Tryparedoxin-like protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

tryparedoxin-like protein

Species:

Leishmania braziliensis

UniProt:

A4HHC4_LEIBR

TriTrypDb:

LbrM.29.1200 , LBRM2903_250024200

Length:

373

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	6
GO:0110165	cellular anatomical entity	1	6

Expansion

Sequence features

A4HHC4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HHC4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	194	196	PF00675	0.580
CLV_NRD_NRD_1	289	291	PF00675	0.777
CLV_NRD_NRD_1	94	96	PF00675	0.638
CLV_NRD_NRD_1	99	101	PF00675	0.628
CLV_PCSK_KEX2_1	103	105	PF00082	0.640
CLV_PCSK_KEX2_1	166	168	PF00082	0.677
CLV_PCSK_KEX2_1	193	195	PF00082	0.653
CLV_PCSK_KEX2_1	289	291	PF00082	0.777
CLV_PCSK_KEX2_1	62	64	PF00082	0.448
CLV_PCSK_KEX2_1	94	96	PF00082	0.638
CLV_PCSK_PC1ET2_1	103	105	PF00082	0.633
CLV_PCSK_PC1ET2_1	166	168	PF00082	0.670
CLV_PCSK_PC1ET2_1	193	195	PF00082	0.593
CLV_PCSK_PC1ET2_1	62	64	PF00082	0.448
CLV_PCSK_SKI1_1	217	221	PF00082	0.591
CLV_PCSK_SKI1_1	80	84	PF00082	0.469
CLV_Separin_Metazoa	11	15	PF03568	0.311
DEG_Nend_UBRbox_3	1	3	PF02207	0.351
DOC_CKS1_1	248	253	PF01111	0.408
DOC_CKS1_1	291	296	PF01111	0.423
DOC_CYCLIN_yCln2_LP_2	240	243	PF00134	0.432
DOC_MAPK_FxFP_2	219	222	PF00069	0.335
DOC_MAPK_gen_1	100	111	PF00069	0.347
DOC_MAPK_gen_1	289	298	PF00069	0.468
DOC_MAPK_gen_1	331	340	PF00069	0.269
DOC_MAPK_gen_1	62	69	PF00069	0.214
DOC_MAPK_MEF2A_6	217	226	PF00069	0.318
DOC_MAPK_MEF2A_6	27	36	PF00069	0.263
DOC_MAPK_MEF2A_6	289	298	PF00069	0.367
DOC_PP2B_LxvP_1	240	243	PF13499	0.456
DOC_PP2B_LxvP_1	256	259	PF13499	0.481
DOC_PP4_FxxP_1	219	222	PF00568	0.335
DOC_PP4_FxxP_1	39	42	PF00568	0.214
DOC_PP4_MxPP_1	273	276	PF00568	0.405
DOC_SPAK_OSR1_1	63	67	PF12202	0.214
DOC_USP7_MATH_1	188	192	PF00917	0.454
DOC_USP7_MATH_1	252	256	PF00917	0.533
DOC_USP7_MATH_1	265	269	PF00917	0.458
DOC_USP7_MATH_1	363	367	PF00917	0.638
DOC_WW_Pin1_4	247	252	PF00397	0.432
DOC_WW_Pin1_4	254	259	PF00397	0.410
DOC_WW_Pin1_4	290	295	PF00397	0.393
DOC_WW_Pin1_4	38	43	PF00397	0.320
LIG_14-3-3_CanoR_1	107	112	PF00244	0.354
LIG_14-3-3_CanoR_1	153	158	PF00244	0.569
LIG_14-3-3_CanoR_1	217	222	PF00244	0.335
LIG_14-3-3_CanoR_1	231	237	PF00244	0.426
LIG_Clathr_ClatBox_1	108	112	PF01394	0.357
LIG_CSL_BTD_1	39	42	PF09270	0.214
LIG_DLG_GKlike_1	27	34	PF00625	0.214
LIG_EVH1_1	241	245	PF00568	0.424
LIG_FHA_1	103	109	PF00498	0.348
LIG_FHA_1	122	128	PF00498	0.395
LIG_FHA_1	176	182	PF00498	0.427
LIG_FHA_1	21	27	PF00498	0.270
LIG_FHA_1	291	297	PF00498	0.433
LIG_FHA_1	345	351	PF00498	0.304
LIG_HP1_1	294	298	PF01393	0.360
LIG_LIR_Apic_2	352	356	PF02991	0.347
LIG_LIR_Gen_1	28	39	PF02991	0.269
LIG_LIR_Gen_1	45	55	PF02991	0.269
LIG_LIR_Nem_3	220	224	PF02991	0.312
LIG_LIR_Nem_3	28	34	PF02991	0.287
LIG_LIR_Nem_3	300	305	PF02991	0.359
LIG_LIR_Nem_3	45	50	PF02991	0.365
LIG_LYPXL_yS_3	221	224	PF13949	0.299
LIG_LYPXL_yS_3	302	305	PF13949	0.339
LIG_MYND_2	276	280	PF01753	0.386
LIG_PCNA_PIPBox_1	48	57	PF02747	0.269
LIG_Pex14_1	198	202	PF04695	0.337
LIG_Pex14_2	36	40	PF04695	0.269
LIG_SH2_CRK	248	252	PF00017	0.409
LIG_SH2_NCK_1	202	206	PF00017	0.317
LIG_SH2_NCK_1	73	77	PF00017	0.269
LIG_SH2_PTP2	31	34	PF00017	0.269
LIG_SH2_SRC	202	205	PF00017	0.316
LIG_SH2_STAT3	3	6	PF00017	0.331
LIG_SH2_STAT5	3	6	PF00017	0.331
LIG_SH2_STAT5	31	34	PF00017	0.269
LIG_SH2_STAT5	68	71	PF00017	0.269
LIG_SH3_3	205	211	PF00018	0.364
LIG_SH3_3	239	245	PF00018	0.470
LIG_SH3_3	293	299	PF00018	0.462
LIG_SUMO_SIM_anti_2	30	36	PF11976	0.214
LIG_SUMO_SIM_anti_2	347	352	PF11976	0.369
LIG_SUMO_SIM_anti_2	8	14	PF11976	0.369
LIG_SUMO_SIM_par_1	107	112	PF11976	0.358
LIG_SUMO_SIM_par_1	293	300	PF11976	0.360
LIG_SUMO_SIM_par_1	341	347	PF11976	0.308
LIG_SxIP_EBH_1	153	167	PF03271	0.467
LIG_TRAF2_1	264	267	PF00917	0.443
LIG_TYR_ITIM	200	205	PF00017	0.312
LIG_TYR_ITIM	29	34	PF00017	0.283
LIG_WW_2	242	245	PF00397	0.429
MOD_CK1_1	152	158	PF00069	0.492
MOD_CK1_1	366	372	PF00069	0.594
MOD_CK2_1	265	271	PF00069	0.494
MOD_CK2_1	366	372	PF00069	0.594
MOD_CK2_1	5	11	PF00069	0.382
MOD_CK2_1	71	77	PF00069	0.269
MOD_Cter_Amidation	98	101	PF01082	0.535
MOD_GlcNHglycan	136	139	PF01048	0.652
MOD_GlcNHglycan	141	144	PF01048	0.646
MOD_GlcNHglycan	178	181	PF01048	0.749
MOD_GlcNHglycan	182	185	PF01048	0.713
MOD_GlcNHglycan	232	235	PF01048	0.668
MOD_GlcNHglycan	317	321	PF01048	0.565
MOD_GlcNHglycan	333	336	PF01048	0.401
MOD_GlcNHglycan	88	91	PF01048	0.604
MOD_GSK3_1	148	155	PF00069	0.482
MOD_GSK3_1	169	176	PF00069	0.442
MOD_GSK3_1	327	334	PF00069	0.397
MOD_GSK3_1	67	74	PF00069	0.269
MOD_GSK3_1	82	89	PF00069	0.384
MOD_LATS_1	215	221	PF00433	0.341
MOD_N-GLC_1	173	178	PF02516	0.626
MOD_NEK2_1	157	162	PF00069	0.446
MOD_NEK2_1	173	178	PF00069	0.401
MOD_NEK2_2	188	193	PF00069	0.386
MOD_PIKK_1	366	372	PF00454	0.622
MOD_PIKK_1	71	77	PF00454	0.214
MOD_PK_1	107	113	PF00069	0.369
MOD_PKA_2	152	158	PF00069	0.516
MOD_PKA_2	230	236	PF00069	0.428
MOD_PKA_2	86	92	PF00069	0.405
MOD_Plk_1	169	175	PF00069	0.491
MOD_Plk_1	27	33	PF00069	0.214
MOD_Plk_4	236	242	PF00069	0.374
MOD_Plk_4	27	33	PF00069	0.214
MOD_Plk_4	275	281	PF00069	0.382
MOD_Plk_4	344	350	PF00069	0.362
MOD_ProDKin_1	247	253	PF00069	0.431
MOD_ProDKin_1	254	260	PF00069	0.413
MOD_ProDKin_1	290	296	PF00069	0.392
MOD_ProDKin_1	38	44	PF00069	0.320
MOD_SUMO_rev_2	112	121	PF00179	0.506
MOD_SUMO_rev_2	56	64	PF00179	0.341
TRG_DiLeu_BaEn_2	42	48	PF01217	0.316
TRG_DiLeu_BaLyEn_6	104	109	PF01217	0.349
TRG_ENDOCYTIC_2	202	205	PF00928	0.316
TRG_ENDOCYTIC_2	221	224	PF00928	0.212
TRG_ENDOCYTIC_2	302	305	PF00928	0.339
TRG_ENDOCYTIC_2	31	34	PF00928	0.283
TRG_Pf-PMV_PEXEL_1	107	112	PF00026	0.613

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P6T6	Leptomonas seymouri	48%	100%
A0A3Q8IE94	Leishmania donovani	75%	100%
A4I4H0	Leishmania infantum	75%	100%
E9ADX1	Leishmania major	72%	99%
E9ALW0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	76%	100%