DUF2040 domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HHB5_LEIBR

TriTrypDb:

LbrM.29.1110 , LBRM2903_290018000

Length:

197

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 14
NetGPI	no	yes: 0, no: 14

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HHB5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HHB5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	109	111	PF00675	0.520
CLV_NRD_NRD_1	115	117	PF00675	0.433
CLV_NRD_NRD_1	122	124	PF00675	0.359
CLV_NRD_NRD_1	42	44	PF00675	0.561
CLV_NRD_NRD_1	85	87	PF00675	0.590
CLV_PCSK_FUR_1	120	124	PF00082	0.334
CLV_PCSK_KEX2_1	109	111	PF00082	0.498
CLV_PCSK_KEX2_1	122	124	PF00082	0.367
CLV_PCSK_KEX2_1	158	160	PF00082	0.470
CLV_PCSK_KEX2_1	42	44	PF00082	0.523
CLV_PCSK_PC1ET2_1	158	160	PF00082	0.470
CLV_PCSK_PC7_1	38	44	PF00082	0.502
CLV_PCSK_SKI1_1	123	127	PF00082	0.389
CLV_PCSK_SKI1_1	129	133	PF00082	0.483
CLV_PCSK_SKI1_1	142	146	PF00082	0.536
CLV_PCSK_SKI1_1	42	46	PF00082	0.468
DEG_Nend_UBRbox_2	1	3	PF02207	0.443
DOC_USP7_MATH_1	125	129	PF00917	0.342
DOC_USP7_UBL2_3	137	141	PF12436	0.453
DOC_USP7_UBL2_3	55	59	PF12436	0.583
DOC_USP7_UBL2_3	94	98	PF12436	0.670
DOC_WW_Pin1_4	13	18	PF00397	0.578
LIG_14-3-3_CanoR_1	129	139	PF00244	0.671
LIG_14-3-3_CanoR_1	150	156	PF00244	0.472
LIG_14-3-3_CanoR_1	42	47	PF00244	0.523
LIG_14-3-3_CanoR_1	50	57	PF00244	0.543
LIG_FHA_1	173	179	PF00498	0.480
LIG_LIR_Gen_1	5	11	PF02991	0.690
LIG_LIR_Nem_3	161	167	PF02991	0.467
LIG_LIR_Nem_3	5	9	PF02991	0.676
LIG_Rb_pABgroove_1	64	72	PF01858	0.571
LIG_SH2_CRK	6	10	PF00017	0.677
LIG_SH2_PTP2	167	170	PF00017	0.528
LIG_SH2_SRC	167	170	PF00017	0.515
LIG_SH2_STAP1	70	74	PF00017	0.418
LIG_SH2_STAT3	28	31	PF00017	0.440
LIG_SH2_STAT3	70	73	PF00017	0.433
LIG_SH2_STAT5	130	133	PF00017	0.406
LIG_SH2_STAT5	167	170	PF00017	0.551
LIG_SH3_1	167	173	PF00018	0.488
LIG_SH3_3	167	173	PF00018	0.450
LIG_TRAF2_1	17	20	PF00917	0.486
LIG_TRAF2_1	58	61	PF00917	0.395
LIG_TYR_ITIM	4	9	PF00017	0.437
MOD_CK1_1	7	13	PF00069	0.440
MOD_CK2_1	13	19	PF00069	0.537
MOD_CK2_1	176	182	PF00069	0.398
MOD_CK2_1	55	61	PF00069	0.522
MOD_CK2_1	77	83	PF00069	0.500
MOD_Cter_Amidation	139	142	PF01082	0.601
MOD_GSK3_1	172	179	PF00069	0.476
MOD_GSK3_1	189	196	PF00069	0.550
MOD_NEK2_1	190	195	PF00069	0.640
MOD_NEK2_1	77	82	PF00069	0.582
MOD_PIKK_1	50	56	PF00454	0.575
MOD_PKA_1	116	122	PF00069	0.434
MOD_PKA_1	42	48	PF00069	0.639
MOD_PKA_2	149	155	PF00069	0.470
MOD_PKA_2	176	182	PF00069	0.480
MOD_PKA_2	188	194	PF00069	0.516
MOD_PKA_2	42	48	PF00069	0.618
MOD_PKB_1	48	56	PF00069	0.490
MOD_Plk_1	4	10	PF00069	0.438
MOD_ProDKin_1	13	19	PF00069	0.573
MOD_SUMO_rev_2	113	119	PF00179	0.579
MOD_SUMO_rev_2	80	88	PF00179	0.571
MOD_SUMO_rev_2	90	99	PF00179	0.389
TRG_DiLeu_BaEn_1	19	24	PF01217	0.471
TRG_DiLeu_BaEn_1	61	66	PF01217	0.488
TRG_ENDOCYTIC_2	29	32	PF00928	0.518
TRG_ENDOCYTIC_2	6	9	PF00928	0.676
TRG_ER_diArg_1	108	110	PF00400	0.510
TRG_ER_diArg_1	120	123	PF00400	0.367
TRG_NLS_MonoExtN_4	116	121	PF00514	0.334

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HS21	Leptomonas seymouri	28%	100%
A0A0N1PE73	Leptomonas seymouri	66%	99%
A0A0S4KEQ5	Bodo saltans	37%	100%
A0A1X0P0C6	Trypanosomatidae	58%	100%
A0A3Q8IR92	Leishmania donovani	81%	100%
A0A3R7K1K7	Trypanosoma rangeli	31%	100%
A0A422NF15	Trypanosoma rangeli	58%	100%
A0A422NMA5	Trypanosoma rangeli	28%	100%
A4I4G2	Leishmania infantum	80%	100%
C9ZLL0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	54%	100%
E9ADW1	Leishmania major	82%	100%
E9ALW9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	82%	100%
V5B1S3	Trypanosoma cruzi	55%	100%