EF-hand domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HHC9_LEIBR

TriTrypDb:

LbrM.29.1250 , LBRM2903_290018800

Length:

368

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HHC9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HHC9

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	7
GO:0005509	calcium ion binding	5	7
GO:0043167	ion binding	2	7
GO:0043169	cation binding	3	7
GO:0046872	metal ion binding	4	7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	180	184	PF00656	0.706
CLV_C14_Caspase3-7	207	211	PF00656	0.821
CLV_C14_Caspase3-7	25	29	PF00656	0.539
CLV_MEL_PAP_1	142	148	PF00089	0.715
CLV_NRD_NRD_1	162	164	PF00675	0.655
CLV_PCSK_KEX2_1	162	164	PF00082	0.688
CLV_PCSK_SKI1_1	285	289	PF00082	0.648
CLV_PCSK_SKI1_1	312	316	PF00082	0.443
DEG_Nend_Nbox_1	1	3	PF02207	0.755
DEG_SCF_TRCP1_1	183	188	PF00400	0.581
DEG_SPOP_SBC_1	171	175	PF00917	0.634
DOC_CKS1_1	81	86	PF01111	0.469
DOC_PP2B_LxvP_1	331	334	PF13499	0.661
DOC_PP4_FxxP_1	136	139	PF00568	0.739
DOC_USP7_MATH_1	107	111	PF00917	0.559
DOC_USP7_MATH_1	166	170	PF00917	0.795
DOC_USP7_MATH_1	189	193	PF00917	0.774
DOC_USP7_MATH_1	247	251	PF00917	0.530
DOC_USP7_MATH_2	107	113	PF00917	0.558
DOC_USP7_MATH_2	47	53	PF00917	0.610
DOC_WW_Pin1_4	112	117	PF00397	0.583
DOC_WW_Pin1_4	172	177	PF00397	0.570
DOC_WW_Pin1_4	259	264	PF00397	0.592
DOC_WW_Pin1_4	276	281	PF00397	0.679
DOC_WW_Pin1_4	288	293	PF00397	0.527
DOC_WW_Pin1_4	80	85	PF00397	0.512
LIG_14-3-3_CanoR_1	14	24	PF00244	0.471
LIG_14-3-3_CanoR_1	162	171	PF00244	0.673
LIG_14-3-3_CanoR_1	257	263	PF00244	0.526
LIG_14-3-3_CanoR_1	312	318	PF00244	0.488
LIG_14-3-3_CanoR_1	34	39	PF00244	0.531
LIG_14-3-3_CanoR_1	80	84	PF00244	0.629
LIG_14-3-3_CanoR_1	99	107	PF00244	0.494
LIG_BRCT_BRCA1_1	191	195	PF00533	0.810
LIG_CaM_IQ_9	51	67	PF13499	0.646
LIG_FHA_1	253	259	PF00498	0.599
LIG_FHA_1	34	40	PF00498	0.502
LIG_FHA_1	4	10	PF00498	0.561
LIG_FHA_1	64	70	PF00498	0.685
LIG_FHA_1	81	87	PF00498	0.437
LIG_FHA_2	113	119	PF00498	0.557
LIG_FHA_2	123	129	PF00498	0.479
LIG_FHA_2	178	184	PF00498	0.787
LIG_FHA_2	294	300	PF00498	0.586
LIG_LIR_Gen_1	150	159	PF02991	0.581
LIG_LIR_Gen_1	250	260	PF02991	0.423
LIG_LIR_Gen_1	302	309	PF02991	0.500
LIG_LIR_Gen_1	335	345	PF02991	0.482
LIG_LIR_Gen_1	354	363	PF02991	0.453
LIG_LIR_Gen_1	40	48	PF02991	0.603
LIG_LIR_Nem_3	150	155	PF02991	0.593
LIG_LIR_Nem_3	250	256	PF02991	0.417
LIG_LIR_Nem_3	302	307	PF02991	0.499
LIG_LIR_Nem_3	335	340	PF02991	0.393
LIG_LIR_Nem_3	354	358	PF02991	0.452
LIG_LIR_Nem_3	40	45	PF02991	0.599
LIG_LIR_Nem_3	76	81	PF02991	0.769
LIG_PALB2_WD40_1	299	307	PF16756	0.501
LIG_SH2_CRK	253	257	PF00017	0.530
LIG_SH2_CRK	81	85	PF00017	0.628
LIG_SH2_STAT5	231	234	PF00017	0.521
LIG_SH2_STAT5	265	268	PF00017	0.739
LIG_SH2_STAT5	360	363	PF00017	0.457
LIG_SH2_STAT5	81	84	PF00017	0.622
LIG_SH2_STAT5	96	99	PF00017	0.531
LIG_SH3_2	244	249	PF14604	0.717
LIG_SH3_3	116	122	PF00018	0.570
LIG_SH3_3	173	179	PF00018	0.655
LIG_SH3_3	241	247	PF00018	0.663
LIG_SH3_3	274	280	PF00018	0.531
LIG_SH3_3	41	47	PF00018	0.614
LIG_Sin3_3	359	366	PF02671	0.355
LIG_SUMO_SIM_par_1	313	319	PF11976	0.587
LIG_TRAF2_1	202	205	PF00917	0.560
LIG_TRAF2_1	296	299	PF00917	0.639
LIG_TRAF2_1	316	319	PF00917	0.257
LIG_UBA3_1	23	32	PF00899	0.535
MOD_CDK_SPK_2	80	85	PF00069	0.482
MOD_CK1_1	112	118	PF00069	0.671
MOD_CK1_1	222	228	PF00069	0.663
MOD_CK2_1	112	118	PF00069	0.557
MOD_CK2_1	147	153	PF00069	0.706
MOD_CK2_1	270	276	PF00069	0.781
MOD_CK2_1	293	299	PF00069	0.650
MOD_CK2_1	313	319	PF00069	0.256
MOD_Cter_Amidation	160	163	PF01082	0.457
MOD_GlcNHglycan	10	13	PF01048	0.689
MOD_GlcNHglycan	183	186	PF01048	0.618
MOD_GlcNHglycan	191	194	PF01048	0.553
MOD_GlcNHglycan	215	219	PF01048	0.715
MOD_GlcNHglycan	221	224	PF01048	0.665
MOD_GSK3_1	162	169	PF00069	0.668
MOD_GSK3_1	177	184	PF00069	0.812
MOD_GSK3_1	185	192	PF00069	0.723
MOD_GSK3_1	210	217	PF00069	0.818
MOD_GSK3_1	265	272	PF00069	0.763
MOD_GSK3_1	33	40	PF00069	0.609
MOD_GSK3_1	332	339	PF00069	0.636
MOD_GSK3_1	63	70	PF00069	0.477
MOD_N-GLC_1	171	176	PF02516	0.778
MOD_N-GLC_1	288	293	PF02516	0.623
MOD_NEK2_1	214	219	PF00069	0.553
MOD_NEK2_1	237	242	PF00069	0.527
MOD_NEK2_1	258	263	PF00069	0.530
MOD_NEK2_1	69	74	PF00069	0.439
MOD_NEK2_2	147	152	PF00069	0.744
MOD_NEK2_2	252	257	PF00069	0.378
MOD_PIKK_1	15	21	PF00454	0.488
MOD_PKA_1	162	168	PF00069	0.667
MOD_PKA_2	107	113	PF00069	0.777
MOD_PKA_2	161	167	PF00069	0.756
MOD_PKA_2	33	39	PF00069	0.506
MOD_PKA_2	79	85	PF00069	0.698
MOD_Plk_2-3	109	115	PF00069	0.616
MOD_Plk_2-3	210	216	PF00069	0.567
MOD_Plk_2-3	336	342	PF00069	0.606
MOD_Plk_4	147	153	PF00069	0.640
MOD_Plk_4	166	172	PF00069	0.697
MOD_Plk_4	283	289	PF00069	0.547
MOD_Plk_4	34	40	PF00069	0.459
MOD_Plk_4	49	55	PF00069	0.394
MOD_ProDKin_1	112	118	PF00069	0.584
MOD_ProDKin_1	172	178	PF00069	0.570
MOD_ProDKin_1	259	265	PF00069	0.593
MOD_ProDKin_1	276	282	PF00069	0.679
MOD_ProDKin_1	288	294	PF00069	0.522
MOD_ProDKin_1	80	86	PF00069	0.505
MOD_SUMO_rev_2	103	112	PF00179	0.548
TRG_DiLeu_BaEn_2	48	54	PF01217	0.504
TRG_DiLeu_BaLyEn_6	96	101	PF01217	0.621
TRG_ENDOCYTIC_2	152	155	PF00928	0.629
TRG_ENDOCYTIC_2	253	256	PF00928	0.524
TRG_ENDOCYTIC_2	337	340	PF00928	0.526
TRG_ENDOCYTIC_2	360	363	PF00928	0.408
TRG_ENDOCYTIC_2	42	45	PF00928	0.594
TRG_Pf-PMV_PEXEL_1	99	103	PF00026	0.523

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I7W0	Leptomonas seymouri	48%	100%
A0A3Q8IRA6	Leishmania donovani	73%	99%
A4I4H4	Leishmania infantum	72%	99%
E9ADX5	Leishmania major	71%	100%
E9ALV6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	70%	100%