PDZ domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HHB2_LEIBR

TriTrypDb:

LbrM.29.1080 , LBRM2903_290017700

Length:

628

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HHB2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HHB2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	111	115	PF00656	0.332
CLV_C14_Caspase3-7	250	254	PF00656	0.564
CLV_MEL_PAP_1	146	152	PF00089	0.494
CLV_NRD_NRD_1	179	181	PF00675	0.563
CLV_NRD_NRD_1	348	350	PF00675	0.668
CLV_NRD_NRD_1	443	445	PF00675	0.537
CLV_NRD_NRD_1	466	468	PF00675	0.655
CLV_NRD_NRD_1	480	482	PF00675	0.454
CLV_NRD_NRD_1	494	496	PF00675	0.388
CLV_NRD_NRD_1	512	514	PF00675	0.549
CLV_PCSK_KEX2_1	126	128	PF00082	0.508
CLV_PCSK_KEX2_1	179	181	PF00082	0.563
CLV_PCSK_KEX2_1	298	300	PF00082	0.609
CLV_PCSK_KEX2_1	348	350	PF00082	0.668
CLV_PCSK_KEX2_1	443	445	PF00082	0.562
CLV_PCSK_KEX2_1	466	468	PF00082	0.706
CLV_PCSK_KEX2_1	480	482	PF00082	0.454
CLV_PCSK_KEX2_1	493	495	PF00082	0.398
CLV_PCSK_PC1ET2_1	126	128	PF00082	0.536
CLV_PCSK_PC1ET2_1	298	300	PF00082	0.590
CLV_PCSK_SKI1_1	101	105	PF00082	0.436
CLV_PCSK_SKI1_1	195	199	PF00082	0.617
CLV_PCSK_SKI1_1	214	218	PF00082	0.295
CLV_PCSK_SKI1_1	524	528	PF00082	0.533
CLV_PCSK_SKI1_1	597	601	PF00082	0.554
CLV_PCSK_SKI1_1	69	73	PF00082	0.677
CLV_Separin_Metazoa	463	467	PF03568	0.639
DEG_APCC_DBOX_1	47	55	PF00400	0.492
DEG_APCC_DBOX_1	512	520	PF00400	0.459
DEG_COP1_1	5	14	PF00400	0.595
DEG_SPOP_SBC_1	425	429	PF00917	0.542
DEG_SPOP_SBC_1	601	605	PF00917	0.641
DOC_CYCLIN_RxL_1	345	354	PF00134	0.531
DOC_CYCLIN_yCln2_LP_2	595	601	PF00134	0.634
DOC_MAPK_gen_1	193	200	PF00069	0.523
DOC_MAPK_gen_1	480	486	PF00069	0.711
DOC_MAPK_MEF2A_6	25	34	PF00069	0.413
DOC_MIT_MIM_1	345	353	PF04212	0.375
DOC_PP2B_LxvP_1	198	201	PF13499	0.545
DOC_PP2B_PxIxI_1	1	7	PF00149	0.654
DOC_USP7_MATH_1	227	231	PF00917	0.558
DOC_USP7_MATH_1	233	237	PF00917	0.570
DOC_USP7_MATH_1	251	255	PF00917	0.645
DOC_USP7_MATH_1	391	395	PF00917	0.678
DOC_USP7_MATH_1	426	430	PF00917	0.733
DOC_USP7_MATH_1	526	530	PF00917	0.517
DOC_USP7_MATH_1	548	552	PF00917	0.754
DOC_USP7_UBL2_3	510	514	PF12436	0.510
DOC_WW_Pin1_4	436	441	PF00397	0.740
DOC_WW_Pin1_4	618	623	PF00397	0.667
LIG_14-3-3_CanoR_1	127	135	PF00244	0.505
LIG_14-3-3_CanoR_1	149	157	PF00244	0.440
LIG_14-3-3_CanoR_1	179	186	PF00244	0.658
LIG_14-3-3_CanoR_1	195	201	PF00244	0.368
LIG_14-3-3_CanoR_1	237	242	PF00244	0.524
LIG_14-3-3_CanoR_1	25	33	PF00244	0.477
LIG_14-3-3_CanoR_1	320	325	PF00244	0.503
LIG_14-3-3_CanoR_1	348	353	PF00244	0.502
LIG_14-3-3_CanoR_1	443	449	PF00244	0.727
LIG_14-3-3_CanoR_1	480	485	PF00244	0.719
LIG_14-3-3_CanoR_1	524	533	PF00244	0.465
LIG_14-3-3_CanoR_1	569	577	PF00244	0.670
LIG_14-3-3_CanoR_1	587	595	PF00244	0.721
LIG_Actin_WH2_2	501	519	PF00022	0.365
LIG_DLG_GKlike_1	237	245	PF00625	0.563
LIG_eIF4E_1	553	559	PF01652	0.643
LIG_FHA_1	105	111	PF00498	0.529
LIG_FHA_1	192	198	PF00498	0.575
LIG_FHA_1	227	233	PF00498	0.417
LIG_FHA_1	240	246	PF00498	0.433
LIG_FHA_1	25	31	PF00498	0.449
LIG_FHA_1	326	332	PF00498	0.451
LIG_FHA_1	367	373	PF00498	0.695
LIG_FHA_1	377	383	PF00498	0.496
LIG_FHA_1	459	465	PF00498	0.756
LIG_FHA_1	550	556	PF00498	0.495
LIG_FHA_1	590	596	PF00498	0.728
LIG_FHA_1	77	83	PF00498	0.547
LIG_FHA_1	98	104	PF00498	0.550
LIG_FHA_2	301	307	PF00498	0.601
LIG_FHA_2	429	435	PF00498	0.772
LIG_Integrin_isoDGR_2	478	480	PF01839	0.495
LIG_LIR_Apic_2	551	556	PF02991	0.524
LIG_LIR_Gen_1	20	30	PF02991	0.392
LIG_LIR_Gen_1	202	210	PF02991	0.442
LIG_LIR_Nem_3	20	26	PF02991	0.391
LIG_LIR_Nem_3	395	401	PF02991	0.518
LIG_MYND_1	556	560	PF01753	0.708
LIG_MYND_3	280	284	PF01753	0.614
LIG_NRBOX	212	218	PF00104	0.550
LIG_NRBOX	320	326	PF00104	0.609
LIG_Pex14_2	163	167	PF04695	0.435
LIG_RPA_C_Fungi	232	244	PF08784	0.549
LIG_SH2_CRK	23	27	PF00017	0.402
LIG_SH2_CRK	553	557	PF00017	0.646
LIG_SH2_NCK_1	553	557	PF00017	0.646
LIG_SH2_STAP1	120	124	PF00017	0.444
LIG_SH2_STAP1	241	245	PF00017	0.412
LIG_SH2_STAT5	196	199	PF00017	0.440
LIG_SH2_STAT5	241	244	PF00017	0.568
LIG_SH2_STAT5	608	611	PF00017	0.651
LIG_SH3_2	557	562	PF14604	0.657
LIG_SH3_3	242	248	PF00018	0.508
LIG_SH3_3	387	393	PF00018	0.574
LIG_SH3_3	414	420	PF00018	0.752
LIG_SH3_3	434	440	PF00018	0.670
LIG_SH3_3	554	560	PF00018	0.670
LIG_SUMO_SIM_anti_2	461	466	PF11976	0.641
LIG_SUMO_SIM_par_1	196	202	PF11976	0.475
LIG_SUMO_SIM_par_1	257	262	PF11976	0.368
LIG_TRAF2_1	518	521	PF00917	0.572
LIG_TRAF2_1	74	77	PF00917	0.618
LIG_TYR_ITIM	21	26	PF00017	0.403
LIG_WRC_WIRS_1	200	205	PF05994	0.467
LIG_WW_3	440	444	PF00397	0.509
MOD_CDK_SPxxK_3	436	443	PF00069	0.511
MOD_CK1_1	199	205	PF00069	0.477
MOD_CK1_1	236	242	PF00069	0.504
MOD_CK1_1	24	30	PF00069	0.441
MOD_CK1_1	427	433	PF00069	0.767
MOD_CK1_1	451	457	PF00069	0.714
MOD_CK1_1	471	477	PF00069	0.582
MOD_CK1_1	549	555	PF00069	0.574
MOD_CK1_1	586	592	PF00069	0.736
MOD_CK1_1	603	609	PF00069	0.422
MOD_CK2_1	148	154	PF00069	0.532
MOD_CK2_1	251	257	PF00069	0.690
MOD_CK2_1	298	304	PF00069	0.627
MOD_CK2_1	348	354	PF00069	0.506
MOD_CK2_1	428	434	PF00069	0.656
MOD_Cter_Amidation	177	180	PF01082	0.602
MOD_Cter_Amidation	478	481	PF01082	0.608
MOD_GlcNHglycan	253	257	PF01048	0.626
MOD_GlcNHglycan	284	287	PF01048	0.612
MOD_GlcNHglycan	300	303	PF01048	0.634
MOD_GlcNHglycan	371	375	PF01048	0.671
MOD_GlcNHglycan	408	411	PF01048	0.721
MOD_GlcNHglycan	414	417	PF01048	0.755
MOD_GlcNHglycan	500	505	PF01048	0.416
MOD_GlcNHglycan	564	567	PF01048	0.680
MOD_GlcNHglycan	57	61	PF01048	0.386
MOD_GlcNHglycan	589	592	PF01048	0.664
MOD_GSK3_1	149	156	PF00069	0.402
MOD_GSK3_1	17	24	PF00069	0.400
MOD_GSK3_1	232	239	PF00069	0.562
MOD_GSK3_1	366	373	PF00069	0.706
MOD_GSK3_1	397	404	PF00069	0.640
MOD_GSK3_1	424	431	PF00069	0.625
MOD_GSK3_1	444	451	PF00069	0.662
MOD_GSK3_1	583	590	PF00069	0.659
MOD_GSK3_1	72	79	PF00069	0.494
MOD_GSK3_1	97	104	PF00069	0.382
MOD_N-GLC_1	549	554	PF02516	0.626
MOD_N-GLC_1	616	621	PF02516	0.650
MOD_NEK2_1	19	24	PF00069	0.403
MOD_NEK2_1	282	287	PF00069	0.467
MOD_NEK2_1	448	453	PF00069	0.764
MOD_NEK2_1	600	605	PF00069	0.616
MOD_NEK2_1	85	90	PF00069	0.616
MOD_PIKK_1	468	474	PF00454	0.680
MOD_PIKK_1	526	532	PF00454	0.382
MOD_PK_1	480	486	PF00069	0.690
MOD_PKA_1	126	132	PF00069	0.375
MOD_PKA_1	298	304	PF00069	0.560
MOD_PKA_1	348	354	PF00069	0.533
MOD_PKA_1	443	449	PF00069	0.531
MOD_PKA_1	480	486	PF00069	0.670
MOD_PKA_2	126	132	PF00069	0.504
MOD_PKA_2	148	154	PF00069	0.491
MOD_PKA_2	178	184	PF00069	0.612
MOD_PKA_2	233	239	PF00069	0.507
MOD_PKA_2	24	30	PF00069	0.469
MOD_PKA_2	298	304	PF00069	0.560
MOD_PKA_2	348	354	PF00069	0.600
MOD_PKA_2	391	397	PF00069	0.693
MOD_PKA_2	443	449	PF00069	0.697
MOD_PKA_2	480	486	PF00069	0.668
MOD_PKA_2	586	592	PF00069	0.655
MOD_Plk_1	153	159	PF00069	0.547
MOD_Plk_1	186	192	PF00069	0.584
MOD_Plk_1	500	506	PF00069	0.390
MOD_Plk_1	549	555	PF00069	0.504
MOD_Plk_1	56	62	PF00069	0.542
MOD_Plk_1	6	12	PF00069	0.501
MOD_Plk_1	616	622	PF00069	0.693
MOD_Plk_2-3	7	13	PF00069	0.495
MOD_Plk_4	320	326	PF00069	0.631
MOD_Plk_4	348	354	PF00069	0.533
MOD_Plk_4	444	450	PF00069	0.530
MOD_Plk_4	471	477	PF00069	0.718
MOD_Plk_4	603	609	PF00069	0.698
MOD_ProDKin_1	436	442	PF00069	0.734
MOD_ProDKin_1	618	624	PF00069	0.665
MOD_SUMO_rev_2	507	516	PF00179	0.395
MOD_SUMO_rev_2	83	88	PF00179	0.519
TRG_DiLeu_BaEn_3	500	506	PF01217	0.534
TRG_DiLeu_BaEn_4	208	214	PF01217	0.495
TRG_DiLeu_BaLyEn_6	263	268	PF01217	0.468
TRG_DiLeu_BaLyEn_6	278	283	PF01217	0.475
TRG_ENDOCYTIC_2	23	26	PF00928	0.401
TRG_ER_diArg_1	193	196	PF00400	0.547
TRG_ER_diArg_1	348	350	PF00400	0.593
TRG_ER_diArg_1	442	444	PF00400	0.517
TRG_ER_diArg_1	465	467	PF00400	0.707
TRG_ER_diArg_1	480	482	PF00400	0.664
TRG_ER_diArg_1	492	495	PF00400	0.407
TRG_NES_CRM1_1	257	271	PF08389	0.481
TRG_Pf-PMV_PEXEL_1	214	218	PF00026	0.549
TRG_Pf-PMV_PEXEL_1	266	270	PF00026	0.534
TRG_Pf-PMV_PEXEL_1	31	35	PF00026	0.426

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IB58	Leptomonas seymouri	55%	100%
A0A0S4JM28	Bodo saltans	23%	100%
A0A1X0P0W9	Trypanosomatidae	33%	100%
A0A3R7MKA9	Trypanosoma rangeli	30%	100%
A0A3S7X2E5	Leishmania donovani	77%	100%
A4I4F8	Leishmania infantum	75%	98%
C9ZLK7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	28%	100%
E9ADV8	Leishmania major	74%	99%
E9ALX2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	78%	100%
V5BH56	Trypanosoma cruzi	30%	100%