GO:0044249	cellular biosynthetic process	3	11
GO:0044271	cellular nitrogen compound biosynthetic process	4	11
GO:0046483	heterocycle metabolic process	3	11
GO:0071704	organic substance metabolic process	2	11
GO:0090304	nucleic acid metabolic process	4	11
GO:0097659	nucleic acid-templated transcription	6	11
GO:1901360	organic cyclic compound metabolic process	3	11
GO:1901362	organic cyclic compound biosynthetic process	4	11
GO:1901576	organic substance biosynthetic process	3	11

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	1
GO:0003899	DNA-directed 5'-3' RNA polymerase activity	6	1
GO:0016740	transferase activity	2	1
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	1
GO:0016779	nucleotidyltransferase activity	4	1
GO:0034062	5'-3' RNA polymerase activity	5	1
GO:0097747	RNA polymerase activity	4	1
GO:0140098	catalytic activity, acting on RNA	3	1
GO:0140640	catalytic activity, acting on a nucleic acid	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	230	234	PF00656	0.424
CLV_C14_Caspase3-7	399	403	PF00656	0.454
CLV_NRD_NRD_1	167	169	PF00675	0.338
CLV_NRD_NRD_1	177	179	PF00675	0.330
CLV_NRD_NRD_1	315	317	PF00675	0.480
CLV_NRD_NRD_1	57	59	PF00675	0.355
CLV_PCSK_FUR_1	131	135	PF00082	0.335
CLV_PCSK_FUR_1	29	33	PF00082	0.441
CLV_PCSK_FUR_1	55	59	PF00082	0.447
CLV_PCSK_KEX2_1	133	135	PF00082	0.395
CLV_PCSK_KEX2_1	167	169	PF00082	0.335
CLV_PCSK_KEX2_1	177	179	PF00082	0.335
CLV_PCSK_KEX2_1	186	188	PF00082	0.447
CLV_PCSK_KEX2_1	31	33	PF00082	0.441
CLV_PCSK_KEX2_1	315	317	PF00082	0.480
CLV_PCSK_KEX2_1	57	59	PF00082	0.355
CLV_PCSK_PC1ET2_1	133	135	PF00082	0.395
CLV_PCSK_PC1ET2_1	186	188	PF00082	0.447
CLV_PCSK_PC1ET2_1	31	33	PF00082	0.441
CLV_PCSK_PC7_1	53	59	PF00082	0.447
CLV_PCSK_SKI1_1	111	115	PF00082	0.323
CLV_PCSK_SKI1_1	126	130	PF00082	0.342
CLV_PCSK_SKI1_1	168	172	PF00082	0.449
CLV_PCSK_SKI1_1	308	312	PF00082	0.354
DEG_MDM2_SWIB_1	162	170	PF02201	0.447
DEG_SCF_FBW7_1	348	355	PF00400	0.227
DEG_SPOP_SBC_1	251	255	PF00917	0.448
DOC_CKS1_1	205	210	PF01111	0.227
DOC_CKS1_1	293	298	PF01111	0.480
DOC_CYCLIN_RxL_1	29	39	PF00134	0.447
DOC_CYCLIN_yCln2_LP_2	389	395	PF00134	0.378
DOC_MAPK_gen_1	29	36	PF00069	0.417
DOC_MAPK_gen_1	333	342	PF00069	0.383
DOC_MAPK_HePTP_8	259	271	PF00069	0.227
DOC_MAPK_HePTP_8	54	70	PF00069	0.378
DOC_MAPK_MEF2A_6	262	271	PF00069	0.227
DOC_MAPK_MEF2A_6	335	344	PF00069	0.383
DOC_PP1_RVXF_1	10	17	PF00149	0.227
DOC_PP1_RVXF_1	176	183	PF00149	0.447
DOC_USP7_MATH_1	191	195	PF00917	0.406
DOC_USP7_MATH_1	251	255	PF00917	0.368
DOC_USP7_MATH_1	258	262	PF00917	0.369
DOC_USP7_MATH_1	350	354	PF00917	0.465
DOC_USP7_UBL2_3	119	123	PF12436	0.447
DOC_WW_Pin1_4	204	209	PF00397	0.444
DOC_WW_Pin1_4	292	297	PF00397	0.438
DOC_WW_Pin1_4	348	353	PF00397	0.227
LIG_14-3-3_CanoR_1	103	113	PF00244	0.369
LIG_14-3-3_CanoR_1	134	139	PF00244	0.447
LIG_14-3-3_CanoR_1	172	180	PF00244	0.372
LIG_14-3-3_CanoR_1	308	317	PF00244	0.342
LIG_14-3-3_CanoR_1	320	329	PF00244	0.321
LIG_Actin_WH2_2	41	59	PF00022	0.335
LIG_BIR_II_1	1	5	PF00653	0.587
LIG_Clathr_ClatBox_1	138	142	PF01394	0.335
LIG_deltaCOP1_diTrp_1	164	173	PF00928	0.447
LIG_FHA_1	169	175	PF00498	0.474
LIG_FHA_1	205	211	PF00498	0.412
LIG_FHA_1	273	279	PF00498	0.341
LIG_FHA_1	288	294	PF00498	0.272
LIG_FHA_1	309	315	PF00498	0.255
LIG_FHA_1	378	384	PF00498	0.443
LIG_FHA_1	94	100	PF00498	0.428
LIG_FHA_2	17	23	PF00498	0.383
LIG_FHA_2	228	234	PF00498	0.447
LIG_FHA_2	322	328	PF00498	0.432
LIG_GBD_Chelix_1	70	78	PF00786	0.447
LIG_LIR_Gen_1	181	189	PF02991	0.480
LIG_LIR_Gen_1	254	264	PF02991	0.467
LIG_LIR_Gen_1	405	415	PF02991	0.447
LIG_LIR_Gen_1	64	74	PF02991	0.359
LIG_LIR_LC3C_4	207	212	PF02991	0.227
LIG_LIR_Nem_3	181	185	PF02991	0.480
LIG_LIR_Nem_3	254	260	PF02991	0.467
LIG_LIR_Nem_3	64	70	PF02991	0.359
LIG_Pex14_2	162	166	PF04695	0.442
LIG_SH2_CRK	257	261	PF00017	0.480
LIG_SH2_NCK_1	257	261	PF00017	0.227
LIG_SH2_PTP2	67	70	PF00017	0.335
LIG_SH2_STAT5	136	139	PF00017	0.335
LIG_SH2_STAT5	153	156	PF00017	0.335
LIG_SH2_STAT5	441	444	PF00017	0.335
LIG_SH2_STAT5	67	70	PF00017	0.319
LIG_SH3_3	290	296	PF00018	0.368
LIG_SH3_3	311	317	PF00018	0.411
LIG_SH3_3	342	348	PF00018	0.266
LIG_SH3_3	392	398	PF00018	0.378
LIG_SH3_3	410	416	PF00018	0.192
LIG_SH3_3	430	436	PF00018	0.335
LIG_SH3_3	99	105	PF00018	0.355
LIG_SUMO_SIM_anti_2	76	83	PF11976	0.408
LIG_SUMO_SIM_par_1	274	279	PF11976	0.335
LIG_TRAF2_1	20	23	PF00917	0.237
LIG_TRAF2_1	334	337	PF00917	0.227
LIG_TYR_ITIM	25	30	PF00017	0.447
LIG_WRC_WIRS_1	179	184	PF05994	0.480
MOD_CK1_1	145	151	PF00069	0.227
MOD_CK1_1	215	221	PF00069	0.422
MOD_CK1_1	245	251	PF00069	0.397
MOD_CK1_1	252	258	PF00069	0.224
MOD_CK1_1	377	383	PF00069	0.480
MOD_CK1_1	385	391	PF00069	0.330
MOD_CK1_1	396	402	PF00069	0.344
MOD_CK2_1	16	22	PF00069	0.292
MOD_CK2_1	321	327	PF00069	0.402
MOD_CK2_1	36	42	PF00069	0.454
MOD_CK2_1	376	382	PF00069	0.482
MOD_CK2_1	385	391	PF00069	0.370
MOD_GlcNHglycan	19	22	PF01048	0.418
MOD_GlcNHglycan	193	196	PF01048	0.349
MOD_GlcNHglycan	202	205	PF01048	0.314
MOD_GlcNHglycan	215	218	PF01048	0.370
MOD_GlcNHglycan	233	236	PF01048	0.370
MOD_GlcNHglycan	247	250	PF01048	0.274
MOD_GlcNHglycan	348	351	PF01048	0.488
MOD_GlcNHglycan	364	367	PF01048	0.233
MOD_GlcNHglycan	38	41	PF01048	0.447
MOD_GlcNHglycan	87	90	PF01048	0.335
MOD_GSK3_1	141	148	PF00069	0.335
MOD_GSK3_1	168	175	PF00069	0.480
MOD_GSK3_1	200	207	PF00069	0.322
MOD_GSK3_1	212	219	PF00069	0.403
MOD_GSK3_1	227	234	PF00069	0.339
MOD_GSK3_1	245	252	PF00069	0.233
MOD_GSK3_1	258	265	PF00069	0.394
MOD_GSK3_1	346	353	PF00069	0.437
MOD_GSK3_1	393	400	PF00069	0.415
MOD_GSK3_1	93	100	PF00069	0.442
MOD_N-GLC_1	212	217	PF02516	0.317
MOD_N-GLC_1	74	79	PF02516	0.393
MOD_NEK2_1	173	178	PF00069	0.447
MOD_NEK2_1	231	236	PF00069	0.408
MOD_NEK2_1	250	255	PF00069	0.250
MOD_NEK2_1	272	277	PF00069	0.335
MOD_NEK2_1	36	41	PF00069	0.348
MOD_NEK2_1	376	381	PF00069	0.480
MOD_NEK2_1	384	389	PF00069	0.413
MOD_NEK2_2	426	431	PF00069	0.482
MOD_PIKK_1	217	223	PF00454	0.480
MOD_PIKK_1	382	388	PF00454	0.424
MOD_PIKK_1	393	399	PF00454	0.398
MOD_PIKK_1	61	67	PF00454	0.480
MOD_PIKK_1	93	99	PF00454	0.447
MOD_PKA_2	85	91	PF00069	0.322
MOD_PKB_1	318	326	PF00069	0.442
MOD_Plk_1	168	174	PF00069	0.480
MOD_Plk_1	74	80	PF00069	0.441
MOD_Plk_1	93	99	PF00069	0.287
MOD_Plk_4	134	140	PF00069	0.402
MOD_Plk_4	272	278	PF00069	0.304
MOD_Plk_4	302	308	PF00069	0.480
MOD_Plk_4	385	391	PF00069	0.447
MOD_Plk_4	437	443	PF00069	0.428
MOD_Plk_4	76	82	PF00069	0.364
MOD_ProDKin_1	204	210	PF00069	0.444
MOD_ProDKin_1	292	298	PF00069	0.438
MOD_ProDKin_1	348	354	PF00069	0.227
MOD_SUMO_for_1	105	108	PF00179	0.335
MOD_SUMO_for_1	30	33	PF00179	0.447
TRG_DiLeu_BaEn_1	76	81	PF01217	0.335
TRG_DiLeu_BaEn_2	168	174	PF01217	0.447
TRG_DiLeu_BaLyEn_6	418	423	PF01217	0.447
TRG_ENDOCYTIC_2	136	139	PF00928	0.335
TRG_ENDOCYTIC_2	257	260	PF00928	0.480
TRG_ENDOCYTIC_2	27	30	PF00928	0.447
TRG_ENDOCYTIC_2	67	70	PF00928	0.335
TRG_ER_diArg_1	166	168	PF00400	0.335
TRG_ER_diArg_1	177	179	PF00400	0.335
TRG_ER_diArg_1	314	316	PF00400	0.450
TRG_ER_diArg_1	317	320	PF00400	0.444
TRG_ER_diArg_1	53	56	PF00400	0.364
TRG_NES_CRM1_1	268	279	PF08389	0.447
TRG_Pf-PMV_PEXEL_1	46	50	PF00026	0.335

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1ILC6	Leptomonas seymouri	65%	100%
A0A1X0NZS8	Trypanosomatidae	42%	100%
A0A3Q8IBH1	Leishmania donovani	86%	100%
A0A3R7NQJ5	Trypanosoma rangeli	40%	100%
A4I4I9	Leishmania infantum	87%	100%
C9ZL77	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	37%	100%
E9ADZ0	Leishmania major	86%	100%
E9ALU1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%
V5B1R1	Trypanosoma cruzi	39%	100%