Protein MAIN-LIKE 1-like

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HHE1_LEIBR

TriTrypDb:

LbrM.29.1380 , LBRM2903_290020300

Length:

296

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 12
NetGPI	no	yes: 0, no: 12

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HHE1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HHE1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	131	133	PF00675	0.395
CLV_NRD_NRD_1	144	146	PF00675	0.474
CLV_PCSK_KEX2_1	131	133	PF00082	0.395
CLV_PCSK_KEX2_1	143	145	PF00082	0.490
CLV_PCSK_PC7_1	140	146	PF00082	0.405
CLV_PCSK_SKI1_1	105	109	PF00082	0.436
CLV_PCSK_SKI1_1	131	135	PF00082	0.419
CLV_PCSK_SKI1_1	145	149	PF00082	0.466
CLV_PCSK_SKI1_1	20	24	PF00082	0.626
CLV_PCSK_SKI1_1	76	80	PF00082	0.525
DEG_APCC_DBOX_1	144	152	PF00400	0.460
DEG_APCC_DBOX_1	168	176	PF00400	0.488
DEG_SCF_FBW7_1	30	35	PF00400	0.589
DOC_CKS1_1	29	34	PF01111	0.591
DOC_MAPK_gen_1	131	138	PF00069	0.442
DOC_PP4_FxxP_1	21	24	PF00568	0.583
DOC_PP4_FxxP_1	255	258	PF00568	0.394
DOC_PP4_FxxP_1	29	32	PF00568	0.525
DOC_USP7_MATH_1	160	164	PF00917	0.487
DOC_USP7_MATH_1	288	292	PF00917	0.609
DOC_USP7_MATH_1	5	9	PF00917	0.607
DOC_WW_Pin1_4	254	259	PF00397	0.406
DOC_WW_Pin1_4	28	33	PF00397	0.560
LIG_14-3-3_CanoR_1	131	138	PF00244	0.442
LIG_14-3-3_CanoR_1	234	243	PF00244	0.402
LIG_14-3-3_CanoR_1	277	282	PF00244	0.554
LIG_14-3-3_CanoR_1	33	40	PF00244	0.532
LIG_14-3-3_CanoR_1	76	81	PF00244	0.519
LIG_Actin_WH2_2	9	25	PF00022	0.601
LIG_BIR_II_1	1	5	PF00653	0.667
LIG_BIR_III_3	1	5	PF00653	0.667
LIG_Clathr_ClatBox_1	107	111	PF01394	0.566
LIG_deltaCOP1_diTrp_1	103	108	PF00928	0.430
LIG_FHA_1	116	122	PF00498	0.396
LIG_FHA_1	257	263	PF00498	0.545
LIG_FHA_1	33	39	PF00498	0.537
LIG_FHA_2	152	158	PF00498	0.459
LIG_FHA_2	160	166	PF00498	0.487
LIG_FHA_2	278	284	PF00498	0.684
LIG_LIR_Apic_2	18	24	PF02991	0.584
LIG_LIR_Apic_2	27	32	PF02991	0.540
LIG_LIR_Gen_1	109	119	PF02991	0.451
LIG_LIR_Gen_1	225	235	PF02991	0.383
LIG_LIR_Gen_1	237	248	PF02991	0.402
LIG_LIR_Gen_1	265	275	PF02991	0.534
LIG_LIR_Nem_3	103	107	PF02991	0.428
LIG_LIR_Nem_3	116	122	PF02991	0.372
LIG_LIR_Nem_3	12	16	PF02991	0.521
LIG_LIR_Nem_3	225	230	PF02991	0.387
LIG_LIR_Nem_3	237	243	PF02991	0.390
LIG_LIR_Nem_3	265	270	PF02991	0.531
LIG_LIR_Nem_3	54	59	PF02991	0.495
LIG_NRBOX	147	153	PF00104	0.578
LIG_PDZ_Class_1	291	296	PF00595	0.475
LIG_Pex14_1	104	108	PF04695	0.414
LIG_Pex14_2	208	212	PF04695	0.402
LIG_Rb_pABgroove_1	150	158	PF01858	0.489
LIG_SH2_CRK	227	231	PF00017	0.384
LIG_SH2_NCK_1	267	271	PF00017	0.543
LIG_SH2_SRC	272	275	PF00017	0.613
LIG_SH2_STAP1	267	271	PF00017	0.559
LIG_SH2_STAP1	272	276	PF00017	0.558
LIG_SH2_STAT5	122	125	PF00017	0.374
LIG_SH2_STAT5	178	181	PF00017	0.464
LIG_SH2_STAT5	184	187	PF00017	0.436
LIG_SH2_STAT5	227	230	PF00017	0.398
LIG_SH2_STAT5	232	235	PF00017	0.394
LIG_SH3_3	255	261	PF00018	0.451
LIG_SH3_3	58	64	PF00018	0.464
LIG_TRAF2_1	244	247	PF00917	0.546
LIG_TRAF2_1	280	283	PF00917	0.705
LIG_TRAF2_1	40	43	PF00917	0.617
LIG_TYR_ITIM	270	275	PF00017	0.670
LIG_TYR_ITSM	223	230	PF00017	0.401
MOD_CDK_SPK_2	28	33	PF00069	0.555
MOD_CK1_1	265	271	PF00069	0.656
MOD_CK1_1	287	293	PF00069	0.769
MOD_CK2_1	12	18	PF00069	0.652
MOD_CK2_1	277	283	PF00069	0.588
MOD_CK2_1	97	103	PF00069	0.463
MOD_GlcNHglycan	286	289	PF01048	0.683
MOD_GlcNHglycan	290	293	PF01048	0.654
MOD_GlcNHglycan	91	94	PF01048	0.429
MOD_GSK3_1	127	134	PF00069	0.407
MOD_GSK3_1	28	35	PF00069	0.533
MOD_GSK3_1	284	291	PF00069	0.610
MOD_GSK3_1	85	92	PF00069	0.424
MOD_NEK2_1	115	120	PF00069	0.410
MOD_NEK2_1	151	156	PF00069	0.463
MOD_NEK2_1	262	267	PF00069	0.602
MOD_PIKK_1	262	268	PF00454	0.382
MOD_PK_1	132	138	PF00069	0.447
MOD_PKA_1	131	137	PF00069	0.430
MOD_PKA_2	131	137	PF00069	0.430
MOD_PKA_2	32	38	PF00069	0.533
MOD_PKB_1	74	82	PF00069	0.510
MOD_Plk_1	115	121	PF00069	0.405
MOD_Plk_2-3	12	18	PF00069	0.652
MOD_Plk_4	115	121	PF00069	0.405
MOD_Plk_4	151	157	PF00069	0.454
MOD_Plk_4	225	231	PF00069	0.401
MOD_ProDKin_1	254	260	PF00069	0.408
MOD_ProDKin_1	28	34	PF00069	0.559
MOD_SUMO_rev_2	100	107	PF00179	0.444
MOD_SUMO_rev_2	282	287	PF00179	0.642
MOD_SUMO_rev_2	8	16	PF00179	0.564
TRG_DiLeu_BaLyEn_6	258	263	PF01217	0.572
TRG_ENDOCYTIC_2	112	115	PF00928	0.472
TRG_ENDOCYTIC_2	226	229	PF00928	0.388
TRG_ENDOCYTIC_2	232	235	PF00928	0.375
TRG_ENDOCYTIC_2	267	270	PF00928	0.540
TRG_ENDOCYTIC_2	272	275	PF00928	0.543
TRG_ENDOCYTIC_2	56	59	PF00928	0.472
TRG_ER_diArg_1	143	145	PF00400	0.490
TRG_ER_diArg_1	74	77	PF00400	0.516
TRG_PTS1	293	296	PF00515	0.474

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I7V3	Leptomonas seymouri	91%	81%
A0A0S4IPL1	Bodo saltans	75%	86%
A0A1X0NZU1	Trypanosomatidae	79%	93%
A0A3Q8IEE3	Leishmania donovani	95%	100%
A0A3R7KGQ0	Trypanosoma rangeli	81%	92%
A4HHE6	Leishmania braziliensis	100%	100%
A4I4I7	Leishmania infantum	95%	100%
C9ZL74	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	80%	92%
E9ADY8	Leishmania major	94%	100%
E9ALU3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	100%
V5BRA3	Trypanosoma cruzi	80%	92%