ANK_REP_REGION domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Ankyrin repeats (3 copies), putative

Species:

Leishmania braziliensis

UniProt:

A4HHC0_LEIBR

TriTrypDb:

LbrM.29.1160 , LBRM2903_250023900

Length:

360

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 3
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 8

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 12
NetGPI	no	yes: 0, no: 12

Cellular components
Term	Name	Level	Count
GO:0005930	axoneme	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HHC0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HHC0

PDB structure(s): 3ljn_A

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_MEL_PAP_1	44	50	PF00089	0.321
CLV_NRD_NRD_1	24	26	PF00675	0.299
CLV_NRD_NRD_1	325	327	PF00675	0.724
CLV_NRD_NRD_1	33	35	PF00675	0.330
CLV_PCSK_KEX2_1	325	327	PF00082	0.648
CLV_PCSK_KEX2_1	33	35	PF00082	0.318
CLV_PCSK_KEX2_1	335	337	PF00082	0.537
CLV_PCSK_PC1ET2_1	325	327	PF00082	0.666
CLV_PCSK_PC1ET2_1	335	337	PF00082	0.584
CLV_PCSK_SKI1_1	182	186	PF00082	0.443
CLV_PCSK_SKI1_1	335	339	PF00082	0.590
DEG_APCC_DBOX_1	181	189	PF00400	0.313
DOC_MAPK_JIP1_4	82	88	PF00069	0.329
DOC_MAPK_MEF2A_6	225	233	PF00069	0.451
DOC_MAPK_MEF2A_6	92	99	PF00069	0.494
DOC_PP1_RVXF_1	281	287	PF00149	0.370
DOC_USP7_UBL2_3	325	329	PF12436	0.600
DOC_WW_Pin1_4	106	111	PF00397	0.526
DOC_WW_Pin1_4	158	163	PF00397	0.296
DOC_WW_Pin1_4	168	173	PF00397	0.328
DOC_WW_Pin1_4	38	43	PF00397	0.403
LIG_14-3-3_CanoR_1	25	35	PF00244	0.276
LIG_14-3-3_CanoR_1	47	55	PF00244	0.321
LIG_BRCT_BRCA1_1	262	266	PF00533	0.356
LIG_FHA_1	239	245	PF00498	0.439
LIG_FHA_1	27	33	PF00498	0.276
LIG_FHA_1	311	317	PF00498	0.462
LIG_FHA_2	161	167	PF00498	0.392
LIG_FHA_2	215	221	PF00498	0.251
LIG_LIR_LC3C_4	94	97	PF02991	0.368
LIG_LIR_Nem_3	2	7	PF02991	0.542
LIG_PTAP_UEV_1	340	345	PF05743	0.538
LIG_SH2_STAT5	148	151	PF00017	0.335
LIG_SH2_STAT5	245	248	PF00017	0.424
LIG_SH2_STAT5	67	70	PF00017	0.380
LIG_SH3_1	338	344	PF00018	0.583
LIG_SH3_2	341	346	PF14604	0.546
LIG_SH3_3	338	344	PF00018	0.538
LIG_SUMO_SIM_par_1	94	101	PF11976	0.369
LIG_TRAF2_1	297	300	PF00917	0.487
MOD_CDK_SPxxK_3	158	165	PF00069	0.276
MOD_CDK_SPxxK_3	168	175	PF00069	0.276
MOD_CK2_1	214	220	PF00069	0.215
MOD_CK2_1	67	73	PF00069	0.475
MOD_Cter_Amidation	323	326	PF01082	0.444
MOD_GlcNHglycan	341	344	PF01048	0.539
MOD_GSK3_1	346	353	PF00069	0.635
MOD_LATS_1	131	137	PF00433	0.453
MOD_N-GLC_1	260	265	PF02516	0.425
MOD_N-GLC_1	274	279	PF02516	0.379
MOD_N-GLC_2	115	117	PF02516	0.402
MOD_NEK2_1	267	272	PF00069	0.425
MOD_NEK2_1	35	40	PF00069	0.468
MOD_NEK2_1	48	53	PF00069	0.276
MOD_PKA_2	353	359	PF00069	0.499
MOD_PKB_1	346	354	PF00069	0.695
MOD_Plk_1	13	19	PF00069	0.299
MOD_Plk_1	238	244	PF00069	0.381
MOD_Plk_2-3	13	19	PF00069	0.299
MOD_Plk_4	109	115	PF00069	0.520
MOD_ProDKin_1	106	112	PF00069	0.530
MOD_ProDKin_1	158	164	PF00069	0.296
MOD_ProDKin_1	168	174	PF00069	0.328
MOD_ProDKin_1	38	44	PF00069	0.403
MOD_SUMO_for_1	297	300	PF00179	0.377
TRG_DiLeu_BaEn_1	300	305	PF01217	0.387
TRG_DiLeu_BaEn_1	31	36	PF01217	0.321
TRG_DiLeu_LyEn_5	31	36	PF01217	0.403
TRG_ENDOCYTIC_2	148	151	PF00928	0.335
TRG_ENDOCYTIC_2	245	248	PF00928	0.433
TRG_ER_diArg_1	179	182	PF00400	0.418
TRG_ER_diArg_1	32	34	PF00400	0.368
TRG_ER_diArg_1	347	350	PF00400	0.586
TRG_NES_CRM1_1	220	232	PF08389	0.345
TRG_NLS_Bipartite_1	325	339	PF00514	0.717
TRG_NLS_MonoCore_2	324	329	PF00514	0.647
TRG_NLS_MonoExtC_3	324	329	PF00514	0.651
TRG_NLS_MonoExtN_4	325	331	PF00514	0.589
TRG_NLS_MonoExtN_4	332	339	PF00514	0.563
TRG_Pf-PMV_PEXEL_1	33	37	PF00026	0.395

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1P9S9	Leptomonas seymouri	74%	99%
A0A1X0NZR2	Trypanosomatidae	56%	100%
A0A3Q8IDM3	Leishmania donovani	88%	100%
A0A422MZY2	Trypanosoma rangeli	56%	100%
A4I4G8	Leishmania infantum	89%	100%
B6DTG8	Bodo saltans	53%	100%
C9ZLL6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	55%	100%
D0A6Y4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	23%	92%
E9ADW8	Leishmania major	87%	100%
E9ALW3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%
E9B1A1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	26%	88%
Q495B1	Homo sapiens	25%	69%
Q91ZT7	Mus musculus	25%	77%
Q9J516	Fowlpox virus (strain NVSL)	22%	83%
V5BMS1	Trypanosoma cruzi	27%	87%