EXS domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Etoposide-induced protein 2.4 (EI24), putative

Species:

Leishmania braziliensis

UniProt:

A4HHD1_LEIBR

TriTrypDb:

LbrM.29.1270 , LBRM2903_290019000

Length:

595

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	7
GO:0110165	cellular anatomical entity	1	7
GO:0005783	endoplasmic reticulum	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1

Expansion

Sequence features

A4HHD1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HHD1

Function

Biological processes
Term	Name	Level	Count
GO:0006914	autophagy	3	1
GO:0008152	metabolic process	1	1
GO:0009056	catabolic process	2	1
GO:0009987	cellular process	1	1
GO:0016236	macroautophagy	4	1
GO:0044237	cellular metabolic process	2	1
GO:0044248	cellular catabolic process	3	1
GO:0061919	process utilizing autophagic mechanism	2	1

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	97	101	PF00656	0.616
CLV_NRD_NRD_1	126	128	PF00675	0.405
CLV_NRD_NRD_1	239	241	PF00675	0.435
CLV_NRD_NRD_1	38	40	PF00675	0.518
CLV_NRD_NRD_1	51	53	PF00675	0.465
CLV_PCSK_KEX2_1	37	39	PF00082	0.445
CLV_PCSK_KEX2_1	51	53	PF00082	0.508
CLV_PCSK_PC1ET2_1	37	39	PF00082	0.445
CLV_PCSK_SKI1_1	106	110	PF00082	0.448
CLV_PCSK_SKI1_1	128	132	PF00082	0.385
CLV_PCSK_SKI1_1	187	191	PF00082	0.275
CLV_PCSK_SKI1_1	336	340	PF00082	0.358
CLV_PCSK_SKI1_1	351	355	PF00082	0.511
CLV_PCSK_SKI1_1	90	94	PF00082	0.439
DEG_APCC_DBOX_1	202	210	PF00400	0.444
DEG_APCC_DBOX_1	335	343	PF00400	0.560
DEG_SPOP_SBC_1	279	283	PF00917	0.637
DOC_AGCK_PIF_2	463	468	PF00069	0.403
DOC_CKS1_1	448	453	PF01111	0.312
DOC_CYCLIN_yClb5_NLxxxL_5	125	134	PF00134	0.529
DOC_MAPK_gen_1	118	126	PF00069	0.639
DOC_MAPK_MEF2A_6	572	580	PF00069	0.388
DOC_MAPK_RevD_3	25	39	PF00069	0.685
DOC_PP2B_LxvP_1	53	56	PF13499	0.655
DOC_PP2B_LxvP_1	580	583	PF13499	0.312
DOC_PP2B_LxvP_1	84	87	PF13499	0.605
DOC_PP4_FxxP_1	108	111	PF00568	0.687
DOC_PP4_FxxP_1	276	279	PF00568	0.645
DOC_PP4_FxxP_1	540	543	PF00568	0.590
DOC_USP7_MATH_1	185	189	PF00917	0.652
DOC_USP7_MATH_1	255	259	PF00917	0.734
DOC_USP7_MATH_1	280	284	PF00917	0.678
DOC_USP7_MATH_1	288	292	PF00917	0.591
DOC_USP7_MATH_1	323	327	PF00917	0.594
DOC_USP7_MATH_1	378	382	PF00917	0.691
DOC_USP7_MATH_1	395	399	PF00917	0.614
DOC_USP7_MATH_1	431	435	PF00917	0.343
DOC_USP7_MATH_1	543	547	PF00917	0.595
DOC_USP7_MATH_1	59	63	PF00917	0.712
DOC_WW_Pin1_4	281	286	PF00397	0.761
DOC_WW_Pin1_4	405	410	PF00397	0.630
DOC_WW_Pin1_4	447	452	PF00397	0.312
DOC_WW_Pin1_4	51	56	PF00397	0.713
LIG_14-3-3_CanoR_1	103	109	PF00244	0.789
LIG_14-3-3_CanoR_1	187	197	PF00244	0.529
LIG_14-3-3_CanoR_1	203	207	PF00244	0.224
LIG_14-3-3_CanoR_1	321	330	PF00244	0.655
LIG_14-3-3_CanoR_1	343	350	PF00244	0.691
LIG_14-3-3_CanoR_1	351	358	PF00244	0.671
LIG_Actin_WH2_2	195	212	PF00022	0.388
LIG_Actin_WH2_2	323	338	PF00022	0.653
LIG_AP2alpha_2	410	412	PF02296	0.700
LIG_BRCT_BRCA1_1	272	276	PF00533	0.643
LIG_BRCT_BRCA1_1	553	557	PF00533	0.573
LIG_CtBP_PxDLS_1	2	6	PF00389	0.725
LIG_deltaCOP1_diTrp_1	235	243	PF00928	0.613
LIG_eIF4E_1	233	239	PF01652	0.598
LIG_EVH1_1	276	280	PF00568	0.645
LIG_EVH1_2	56	60	PF00568	0.619
LIG_FHA_1	184	190	PF00498	0.738
LIG_FHA_1	234	240	PF00498	0.606
LIG_FHA_1	343	349	PF00498	0.608
LIG_FHA_1	357	363	PF00498	0.644
LIG_FHA_1	412	418	PF00498	0.645
LIG_FHA_1	485	491	PF00498	0.574
LIG_FHA_1	513	519	PF00498	0.426
LIG_FHA_1	89	95	PF00498	0.766
LIG_FHA_2	405	411	PF00498	0.653
LIG_LIR_Apic_2	107	111	PF02991	0.686
LIG_LIR_Apic_2	273	279	PF02991	0.643
LIG_LIR_Apic_2	538	543	PF02991	0.576
LIG_LIR_Gen_1	112	120	PF02991	0.687
LIG_LIR_Gen_1	192	202	PF02991	0.388
LIG_LIR_Gen_1	410	419	PF02991	0.632
LIG_LIR_Gen_1	432	442	PF02991	0.312
LIG_LIR_Gen_1	532	541	PF02991	0.432
LIG_LIR_Gen_1	62	71	PF02991	0.614
LIG_LIR_Nem_3	112	116	PF02991	0.682
LIG_LIR_Nem_3	140	146	PF02991	0.312
LIG_LIR_Nem_3	192	198	PF02991	0.388
LIG_LIR_Nem_3	23	28	PF02991	0.672
LIG_LIR_Nem_3	410	415	PF02991	0.637
LIG_LIR_Nem_3	424	430	PF02991	0.493
LIG_LIR_Nem_3	432	438	PF02991	0.183
LIG_LIR_Nem_3	497	503	PF02991	0.529
LIG_LIR_Nem_3	532	536	PF02991	0.324
LIG_LIR_Nem_3	554	560	PF02991	0.583
LIG_LIR_Nem_3	62	66	PF02991	0.623
LIG_NRBOX	121	127	PF00104	0.628
LIG_NRBOX	192	198	PF00104	0.388
LIG_PALB2_WD40_1	224	232	PF16756	0.388
LIG_PDZ_Class_1	590	595	PF00595	0.590
LIG_Pex14_1	207	211	PF04695	0.405
LIG_Pex14_2	553	557	PF04695	0.573
LIG_SH2_CRK	143	147	PF00017	0.312
LIG_SH2_CRK	218	222	PF00017	0.312
LIG_SH2_STAP1	531	535	PF00017	0.312
LIG_SH2_STAP1	558	562	PF00017	0.575
LIG_SH2_STAP1	567	571	PF00017	0.620
LIG_SH2_STAT3	211	214	PF00017	0.409
LIG_SH2_STAT3	470	473	PF00017	0.584
LIG_SH2_STAT3	531	534	PF00017	0.312
LIG_SH2_STAT5	211	214	PF00017	0.409
LIG_SH2_STAT5	218	221	PF00017	0.312
LIG_SH2_STAT5	341	344	PF00017	0.724
LIG_SH2_STAT5	461	464	PF00017	0.326
LIG_SH2_STAT5	581	584	PF00017	0.312
LIG_SH3_1	52	58	PF00018	0.617
LIG_SH3_3	274	280	PF00018	0.644
LIG_SH3_3	298	304	PF00018	0.608
LIG_SH3_3	386	392	PF00018	0.612
LIG_SH3_3	52	58	PF00018	0.667
LIG_SH3_3	539	545	PF00018	0.603
LIG_SH3_3	79	85	PF00018	0.656
LIG_SH3_3	96	102	PF00018	0.615
LIG_SUMO_SIM_anti_2	324	331	PF11976	0.690
LIG_SUMO_SIM_par_1	26	33	PF11976	0.689
LIG_TYR_ITIM	141	146	PF00017	0.312
LIG_WRC_WIRS_1	22	27	PF05994	0.610
LIG_WRC_WIRS_1	60	65	PF05994	0.625
MOD_CK1_1	152	158	PF00069	0.443
MOD_CK1_1	174	180	PF00069	0.539
MOD_CK1_1	188	194	PF00069	0.315
MOD_CK1_1	258	264	PF00069	0.667
MOD_CK1_1	270	276	PF00069	0.760
MOD_CK1_1	281	287	PF00069	0.626
MOD_CK1_1	305	311	PF00069	0.655
MOD_CK1_1	381	387	PF00069	0.712
MOD_CK1_1	484	490	PF00069	0.595
MOD_CK2_1	111	117	PF00069	0.606
MOD_CK2_1	437	443	PF00069	0.312
MOD_GlcNHglycan	160	163	PF01048	0.341
MOD_GlcNHglycan	173	176	PF01048	0.468
MOD_GlcNHglycan	257	260	PF01048	0.518
MOD_GlcNHglycan	269	272	PF01048	0.477
MOD_GlcNHglycan	286	289	PF01048	0.457
MOD_GlcNHglycan	290	293	PF01048	0.508
MOD_GlcNHglycan	304	307	PF01048	0.489
MOD_GlcNHglycan	310	313	PF01048	0.487
MOD_GlcNHglycan	32	35	PF01048	0.433
MOD_GlcNHglycan	384	387	PF01048	0.571
MOD_GlcNHglycan	439	442	PF01048	0.502
MOD_GlcNHglycan	483	486	PF01048	0.393
MOD_GlcNHglycan	506	509	PF01048	0.332
MOD_GlcNHglycan	537	540	PF01048	0.366
MOD_GlcNHglycan	94	97	PF01048	0.512
MOD_GSK3_1	1	8	PF00069	0.761
MOD_GSK3_1	151	158	PF00069	0.474
MOD_GSK3_1	176	183	PF00069	0.718
MOD_GSK3_1	185	192	PF00069	0.429
MOD_GSK3_1	280	287	PF00069	0.779
MOD_GSK3_1	330	337	PF00069	0.638
MOD_GSK3_1	378	385	PF00069	0.718
MOD_GSK3_1	391	398	PF00069	0.714
MOD_GSK3_1	399	406	PF00069	0.732
MOD_GSK3_1	504	511	PF00069	0.342
MOD_GSK3_1	525	532	PF00069	0.319
MOD_GSK3_1	88	95	PF00069	0.759
MOD_N-GLC_1	180	185	PF02516	0.466
MOD_N-GLC_2	16	18	PF02516	0.359
MOD_NEK2_1	104	109	PF00069	0.569
MOD_NEK2_1	144	149	PF00069	0.313
MOD_NEK2_1	189	194	PF00069	0.407
MOD_NEK2_1	29	34	PF00069	0.733
MOD_NEK2_1	330	335	PF00069	0.701
MOD_NEK2_1	399	404	PF00069	0.625
MOD_NEK2_1	437	442	PF00069	0.285
MOD_NEK2_1	5	10	PF00069	0.737
MOD_NEK2_1	512	517	PF00069	0.344
MOD_NEK2_1	590	595	PF00069	0.620
MOD_NEK2_1	88	93	PF00069	0.719
MOD_NEK2_1	94	99	PF00069	0.792
MOD_NEK2_2	395	400	PF00069	0.634
MOD_PIKK_1	399	405	PF00454	0.732
MOD_PIKK_1	5	11	PF00454	0.757
MOD_PKA_2	158	164	PF00069	0.233
MOD_PKA_2	202	208	PF00069	0.231
MOD_PKA_2	233	239	PF00069	0.598
MOD_PKA_2	245	251	PF00069	0.650
MOD_PKA_2	342	348	PF00069	0.668
MOD_PKA_2	481	487	PF00069	0.607
MOD_Plk_1	180	186	PF00069	0.582
MOD_Plk_4	1	7	PF00069	0.789
MOD_Plk_4	137	143	PF00069	0.388
MOD_Plk_4	189	195	PF00069	0.388
MOD_Plk_4	202	208	PF00069	0.325
MOD_Plk_4	216	222	PF00069	0.298
MOD_Plk_4	233	239	PF00069	0.598
MOD_Plk_4	295	301	PF00069	0.664
MOD_Plk_4	323	329	PF00069	0.644
MOD_Plk_4	330	336	PF00069	0.590
MOD_Plk_4	411	417	PF00069	0.661
MOD_Plk_4	494	500	PF00069	0.624
MOD_Plk_4	508	514	PF00069	0.235
MOD_Plk_4	517	523	PF00069	0.312
MOD_Plk_4	525	531	PF00069	0.312
MOD_ProDKin_1	281	287	PF00069	0.758
MOD_ProDKin_1	405	411	PF00069	0.627
MOD_ProDKin_1	447	453	PF00069	0.312
MOD_ProDKin_1	51	57	PF00069	0.712
MOD_SUMO_rev_2	114	122	PF00179	0.599
TRG_DiLeu_BaEn_4	48	54	PF01217	0.618
TRG_DiLeu_BaLyEn_6	84	89	PF01217	0.610
TRG_DiLeu_LyEn_5	443	448	PF01217	0.329
TRG_ENDOCYTIC_2	143	146	PF00928	0.312
TRG_ENDOCYTIC_2	218	221	PF00928	0.312
TRG_ENDOCYTIC_2	567	570	PF00928	0.625
TRG_ENDOCYTIC_2	581	584	PF00928	0.312
TRG_ER_diArg_1	38	41	PF00400	0.704
TRG_ER_diArg_1	51	53	PF00400	0.639

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PDR7	Leptomonas seymouri	49%	100%
A0A3S7X2B9	Leishmania donovani	84%	100%
A4I4H6	Leishmania infantum	84%	100%
E9ADX7	Leishmania major	82%	100%
E9ALV4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	83%	100%