Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HHB4_LEIBR

TriTrypDb:

LbrM.29.1100 , LBRM2903_290017900

Length:

724

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HHB4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HHB4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	100	104	PF00656	0.524
CLV_C14_Caspase3-7	272	276	PF00656	0.610
CLV_C14_Caspase3-7	294	298	PF00656	0.502
CLV_NRD_NRD_1	236	238	PF00675	0.576
CLV_NRD_NRD_1	25	27	PF00675	0.511
CLV_NRD_NRD_1	340	342	PF00675	0.728
CLV_NRD_NRD_1	365	367	PF00675	0.665
CLV_NRD_NRD_1	373	375	PF00675	0.741
CLV_NRD_NRD_1	45	47	PF00675	0.369
CLV_NRD_NRD_1	544	546	PF00675	0.652
CLV_NRD_NRD_1	649	651	PF00675	0.487
CLV_PCSK_FUR_1	42	46	PF00082	0.433
CLV_PCSK_FUR_1	637	641	PF00082	0.546
CLV_PCSK_KEX2_1	128	130	PF00082	0.669
CLV_PCSK_KEX2_1	236	238	PF00082	0.576
CLV_PCSK_KEX2_1	24	26	PF00082	0.511
CLV_PCSK_KEX2_1	340	342	PF00082	0.816
CLV_PCSK_KEX2_1	365	367	PF00082	0.752
CLV_PCSK_KEX2_1	372	374	PF00082	0.720
CLV_PCSK_KEX2_1	404	406	PF00082	0.453
CLV_PCSK_KEX2_1	44	46	PF00082	0.374
CLV_PCSK_KEX2_1	544	546	PF00082	0.652
CLV_PCSK_KEX2_1	639	641	PF00082	0.537
CLV_PCSK_KEX2_1	649	651	PF00082	0.556
CLV_PCSK_PC1ET2_1	128	130	PF00082	0.479
CLV_PCSK_PC1ET2_1	404	406	PF00082	0.453
CLV_PCSK_PC1ET2_1	639	641	PF00082	0.537
CLV_PCSK_PC7_1	368	374	PF00082	0.602
CLV_PCSK_SKI1_1	343	347	PF00082	0.542
CLV_PCSK_SKI1_1	373	377	PF00082	0.529
CLV_PCSK_SKI1_1	397	401	PF00082	0.446
CLV_PCSK_SKI1_1	420	424	PF00082	0.584
CLV_PCSK_SKI1_1	473	477	PF00082	0.535
CLV_Separin_Metazoa	109	113	PF03568	0.473
DEG_APCC_DBOX_1	104	112	PF00400	0.497
DEG_APCC_DBOX_1	23	31	PF00400	0.508
DEG_APCC_DBOX_1	43	51	PF00400	0.365
DEG_Nend_Nbox_1	1	3	PF02207	0.566
DEG_SPOP_SBC_1	60	64	PF00917	0.614
DOC_ANK_TNKS_1	347	354	PF00023	0.542
DOC_CKS1_1	421	426	PF01111	0.580
DOC_CYCLIN_RxL_1	76	87	PF00134	0.412
DOC_MAPK_gen_1	102	110	PF00069	0.500
DOC_PP1_RVXF_1	5	11	PF00149	0.475
DOC_PP4_FxxP_1	122	125	PF00568	0.590
DOC_PP4_FxxP_1	431	434	PF00568	0.545
DOC_PP4_FxxP_1	700	703	PF00568	0.645
DOC_USP7_MATH_1	177	181	PF00917	0.514
DOC_USP7_MATH_1	229	233	PF00917	0.632
DOC_USP7_MATH_1	258	262	PF00917	0.700
DOC_USP7_MATH_1	356	360	PF00917	0.598
DOC_USP7_MATH_1	441	445	PF00917	0.578
DOC_USP7_MATH_1	539	543	PF00917	0.466
DOC_USP7_MATH_1	60	64	PF00917	0.636
DOC_WW_Pin1_4	121	126	PF00397	0.525
DOC_WW_Pin1_4	274	279	PF00397	0.678
DOC_WW_Pin1_4	420	425	PF00397	0.627
DOC_WW_Pin1_4	462	467	PF00397	0.542
DOC_WW_Pin1_4	550	555	PF00397	0.636
LIG_14-3-3_CanoR_1	372	378	PF00244	0.538
LIG_14-3-3_CanoR_1	649	655	PF00244	0.494
LIG_BRCT_BRCA1_1	191	195	PF00533	0.479
LIG_BRCT_BRCA1_1	501	505	PF00533	0.415
LIG_eIF4E_1	578	584	PF01652	0.445
LIG_FHA_1	191	197	PF00498	0.468
LIG_FHA_1	3	9	PF00498	0.522
LIG_FHA_1	474	480	PF00498	0.531
LIG_FHA_1	562	568	PF00498	0.508
LIG_FHA_1	575	581	PF00498	0.460
LIG_FHA_1	687	693	PF00498	0.598
LIG_FHA_1	713	719	PF00498	0.598
LIG_FHA_2	104	110	PF00498	0.498
LIG_FHA_2	150	156	PF00498	0.555
LIG_FHA_2	184	190	PF00498	0.509
LIG_FHA_2	220	226	PF00498	0.617
LIG_FHA_2	270	276	PF00498	0.678
LIG_FHA_2	287	293	PF00498	0.591
LIG_FHA_2	396	402	PF00498	0.471
LIG_FHA_2	404	410	PF00498	0.505
LIG_FHA_2	585	591	PF00498	0.465
LIG_IRF3_LxIS_1	94	99	PF10401	0.569
LIG_LIR_Apic_2	121	125	PF02991	0.591
LIG_LIR_Apic_2	697	703	PF02991	0.585
LIG_LIR_Gen_1	143	151	PF02991	0.516
LIG_LIR_Gen_1	153	164	PF02991	0.468
LIG_LIR_Gen_1	299	310	PF02991	0.575
LIG_LIR_Gen_1	406	416	PF02991	0.484
LIG_LIR_Gen_1	500	506	PF02991	0.424
LIG_LIR_Gen_1	577	584	PF02991	0.539
LIG_LIR_Gen_1	590	599	PF02991	0.404
LIG_LIR_Nem_3	143	148	PF02991	0.635
LIG_LIR_Nem_3	153	159	PF02991	0.465
LIG_LIR_Nem_3	406	411	PF02991	0.472
LIG_LIR_Nem_3	427	431	PF02991	0.476
LIG_LIR_Nem_3	500	504	PF02991	0.424
LIG_LIR_Nem_3	577	581	PF02991	0.515
LIG_LIR_Nem_3	590	596	PF02991	0.411
LIG_LIR_Nem_3	697	702	PF02991	0.650
LIG_LYPXL_SIV_4	489	497	PF13949	0.446
LIG_MLH1_MIPbox_1	501	505	PF16413	0.415
LIG_MYND_1	430	434	PF01753	0.541
LIG_NRBOX	46	52	PF00104	0.485
LIG_Pex14_2	160	164	PF04695	0.479
LIG_Pex14_2	431	435	PF04695	0.542
LIG_Pex14_2	501	505	PF04695	0.415
LIG_SH2_PTP2	145	148	PF00017	0.513
LIG_SH2_PTP2	156	159	PF00017	0.472
LIG_SH2_STAP1	578	582	PF00017	0.444
LIG_SH2_STAT5	145	148	PF00017	0.513
LIG_SH2_STAT5	156	159	PF00017	0.472
LIG_SH2_STAT5	439	442	PF00017	0.550
LIG_SH2_STAT5	490	493	PF00017	0.449
LIG_SH2_STAT5	572	575	PF00017	0.429
LIG_SH2_STAT5	699	702	PF00017	0.628
LIG_SH2_STAT5	707	710	PF00017	0.543
LIG_SH3_3	165	171	PF00018	0.489
LIG_SH3_3	185	191	PF00018	0.464
LIG_SH3_3	323	329	PF00018	0.560
LIG_SH3_3	457	463	PF00018	0.536
LIG_SH3_3	517	523	PF00018	0.464
LIG_SUMO_SIM_anti_2	106	112	PF11976	0.488
LIG_SUMO_SIM_anti_2	455	461	PF11976	0.540
LIG_SUMO_SIM_anti_2	579	588	PF11976	0.445
LIG_SUMO_SIM_anti_2	610	616	PF11976	0.482
LIG_SUMO_SIM_par_1	579	588	PF11976	0.445
LIG_TRAF2_1	222	225	PF00917	0.634
LIG_TRAF2_1	240	243	PF00917	0.542
LIG_TRAF2_1	249	252	PF00917	0.576
LIG_TRAF2_1	36	39	PF00917	0.431
LIG_TRAF2_1	588	591	PF00917	0.463
LIG_TYR_ITIM	154	159	PF00017	0.472
LIG_TYR_ITIM	576	581	PF00017	0.520
LIG_WRC_WIRS_1	119	124	PF05994	0.590
LIG_WRC_WIRS_1	425	430	PF05994	0.500
MOD_CDK_SPK_2	274	279	PF00069	0.565
MOD_CDK_SPxxK_3	121	128	PF00069	0.527
MOD_CK1_1	121	127	PF00069	0.525
MOD_CK1_1	178	184	PF00069	0.605
MOD_CK1_1	215	221	PF00069	0.549
MOD_CK1_1	232	238	PF00069	0.538
MOD_CK1_1	277	283	PF00069	0.633
MOD_CK1_1	318	324	PF00069	0.698
MOD_CK1_1	395	401	PF00069	0.578
MOD_CK1_1	514	520	PF00069	0.515
MOD_CK1_1	546	552	PF00069	0.612
MOD_CK1_1	59	65	PF00069	0.679
MOD_CK1_1	695	701	PF00069	0.626
MOD_CK1_1	97	103	PF00069	0.441
MOD_CK2_1	103	109	PF00069	0.556
MOD_CK2_1	183	189	PF00069	0.512
MOD_CK2_1	219	225	PF00069	0.611
MOD_CK2_1	237	243	PF00069	0.640
MOD_CK2_1	403	409	PF00069	0.537
MOD_CK2_1	462	468	PF00069	0.543
MOD_CK2_1	550	556	PF00069	0.635
MOD_CK2_1	584	590	PF00069	0.490
MOD_CK2_1	632	638	PF00069	0.552
MOD_Cter_Amidation	126	129	PF01082	0.469
MOD_Cter_Amidation	370	373	PF01082	0.593
MOD_Cter_Amidation	542	545	PF01082	0.635
MOD_GlcNHglycan	170	174	PF01048	0.508
MOD_GlcNHglycan	177	180	PF01048	0.496
MOD_GlcNHglycan	217	220	PF01048	0.592
MOD_GlcNHglycan	231	234	PF01048	0.603
MOD_GlcNHglycan	239	242	PF01048	0.628
MOD_GlcNHglycan	260	263	PF01048	0.709
MOD_GlcNHglycan	382	385	PF01048	0.594
MOD_GlcNHglycan	394	397	PF01048	0.702
MOD_GlcNHglycan	513	516	PF01048	0.427
MOD_GlcNHglycan	541	544	PF01048	0.566
MOD_GlcNHglycan	548	551	PF01048	0.581
MOD_GlcNHglycan	58	61	PF01048	0.599
MOD_GlcNHglycan	640	643	PF01048	0.469
MOD_GlcNHglycan	674	677	PF01048	0.587
MOD_GlcNHglycan	68	71	PF01048	0.508
MOD_GlcNHglycan	694	697	PF01048	0.576
MOD_GSK3_1	114	121	PF00069	0.513
MOD_GSK3_1	175	182	PF00069	0.585
MOD_GSK3_1	215	222	PF00069	0.525
MOD_GSK3_1	265	272	PF00069	0.584
MOD_GSK3_1	273	280	PF00069	0.519
MOD_GSK3_1	287	294	PF00069	0.511
MOD_GSK3_1	403	410	PF00069	0.571
MOD_GSK3_1	420	427	PF00069	0.625
MOD_GSK3_1	469	476	PF00069	0.597
MOD_GSK3_1	539	546	PF00069	0.558
MOD_GSK3_1	54	61	PF00069	0.597
MOD_GSK3_1	585	592	PF00069	0.459
MOD_GSK3_1	686	693	PF00069	0.688
MOD_GSK3_1	701	708	PF00069	0.579
MOD_N-GLC_1	115	120	PF02516	0.512
MOD_N-GLC_1	448	453	PF02516	0.505
MOD_N-GLC_1	690	695	PF02516	0.511
MOD_NEK2_1	1	6	PF00069	0.606
MOD_NEK2_1	114	119	PF00069	0.534
MOD_NEK2_1	175	180	PF00069	0.584
MOD_NEK2_1	200	205	PF00069	0.437
MOD_NEK2_1	291	296	PF00069	0.648
MOD_NEK2_1	30	35	PF00069	0.580
MOD_NEK2_1	301	306	PF00069	0.562
MOD_NEK2_1	504	509	PF00069	0.363
MOD_NEK2_1	583	588	PF00069	0.448
MOD_NEK2_1	589	594	PF00069	0.475
MOD_NEK2_1	96	101	PF00069	0.448
MOD_PIKK_1	280	286	PF00454	0.770
MOD_PIKK_1	533	539	PF00454	0.557
MOD_PIKK_1	690	696	PF00454	0.513
MOD_PK_1	600	606	PF00069	0.453
MOD_PKA_1	373	379	PF00069	0.664
MOD_PKA_2	10	16	PF00069	0.496
MOD_PKA_2	30	36	PF00069	0.475
MOD_PKA_2	373	379	PF00069	0.750
MOD_PKA_2	380	386	PF00069	0.555
MOD_PKA_2	543	549	PF00069	0.648
MOD_Plk_1	115	121	PF00069	0.515
MOD_Plk_1	219	225	PF00069	0.611
MOD_Plk_1	269	275	PF00069	0.625
MOD_Plk_1	291	297	PF00069	0.527
MOD_Plk_1	441	447	PF00069	0.505
MOD_Plk_1	448	454	PF00069	0.511
MOD_Plk_1	499	505	PF00069	0.489
MOD_Plk_1	561	567	PF00069	0.512
MOD_Plk_1	589	595	PF00069	0.541
MOD_Plk_1	660	666	PF00069	0.576
MOD_Plk_2-3	103	109	PF00069	0.505
MOD_Plk_2-3	292	298	PF00069	0.520
MOD_Plk_2-3	632	638	PF00069	0.552
MOD_Plk_4	115	121	PF00069	0.515
MOD_Plk_4	301	307	PF00069	0.598
MOD_Plk_4	442	448	PF00069	0.541
MOD_Plk_4	600	606	PF00069	0.464
MOD_Plk_4	695	701	PF00069	0.589
MOD_ProDKin_1	121	127	PF00069	0.525
MOD_ProDKin_1	274	280	PF00069	0.677
MOD_ProDKin_1	420	426	PF00069	0.625
MOD_ProDKin_1	462	468	PF00069	0.543
MOD_ProDKin_1	550	556	PF00069	0.635
MOD_SUMO_for_1	491	494	PF00179	0.449
MOD_SUMO_rev_2	131	137	PF00179	0.548
MOD_SUMO_rev_2	401	406	PF00179	0.607
MOD_SUMO_rev_2	716	720	PF00179	0.662
TRG_DiLeu_BaEn_1	562	567	PF01217	0.658
TRG_DiLeu_BaEn_1	579	584	PF01217	0.348
TRG_DiLeu_LyEn_5	562	567	PF01217	0.571
TRG_ENDOCYTIC_2	145	148	PF00928	0.513
TRG_ENDOCYTIC_2	156	159	PF00928	0.472
TRG_ENDOCYTIC_2	490	493	PF00928	0.449
TRG_ENDOCYTIC_2	578	581	PF00928	0.508
TRG_ENDOCYTIC_2	699	702	PF00928	0.650
TRG_ER_diArg_1	23	26	PF00400	0.475
TRG_ER_diArg_1	340	343	PF00400	0.644
TRG_ER_diArg_1	364	366	PF00400	0.581
TRG_ER_diArg_1	372	374	PF00400	0.524
TRG_ER_diArg_1	44	46	PF00400	0.469
TRG_ER_diArg_1	544	547	PF00400	0.751
TRG_ER_diArg_1	563	566	PF00400	0.479
TRG_ER_diArg_1	649	652	PF00400	0.478
TRG_Pf-PMV_PEXEL_1	28	32	PF00026	0.550
TRG_Pf-PMV_PEXEL_1	478	483	PF00026	0.518
TRG_Pf-PMV_PEXEL_1	565	569	PF00026	0.507
TRG_Pf-PMV_PEXEL_1	652	656	PF00026	0.524

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I7Y8	Leptomonas seymouri	52%	100%
A0A3S7X2C1	Leishmania donovani	76%	100%
A4I4G1	Leishmania infantum	76%	100%
E9ADW0	Leishmania major	75%	100%
E9ALX0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	75%	100%