Putative carnitine/choline acetyltransferase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

carnitine/choline acetyltransferase, putative

Species:

Leishmania braziliensis

UniProt:

A4HHE2_LEIBR

TriTrypDb:

LbrM.29.1390 , LBRM2903_290020400

Length:

627

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 25

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 8

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 13
NetGPI	no	yes: 0, no: 13

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0005739	mitochondrion	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HHE2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HHE2

Function

Biological processes
Term	Name	Level	Count
GO:0006082	organic acid metabolic process	3	1
GO:0006629	lipid metabolic process	3	1
GO:0006631	fatty acid metabolic process	4	1
GO:0006635	fatty acid beta-oxidation	6	1
GO:0008152	metabolic process	1	1
GO:0009056	catabolic process	2	1
GO:0009062	fatty acid catabolic process	5	1
GO:0009987	cellular process	1	1
GO:0016042	lipid catabolic process	4	1
GO:0016054	organic acid catabolic process	4	1
GO:0019395	fatty acid oxidation	5	1
GO:0019752	carboxylic acid metabolic process	5	1
GO:0030258	lipid modification	4	1
GO:0032787	monocarboxylic acid metabolic process	6	1
GO:0034440	lipid oxidation	5	1
GO:0043436	oxoacid metabolic process	4	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0044242	cellular lipid catabolic process	4	1
GO:0044248	cellular catabolic process	3	1
GO:0044255	cellular lipid metabolic process	3	1
GO:0044281	small molecule metabolic process	2	1
GO:0044282	small molecule catabolic process	3	1
GO:0046395	carboxylic acid catabolic process	5	1
GO:0071704	organic substance metabolic process	2	1
GO:0072329	monocarboxylic acid catabolic process	6	1
GO:1901575	organic substance catabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	14
GO:0016740	transferase activity	2	14
GO:0016746	acyltransferase activity	3	14
GO:0004095	carnitine O-palmitoyltransferase activity	7	3
GO:0008374	O-acyltransferase activity	5	4
GO:0016406	carnitine O-acyltransferase activity	6	4
GO:0016409	palmitoyltransferase activity	5	3
GO:0016416	O-palmitoyltransferase activity	6	3
GO:0016747	acyltransferase activity, transferring groups other than amino-acyl groups	4	4
GO:0004092	carnitine O-acetyltransferase activity	7	1
GO:0016407	acetyltransferase activity	5	1
GO:0016413	O-acetyltransferase activity	6	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	350	354	PF00656	0.508
CLV_NRD_NRD_1	208	210	PF00675	0.475
CLV_PCSK_KEX2_1	2	4	PF00082	0.490
CLV_PCSK_PC1ET2_1	2	4	PF00082	0.508
CLV_PCSK_SKI1_1	526	530	PF00082	0.461
CLV_PCSK_SKI1_1	598	602	PF00082	0.426
CLV_PCSK_SKI1_1	619	623	PF00082	0.504
CLV_Separin_Metazoa	249	253	PF03568	0.406
CLV_Separin_Metazoa	258	262	PF03568	0.440
DEG_APCC_DBOX_1	31	39	PF00400	0.497
DEG_Nend_UBRbox_1	1	4	PF02207	0.530
DEG_SPOP_SBC_1	450	454	PF00917	0.461
DEG_SPOP_SBC_1	544	548	PF00917	0.479
DOC_CKS1_1	251	256	PF01111	0.404
DOC_MAPK_gen_1	182	189	PF00069	0.273
DOC_MAPK_gen_1	377	386	PF00069	0.391
DOC_MAPK_MEF2A_6	214	222	PF00069	0.497
DOC_PP1_RVXF_1	323	329	PF00149	0.467
DOC_PP2B_LxvP_1	14	17	PF13499	0.444
DOC_PP2B_LxvP_1	19	22	PF13499	0.336
DOC_PP4_FxxP_1	550	553	PF00568	0.494
DOC_SPAK_OSR1_1	152	156	PF12202	0.244
DOC_USP7_MATH_1	20	24	PF00917	0.417
DOC_USP7_MATH_1	284	288	PF00917	0.479
DOC_USP7_MATH_1	320	324	PF00917	0.244
DOC_USP7_MATH_1	355	359	PF00917	0.513
DOC_USP7_MATH_1	501	505	PF00917	0.473
DOC_USP7_MATH_1	562	566	PF00917	0.493
DOC_USP7_MATH_1	73	77	PF00917	0.478
DOC_USP7_MATH_1	92	96	PF00917	0.267
DOC_USP7_UBL2_3	210	214	PF12436	0.244
DOC_USP7_UBL2_3	425	429	PF12436	0.403
DOC_WW_Pin1_4	153	158	PF00397	0.387
DOC_WW_Pin1_4	175	180	PF00397	0.376
DOC_WW_Pin1_4	220	225	PF00397	0.373
DOC_WW_Pin1_4	227	232	PF00397	0.369
DOC_WW_Pin1_4	250	255	PF00397	0.404
DOC_WW_Pin1_4	37	42	PF00397	0.479
DOC_WW_Pin1_4	586	591	PF00397	0.371
LIG_14-3-3_CanoR_1	3	13	PF00244	0.573
LIG_14-3-3_CanoR_1	32	36	PF00244	0.483
LIG_14-3-3_CanoR_1	362	367	PF00244	0.413
LIG_14-3-3_CanoR_1	556	561	PF00244	0.405
LIG_14-3-3_CanoR_1	580	590	PF00244	0.359
LIG_APCC_ABBA_1	197	202	PF00400	0.387
LIG_APCC_ABBA_1	260	265	PF00400	0.479
LIG_APCC_Cbox_2	494	500	PF00515	0.497
LIG_CSL_BTD_1	38	41	PF09270	0.497
LIG_FHA_1	126	132	PF00498	0.452
LIG_FHA_1	138	144	PF00498	0.357
LIG_FHA_1	170	176	PF00498	0.447
LIG_FHA_1	227	233	PF00498	0.397
LIG_FHA_1	347	353	PF00498	0.415
LIG_FHA_1	431	437	PF00498	0.446
LIG_FHA_1	444	450	PF00498	0.286
LIG_FHA_1	540	546	PF00498	0.247
LIG_FHA_1	589	595	PF00498	0.504
LIG_FHA_2	176	182	PF00498	0.377
LIG_FHA_2	319	325	PF00498	0.479
LIG_FHA_2	450	456	PF00498	0.459
LIG_FHA_2	605	611	PF00498	0.550
LIG_FHA_2	80	86	PF00498	0.473
LIG_LIR_Apic_2	547	553	PF02991	0.399
LIG_LIR_Gen_1	412	422	PF02991	0.347
LIG_LIR_Gen_1	607	617	PF02991	0.390
LIG_LIR_LC3C_4	265	270	PF02991	0.479
LIG_LIR_Nem_3	551	557	PF02991	0.407
LIG_LIR_Nem_3	607	612	PF02991	0.322
LIG_PCNA_PIPBox_1	457	466	PF02747	0.244
LIG_PCNA_yPIPBox_3	252	263	PF02747	0.479
LIG_Pex14_1	243	247	PF04695	0.387
LIG_Pex14_1	554	558	PF04695	0.404
LIG_Pex14_2	550	554	PF04695	0.486
LIG_PTB_Apo_2	295	302	PF02174	0.450
LIG_PTB_Phospho_1	295	301	PF10480	0.479
LIG_RPA_C_Fungi	375	387	PF08784	0.387
LIG_SH2_SRC	83	86	PF00017	0.404
LIG_SH2_STAP1	509	513	PF00017	0.497
LIG_SH2_STAT5	558	561	PF00017	0.437
LIG_SH2_STAT5	572	575	PF00017	0.279
LIG_SH2_STAT5	83	86	PF00017	0.352
LIG_SH3_3	105	111	PF00018	0.244
LIG_SH3_3	14	20	PF00018	0.438
LIG_SH3_3	40	46	PF00018	0.423
LIG_SUMO_SIM_anti_2	229	236	PF11976	0.404
LIG_SUMO_SIM_anti_2	265	271	PF11976	0.425
LIG_SUMO_SIM_anti_2	333	341	PF11976	0.494
LIG_SUMO_SIM_anti_2	382	391	PF11976	0.451
LIG_SUMO_SIM_par_1	185	191	PF11976	0.384
LIG_SUMO_SIM_par_1	217	223	PF11976	0.381
LIG_SUMO_SIM_par_1	229	236	PF11976	0.354
LIG_TRAF2_1	246	249	PF00917	0.479
LIG_TRAF2_1	292	295	PF00917	0.497
LIG_TRAF2_1	379	382	PF00917	0.479
LIG_TRAF2_1	453	456	PF00917	0.422
LIG_TRFH_1	107	111	PF08558	0.399
LIG_UBA3_1	457	462	PF00899	0.479
LIG_WRC_WIRS_1	557	562	PF05994	0.452
MOD_CDK_SPxxK_3	175	182	PF00069	0.404
MOD_CK1_1	125	131	PF00069	0.479
MOD_CK1_1	169	175	PF00069	0.497
MOD_CK1_1	230	236	PF00069	0.397
MOD_CK1_1	279	285	PF00069	0.382
MOD_CK1_1	371	377	PF00069	0.416
MOD_CK1_1	481	487	PF00069	0.508
MOD_CK1_1	543	549	PF00069	0.371
MOD_CK1_1	584	590	PF00069	0.372
MOD_CK1_1	604	610	PF00069	0.536
MOD_CK2_1	175	181	PF00069	0.383
MOD_CK2_1	2	8	PF00069	0.586
MOD_CK2_1	279	285	PF00069	0.402
MOD_CK2_1	289	295	PF00069	0.399
MOD_CK2_1	449	455	PF00069	0.369
MOD_CK2_1	501	507	PF00069	0.440
MOD_CK2_1	543	549	PF00069	0.458
MOD_CK2_1	604	610	PF00069	0.529
MOD_CK2_1	79	85	PF00069	0.345
MOD_CMANNOS	328	331	PF00535	0.371
MOD_GlcNHglycan	124	127	PF01048	0.479
MOD_GlcNHglycan	145	148	PF01048	0.403
MOD_GlcNHglycan	285	289	PF01048	0.497
MOD_GlcNHglycan	343	346	PF01048	0.429
MOD_GlcNHglycan	357	360	PF01048	0.276
MOD_GlcNHglycan	4	7	PF01048	0.565
MOD_GlcNHglycan	404	407	PF01048	0.467
MOD_GlcNHglycan	565	568	PF01048	0.392
MOD_GlcNHglycan	57	60	PF01048	0.402
MOD_GlcNHglycan	583	586	PF01048	0.355
MOD_GlcNHglycan	75	78	PF01048	0.166
MOD_GlcNHglycan	90	93	PF01048	0.383
MOD_GSK3_1	137	144	PF00069	0.465
MOD_GSK3_1	153	160	PF00069	0.473
MOD_GSK3_1	162	169	PF00069	0.419
MOD_GSK3_1	20	27	PF00069	0.383
MOD_GSK3_1	226	233	PF00069	0.378
MOD_GSK3_1	272	279	PF00069	0.375
MOD_GSK3_1	330	337	PF00069	0.375
MOD_GSK3_1	341	348	PF00069	0.397
MOD_GSK3_1	364	371	PF00069	0.388
MOD_GSK3_1	37	44	PF00069	0.314
MOD_GSK3_1	387	394	PF00069	0.457
MOD_GSK3_1	431	438	PF00069	0.416
MOD_GSK3_1	497	504	PF00069	0.481
MOD_GSK3_1	539	546	PF00069	0.356
MOD_GSK3_1	584	591	PF00069	0.379
MOD_GSK3_1	88	95	PF00069	0.426
MOD_N-GLC_1	227	232	PF02516	0.397
MOD_N-GLC_1	55	60	PF02516	0.497
MOD_NEK2_1	162	167	PF00069	0.353
MOD_NEK2_1	174	179	PF00069	0.351
MOD_NEK2_1	218	223	PF00069	0.432
MOD_NEK2_1	263	268	PF00069	0.451
MOD_NEK2_1	272	277	PF00069	0.452
MOD_NEK2_1	318	323	PF00069	0.423
MOD_NEK2_1	364	369	PF00069	0.356
MOD_NEK2_1	449	454	PF00069	0.461
MOD_NEK2_1	537	542	PF00069	0.369
MOD_NEK2_1	54	59	PF00069	0.359
MOD_NEK2_1	563	568	PF00069	0.466
MOD_NEK2_1	601	606	PF00069	0.467
MOD_NEK2_1	88	93	PF00069	0.430
MOD_NEK2_2	31	36	PF00069	0.423
MOD_PIKK_1	116	122	PF00454	0.363
MOD_PIKK_1	462	468	PF00454	0.343
MOD_PIKK_1	548	554	PF00454	0.491
MOD_PK_1	362	368	PF00069	0.462
MOD_PKA_1	2	8	PF00069	0.600
MOD_PKA_2	2	8	PF00069	0.596
MOD_PKA_2	31	37	PF00069	0.382
MOD_PKA_2	341	347	PF00069	0.458
MOD_PKA_2	579	585	PF00069	0.450
MOD_Plk_1	279	285	PF00069	0.457
MOD_Plk_4	20	26	PF00069	0.366
MOD_Plk_4	230	236	PF00069	0.383
MOD_Plk_4	263	269	PF00069	0.488
MOD_Plk_4	334	340	PF00069	0.493
MOD_Plk_4	368	374	PF00069	0.437
MOD_Plk_4	540	546	PF00069	0.344
MOD_Plk_4	604	610	PF00069	0.317
MOD_ProDKin_1	153	159	PF00069	0.387
MOD_ProDKin_1	175	181	PF00069	0.376
MOD_ProDKin_1	220	226	PF00069	0.373
MOD_ProDKin_1	227	233	PF00069	0.369
MOD_ProDKin_1	250	256	PF00069	0.404
MOD_ProDKin_1	37	43	PF00069	0.479
MOD_ProDKin_1	586	592	PF00069	0.371
MOD_SUMO_for_1	407	410	PF00179	0.466
MOD_SUMO_rev_2	202	212	PF00179	0.403
TRG_DiLeu_BaEn_2	409	415	PF01217	0.466
TRG_DiLeu_BaEn_2	532	538	PF01217	0.497
TRG_DiLeu_BaEn_4	455	461	PF01217	0.497
TRG_DiLeu_BaLyEn_6	154	159	PF01217	0.425
TRG_ENDOCYTIC_2	247	250	PF00928	0.387
TRG_ENDOCYTIC_2	557	560	PF00928	0.437
TRG_Pf-PMV_PEXEL_1	209	213	PF00026	0.461
TRG_Pf-PMV_PEXEL_1	64	68	PF00026	0.479

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P6E3	Leptomonas seymouri	75%	100%
A0A0N1I7U1	Leptomonas seymouri	23%	72%
A0A0S4JAG1	Bodo saltans	26%	86%
A0A0S4JRH6	Bodo saltans	27%	92%
A0A0S4JRL8	Bodo saltans	24%	78%
A0A0S4JY55	Bodo saltans	36%	100%
A0A0S4KE24	Bodo saltans	25%	76%
A0A1X0NR41	Trypanosomatidae	22%	92%
A0A1X0NT49	Trypanosomatidae	25%	85%
A0A1X0NT60	Trypanosomatidae	23%	92%
A0A1X0NZS6	Trypanosomatidae	50%	100%
A0A1X0P523	Trypanosomatidae	24%	83%
A0A1X0P5Y2	Trypanosomatidae	24%	79%
A0A3Q8IRB8	Leishmania donovani	91%	100%
A0A3R7K5Z4	Trypanosoma rangeli	22%	92%
A0A3R7L2D0	Trypanosoma rangeli	49%	100%
A0A3S5IQT1	Trypanosoma rangeli	27%	84%
A0A3S7WX31	Leishmania donovani	23%	93%
A0A422NAV0	Trypanosoma rangeli	23%	85%
A0A422NSK2	Trypanosoma rangeli	25%	93%
A4HAA3	Leishmania braziliensis	23%	72%
A4HC81	Leishmania braziliensis	22%	100%
A4HZQ9	Leishmania infantum	24%	93%
A4I4I8	Leishmania infantum	91%	100%
B2ZGJ1	Danio rerio	22%	98%
C9ZL75	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	49%	100%
C9ZRI9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	23%	94%
D0A627	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	26%	81%
E9ADY9	Leishmania major	90%	100%
E9ALU2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
E9AVL5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	24%	92%
F1LN46	Rattus norvegicus	24%	78%
O19094	Bos taurus	25%	100%
P07668	Drosophila melanogaster	24%	87%
P11466	Rattus norvegicus	24%	100%
P13222	Sus scrofa	22%	98%
P18886	Rattus norvegicus	26%	95%
P23786	Homo sapiens	25%	95%
P28329	Homo sapiens	24%	84%
P32198	Rattus norvegicus	26%	81%
P32738	Rattus norvegicus	22%	98%
P32756	Caenorhabditis elegans	22%	100%
P32796	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	22%	94%
P43155	Homo sapiens	25%	100%
P47934	Mus musculus	26%	100%
P50416	Homo sapiens	26%	81%
P52825	Mus musculus	26%	95%
P52826	Columba livia	25%	100%
P75448	Mycoplasma pneumoniae (strain ATCC 29342 / M129 / Subtype 1)	22%	100%
P80235	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	25%	91%
P97742	Mus musculus	26%	81%
Q00614	Candida tropicalis	24%	100%
Q03059	Mus musculus	23%	98%
Q2KJB7	Bos taurus	25%	95%
Q4QBW4	Leishmania major	23%	100%
Q58DK1	Bos taurus	26%	81%
Q5U3U3	Danio rerio	26%	94%
Q60HG9	Macaca fascicularis	25%	95%
Q63704	Rattus norvegicus	27%	81%
Q68Y62	Equus caballus	26%	81%
Q6P4X5	Xenopus tropicalis	27%	95%
Q704S8	Rattus norvegicus	26%	100%
Q7ZXE1	Xenopus laevis	27%	95%
Q8BGD5	Mus musculus	24%	79%
Q8HY46	Sus scrofa	26%	81%
Q8TCG5	Homo sapiens	24%	78%
Q90YJ9	Gallus gallus	23%	98%
Q924X2	Mus musculus	26%	81%
Q92523	Homo sapiens	26%	81%
Q9DC50	Mus musculus	23%	100%
Q9UKG9	Homo sapiens	24%	100%
V5BH74	Trypanosoma cruzi	49%	100%
V5BJG0	Trypanosoma cruzi	27%	100%
V5BP17	Trypanosoma cruzi	21%	92%
V5BQH8	Trypanosoma cruzi	27%	79%
V5D4R1	Trypanosoma cruzi	26%	79%
V5DBT5	Trypanosoma cruzi	24%	92%