Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HHC1_LEIBR

TriTrypDb:

LbrM.29.1170 , LBRM2903_250024000

Length:

625

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HHC1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HHC1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	254	258	PF00656	0.582
CLV_C14_Caspase3-7	44	48	PF00656	0.584
CLV_C14_Caspase3-7	96	100	PF00656	0.618
CLV_NRD_NRD_1	129	131	PF00675	0.661
CLV_NRD_NRD_1	301	303	PF00675	0.524
CLV_NRD_NRD_1	370	372	PF00675	0.440
CLV_PCSK_KEX2_1	129	131	PF00082	0.682
CLV_PCSK_KEX2_1	136	138	PF00082	0.660
CLV_PCSK_KEX2_1	298	300	PF00082	0.557
CLV_PCSK_KEX2_1	370	372	PF00082	0.474
CLV_PCSK_KEX2_1	599	601	PF00082	0.691
CLV_PCSK_PC1ET2_1	136	138	PF00082	0.747
CLV_PCSK_PC1ET2_1	298	300	PF00082	0.575
CLV_PCSK_PC1ET2_1	599	601	PF00082	0.702
CLV_PCSK_PC7_1	125	131	PF00082	0.733
CLV_PCSK_SKI1_1	125	129	PF00082	0.689
CLV_PCSK_SKI1_1	346	350	PF00082	0.532
CLV_PCSK_SKI1_1	493	497	PF00082	0.658
CLV_PCSK_SKI1_1	53	57	PF00082	0.680
CLV_Separin_Metazoa	237	241	PF03568	0.438
DEG_Nend_UBRbox_2	1	3	PF02207	0.739
DEG_SPOP_SBC_1	147	151	PF00917	0.740
DEG_SPOP_SBC_1	514	518	PF00917	0.472
DOC_CDC14_PxL_1	188	196	PF14671	0.702
DOC_MAPK_DCC_7	406	416	PF00069	0.504
DOC_MAPK_gen_1	370	376	PF00069	0.451
DOC_USP7_MATH_1	156	160	PF00917	0.684
DOC_USP7_MATH_1	319	323	PF00917	0.473
DOC_USP7_MATH_1	400	404	PF00917	0.481
DOC_USP7_MATH_1	531	535	PF00917	0.607
DOC_USP7_MATH_1	580	584	PF00917	0.761
DOC_USP7_MATH_1	587	591	PF00917	0.794
DOC_USP7_MATH_1	612	616	PF00917	0.781
DOC_USP7_UBL2_3	394	398	PF12436	0.369
DOC_WW_Pin1_4	315	320	PF00397	0.489
LIG_14-3-3_CanoR_1	199	209	PF00244	0.552
LIG_14-3-3_CanoR_1	217	223	PF00244	0.693
LIG_14-3-3_CanoR_1	276	284	PF00244	0.568
LIG_14-3-3_CanoR_1	354	363	PF00244	0.515
LIG_14-3-3_CanoR_1	401	407	PF00244	0.622
LIG_14-3-3_CanoR_1	498	507	PF00244	0.605
LIG_Actin_WH2_2	392	410	PF00022	0.640
LIG_APCC_ABBA_1	570	575	PF00400	0.598
LIG_BIR_III_4	34	38	PF00653	0.739
LIG_BRCT_BRCA1_1	311	315	PF00533	0.496
LIG_eIF4E_1	202	208	PF01652	0.570
LIG_FHA_1	101	107	PF00498	0.655
LIG_FHA_1	22	28	PF00498	0.611
LIG_FHA_1	233	239	PF00498	0.650
LIG_FHA_1	283	289	PF00498	0.423
LIG_FHA_1	331	337	PF00498	0.563
LIG_FHA_1	351	357	PF00498	0.421
LIG_FHA_1	384	390	PF00498	0.575
LIG_FHA_1	561	567	PF00498	0.668
LIG_FHA_1	86	92	PF00498	0.687
LIG_FHA_2	232	238	PF00498	0.676
LIG_FHA_2	400	406	PF00498	0.638
LIG_Integrin_RGD_1	32	34	PF01839	0.754
LIG_LIR_Apic_2	60	65	PF02991	0.609
LIG_LIR_Gen_1	248	256	PF02991	0.484
LIG_LIR_Gen_1	257	268	PF02991	0.417
LIG_LIR_Gen_1	485	495	PF02991	0.690
LIG_LIR_Gen_1	504	515	PF02991	0.664
LIG_LIR_Gen_1	567	577	PF02991	0.541
LIG_LIR_Nem_3	2	6	PF02991	0.698
LIG_LIR_Nem_3	248	253	PF02991	0.481
LIG_LIR_Nem_3	257	263	PF02991	0.431
LIG_LIR_Nem_3	342	348	PF02991	0.429
LIG_LIR_Nem_3	485	491	PF02991	0.654
LIG_LIR_Nem_3	504	510	PF02991	0.578
LIG_LIR_Nem_3	540	546	PF02991	0.591
LIG_LIR_Nem_3	63	69	PF02991	0.524
LIG_LYPXL_yS_3	66	69	PF13949	0.705
LIG_NRBOX	287	293	PF00104	0.457
LIG_Pex14_1	289	293	PF04695	0.401
LIG_Pex14_1	62	66	PF04695	0.620
LIG_Pex14_2	311	315	PF04695	0.496
LIG_PTB_Apo_2	406	413	PF02174	0.655
LIG_PTB_Phospho_1	406	412	PF10480	0.667
LIG_SH2_CRK	390	394	PF00017	0.527
LIG_SH2_CRK	507	511	PF00017	0.699
LIG_SH2_CRK	546	550	PF00017	0.521
LIG_SH2_GRB2like	390	393	PF00017	0.537
LIG_SH2_NCK_1	202	206	PF00017	0.637
LIG_SH2_NCK_1	546	550	PF00017	0.606
LIG_SH2_STAP1	341	345	PF00017	0.516
LIG_SH2_STAP1	352	356	PF00017	0.417
LIG_SH2_STAT5	202	205	PF00017	0.546
LIG_SH2_STAT5	352	355	PF00017	0.365
LIG_SH2_STAT5	359	362	PF00017	0.436
LIG_SH2_STAT5	385	388	PF00017	0.554
LIG_SH2_STAT5	390	393	PF00017	0.506
LIG_SH2_STAT5	520	523	PF00017	0.532
LIG_SH2_STAT5	543	546	PF00017	0.566
LIG_SH2_STAT5	569	572	PF00017	0.516
LIG_SH3_3	112	118	PF00018	0.663
LIG_SH3_3	194	200	PF00018	0.687
LIG_SH3_3	415	421	PF00018	0.454
LIG_SH3_3	453	459	PF00018	0.525
LIG_SH3_3	61	67	PF00018	0.584
LIG_SH3_3	611	617	PF00018	0.555
LIG_SUMO_SIM_par_1	4	10	PF11976	0.742
LIG_TRAF2_1	234	237	PF00917	0.697
LIG_TRAF2_1	7	10	PF00917	0.752
LIG_TRFH_1	114	118	PF08558	0.629
LIG_TYR_ITIM	111	116	PF00017	0.617
LIG_TYR_ITIM	544	549	PF00017	0.583
LIG_TYR_ITIM	64	69	PF00017	0.684
MOD_CK1_1	149	155	PF00069	0.727
MOD_CK1_1	313	319	PF00069	0.489
MOD_CK1_1	339	345	PF00069	0.560
MOD_CK1_1	500	506	PF00069	0.463
MOD_CK1_1	516	522	PF00069	0.509
MOD_CK1_1	583	589	PF00069	0.631
MOD_CK2_1	231	237	PF00069	0.678
MOD_CK2_1	4	10	PF00069	0.742
MOD_GlcNHglycan	153	156	PF01048	0.773
MOD_GlcNHglycan	257	260	PF01048	0.399
MOD_GlcNHglycan	402	405	PF01048	0.668
MOD_GlcNHglycan	421	424	PF01048	0.542
MOD_GlcNHglycan	591	594	PF01048	0.799
MOD_GSK3_1	145	152	PF00069	0.679
MOD_GSK3_1	251	258	PF00069	0.536
MOD_GSK3_1	309	316	PF00069	0.432
MOD_GSK3_1	336	343	PF00069	0.513
MOD_GSK3_1	350	357	PF00069	0.465
MOD_GSK3_1	37	44	PF00069	0.664
MOD_GSK3_1	493	500	PF00069	0.575
MOD_GSK3_1	558	565	PF00069	0.695
MOD_GSK3_1	583	590	PF00069	0.719
MOD_N-GLC_1	156	161	PF02516	0.802
MOD_N-GLC_1	21	26	PF02516	0.717
MOD_N-GLC_1	277	282	PF02516	0.316
MOD_N-GLC_1	558	563	PF02516	0.735
MOD_NEK2_1	105	110	PF00069	0.592
MOD_NEK2_1	282	287	PF00069	0.407
MOD_NEK2_1	336	341	PF00069	0.376
MOD_NEK2_1	350	355	PF00069	0.260
MOD_NEK2_1	399	404	PF00069	0.566
MOD_NEK2_1	407	412	PF00069	0.594
MOD_NEK2_1	474	479	PF00069	0.375
MOD_NEK2_1	515	520	PF00069	0.707
MOD_NEK2_1	84	89	PF00069	0.709
MOD_PIKK_1	11	17	PF00454	0.755
MOD_PIKK_1	192	198	PF00454	0.686
MOD_PIKK_1	218	224	PF00454	0.669
MOD_PIKK_1	251	257	PF00454	0.549
MOD_PIKK_1	336	342	PF00454	0.419
MOD_PIKK_1	37	43	PF00454	0.710
MOD_PKA_2	282	288	PF00069	0.468
MOD_PKA_2	330	336	PF00069	0.531
MOD_PKA_2	400	406	PF00069	0.593
MOD_PKA_2	497	503	PF00069	0.649
MOD_Plk_1	277	283	PF00069	0.500
MOD_Plk_1	449	455	PF00069	0.588
MOD_Plk_1	503	509	PF00069	0.579
MOD_Plk_1	85	91	PF00069	0.714
MOD_Plk_4	175	181	PF00069	0.494
MOD_Plk_4	246	252	PF00069	0.463
MOD_Plk_4	310	316	PF00069	0.274
MOD_Plk_4	407	413	PF00069	0.644
MOD_Plk_4	516	522	PF00069	0.564
MOD_ProDKin_1	315	321	PF00069	0.489
MOD_SUMO_for_1	598	601	PF00179	0.814
MOD_SUMO_rev_2	79	84	PF00179	0.706
TRG_DiLeu_BaEn_2	440	446	PF01217	0.597
TRG_DiLeu_BaEn_4	441	447	PF01217	0.601
TRG_DiLeu_BaLyEn_6	344	349	PF01217	0.508
TRG_ENDOCYTIC_2	113	116	PF00928	0.619
TRG_ENDOCYTIC_2	202	205	PF00928	0.546
TRG_ENDOCYTIC_2	390	393	PF00928	0.537
TRG_ENDOCYTIC_2	507	510	PF00928	0.694
TRG_ENDOCYTIC_2	546	549	PF00928	0.518
TRG_ENDOCYTIC_2	569	572	PF00928	0.521
TRG_ENDOCYTIC_2	66	69	PF00928	0.625
TRG_ENDOCYTIC_2	81	84	PF00928	0.589
TRG_ER_diArg_1	128	130	PF00400	0.731
TRG_ER_diArg_1	161	164	PF00400	0.770
TRG_NLS_MonoExtN_4	133	139	PF00514	0.509
TRG_Pf-PMV_PEXEL_1	199	204	PF00026	0.544
TRG_Pf-PMV_PEXEL_1	262	266	PF00026	0.469
TRG_Pf-PMV_PEXEL_1	346	351	PF00026	0.503

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IHI1	Leptomonas seymouri	66%	100%
A0A0S4JMH1	Bodo saltans	28%	100%
A0A1X0P058	Trypanosomatidae	34%	96%
A0A3R7M9T5	Trypanosoma rangeli	33%	98%
A0A3S7X2F4	Leishmania donovani	88%	100%
C9ZLL7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	33%	97%
E9ADW9	Leishmania major	87%	100%
E9AHI6	Leishmania infantum	88%	100%
E9ALW2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%
V5DI43	Trypanosoma cruzi	34%	99%