PKS_ER domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

putative NAD(P)H quinone oxidoreductase, PIG3 family, putative

Species:

Leishmania braziliensis

UniProt:

A4HHB3_LEIBR

TriTrypDb:

LbrM.29.1090 , LBRM2903_290017800

Length:

350

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 17
NetGPI	no	yes: 0, no: 17

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HHB3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HHB3

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	18
GO:0016491	oxidoreductase activity	2	18
GO:0000166	nucleotide binding	3	2
GO:0005488	binding	1	2
GO:0016651	oxidoreductase activity, acting on NAD(P)H	3	8
GO:0036094	small molecule binding	2	2
GO:0043167	ion binding	2	2
GO:0043168	anion binding	3	2
GO:0050661	NADP binding	4	2
GO:0070402	NADPH binding	4	2
GO:0097159	organic cyclic compound binding	2	2
GO:1901265	nucleoside phosphate binding	3	2
GO:1901363	heterocyclic compound binding	2	2
GO:0003960	NADPH:quinone reductase activity	5	7
GO:0016655	oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor	4	7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	141	143	PF00675	0.348
CLV_PCSK_SKI1_1	208	212	PF00082	0.355
CLV_PCSK_SKI1_1	289	293	PF00082	0.267
CLV_PCSK_SKI1_1	32	36	PF00082	0.296
CLV_PCSK_SKI1_1	328	332	PF00082	0.284
CLV_PCSK_SKI1_1	5	9	PF00082	0.328
CLV_PCSK_SKI1_1	81	85	PF00082	0.254
DEG_APCC_DBOX_1	31	39	PF00400	0.296
DEG_APCC_KENBOX_2	279	283	PF00400	0.216
DEG_MDM2_SWIB_1	128	135	PF02201	0.298
DEG_Nend_UBRbox_3	1	3	PF02207	0.514
DEG_SCF_FBW7_1	192	199	PF00400	0.452
DEG_SPOP_SBC_1	172	176	PF00917	0.372
DOC_CDC14_PxL_1	255	263	PF14671	0.387
DOC_CKS1_1	345	350	PF01111	0.486
DOC_CYCLIN_RxL_1	205	213	PF00134	0.387
DOC_MAPK_gen_1	142	149	PF00069	0.400
DOC_MAPK_gen_1	238	247	PF00069	0.414
DOC_MAPK_gen_1	262	269	PF00069	0.293
DOC_MAPK_gen_1	30	38	PF00069	0.387
DOC_MAPK_HePTP_8	235	247	PF00069	0.387
DOC_MAPK_MEF2A_6	238	247	PF00069	0.414
DOC_MAPK_MEF2A_6	30	38	PF00069	0.311
DOC_MAPK_MEF2A_6	324	333	PF00069	0.271
DOC_USP7_MATH_1	151	155	PF00917	0.350
DOC_USP7_MATH_1	58	62	PF00917	0.287
DOC_USP7_UBL2_3	84	88	PF12436	0.296
DOC_WW_Pin1_4	192	197	PF00397	0.396
DOC_WW_Pin1_4	201	206	PF00397	0.381
DOC_WW_Pin1_4	344	349	PF00397	0.616
LIG_14-3-3_CanoR_1	114	119	PF00244	0.313
LIG_14-3-3_CanoR_1	5	10	PF00244	0.337
LIG_FHA_1	13	19	PF00498	0.407
LIG_FHA_1	305	311	PF00498	0.339
LIG_FHA_1	337	343	PF00498	0.602
LIG_FHA_2	173	179	PF00498	0.379
LIG_FHA_2	193	199	PF00498	0.457
LIG_LIR_Gen_1	130	137	PF02991	0.338
LIG_LIR_Gen_1	165	173	PF02991	0.262
LIG_LIR_Nem_3	130	135	PF02991	0.317
LIG_LIR_Nem_3	165	171	PF02991	0.270
LIG_LIR_Nem_3	323	329	PF02991	0.404
LIG_Pex14_2	128	132	PF04695	0.296
LIG_PTB_Apo_2	302	309	PF02174	0.320
LIG_PTB_Phospho_1	302	308	PF10480	0.320
LIG_SH2_GRB2like	294	297	PF00017	0.387
LIG_SH2_SRC	55	58	PF00017	0.300
LIG_SH2_STAP1	98	102	PF00017	0.311
LIG_SH2_STAT5	228	231	PF00017	0.283
LIG_SH2_STAT5	294	297	PF00017	0.216
LIG_SH2_STAT5	55	58	PF00017	0.203
LIG_SH3_3	296	302	PF00018	0.389
LIG_TRAF2_1	309	312	PF00917	0.331
LIG_UBA3_1	17	25	PF00899	0.349
LIG_WRC_WIRS_1	284	289	PF05994	0.331
LIG_WRC_WIRS_1	330	335	PF05994	0.453
MOD_CDK_SPK_2	201	206	PF00069	0.321
MOD_CDK_SPK_2	344	349	PF00069	0.481
MOD_CDK_SPxxK_3	201	208	PF00069	0.317
MOD_CK1_1	227	233	PF00069	0.337
MOD_CK1_1	336	342	PF00069	0.641
MOD_CK2_1	114	120	PF00069	0.372
MOD_CK2_1	172	178	PF00069	0.421
MOD_CK2_1	192	198	PF00069	0.274
MOD_GlcNHglycan	153	156	PF01048	0.338
MOD_GlcNHglycan	38	41	PF01048	0.354
MOD_GlcNHglycan	68	72	PF01048	0.250
MOD_GSK3_1	151	158	PF00069	0.335
MOD_GSK3_1	192	199	PF00069	0.435
MOD_GSK3_1	329	336	PF00069	0.418
MOD_N-GLC_1	304	309	PF02516	0.308
MOD_NEK2_1	171	176	PF00069	0.369
MOD_NEK2_1	18	23	PF00069	0.404
MOD_NEK2_1	224	229	PF00069	0.355
MOD_NEK2_1	320	325	PF00069	0.298
MOD_NEK2_1	331	336	PF00069	0.353
MOD_NEK2_1	337	342	PF00069	0.511
MOD_NEK2_1	67	72	PF00069	0.254
MOD_Plk_1	304	310	PF00069	0.372
MOD_Plk_4	105	111	PF00069	0.281
MOD_Plk_4	114	120	PF00069	0.353
MOD_Plk_4	219	225	PF00069	0.312
MOD_ProDKin_1	192	198	PF00069	0.406
MOD_ProDKin_1	201	207	PF00069	0.376
MOD_ProDKin_1	344	350	PF00069	0.623
MOD_SUMO_for_1	179	182	PF00179	0.284
MOD_SUMO_rev_2	176	181	PF00179	0.394
MOD_SUMO_rev_2	74	83	PF00179	0.302
TRG_DiLeu_BaLyEn_6	256	261	PF01217	0.387
TRG_ENDOCYTIC_2	116	119	PF00928	0.283
TRG_ER_diArg_1	261	264	PF00400	0.288
TRG_Pf-PMV_PEXEL_1	208	213	PF00026	0.276

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P6Q4	Leptomonas seymouri	59%	100%
A0A0N1I9E8	Leptomonas seymouri	75%	100%
A0A0N1PB21	Leptomonas seymouri	27%	100%
A0A0N1PDX1	Leptomonas seymouri	80%	100%
A0A0S4ILS9	Bodo saltans	27%	100%
A0A0S4IT20	Bodo saltans	25%	100%
A0A0S4IUY2	Bodo saltans	26%	100%
A0A0S4JJT8	Bodo saltans	27%	90%
A0A0S4KHW9	Bodo saltans	25%	100%
A0A1X0NRR2	Trypanosomatidae	27%	72%
A0A1X0NZZ5	Trypanosomatidae	61%	100%
A0A1X0P8R2	Trypanosomatidae	24%	100%
A0A3Q8ICJ5	Leishmania donovani	59%	100%
A0A3Q8IEG7	Leishmania donovani	23%	100%
A0A3R7L374	Trypanosoma rangeli	24%	100%
A0A3S7X2E3	Leishmania donovani	89%	100%
A0A422NF38	Trypanosoma rangeli	59%	100%
A0A451EJQ8	Leishmania donovani	27%	100%
A4H3L9	Leishmania braziliensis	25%	100%
A4HCV8	Leishmania braziliensis	56%	100%
A4I076	Leishmania infantum	23%	100%
A4I0D8	Leishmania infantum	59%	100%
A4I4G0	Leishmania infantum	88%	100%
A4YGN2	Metallosphaera sedula (strain ATCC 51363 / DSM 5348 / JCM 9185 / NBRC 15509 / TH2)	24%	100%
A6QQF5	Bos taurus	29%	100%
A7RK30	Nematostella vectensis	26%	96%
B0BNC9	Rattus norvegicus	27%	100%
C5E3S4	Lachancea thermotolerans (strain ATCC 56472 / CBS 6340 / NRRL Y-8284)	24%	97%
C9ZLK8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	58%	100%
E9ACK2	Leishmania major	28%	100%
E9ADV9	Leishmania major	88%	100%
E9AG46	Leishmania infantum	27%	100%
E9AJU0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	27%	100%
E9ALX1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%
E9AWA2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	60%	100%
G3XMC6	Aspergillus niger (strain ATCC 1015 / CBS 113.46 / FGSC A1144 / LSHB Ac4 / NCTC 3858a / NRRL 328 / USDA 3528.7)	27%	100%
K4BW79	Solanum lycopersicum	27%	90%
O23939	Fragaria vesca	30%	100%
O35017	Bacillus subtilis (strain 168)	25%	100%
O42909	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	25%	100%
O94564	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	27%	100%
O97764	Bos taurus	28%	100%
P11415	Cavia porcellus	28%	100%
P19333	Tetronarce californica	27%	92%
P28304	Escherichia coli (strain K12)	26%	100%
P38230	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	26%	100%
P39462	Saccharolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2)	23%	100%
P40783	Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)	25%	100%
P42328	Geobacillus stearothermophilus	25%	100%
P43903	Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)	27%	100%
P47199	Mus musculus	27%	100%
Q08257	Homo sapiens	30%	100%
Q0MVN8	Sus scrofa	29%	100%
Q28452	Lama guanicoe	31%	100%
Q3MIE4	Rattus norvegicus	28%	87%
Q3UNZ8	Mus musculus	29%	100%
Q4J781	Sulfolobus acidocaldarius (strain ATCC 33909 / DSM 639 / JCM 8929 / NBRC 15157 / NCIMB 11770)	24%	100%
Q4QB77	Leishmania major	58%	100%
Q4QBD8	Leishmania major	23%	100%
Q53FA7	Homo sapiens	37%	100%
Q54II4	Dictyostelium discoideum	22%	99%
Q59I44	Burkholderia sp.	25%	100%
Q5R4S7	Pongo abelii	29%	100%
Q62465	Mus musculus	27%	86%
Q6AYT0	Rattus norvegicus	27%	100%
Q7T3C7	Danio rerio	30%	90%
Q80TB8	Mus musculus	30%	84%
Q84V25	Fragaria ananassa	27%	100%
Q8BGC4	Mus musculus	26%	93%
Q8JFV8	Danio rerio	29%	72%
Q924D0	Mus musculus	26%	88%
Q941I0	Fragaria ananassa	29%	100%
Q96XE0	Sulfurisphaera tokodaii (strain DSM 16993 / JCM 10545 / NBRC 100140 / 7)	25%	100%
Q975C8	Sulfurisphaera tokodaii (strain DSM 16993 / JCM 10545 / NBRC 100140 / 7)	24%	100%
Q99536	Homo sapiens	27%	89%
Q9HCJ6	Homo sapiens	29%	84%
Q9ZUC1	Arabidopsis thaliana	27%	91%
V5B1P3	Trypanosoma cruzi	61%	100%
V5BXF0	Trypanosoma cruzi	25%	100%