Tryparedoxin

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Tryparedoxin

Gene product:

tryparedoxin 1a, putative

Species:

Leishmania braziliensis

UniProt:

A4HHC7_LEIBR

TriTrypDb:

LbrM.29.1230 , LBRM2903_290018600

Length:

144

Annotations

LeishMANIAdb annotations

A large family of kinetoplastid-specific oxidoreductases. Only expanded in the Leptomonas genus. Localization: ER (by feature) / Mitochondial outer membrane (by feature)

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 4
Forrest at al. (procyclic)	no	yes: 4
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 33

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 6

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 26
NetGPI	no	yes: 0, no: 26

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	6
GO:0110165	cellular anatomical entity	1	8
GO:0005739	mitochondrion	5	1
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0005634	nucleus	5	1
GO:0005829	cytosol	2	1

Expansion

Sequence features

A4HHC7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HHC7

PDB structure(s): 3s9f_A

Function

Biological processes
Term	Name	Level	Count
GO:0008152	metabolic process	1	2
GO:0009056	catabolic process	2	2
GO:0009987	cellular process	1	2
GO:0042743	hydrogen peroxide metabolic process	4	2
GO:0042744	hydrogen peroxide catabolic process	4	2
GO:0044237	cellular metabolic process	2	2
GO:0044248	cellular catabolic process	3	2
GO:0072593	reactive oxygen species metabolic process	3	2
GO:0009892	negative regulation of metabolic process	4	1
GO:0009966	regulation of signal transduction	4	1
GO:0009968	negative regulation of signal transduction	5	1
GO:0010605	negative regulation of macromolecule metabolic process	5	1
GO:0010646	regulation of cell communication	4	1
GO:0010648	negative regulation of cell communication	5	1
GO:0019222	regulation of metabolic process	3	1
GO:0023051	regulation of signaling	3	1
GO:0023057	negative regulation of signaling	4	1
GO:0030111	regulation of Wnt signaling pathway	5	1
GO:0030178	negative regulation of Wnt signaling pathway	6	1
GO:0031396	regulation of protein ubiquitination	8	1
GO:0031397	negative regulation of protein ubiquitination	9	1
GO:0031399	regulation of protein modification process	6	1
GO:0031400	negative regulation of protein modification process	7	1
GO:0048519	negative regulation of biological process	3	1
GO:0048523	negative regulation of cellular process	4	1
GO:0048583	regulation of response to stimulus	3	1
GO:0048585	negative regulation of response to stimulus	4	1
GO:0050789	regulation of biological process	2	1
GO:0050794	regulation of cellular process	3	1
GO:0051171	regulation of nitrogen compound metabolic process	4	1
GO:0051172	negative regulation of nitrogen compound metabolic process	5	1
GO:0051246	regulation of protein metabolic process	5	1
GO:0051248	negative regulation of protein metabolic process	6	1
GO:0060255	regulation of macromolecule metabolic process	4	1
GO:0065007	biological regulation	1	1
GO:0080090	regulation of primary metabolic process	4	1
GO:1903320	regulation of protein modification by small protein conjugation or removal	7	1
GO:1903321	negative regulation of protein modification by small protein conjugation or removal	8	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	19
GO:0004791	thioredoxin-disulfide reductase activity	2	19
GO:0015035	protein-disulfide reductase activity	3	19
GO:0015036	disulfide oxidoreductase activity	4	19
GO:0016209	antioxidant activity	1	19
GO:0016491	oxidoreductase activity	2	19
GO:0016667	oxidoreductase activity, acting on a sulfur group of donors	3	19
GO:0016668	oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor	4	19
GO:0047134	protein-disulfide reductase (NAD(P)) activity	4	19
GO:0140096	catalytic activity, acting on a protein	2	19

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_PCSK_SKI1_1	102	106	PF00082	0.276
CLV_PCSK_SKI1_1	128	132	PF00082	0.576
CLV_PCSK_SKI1_1	29	33	PF00082	0.300
CLV_PCSK_SKI1_1	44	48	PF00082	0.314
DOC_ANK_TNKS_1	93	100	PF00023	0.415
DOC_CYCLIN_yClb5_NLxxxL_5	61	67	PF00134	0.415
DOC_MAPK_MEF2A_6	44	53	PF00069	0.552
DOC_MAPK_MEF2A_6	83	91	PF00069	0.506
DOC_PP1_RVXF_1	27	34	PF00149	0.325
DOC_PP2B_LxvP_1	87	90	PF13499	0.507
DOC_WW_Pin1_4	44	49	PF00397	0.511
LIG_BIR_II_1	1	5	PF00653	0.487
LIG_FHA_1	117	123	PF00498	0.444
LIG_FHA_1	45	51	PF00498	0.516
LIG_FHA_2	67	73	PF00498	0.563
LIG_LIR_Apic_2	36	42	PF02991	0.505
LIG_LIR_Nem_3	30	35	PF02991	0.512
LIG_LIR_Nem_3	52	57	PF02991	0.466
LIG_LIR_Nem_3	74	80	PF02991	0.509
LIG_PCNA_PIPBox_1	1	10	PF02747	0.526
LIG_Pex14_2	35	39	PF04695	0.508
LIG_SH2_STAT5	34	37	PF00017	0.502
LIG_SUMO_SIM_anti_2	64	69	PF11976	0.506
LIG_SUMO_SIM_par_1	47	52	PF11976	0.548
LIG_SUMO_SIM_par_1	64	69	PF11976	0.425
MOD_CK1_1	108	114	PF00069	0.520
MOD_CK1_1	19	25	PF00069	0.434
MOD_CK1_1	27	33	PF00069	0.371
MOD_CK2_1	66	72	PF00069	0.520
MOD_GlcNHglycan	1	4	PF01048	0.487
MOD_GlcNHglycan	26	29	PF01048	0.426
MOD_GlcNHglycan	35	38	PF01048	0.282
MOD_NEK2_1	33	38	PF00069	0.515
MOD_PIKK_1	129	135	PF00454	0.577
MOD_PIKK_1	89	95	PF00454	0.563
MOD_PK_1	105	111	PF00069	0.477
MOD_Plk_1	19	25	PF00069	0.513
MOD_Plk_4	108	114	PF00069	0.522
MOD_Plk_4	27	33	PF00069	0.317
MOD_ProDKin_1	44	50	PF00069	0.511
MOD_SUMO_for_1	104	107	PF00179	0.467
MOD_SUMO_rev_2	55	63	PF00179	0.488
TRG_DiLeu_BaLyEn_6	45	50	PF01217	0.563
TRG_ENDOCYTIC_2	81	84	PF00928	0.510
TRG_Pf-PMV_PEXEL_1	94	98	PF00026	0.258

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HT51	Leptomonas seymouri	36%	78%
A0A0N1HZM3	Leptomonas seymouri	57%	95%
A0A0N1I697	Leptomonas seymouri	70%	99%
A0A1X0P005	Trypanosomatidae	65%	100%
A0A1X0P190	Trypanosomatidae	35%	73%
A0A3Q8IED6	Leishmania donovani	76%	99%
A0A3Q8IG90	Leishmania donovani	36%	77%
A0A3S7X2H1	Leishmania donovani	59%	97%
A0A422MZX1	Trypanosoma rangeli	36%	75%
A0A422MZX8	Trypanosoma rangeli	68%	100%
A0A6L0XIW2	Leishmania infantum	59%	97%
A0A6L0XKX4	Leishmania infantum	76%	99%
A4HHC6	Leishmania braziliensis	57%	100%
A4HHC8	Leishmania braziliensis	97%	100%
A4HJH8	Leishmania braziliensis	34%	77%
A4I6X1	Leishmania infantum	36%	77%
B6DTG3	Bodo saltans	40%	82%
B6DTG4	Bodo saltans	56%	100%
C9ZKL4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	32%	73%
C9ZL57	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	61%	100%
E9ADX3	Leishmania major	59%	100%
E9ADX4	Leishmania major	73%	100%
E9ALV7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	76%	99%
E9ALV8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	59%	97%
E9B1Z5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	33%	75%
E9B1Z6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	34%	80%
O77404	Trypanosoma brucei brucei	61%	100%
Q4Q665	Leishmania major	35%	100%
Q4Q666	Leishmania major	33%	100%
Q5VZ03	Homo sapiens	30%	92%
Q68EV9	Xenopus laevis	28%	67%
Q8VC33	Mus musculus	31%	66%
Q96CM4	Homo sapiens	33%	68%
Q9D531	Mus musculus	32%	92%