TPR_REGION domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Hsp70 protein/TPR repeat, putative

Species:

Leishmania braziliensis

UniProt:

A4HHD6_LEIBR

TriTrypDb:

LbrM.29.1320 , LBRM2903_290019500

Length:

720

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 3
Silverman et al.	no	yes: 3
Pissara et al.	yes	yes: 12

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 6

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0043226	organelle	2	8
GO:0110165	cellular anatomical entity	1	8
GO:0005737	cytoplasm	2	1

Expansion

Sequence features

A4HHD6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HHD6

Function

Biological processes
Term	Name	Level	Count
GO:0000413	protein peptidyl-prolyl isomerization	7	1
GO:0006457	protein folding	2	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0009987	cellular process	1	1
GO:0018193	peptidyl-amino acid modification	5	1
GO:0018208	peptidyl-proline modification	6	1
GO:0019538	protein metabolic process	3	1
GO:0036211	protein modification process	4	1
GO:0043170	macromolecule metabolic process	3	1
GO:0043412	macromolecule modification	4	1
GO:0044238	primary metabolic process	2	1
GO:0061077	chaperone-mediated protein folding	3	1
GO:0071704	organic substance metabolic process	2	1
GO:1901564	organonitrogen compound metabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	8
GO:0005488	binding	1	8
GO:0005524	ATP binding	5	8
GO:0017076	purine nucleotide binding	4	8
GO:0030554	adenyl nucleotide binding	5	8
GO:0032553	ribonucleotide binding	3	8
GO:0032555	purine ribonucleotide binding	4	8
GO:0032559	adenyl ribonucleotide binding	5	8
GO:0035639	purine ribonucleoside triphosphate binding	4	8
GO:0036094	small molecule binding	2	8
GO:0043167	ion binding	2	8
GO:0043168	anion binding	3	8
GO:0044183	protein folding chaperone	1	8
GO:0097159	organic cyclic compound binding	2	8
GO:0097367	carbohydrate derivative binding	2	8
GO:0140657	ATP-dependent activity	1	8
GO:0140662	ATP-dependent protein folding chaperone	2	8
GO:1901265	nucleoside phosphate binding	3	8
GO:1901363	heterocyclic compound binding	2	8
GO:0003755	peptidyl-prolyl cis-trans isomerase activity	3	1
GO:0003824	catalytic activity	1	1
GO:0016853	isomerase activity	2	1
GO:0016859	cis-trans isomerase activity	3	1
GO:0140096	catalytic activity, acting on a protein	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	220	224	PF00656	0.333
CLV_C14_Caspase3-7	419	423	PF00656	0.500
CLV_C14_Caspase3-7	450	454	PF00656	0.520
CLV_C14_Caspase3-7	475	479	PF00656	0.353
CLV_NRD_NRD_1	252	254	PF00675	0.346
CLV_NRD_NRD_1	259	261	PF00675	0.311
CLV_NRD_NRD_1	381	383	PF00675	0.486
CLV_NRD_NRD_1	576	578	PF00675	0.447
CLV_NRD_NRD_1	662	664	PF00675	0.335
CLV_PCSK_KEX2_1	381	383	PF00082	0.538
CLV_PCSK_KEX2_1	575	577	PF00082	0.457
CLV_PCSK_KEX2_1	662	664	PF00082	0.330
CLV_PCSK_PC1ET2_1	575	577	PF00082	0.500
CLV_PCSK_PC7_1	571	577	PF00082	0.513
CLV_PCSK_SKI1_1	106	110	PF00082	0.330
CLV_PCSK_SKI1_1	140	144	PF00082	0.429
CLV_PCSK_SKI1_1	253	257	PF00082	0.389
CLV_PCSK_SKI1_1	260	264	PF00082	0.389
CLV_PCSK_SKI1_1	306	310	PF00082	0.494
CLV_PCSK_SKI1_1	35	39	PF00082	0.381
CLV_PCSK_SKI1_1	352	356	PF00082	0.330
CLV_PCSK_SKI1_1	6	10	PF00082	0.370
CLV_PCSK_SKI1_1	658	662	PF00082	0.381
CLV_PCSK_SKI1_1	701	705	PF00082	0.489
CLV_PCSK_SKI1_1	712	716	PF00082	0.444
CLV_Separin_Metazoa	116	120	PF03568	0.248
CLV_Separin_Metazoa	331	335	PF03568	0.248
DEG_APCC_DBOX_1	272	280	PF00400	0.276
DEG_APCC_DBOX_1	305	313	PF00400	0.389
DEG_SPOP_SBC_1	265	269	PF00917	0.351
DOC_ANK_TNKS_1	333	340	PF00023	0.389
DOC_CYCLIN_yCln2_LP_2	94	100	PF00134	0.406
DOC_MAPK_gen_1	615	623	PF00069	0.430
DOC_MAPK_MEF2A_6	119	127	PF00069	0.406
DOC_MAPK_MEF2A_6	62	70	PF00069	0.406
DOC_PP2B_LxvP_1	125	128	PF13499	0.389
DOC_PP2B_LxvP_1	316	319	PF13499	0.524
DOC_USP7_MATH_1	126	130	PF00917	0.363
DOC_USP7_MATH_1	371	375	PF00917	0.389
DOC_USP7_MATH_1	630	634	PF00917	0.445
DOC_USP7_UBL2_3	250	254	PF12436	0.330
DOC_USP7_UBL2_3	708	712	PF12436	0.450
DOC_USP7_UBL2_3	713	717	PF12436	0.483
DOC_WW_Pin1_4	402	407	PF00397	0.671
DOC_WW_Pin1_4	422	427	PF00397	0.419
DOC_WW_Pin1_4	69	74	PF00397	0.389
LIG_14-3-3_CanoR_1	140	145	PF00244	0.333
LIG_14-3-3_CanoR_1	306	316	PF00244	0.399
LIG_14-3-3_CanoR_1	359	365	PF00244	0.373
LIG_14-3-3_CanoR_1	381	386	PF00244	0.390
LIG_Actin_WH2_2	203	218	PF00022	0.389
LIG_APCC_ABBA_1	531	536	PF00400	0.371
LIG_deltaCOP1_diTrp_1	586	596	PF00928	0.431
LIG_FHA_1	118	124	PF00498	0.408
LIG_FHA_1	12	18	PF00498	0.389
LIG_FHA_1	324	330	PF00498	0.282
LIG_FHA_1	508	514	PF00498	0.467
LIG_FHA_1	592	598	PF00498	0.410
LIG_FHA_1	645	651	PF00498	0.470
LIG_FHA_1	692	698	PF00498	0.415
LIG_FHA_2	266	272	PF00498	0.389
LIG_FHA_2	41	47	PF00498	0.354
LIG_FHA_2	414	420	PF00498	0.339
LIG_FHA_2	473	479	PF00498	0.350
LIG_FHA_2	53	59	PF00498	0.389
LIG_Integrin_RGD_1	246	248	PF01839	0.389
LIG_LIR_Gen_1	135	144	PF02991	0.398
LIG_LIR_Gen_1	416	426	PF02991	0.341
LIG_LIR_Gen_1	441	449	PF02991	0.505
LIG_LIR_Gen_1	624	634	PF02991	0.422
LIG_LIR_Nem_3	135	139	PF02991	0.398
LIG_LIR_Nem_3	228	234	PF02991	0.389
LIG_LIR_Nem_3	251	255	PF02991	0.330
LIG_LIR_Nem_3	416	421	PF02991	0.327
LIG_LIR_Nem_3	441	445	PF02991	0.505
LIG_LIR_Nem_3	525	531	PF02991	0.434
LIG_LIR_Nem_3	624	629	PF02991	0.427
LIG_NRBOX	104	110	PF00104	0.276
LIG_Pex14_1	50	54	PF04695	0.389
LIG_Pex14_2	715	719	PF04695	0.490
LIG_Rb_pABgroove_1	601	609	PF01858	0.455
LIG_RPA_C_Fungi	658	670	PF08784	0.389
LIG_SH2_CRK	171	175	PF00017	0.389
LIG_SH2_CRK	667	671	PF00017	0.406
LIG_SH2_GRB2like	626	629	PF00017	0.426
LIG_SH2_SRC	221	224	PF00017	0.333
LIG_SH2_SRC	607	610	PF00017	0.431
LIG_SH2_SRC	626	629	PF00017	0.426
LIG_SH2_STAT3	469	472	PF00017	0.409
LIG_SH2_STAT5	104	107	PF00017	0.428
LIG_SH2_STAT5	165	168	PF00017	0.389
LIG_SH2_STAT5	221	224	PF00017	0.389
LIG_SH2_STAT5	469	472	PF00017	0.409
LIG_SH2_STAT5	493	496	PF00017	0.478
LIG_SH2_STAT5	500	503	PF00017	0.496
LIG_SH2_STAT5	54	57	PF00017	0.389
LIG_SH2_STAT5	626	629	PF00017	0.426
LIG_SH3_3	651	657	PF00018	0.434
LIG_SH3_3	67	73	PF00018	0.389
LIG_SUMO_SIM_anti_2	282	288	PF11976	0.389
LIG_SUMO_SIM_par_1	183	189	PF11976	0.338
LIG_SUMO_SIM_par_1	284	290	PF11976	0.406
LIG_TRAF2_1	113	116	PF00917	0.248
LIG_TRAF2_1	610	613	PF00917	0.556
LIG_TYR_ITIM	169	174	PF00017	0.406
LIG_TYR_ITIM	533	538	PF00017	0.380
LIG_UBA3_1	308	315	PF00899	0.406
LIG_UBA3_1	347	352	PF00899	0.248
LIG_WRC_WIRS_1	17	22	PF05994	0.389
LIG_WRC_WIRS_1	249	254	PF05994	0.389
MOD_CK1_1	195	201	PF00069	0.398
MOD_CK1_1	72	78	PF00069	0.406
MOD_CK2_1	24	30	PF00069	0.420
MOD_CK2_1	265	271	PF00069	0.389
MOD_CK2_1	366	372	PF00069	0.536
MOD_CK2_1	413	419	PF00069	0.419
MOD_CK2_1	489	495	PF00069	0.409
MOD_CK2_1	52	58	PF00069	0.389
MOD_CK2_1	534	540	PF00069	0.540
MOD_CK2_1	607	613	PF00069	0.557
MOD_GlcNHglycan	128	131	PF01048	0.360
MOD_GlcNHglycan	343	346	PF01048	0.457
MOD_GlcNHglycan	372	376	PF01048	0.389
MOD_GlcNHglycan	55	58	PF01048	0.406
MOD_GlcNHglycan	667	670	PF01048	0.378
MOD_GSK3_1	12	19	PF00069	0.398
MOD_GSK3_1	155	162	PF00069	0.420
MOD_GSK3_1	265	272	PF00069	0.332
MOD_GSK3_1	395	402	PF00069	0.762
MOD_GSK3_1	507	514	PF00069	0.404
MOD_GSK3_1	558	565	PF00069	0.600
MOD_GSK3_1	691	698	PF00069	0.422
MOD_N-GLC_1	366	371	PF02516	0.406
MOD_N-GLC_1	613	618	PF02516	0.502
MOD_N-GLC_1	644	649	PF02516	0.454
MOD_N-GLC_2	644	646	PF02516	0.461
MOD_NEK2_1	117	122	PF00069	0.385
MOD_NEK2_1	225	230	PF00069	0.389
MOD_NEK2_1	355	360	PF00069	0.389
MOD_NEK2_1	421	426	PF00069	0.354
MOD_NEK2_1	52	57	PF00069	0.389
MOD_NEK2_1	82	87	PF00069	0.354
MOD_NEK2_2	534	539	PF00069	0.537
MOD_NEK2_2	630	635	PF00069	0.428
MOD_OFUCOSY	625	632	PF10250	0.359
MOD_PIKK_1	200	206	PF00454	0.373
MOD_PIKK_1	684	690	PF00454	0.406
MOD_PIKK_1	87	93	PF00454	0.359
MOD_PK_1	381	387	PF00069	0.371
MOD_PK_1	682	688	PF00069	0.248
MOD_PKA_1	381	387	PF00069	0.468
MOD_PKA_2	381	387	PF00069	0.501
MOD_Plk_1	150	156	PF00069	0.406
MOD_Plk_1	159	165	PF00069	0.525
MOD_Plk_1	269	275	PF00069	0.389
MOD_Plk_1	366	372	PF00069	0.489
MOD_Plk_1	619	625	PF00069	0.461
MOD_Plk_2-3	24	30	PF00069	0.406
MOD_Plk_2-3	489	495	PF00069	0.367
MOD_Plk_2-3	608	614	PF00069	0.543
MOD_Plk_4	104	110	PF00069	0.343
MOD_Plk_4	13	19	PF00069	0.413
MOD_Plk_4	140	146	PF00069	0.431
MOD_Plk_4	150	156	PF00069	0.355
MOD_Plk_4	195	201	PF00069	0.389
MOD_Plk_4	40	46	PF00069	0.389
MOD_Plk_4	465	471	PF00069	0.435
MOD_Plk_4	598	604	PF00069	0.415
MOD_ProDKin_1	402	408	PF00069	0.667
MOD_ProDKin_1	422	428	PF00069	0.415
MOD_ProDKin_1	69	75	PF00069	0.389
MOD_SUMO_for_1	584	587	PF00179	0.435
MOD_SUMO_rev_2	233	238	PF00179	0.347
MOD_SUMO_rev_2	483	488	PF00179	0.514
MOD_SUMO_rev_2	558	565	PF00179	0.592
MOD_SUMO_rev_2	668	676	PF00179	0.276
MOD_SUMO_rev_2	705	715	PF00179	0.378
TRG_DiLeu_BaEn_4	547	553	PF01217	0.527
TRG_ENDOCYTIC_2	171	174	PF00928	0.389
TRG_ENDOCYTIC_2	231	234	PF00928	0.389
TRG_ENDOCYTIC_2	535	538	PF00928	0.518
TRG_ENDOCYTIC_2	626	629	PF00928	0.426
TRG_ENDOCYTIC_2	667	670	PF00928	0.406
TRG_ER_diArg_1	380	382	PF00400	0.345
TRG_ER_diArg_1	569	572	PF00400	0.554
TRG_ER_diArg_1	661	663	PF00400	0.330
TRG_ER_FFAT_1	668	679	PF00635	0.389
TRG_Pf-PMV_PEXEL_1	254	258	PF00026	0.330
TRG_Pf-PMV_PEXEL_1	86	91	PF00026	0.389

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P6E2	Leptomonas seymouri	72%	93%
A0A0S4JRE7	Bodo saltans	41%	100%
A0A3S7X2D2	Leishmania donovani	86%	99%
A4I4I1	Leishmania infantum	86%	99%
E9ADY2	Leishmania major	85%	100%
E9ALU9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	85%	99%
Q875P5	Lachancea kluyveri (strain ATCC 58438 / CBS 3082 / BCRC 21498 / NBRC 1685 / JCM 7257 / NCYC 543 / NRRL Y-12651)	20%	100%