Tryparedoxin-like protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

tryparedoxin-like protein

Species:

Leishmania braziliensis

UniProt:

A4HHC5_LEIBR

TriTrypDb:

LbrM.29.1210 , LBRM2903_250024300

Length:

271

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 18

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	6
GO:0110165	cellular anatomical entity	1	6

Expansion

Sequence features

A4HHC5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HHC5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	98	100	PF00675	0.471
CLV_PCSK_KEX2_1	98	100	PF00082	0.471
CLV_PCSK_SKI1_1	37	41	PF00082	0.275
DEG_SPOP_SBC_1	102	106	PF00917	0.716
DOC_CKS1_1	163	168	PF01111	0.615
DOC_CYCLIN_yCln2_LP_2	232	238	PF00134	0.485
DOC_MAPK_gen_1	34	43	PF00069	0.475
DOC_MAPK_gen_1	66	75	PF00069	0.475
DOC_MAPK_MEF2A_6	251	260	PF00069	0.478
DOC_MAPK_MEF2A_6	34	43	PF00069	0.501
DOC_MAPK_NFAT4_5	251	259	PF00069	0.442
DOC_PP2B_LxvP_1	169	172	PF13499	0.647
DOC_PP2B_LxvP_1	181	184	PF13499	0.640
DOC_USP7_MATH_1	102	106	PF00917	0.716
DOC_USP7_MATH_1	109	113	PF00917	0.607
DOC_USP7_MATH_1	172	176	PF00917	0.631
DOC_WW_Pin1_4	152	157	PF00397	0.682
DOC_WW_Pin1_4	162	167	PF00397	0.693
DOC_WW_Pin1_4	52	57	PF00397	0.495
LIG_14-3-3_CanoR_1	196	201	PF00244	0.531
LIG_BRCT_BRCA1_1	29	33	PF00533	0.528
LIG_eIF4E_1	69	75	PF01652	0.529
LIG_FHA_1	102	108	PF00498	0.603
LIG_FHA_1	53	59	PF00498	0.475
LIG_LIR_Apic_2	44	50	PF02991	0.475
LIG_LIR_Gen_1	195	206	PF02991	0.519
LIG_LIR_Nem_3	12	17	PF02991	0.551
LIG_LIR_Nem_3	195	201	PF02991	0.532
LIG_Pex14_2	10	14	PF04695	0.545
LIG_Pex14_2	234	238	PF04695	0.538
LIG_Pex14_2	264	268	PF04695	0.227
LIG_Pex14_2	43	47	PF04695	0.503
LIG_Pex14_2	71	75	PF04695	0.475
LIG_REV1ctd_RIR_1	86	96	PF16727	0.475
LIG_SH2_CRK	198	202	PF00017	0.530
LIG_SH2_NCK_1	198	202	PF00017	0.530
LIG_SH2_PTP2	38	41	PF00017	0.503
LIG_SH2_STAT5	267	270	PF00017	0.415
LIG_SH2_STAT5	38	41	PF00017	0.503
LIG_SH2_STAT5	42	45	PF00017	0.503
LIG_SH2_STAT5	96	99	PF00017	0.630
LIG_SH3_3	160	166	PF00018	0.754
LIG_SH3_3	198	204	PF00018	0.539
LIG_SH3_3	94	100	PF00018	0.636
LIG_SUMO_SIM_anti_2	252	258	PF11976	0.442
LIG_SUMO_SIM_par_1	207	213	PF11976	0.516
MOD_CK1_1	152	158	PF00069	0.699
MOD_CK1_1	199	205	PF00069	0.530
MOD_CK2_1	75	81	PF00069	0.500
MOD_Cter_Amidation	34	37	PF01082	0.397
MOD_GlcNHglycan	135	138	PF01048	0.413
MOD_GlcNHglycan	139	142	PF01048	0.435
MOD_GlcNHglycan	174	177	PF01048	0.421
MOD_GlcNHglycan	43	46	PF01048	0.275
MOD_GSK3_1	116	123	PF00069	0.777
MOD_GSK3_1	129	136	PF00069	0.643
MOD_GSK3_1	148	155	PF00069	0.670
MOD_GSK3_1	158	165	PF00069	0.670
MOD_GSK3_1	192	199	PF00069	0.524
MOD_GSK3_1	23	30	PF00069	0.548
MOD_N-GLC_1	244	249	PF02516	0.444
MOD_N-GLC_1	90	95	PF02516	0.388
MOD_NEK2_1	116	121	PF00069	0.712
MOD_NEK2_1	129	134	PF00069	0.619
MOD_NEK2_1	150	155	PF00069	0.645
MOD_PIKK_1	9	15	PF00454	0.551
MOD_PK_1	196	202	PF00069	0.533
MOD_PKA_2	91	97	PF00069	0.628
MOD_Plk_1	124	130	PF00069	0.708
MOD_Plk_4	196	202	PF00069	0.533
MOD_ProDKin_1	152	158	PF00069	0.682
MOD_ProDKin_1	162	168	PF00069	0.691
MOD_ProDKin_1	52	58	PF00069	0.495
MOD_SUMO_rev_2	12	20	PF00179	0.541
TRG_DiLeu_BaEn_1	252	257	PF01217	0.388
TRG_DiLeu_BaEn_2	188	194	PF01217	0.575
TRG_DiLeu_BaLyEn_6	53	58	PF01217	0.475
TRG_ENDOCYTIC_2	198	201	PF00928	0.532
TRG_ENDOCYTIC_2	265	268	PF00928	0.388
TRG_ENDOCYTIC_2	38	41	PF00928	0.503
TRG_ER_diArg_1	243	246	PF00400	0.647
TRG_ER_diArg_1	97	99	PF00400	0.665

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P6E5	Leptomonas seymouri	60%	96%
A0A3Q8IH82	Leishmania donovani	84%	99%
A4I4H1	Leishmania infantum	84%	99%
E9ADX2	Leishmania major	85%	100%
E9ALV9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	82%	99%