DUF572 domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Family of unknown function (DUF572), putative

Species:

Leishmania braziliensis

UniProt:

A4HHD4_LEIBR

TriTrypDb:

LbrM.29.1300 , LBRM2903_290019300

Length:

473

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005654	nucleoplasm	2	1
GO:0005681	spliceosomal complex	3	1
GO:0005684	U2-type spliceosomal complex	4	1
GO:0005737	cytoplasm	2	1
GO:0032991	protein-containing complex	1	1
GO:0071006	U2-type catalytic step 1 spliceosome	4	1
GO:0071012	catalytic step 1 spliceosome	3	1
GO:0110165	cellular anatomical entity	1	1
GO:0140513	nuclear protein-containing complex	2	1
GO:1902494	catalytic complex	2	1
GO:1990904	ribonucleoprotein complex	2	1

Expansion

Sequence features

A4HHD4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HHD4

Function

Biological processes
Term	Name	Level	Count
GO:0000375	RNA splicing, via transesterification reactions	8	7
GO:0000377	RNA splicing, via transesterification reactions with bulged adenosine as nucleophile	9	7
GO:0000398	mRNA splicing, via spliceosome	8	7
GO:0006139	nucleobase-containing compound metabolic process	3	7
GO:0006396	RNA processing	6	7
GO:0006397	mRNA processing	7	7
GO:0006725	cellular aromatic compound metabolic process	3	7
GO:0006807	nitrogen compound metabolic process	2	7
GO:0008152	metabolic process	1	7
GO:0008380	RNA splicing	7	7
GO:0009987	cellular process	1	7
GO:0016070	RNA metabolic process	5	7
GO:0016071	mRNA metabolic process	6	7
GO:0034641	cellular nitrogen compound metabolic process	3	7
GO:0043170	macromolecule metabolic process	3	7
GO:0044237	cellular metabolic process	2	7
GO:0044238	primary metabolic process	2	7
GO:0046483	heterocycle metabolic process	3	7
GO:0071704	organic substance metabolic process	2	7
GO:0090304	nucleic acid metabolic process	4	7
GO:1901360	organic cyclic compound metabolic process	3	7

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	218	222	PF00656	0.241
CLV_C14_Caspase3-7	394	398	PF00656	0.700
CLV_C14_Caspase3-7	465	469	PF00656	0.540
CLV_NRD_NRD_1	127	129	PF00675	0.231
CLV_NRD_NRD_1	20	22	PF00675	0.312
CLV_NRD_NRD_1	286	288	PF00675	0.312
CLV_NRD_NRD_1	36	38	PF00675	0.312
CLV_NRD_NRD_1	455	457	PF00675	0.626
CLV_NRD_NRD_1	66	68	PF00675	0.312
CLV_NRD_NRD_1	78	80	PF00675	0.312
CLV_PCSK_FUR_1	32	36	PF00082	0.312
CLV_PCSK_KEX2_1	127	129	PF00082	0.312
CLV_PCSK_KEX2_1	286	288	PF00082	0.312
CLV_PCSK_KEX2_1	321	323	PF00082	0.436
CLV_PCSK_KEX2_1	34	36	PF00082	0.312
CLV_PCSK_KEX2_1	455	457	PF00082	0.674
CLV_PCSK_KEX2_1	49	51	PF00082	0.312
CLV_PCSK_KEX2_1	66	68	PF00082	0.312
CLV_PCSK_KEX2_1	78	80	PF00082	0.312
CLV_PCSK_KEX2_1	83	85	PF00082	0.312
CLV_PCSK_PC1ET2_1	321	323	PF00082	0.231
CLV_PCSK_PC1ET2_1	34	36	PF00082	0.312
CLV_PCSK_PC1ET2_1	49	51	PF00082	0.312
CLV_PCSK_PC1ET2_1	83	85	PF00082	0.388
CLV_PCSK_PC7_1	32	38	PF00082	0.231
CLV_PCSK_PC7_1	79	85	PF00082	0.388
CLV_PCSK_SKI1_1	253	257	PF00082	0.327
CLV_PCSK_SKI1_1	321	325	PF00082	0.410
CLV_PCSK_SKI1_1	331	335	PF00082	0.331
DEG_APCC_KENBOX_2	163	167	PF00400	0.231
DEG_SCF_FBW7_1	111	117	PF00400	0.312
DEG_SPOP_SBC_1	229	233	PF00917	0.388
DOC_ANK_TNKS_1	455	462	PF00023	0.543
DOC_CKS1_1	111	116	PF01111	0.312
DOC_MAPK_gen_1	49	57	PF00069	0.312
DOC_MAPK_gen_1	83	91	PF00069	0.388
DOC_PP4_FxxP_1	249	252	PF00568	0.388
DOC_PP4_FxxP_1	369	372	PF00568	0.534
DOC_PP4_FxxP_1	433	436	PF00568	0.695
DOC_PP4_FxxP_1	53	56	PF00568	0.312
DOC_USP7_MATH_1	220	224	PF00917	0.474
DOC_USP7_MATH_1	229	233	PF00917	0.397
DOC_USP7_MATH_1	409	413	PF00917	0.650
DOC_USP7_MATH_1	423	427	PF00917	0.566
DOC_USP7_MATH_1	437	441	PF00917	0.617
DOC_USP7_MATH_1	69	73	PF00917	0.312
DOC_WW_Pin1_4	110	115	PF00397	0.312
DOC_WW_Pin1_4	248	253	PF00397	0.301
DOC_WW_Pin1_4	356	361	PF00397	0.656
DOC_WW_Pin1_4	421	426	PF00397	0.598
DOC_WW_Pin1_4	442	447	PF00397	0.554
LIG_14-3-3_CanoR_1	199	207	PF00244	0.231
LIG_14-3-3_CanoR_1	286	292	PF00244	0.364
LIG_14-3-3_CanoR_1	331	338	PF00244	0.442
LIG_14-3-3_CanoR_1	50	54	PF00244	0.312
LIG_APCC_ABBA_1	382	387	PF00400	0.535
LIG_APCC_ABBAyCdc20_2	381	387	PF00400	0.535
LIG_BIR_II_1	1	5	PF00653	0.527
LIG_BIR_III_4	210	214	PF00653	0.231
LIG_BIR_III_4	221	225	PF00653	0.205
LIG_BRCT_BRCA1_1	245	249	PF00533	0.388
LIG_FHA_1	245	251	PF00498	0.403
LIG_FHA_1	333	339	PF00498	0.376
LIG_FHA_1	422	428	PF00498	0.603
LIG_FHA_1	50	56	PF00498	0.312
LIG_FHA_2	107	113	PF00498	0.312
LIG_FHA_2	231	237	PF00498	0.470
LIG_LIR_Apic_2	10	16	PF02991	0.312
LIG_LIR_Apic_2	246	252	PF02991	0.388
LIG_LIR_Apic_2	368	372	PF02991	0.531
LIG_LIR_Apic_2	431	436	PF02991	0.693
LIG_LIR_Apic_2	52	56	PF02991	0.312
LIG_LIR_Gen_1	400	411	PF02991	0.530
LIG_LIR_Nem_3	130	136	PF02991	0.413
LIG_LIR_Nem_3	17	23	PF02991	0.312
LIG_LIR_Nem_3	274	280	PF02991	0.312
LIG_LIR_Nem_3	285	291	PF02991	0.312
LIG_LIR_Nem_3	400	406	PF02991	0.566
LIG_PDZ_Class_3	468	473	PF00595	0.548
LIG_Pex14_2	53	57	PF04695	0.312
LIG_SH2_GRB2like	75	78	PF00017	0.312
LIG_SH2_PTP2	13	16	PF00017	0.312
LIG_SH2_STAT5	106	109	PF00017	0.316
LIG_SH2_STAT5	120	123	PF00017	0.327
LIG_SH2_STAT5	13	16	PF00017	0.312
LIG_SH2_STAT5	85	88	PF00017	0.312
LIG_SH3_1	108	114	PF00018	0.312
LIG_SH3_3	108	114	PF00018	0.312
LIG_SH3_3	236	242	PF00018	0.326
LIG_SH3_3	354	360	PF00018	0.587
LIG_SH3_3	408	414	PF00018	0.718
LIG_SH3_3	436	442	PF00018	0.741
LIG_SH3_CIN85_PxpxPR_1	442	447	PF14604	0.672
LIG_SUMO_SIM_anti_2	93	98	PF11976	0.312
LIG_TRAF2_1	143	146	PF00917	0.307
LIG_TRAF2_1	182	185	PF00917	0.400
LIG_WRC_WIRS_1	366	371	PF05994	0.535
MOD_CDK_SPK_2	110	115	PF00069	0.312
MOD_CDK_SPK_2	248	253	PF00069	0.231
MOD_CDK_SPK_2	442	447	PF00069	0.539
MOD_CDK_SPxxK_3	421	428	PF00069	0.525
MOD_CK1_1	202	208	PF00069	0.385
MOD_CK1_1	223	229	PF00069	0.353
MOD_CK1_1	231	237	PF00069	0.451
MOD_CK1_1	243	249	PF00069	0.367
MOD_CK1_1	306	312	PF00069	0.262
MOD_CK1_1	356	362	PF00069	0.758
MOD_CK1_1	412	418	PF00069	0.611
MOD_CK2_1	106	112	PF00069	0.312
MOD_CK2_1	230	236	PF00069	0.470
MOD_CK2_1	261	267	PF00069	0.341
MOD_CK2_1	304	310	PF00069	0.315
MOD_CK2_1	464	470	PF00069	0.542
MOD_Cter_Amidation	32	35	PF01082	0.312
MOD_GlcNHglycan	221	225	PF01048	0.373
MOD_GlcNHglycan	233	236	PF01048	0.298
MOD_GlcNHglycan	262	266	PF01048	0.376
MOD_GlcNHglycan	373	376	PF01048	0.756
MOD_GlcNHglycan	417	420	PF01048	0.685
MOD_GlcNHglycan	9	12	PF01048	0.463
MOD_GSK3_1	106	113	PF00069	0.312
MOD_GSK3_1	193	200	PF00069	0.319
MOD_GSK3_1	230	237	PF00069	0.445
MOD_GSK3_1	240	247	PF00069	0.356
MOD_GSK3_1	304	311	PF00069	0.352
MOD_GSK3_1	358	365	PF00069	0.669
MOD_GSK3_1	417	424	PF00069	0.675
MOD_N-GLC_1	4	9	PF02516	0.485
MOD_NEK2_1	197	202	PF00069	0.312
MOD_NEK2_1	228	233	PF00069	0.279
MOD_NEK2_1	245	250	PF00069	0.299
MOD_NEK2_1	362	367	PF00069	0.746
MOD_NEK2_2	85	90	PF00069	0.302
MOD_PIKK_1	342	348	PF00454	0.594
MOD_PIKK_1	409	415	PF00454	0.527
MOD_PIKK_1	437	443	PF00454	0.704
MOD_PKA_1	49	55	PF00069	0.312
MOD_PKA_1	78	84	PF00069	0.302
MOD_PKA_2	49	55	PF00069	0.312
MOD_PKA_2	69	75	PF00069	0.183
MOD_PKA_2	78	84	PF00069	0.312
MOD_Plk_1	303	309	PF00069	0.299
MOD_Plk_1	4	10	PF00069	0.486
MOD_Plk_2-3	304	310	PF00069	0.231
MOD_Plk_2-3	464	470	PF00069	0.618
MOD_Plk_4	193	199	PF00069	0.312
MOD_Plk_4	245	251	PF00069	0.231
MOD_Plk_4	358	364	PF00069	0.527
MOD_Plk_4	365	371	PF00069	0.510
MOD_Plk_4	412	418	PF00069	0.652
MOD_Plk_4	449	455	PF00069	0.708
MOD_ProDKin_1	110	116	PF00069	0.312
MOD_ProDKin_1	248	254	PF00069	0.301
MOD_ProDKin_1	356	362	PF00069	0.656
MOD_ProDKin_1	421	427	PF00069	0.596
MOD_ProDKin_1	442	448	PF00069	0.555
MOD_SUMO_for_1	150	153	PF00179	0.312
MOD_SUMO_rev_2	316	323	PF00179	0.231
TRG_ER_diArg_1	127	129	PF00400	0.231
TRG_ER_diArg_1	198	201	PF00400	0.312
TRG_ER_diArg_1	286	288	PF00400	0.312
TRG_ER_diArg_1	35	37	PF00400	0.231
TRG_ER_diArg_1	454	456	PF00400	0.675
TRG_ER_diArg_1	66	68	PF00400	0.312
TRG_NLS_Bipartite_1	21	38	PF00514	0.312
TRG_NLS_MonoCore_2	33	38	PF00514	0.225
TRG_NLS_MonoExtN_4	32	38	PF00514	0.312
TRG_Pf-PMV_PEXEL_1	170	174	PF00026	0.312
TRG_Pf-PMV_PEXEL_1	177	181	PF00026	0.312
TRG_Pf-PMV_PEXEL_1	21	25	PF00026	0.312
TRG_Pf-PMV_PEXEL_1	289	294	PF00026	0.312
TRG_Pf-PMV_PEXEL_1	455	460	PF00026	0.629

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HY11	Leptomonas seymouri	53%	100%
A0A3Q8IF48	Leishmania donovani	77%	99%
A4I4H9	Leishmania infantum	77%	99%
E9ADY0	Leishmania major	75%	100%
E9ALV1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	74%	99%