Tryparedoxin

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Tryparedoxin

Gene product:

tryparedoxin 2, putative

Species:

Leishmania braziliensis

UniProt:

A4HHC6_LEIBR

TriTrypDb:

LbrM.29.1220 , LBRM2903_290018500

Length:

148

Annotations

LeishMANIAdb annotations

A large family of kinetoplastid-specific oxidoreductases. Only expanded in the Leptomonas genus. Localization: ER (by feature) / Mitochondial outer membrane (by feature)

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 4
Forrest at al. (procyclic)	no	yes: 4
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 33

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 6

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 24
NetGPI	no	yes: 0, no: 24

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	5
GO:0110165	cellular anatomical entity	1	8
GO:0005739	mitochondrion	5	1
GO:0043226	organelle	2	3
GO:0043227	membrane-bounded organelle	3	3
GO:0043229	intracellular organelle	3	3
GO:0043231	intracellular membrane-bounded organelle	4	3
GO:0005634	nucleus	5	2
GO:0032473	cytoplasmic side of mitochondrial outer membrane	4	1
GO:0098552	side of membrane	2	1
GO:0098562	cytoplasmic side of membrane	3	1
GO:0005829	cytosol	2	1

Expansion

Sequence features

A4HHC6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HHC6

PDB structure(s): 3s9f_A

Function

Biological processes
Term	Name	Level	Count
GO:0008152	metabolic process	1	2
GO:0009056	catabolic process	2	2
GO:0009987	cellular process	1	2
GO:0042743	hydrogen peroxide metabolic process	4	2
GO:0042744	hydrogen peroxide catabolic process	4	2
GO:0044237	cellular metabolic process	2	2
GO:0044248	cellular catabolic process	3	2
GO:0072593	reactive oxygen species metabolic process	3	2
GO:0009892	negative regulation of metabolic process	4	2
GO:0009966	regulation of signal transduction	4	2
GO:0009968	negative regulation of signal transduction	5	2
GO:0010605	negative regulation of macromolecule metabolic process	5	2
GO:0010646	regulation of cell communication	4	2
GO:0010648	negative regulation of cell communication	5	2
GO:0019222	regulation of metabolic process	3	2
GO:0023051	regulation of signaling	3	2
GO:0023057	negative regulation of signaling	4	2
GO:0030111	regulation of Wnt signaling pathway	5	2
GO:0030178	negative regulation of Wnt signaling pathway	6	2
GO:0031396	regulation of protein ubiquitination	8	2
GO:0031397	negative regulation of protein ubiquitination	9	2
GO:0031399	regulation of protein modification process	6	2
GO:0031400	negative regulation of protein modification process	7	2
GO:0048519	negative regulation of biological process	3	2
GO:0048523	negative regulation of cellular process	4	2
GO:0048583	regulation of response to stimulus	3	2
GO:0048585	negative regulation of response to stimulus	4	2
GO:0050789	regulation of biological process	2	2
GO:0050794	regulation of cellular process	3	2
GO:0051171	regulation of nitrogen compound metabolic process	4	2
GO:0051172	negative regulation of nitrogen compound metabolic process	5	2
GO:0051246	regulation of protein metabolic process	5	2
GO:0051248	negative regulation of protein metabolic process	6	2
GO:0060255	regulation of macromolecule metabolic process	4	2
GO:0065007	biological regulation	1	2
GO:0080090	regulation of primary metabolic process	4	2
GO:1903320	regulation of protein modification by small protein conjugation or removal	7	2
GO:1903321	negative regulation of protein modification by small protein conjugation or removal	8	2

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	20
GO:0004791	thioredoxin-disulfide reductase activity	2	20
GO:0015035	protein-disulfide reductase activity	3	20
GO:0015036	disulfide oxidoreductase activity	4	20
GO:0016209	antioxidant activity	1	20
GO:0016491	oxidoreductase activity	2	20
GO:0016667	oxidoreductase activity, acting on a sulfur group of donors	3	20
GO:0016668	oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor	4	20
GO:0047134	protein-disulfide reductase (NAD(P)) activity	4	20
GO:0140096	catalytic activity, acting on a protein	2	20

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	94	96	PF00675	0.339
CLV_PCSK_KEX2_1	5	7	PF00082	0.353
CLV_PCSK_PC1ET2_1	5	7	PF00082	0.353
CLV_PCSK_SKI1_1	122	126	PF00082	0.542
CLV_PCSK_SKI1_1	30	34	PF00082	0.298
CLV_PCSK_SKI1_1	45	49	PF00082	0.318
CLV_PCSK_SKI1_1	5	9	PF00082	0.379
DOC_MAPK_MEF2A_6	84	92	PF00069	0.473
DOC_PP2B_LxvP_1	88	91	PF13499	0.522
DOC_PP4_FxxP_1	141	144	PF00568	0.486
DOC_USP7_MATH_1	144	148	PF00917	0.645
DOC_WW_Pin1_4	45	50	PF00397	0.504
LIG_14-3-3_CanoR_1	16	25	PF00244	0.313
LIG_APCC_ABBA_1	7	12	PF00400	0.266
LIG_BIR_II_1	1	5	PF00653	0.420
LIG_Clathr_ClatBox_1	113	117	PF01394	0.525
LIG_FHA_1	118	124	PF00498	0.439
LIG_FHA_1	46	52	PF00498	0.522
LIG_LIR_Apic_2	140	144	PF02991	0.507
LIG_LIR_Apic_2	37	43	PF02991	0.504
LIG_LIR_Gen_1	80	90	PF02991	0.447
LIG_LIR_Nem_3	140	146	PF02991	0.615
LIG_LIR_Nem_3	31	36	PF02991	0.487
LIG_LIR_Nem_3	76	81	PF02991	0.488
LIG_PCNA_PIPBox_1	1	10	PF02747	0.452
LIG_Pex14_2	32	36	PF04695	0.507
LIG_SH2_STAP1	10	14	PF00017	0.322
LIG_SH2_STAT5	10	13	PF00017	0.321
LIG_SH2_STAT5	35	38	PF00017	0.498
LIG_SH3_3	130	136	PF00018	0.372
LIG_SUMO_SIM_anti_2	65	70	PF11976	0.479
MOD_CK1_1	109	115	PF00069	0.515
MOD_CK2_1	67	73	PF00069	0.509
MOD_GlcNHglycan	1	4	PF01048	0.416
MOD_GlcNHglycan	17	20	PF01048	0.497
MOD_GlcNHglycan	36	39	PF01048	0.287
MOD_NEK2_1	100	105	PF00069	0.410
MOD_NEK2_1	15	20	PF00069	0.501
MOD_NEK2_1	34	39	PF00069	0.508
MOD_NEK2_2	28	33	PF00069	0.286
MOD_PIKK_1	123	129	PF00454	0.460
MOD_PK_1	106	112	PF00069	0.495
MOD_PKA_2	15	21	PF00069	0.321
MOD_Plk_1	20	26	PF00069	0.522
MOD_Plk_4	10	16	PF00069	0.479
MOD_Plk_4	109	115	PF00069	0.517
MOD_Plk_4	28	34	PF00069	0.282
MOD_ProDKin_1	45	51	PF00069	0.504
MOD_SUMO_for_1	105	108	PF00179	0.452
MOD_SUMO_rev_2	135	141	PF00179	0.421
MOD_SUMO_rev_2	93	98	PF00179	0.511
TRG_ENDOCYTIC_2	82	85	PF00928	0.492

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HT51	Leptomonas seymouri	42%	80%
A0A0N1HZM3	Leptomonas seymouri	75%	97%
A0A0N1I697	Leptomonas seymouri	59%	100%
A0A1X0P005	Trypanosomatidae	57%	100%
A0A1X0P190	Trypanosomatidae	36%	75%
A0A3Q8IED6	Leishmania donovani	61%	100%
A0A3Q8IG90	Leishmania donovani	37%	80%
A0A3S7X2H1	Leishmania donovani	84%	99%
A0A422MZX1	Trypanosoma rangeli	37%	77%
A0A422MZX8	Trypanosoma rangeli	61%	100%
A0A6L0XIW2	Leishmania infantum	85%	99%
A0A6L0XKX4	Leishmania infantum	61%	100%
A4HHC7	Leishmania braziliensis	57%	100%
A4HHC8	Leishmania braziliensis	58%	100%
A4HJH8	Leishmania braziliensis	40%	80%
A4I6X1	Leishmania infantum	37%	80%
B6DTG3	Bodo saltans	46%	85%
B6DTG4	Bodo saltans	58%	100%
C9ZKL4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	31%	75%
C9ZL57	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	61%	100%
E9ADX3	Leishmania major	84%	100%
E9ADX4	Leishmania major	62%	100%
E9ALV7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	59%	100%
E9ALV8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	83%	99%
E9B1Z5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	38%	77%
E9B1Z6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	41%	82%
O77404	Trypanosoma brucei brucei	61%	100%
Q4Q665	Leishmania major	37%	100%
Q4Q666	Leishmania major	38%	100%
Q5VZ03	Homo sapiens	37%	95%
Q9D531	Mus musculus	34%	95%