Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HHD2_LEIBR

TriTrypDb:

LbrM.29.1280 , LBRM2903_290019100

Length:

599

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	yes	yes: 5, no: 1
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	6
GO:0110165	cellular anatomical entity	1	6

Expansion

Sequence features

A4HHD2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HHD2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	104	108	PF00656	0.481
CLV_C14_Caspase3-7	231	235	PF00656	0.442
CLV_C14_Caspase3-7	380	384	PF00656	0.635
CLV_NRD_NRD_1	187	189	PF00675	0.685
CLV_NRD_NRD_1	283	285	PF00675	0.669
CLV_NRD_NRD_1	305	307	PF00675	0.735
CLV_NRD_NRD_1	46	48	PF00675	0.570
CLV_NRD_NRD_1	476	478	PF00675	0.392
CLV_PCSK_KEX2_1	189	191	PF00082	0.599
CLV_PCSK_KEX2_1	283	285	PF00082	0.669
CLV_PCSK_KEX2_1	46	48	PF00082	0.570
CLV_PCSK_KEX2_1	476	478	PF00082	0.392
CLV_PCSK_PC1ET2_1	189	191	PF00082	0.599
CLV_PCSK_PC7_1	472	478	PF00082	0.330
CLV_PCSK_SKI1_1	124	128	PF00082	0.640
CLV_PCSK_SKI1_1	143	147	PF00082	0.586
CLV_PCSK_SKI1_1	477	481	PF00082	0.489
CLV_PCSK_SKI1_1	502	506	PF00082	0.302
CLV_PCSK_SKI1_1	52	56	PF00082	0.560
CLV_PCSK_SKI1_1	565	569	PF00082	0.405
CLV_PCSK_SKI1_1	586	590	PF00082	0.413
CLV_PCSK_SKI1_1	8	12	PF00082	0.569
DEG_APCC_DBOX_1	187	195	PF00400	0.446
DEG_APCC_DBOX_1	501	509	PF00400	0.349
DEG_Kelch_Keap1_1	381	386	PF01344	0.642
DOC_CKS1_1	415	420	PF01111	0.678
DOC_CYCLIN_yClb5_NLxxxL_5	190	198	PF00134	0.518
DOC_CYCLIN_yCln2_LP_2	175	181	PF00134	0.437
DOC_CYCLIN_yCln2_LP_2	551	557	PF00134	0.369
DOC_MAPK_gen_1	173	181	PF00069	0.464
DOC_MAPK_gen_1	306	314	PF00069	0.402
DOC_MAPK_gen_1	500	509	PF00069	0.304
DOC_MAPK_MEF2A_6	173	181	PF00069	0.405
DOC_MAPK_MEF2A_6	500	509	PF00069	0.304
DOC_MAPK_NFAT4_5	500	508	PF00069	0.304
DOC_PP2B_LxvP_1	175	178	PF13499	0.396
DOC_PP2B_LxvP_1	302	305	PF13499	0.391
DOC_PP2B_LxvP_1	551	554	PF13499	0.369
DOC_PP4_FxxP_1	146	149	PF00568	0.402
DOC_PP4_FxxP_1	537	540	PF00568	0.316
DOC_USP7_MATH_1	132	136	PF00917	0.598
DOC_USP7_MATH_1	211	215	PF00917	0.353
DOC_USP7_MATH_1	246	250	PF00917	0.441
DOC_USP7_MATH_1	296	300	PF00917	0.451
DOC_USP7_MATH_1	342	346	PF00917	0.369
DOC_USP7_MATH_1	435	439	PF00917	0.738
DOC_WW_Pin1_4	294	299	PF00397	0.466
DOC_WW_Pin1_4	411	416	PF00397	0.733
DOC_WW_Pin1_4	419	424	PF00397	0.725
DOC_WW_Pin1_4	431	436	PF00397	0.593
LIG_14-3-3_CanoR_1	159	167	PF00244	0.399
LIG_14-3-3_CanoR_1	406	415	PF00244	0.658
LIG_14-3-3_CanoR_1	492	497	PF00244	0.600
LIG_14-3-3_CanoR_1	8	17	PF00244	0.534
LIG_Actin_WH2_2	550	567	PF00022	0.313
LIG_BIR_II_1	1	5	PF00653	0.529
LIG_BIR_III_2	454	458	PF00653	0.561
LIG_BRCT_BRCA1_1	335	339	PF00533	0.248
LIG_BRCT_BRCA1_1	36	40	PF00533	0.365
LIG_BRCT_BRCA1_1	437	441	PF00533	0.617
LIG_BRCT_BRCA1_1	493	497	PF00533	0.515
LIG_CtBP_PxDLS_1	70	74	PF00389	0.397
LIG_deltaCOP1_diTrp_1	262	272	PF00928	0.369
LIG_deltaCOP1_diTrp_1	359	368	PF00928	0.649
LIG_eIF4E_1	18	24	PF01652	0.364
LIG_FAT_LD_1	94	102	PF03623	0.305
LIG_FHA_1	14	20	PF00498	0.376
LIG_FHA_1	316	322	PF00498	0.499
LIG_FHA_1	336	342	PF00498	0.317
LIG_FHA_1	347	353	PF00498	0.260
LIG_FHA_2	104	110	PF00498	0.390
LIG_FHA_2	378	384	PF00498	0.633
LIG_FHA_2	399	405	PF00498	0.751
LIG_FHA_2	425	431	PF00498	0.631
LIG_FHA_2	63	69	PF00498	0.351
LIG_GBD_Chelix_1	229	237	PF00786	0.539
LIG_GBD_Chelix_1	509	517	PF00786	0.347
LIG_HCF-1_HBM_1	460	463	PF13415	0.550
LIG_LIR_Apic_2	144	149	PF02991	0.405
LIG_LIR_Gen_1	16	26	PF02991	0.367
LIG_LIR_Gen_1	262	271	PF02991	0.343
LIG_LIR_Gen_1	318	327	PF02991	0.550
LIG_LIR_Gen_1	495	505	PF02991	0.456
LIG_LIR_Gen_1	516	525	PF02991	0.574
LIG_LIR_Gen_1	548	558	PF02991	0.384
LIG_LIR_Gen_1	88	98	PF02991	0.347
LIG_LIR_LC3C_4	548	553	PF02991	0.369
LIG_LIR_Nem_3	16	21	PF02991	0.370
LIG_LIR_Nem_3	262	268	PF02991	0.374
LIG_LIR_Nem_3	318	323	PF02991	0.551
LIG_LIR_Nem_3	460	466	PF02991	0.544
LIG_LIR_Nem_3	495	501	PF02991	0.456
LIG_LIR_Nem_3	516	521	PF02991	0.631
LIG_LIR_Nem_3	548	553	PF02991	0.384
LIG_LIR_Nem_3	88	93	PF02991	0.385
LIG_NRBOX	193	199	PF00104	0.531
LIG_NRBOX	500	506	PF00104	0.369
LIG_NRBOX	93	99	PF00104	0.326
LIG_Pex14_1	265	269	PF04695	0.441
LIG_Pex14_2	538	542	PF04695	0.347
LIG_REV1ctd_RIR_1	495	504	PF16727	0.477
LIG_SH2_CRK	219	223	PF00017	0.455
LIG_SH2_CRK	463	467	PF00017	0.584
LIG_SH2_GRB2like	280	283	PF00017	0.359
LIG_SH2_STAT5	152	155	PF00017	0.407
LIG_SH2_STAT5	18	21	PF00017	0.361
LIG_SH2_STAT5	320	323	PF00017	0.466
LIG_SH2_STAT5	463	466	PF00017	0.588
LIG_SH2_STAT5	550	553	PF00017	0.437
LIG_SH2_STAT5	90	93	PF00017	0.389
LIG_SH3_3	251	257	PF00018	0.368
LIG_SH3_3	338	344	PF00018	0.222
LIG_SH3_3	371	377	PF00018	0.603
LIG_SH3_3	412	418	PF00018	0.708
LIG_SH3_3	429	435	PF00018	0.615
LIG_SUMO_SIM_par_1	556	562	PF11976	0.227
LIG_TRAF2_1	570	573	PF00917	0.630
LIG_UBA3_1	301	307	PF00899	0.388
LIG_UBA3_1	496	500	PF00899	0.369
LIG_WRC_WIRS_1	574	579	PF05994	0.599
MOD_CDC14_SPxK_1	422	425	PF00782	0.635
MOD_CDK_SPxK_1	419	425	PF00069	0.641
MOD_CDK_SPxxK_3	414	421	PF00069	0.644
MOD_CK1_1	166	172	PF00069	0.424
MOD_CK1_1	249	255	PF00069	0.448
MOD_CK1_1	333	339	PF00069	0.214
MOD_CK1_1	35	41	PF00069	0.397
MOD_CK1_1	393	399	PF00069	0.690
MOD_CK1_1	409	415	PF00069	0.658
MOD_CK1_1	416	422	PF00069	0.714
MOD_CK1_1	530	536	PF00069	0.418
MOD_CK2_1	141	147	PF00069	0.508
MOD_CK2_1	391	397	PF00069	0.715
MOD_CK2_1	398	404	PF00069	0.736
MOD_CK2_1	424	430	PF00069	0.660
MOD_CK2_1	566	572	PF00069	0.576
MOD_CMANNOS	515	518	PF00535	0.369
MOD_GlcNHglycan	114	117	PF01048	0.663
MOD_GlcNHglycan	332	335	PF01048	0.580
MOD_GlcNHglycan	34	37	PF01048	0.648
MOD_GlcNHglycan	344	347	PF01048	0.342
MOD_GlcNHglycan	392	396	PF01048	0.496
MOD_GlcNHglycan	418	421	PF01048	0.464
MOD_GlcNHglycan	449	452	PF01048	0.434
MOD_GlcNHglycan	529	532	PF01048	0.649
MOD_GlcNHglycan	547	550	PF01048	0.215
MOD_GlcNHglycan	568	571	PF01048	0.376
MOD_GlcNHglycan	57	60	PF01048	0.629
MOD_GSK3_1	137	144	PF00069	0.482
MOD_GSK3_1	246	253	PF00069	0.458
MOD_GSK3_1	292	299	PF00069	0.491
MOD_GSK3_1	30	37	PF00069	0.520
MOD_GSK3_1	329	336	PF00069	0.355
MOD_GSK3_1	342	349	PF00069	0.354
MOD_GSK3_1	393	400	PF00069	0.737
MOD_GSK3_1	405	412	PF00069	0.710
MOD_GSK3_1	431	438	PF00069	0.767
MOD_GSK3_1	521	528	PF00069	0.437
MOD_N-GLC_1	111	116	PF02516	0.636
MOD_N-GLC_1	124	129	PF02516	0.637
MOD_N-GLC_1	291	296	PF02516	0.625
MOD_N-GLC_1	370	375	PF02516	0.497
MOD_N-GLC_1	377	382	PF02516	0.484
MOD_N-GLC_1	525	530	PF02516	0.545
MOD_NEK2_1	1	6	PF00069	0.538
MOD_NEK2_1	179	184	PF00069	0.409
MOD_NEK2_1	330	335	PF00069	0.377
MOD_NEK2_1	34	39	PF00069	0.418
MOD_NEK2_1	369	374	PF00069	0.607
MOD_NEK2_1	390	395	PF00069	0.652
MOD_NEK2_1	485	490	PF00069	0.640
MOD_NEK2_1	513	518	PF00069	0.301
MOD_NEK2_1	521	526	PF00069	0.381
MOD_NEK2_1	527	532	PF00069	0.389
MOD_NEK2_1	55	60	PF00069	0.358
MOD_NEK2_1	97	102	PF00069	0.384
MOD_PIKK_1	398	404	PF00454	0.646
MOD_PKA_2	112	118	PF00069	0.455
MOD_PKA_2	158	164	PF00069	0.395
MOD_PKA_2	405	411	PF00069	0.679
MOD_PKA_2	424	430	PF00069	0.603
MOD_PKA_2	491	497	PF00069	0.655
MOD_Plk_1	141	147	PF00069	0.422
MOD_Plk_1	370	376	PF00069	0.699
MOD_Plk_4	13	19	PF00069	0.381
MOD_Plk_4	166	172	PF00069	0.428
MOD_Plk_4	297	303	PF00069	0.480
MOD_Plk_4	315	321	PF00069	0.505
MOD_Plk_4	485	491	PF00069	0.603
MOD_Plk_4	492	498	PF00069	0.571
MOD_Plk_4	530	536	PF00069	0.374
MOD_Plk_4	538	544	PF00069	0.373
MOD_ProDKin_1	294	300	PF00069	0.465
MOD_ProDKin_1	411	417	PF00069	0.734
MOD_ProDKin_1	419	425	PF00069	0.726
MOD_ProDKin_1	431	437	PF00069	0.592
MOD_SUMO_rev_2	121	126	PF00179	0.439
TRG_DiLeu_BaEn_1	225	230	PF01217	0.442
TRG_DiLeu_BaEn_1	584	589	PF01217	0.564
TRG_DiLeu_BaEn_4	121	127	PF01217	0.459
TRG_DiLeu_BaLyEn_6	499	504	PF01217	0.369
TRG_ENDOCYTIC_2	18	21	PF00928	0.361
TRG_ENDOCYTIC_2	320	323	PF00928	0.408
TRG_ENDOCYTIC_2	463	466	PF00928	0.586
TRG_ENDOCYTIC_2	550	553	PF00928	0.369
TRG_ENDOCYTIC_2	90	93	PF00928	0.343
TRG_ER_diArg_1	188	191	PF00400	0.426
TRG_ER_diArg_1	46	48	PF00400	0.370
TRG_ER_diArg_1	481	484	PF00400	0.597

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IL17	Leptomonas seymouri	30%	100%
A0A3Q8IBG2	Leishmania donovani	69%	99%
A4I4H7	Leishmania infantum	69%	99%
E9ADX8	Leishmania major	68%	100%
E9ALV3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	66%	100%