Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HHD3_LEIBR

TriTrypDb:

LbrM.29.1290 , LBRM2903_290019200

Length:

374

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0031974	membrane-enclosed lumen	2	1
GO:0031981	nuclear lumen	5	1
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	1
GO:0043233	organelle lumen	3	1
GO:0070013	intracellular organelle lumen	4	1
GO:0097014	ciliary plasm	5	1
GO:0099568	cytoplasmic region	3	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HHD3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HHD3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	132	136	PF00656	0.484
CLV_C14_Caspase3-7	342	346	PF00656	0.628
CLV_NRD_NRD_1	144	146	PF00675	0.511
CLV_NRD_NRD_1	280	282	PF00675	0.648
CLV_NRD_NRD_1	331	333	PF00675	0.646
CLV_NRD_NRD_1	348	350	PF00675	0.606
CLV_PCSK_KEX2_1	111	113	PF00082	0.548
CLV_PCSK_KEX2_1	144	146	PF00082	0.550
CLV_PCSK_KEX2_1	279	281	PF00082	0.600
CLV_PCSK_KEX2_1	331	333	PF00082	0.640
CLV_PCSK_KEX2_1	348	350	PF00082	0.535
CLV_PCSK_KEX2_1	78	80	PF00082	0.531
CLV_PCSK_PC1ET2_1	111	113	PF00082	0.422
CLV_PCSK_PC1ET2_1	78	80	PF00082	0.531
CLV_PCSK_SKI1_1	191	195	PF00082	0.502
CLV_PCSK_SKI1_1	298	302	PF00082	0.542
CLV_PCSK_SKI1_1	62	66	PF00082	0.548
CLV_Separin_Metazoa	276	280	PF03568	0.647
DEG_MDM2_SWIB_1	120	128	PF02201	0.577
DEG_MDM2_SWIB_1	360	367	PF02201	0.507
DEG_SPOP_SBC_1	222	226	PF00917	0.524
DEG_SPOP_SBC_1	90	94	PF00917	0.547
DOC_CYCLIN_yCln2_LP_2	252	255	PF00134	0.632
DOC_MAPK_FxFP_2	193	196	PF00069	0.453
DOC_MAPK_gen_1	144	152	PF00069	0.490
DOC_MAPK_HePTP_8	142	154	PF00069	0.572
DOC_MAPK_MEF2A_6	144	152	PF00069	0.438
DOC_PP2B_LxvP_1	252	255	PF13499	0.601
DOC_PP2B_LxvP_1	365	368	PF13499	0.467
DOC_PP4_FxxP_1	193	196	PF00568	0.453
DOC_USP7_MATH_1	216	220	PF00917	0.738
DOC_USP7_MATH_1	222	226	PF00917	0.722
DOC_USP7_MATH_1	322	326	PF00917	0.398
DOC_USP7_MATH_1	71	75	PF00917	0.783
DOC_USP7_MATH_1	88	92	PF00917	0.564
DOC_WW_Pin1_4	160	165	PF00397	0.618
LIG_14-3-3_CanoR_1	14	18	PF00244	0.523
LIG_14-3-3_CanoR_1	162	172	PF00244	0.599
LIG_14-3-3_CanoR_1	191	196	PF00244	0.494
LIG_14-3-3_CanoR_1	348	357	PF00244	0.544
LIG_14-3-3_CanoR_1	46	52	PF00244	0.308
LIG_APCC_ABBA_1	15	20	PF00400	0.420
LIG_APCC_ABBAyCdc20_2	14	20	PF00400	0.520
LIG_BIR_II_1	1	5	PF00653	0.598
LIG_BIR_III_1	1	5	PF00653	0.516
LIG_BIR_III_3	1	5	PF00653	0.516
LIG_Clathr_ClatBox_1	56	60	PF01394	0.573
LIG_deltaCOP1_diTrp_1	327	333	PF00928	0.528
LIG_eIF4E_1	295	301	PF01652	0.546
LIG_EVH1_1	253	257	PF00568	0.580
LIG_EVH1_2	256	260	PF00568	0.598
LIG_FHA_1	137	143	PF00498	0.544
LIG_FHA_1	17	23	PF00498	0.503
LIG_FHA_1	81	87	PF00498	0.731
LIG_FHA_1	93	99	PF00498	0.572
LIG_FHA_2	127	133	PF00498	0.302
LIG_FHA_2	179	185	PF00498	0.544
LIG_FHA_2	25	31	PF00498	0.667
LIG_FHA_2	315	321	PF00498	0.446
LIG_FHA_2	337	343	PF00498	0.650
LIG_Integrin_RGD_1	32	34	PF01839	0.547
LIG_LIR_Apic_2	190	196	PF02991	0.390
LIG_LIR_Gen_1	10	18	PF02991	0.537
LIG_LIR_Gen_1	123	128	PF02991	0.459
LIG_LIR_Gen_1	170	180	PF02991	0.551
LIG_LIR_Gen_1	361	370	PF02991	0.557
LIG_LIR_Nem_3	10	15	PF02991	0.549
LIG_LIR_Nem_3	123	127	PF02991	0.424
LIG_LIR_Nem_3	170	176	PF02991	0.496
LIG_LIR_Nem_3	190	195	PF02991	0.243
LIG_LIR_Nem_3	361	367	PF02991	0.504
LIG_MYND_1	73	77	PF01753	0.748
LIG_Pex14_1	329	333	PF04695	0.529
LIG_Pex14_2	120	124	PF04695	0.608
LIG_Pex14_2	360	364	PF04695	0.491
LIG_SH2_CRK	173	177	PF00017	0.558
LIG_SH2_GRB2like	295	298	PF00017	0.469
LIG_SH2_NCK_1	173	177	PF00017	0.591
LIG_SH2_STAP1	18	22	PF00017	0.312
LIG_SH2_STAT5	173	176	PF00017	0.475
LIG_SH2_STAT5	18	21	PF00017	0.479
LIG_SH2_STAT5	202	205	PF00017	0.623
LIG_SH3_1	280	286	PF00018	0.626
LIG_SH3_2	254	259	PF14604	0.630
LIG_SH3_2	73	78	PF14604	0.535
LIG_SH3_3	200	206	PF00018	0.631
LIG_SH3_3	241	247	PF00018	0.549
LIG_SH3_3	251	257	PF00018	0.300
LIG_SH3_3	280	286	PF00018	0.626
LIG_SH3_3	70	76	PF00018	0.660
LIG_SUMO_SIM_par_1	55	61	PF11976	0.577
LIG_TRAF2_1	167	170	PF00917	0.594
LIG_TYR_ITIM	171	176	PF00017	0.572
MOD_CDK_SPK_2	160	165	PF00069	0.586
MOD_CK1_1	158	164	PF00069	0.618
MOD_CK1_1	178	184	PF00069	0.541
MOD_CK1_1	220	226	PF00069	0.779
MOD_CK1_1	269	275	PF00069	0.530
MOD_CK1_1	89	95	PF00069	0.600
MOD_CK2_1	163	169	PF00069	0.616
MOD_CK2_1	24	30	PF00069	0.613
MOD_GlcNHglycan	165	168	PF01048	0.626
MOD_GlcNHglycan	177	180	PF01048	0.628
MOD_GlcNHglycan	225	228	PF01048	0.750
MOD_GlcNHglycan	268	271	PF01048	0.637
MOD_GlcNHglycan	302	305	PF01048	0.517
MOD_GlcNHglycan	324	327	PF01048	0.579
MOD_GlcNHglycan	47	50	PF01048	0.521
MOD_GlcNHglycan	66	69	PF01048	0.686
MOD_GlcNHglycan	88	91	PF01048	0.571
MOD_GSK3_1	148	155	PF00069	0.424
MOD_GSK3_1	156	163	PF00069	0.548
MOD_GSK3_1	171	178	PF00069	0.588
MOD_GSK3_1	187	194	PF00069	0.348
MOD_GSK3_1	216	223	PF00069	0.699
MOD_GSK3_1	349	356	PF00069	0.457
MOD_GSK3_1	60	67	PF00069	0.582
MOD_GSK3_1	78	85	PF00069	0.670
MOD_GSK3_1	86	93	PF00069	0.620
MOD_N-GLC_1	114	119	PF02516	0.665
MOD_NEK2_1	152	157	PF00069	0.546
MOD_NEK2_1	171	176	PF00069	0.504
MOD_NEK2_1	300	305	PF00069	0.524
MOD_NEK2_1	336	341	PF00069	0.617
MOD_NEK2_2	126	131	PF00069	0.282
MOD_NEK2_2	353	358	PF00069	0.634
MOD_PIKK_1	152	158	PF00454	0.435
MOD_PIKK_1	24	30	PF00454	0.467
MOD_PIKK_1	343	349	PF00454	0.631
MOD_PKA_1	348	354	PF00069	0.412
MOD_PKA_1	78	84	PF00069	0.518
MOD_PKA_2	13	19	PF00069	0.497
MOD_PKA_2	348	354	PF00069	0.412
MOD_PKA_2	45	51	PF00069	0.303
MOD_PKA_2	71	77	PF00069	0.785
MOD_PKA_2	78	84	PF00069	0.638
MOD_Plk_1	114	120	PF00069	0.660
MOD_Plk_4	13	19	PF00069	0.531
MOD_Plk_4	248	254	PF00069	0.647
MOD_Plk_4	60	66	PF00069	0.562
MOD_ProDKin_1	160	166	PF00069	0.608
MOD_SUMO_rev_2	207	216	PF00179	0.746
TRG_DiLeu_BaEn_1	296	301	PF01217	0.420
TRG_DiLeu_BaEn_1	37	42	PF01217	0.568
TRG_DiLeu_BaLyEn_6	280	285	PF01217	0.651
TRG_ENDOCYTIC_2	173	176	PF00928	0.544
TRG_ENDOCYTIC_2	18	21	PF00928	0.426
TRG_ER_diArg_1	278	281	PF00400	0.616
TRG_ER_diArg_1	330	332	PF00400	0.488

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P6E7	Leptomonas seymouri	40%	100%
A0A0S4KK84	Bodo saltans	25%	98%
A0A1X0NZS1	Trypanosomatidae	28%	91%
A0A3Q8IFC4	Leishmania donovani	74%	99%
A0A3R7LZ67	Trypanosoma rangeli	30%	93%
A4I4H8	Leishmania infantum	74%	99%
E9ADX9	Leishmania major	73%	100%
E9ALV2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	75%	100%
V5BR99	Trypanosoma cruzi	30%	92%