FH2 domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HHB1_LEIBR

TriTrypDb:

LbrM.29.1070 , LBRM2903_290017600

Length:

995

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0005930	axoneme	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HHB1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HHB1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	23	27	PF00656	0.491
CLV_MEL_PAP_1	562	568	PF00089	0.525
CLV_NRD_NRD_1	188	190	PF00675	0.530
CLV_NRD_NRD_1	218	220	PF00675	0.670
CLV_NRD_NRD_1	284	286	PF00675	0.685
CLV_NRD_NRD_1	322	324	PF00675	0.538
CLV_NRD_NRD_1	428	430	PF00675	0.478
CLV_NRD_NRD_1	52	54	PF00675	0.588
CLV_NRD_NRD_1	618	620	PF00675	0.495
CLV_NRD_NRD_1	814	816	PF00675	0.607
CLV_NRD_NRD_1	894	896	PF00675	0.711
CLV_NRD_NRD_1	966	968	PF00675	0.546
CLV_PCSK_FUR_1	963	967	PF00082	0.546
CLV_PCSK_KEX2_1	188	190	PF00082	0.530
CLV_PCSK_KEX2_1	217	219	PF00082	0.665
CLV_PCSK_KEX2_1	226	228	PF00082	0.684
CLV_PCSK_KEX2_1	284	286	PF00082	0.669
CLV_PCSK_KEX2_1	322	324	PF00082	0.538
CLV_PCSK_KEX2_1	428	430	PF00082	0.536
CLV_PCSK_KEX2_1	449	451	PF00082	0.485
CLV_PCSK_KEX2_1	52	54	PF00082	0.588
CLV_PCSK_KEX2_1	643	645	PF00082	0.494
CLV_PCSK_KEX2_1	814	816	PF00082	0.607
CLV_PCSK_KEX2_1	849	851	PF00082	0.647
CLV_PCSK_KEX2_1	894	896	PF00082	0.775
CLV_PCSK_KEX2_1	965	967	PF00082	0.555
CLV_PCSK_PC1ET2_1	226	228	PF00082	0.640
CLV_PCSK_PC1ET2_1	449	451	PF00082	0.485
CLV_PCSK_PC1ET2_1	643	645	PF00082	0.554
CLV_PCSK_PC1ET2_1	849	851	PF00082	0.663
CLV_PCSK_SKI1_1	105	109	PF00082	0.536
CLV_PCSK_SKI1_1	122	126	PF00082	0.443
CLV_PCSK_SKI1_1	428	432	PF00082	0.486
CLV_PCSK_SKI1_1	654	658	PF00082	0.661
CLV_PCSK_SKI1_1	72	76	PF00082	0.526
DEG_MDM2_SWIB_1	146	154	PF02201	0.532
DEG_Nend_UBRbox_2	1	3	PF02207	0.668
DEG_SPOP_SBC_1	232	236	PF00917	0.684
DEG_SPOP_SBC_1	277	281	PF00917	0.591
DEG_SPOP_SBC_1	520	524	PF00917	0.690
DOC_CKS1_1	168	173	PF01111	0.586
DOC_CKS1_1	956	961	PF01111	0.534
DOC_CYCLIN_yClb3_PxF_3	858	864	PF00134	0.649
DOC_MAPK_gen_1	282	292	PF00069	0.545
DOC_MAPK_gen_1	619	629	PF00069	0.463
DOC_MAPK_RevD_3	630	644	PF00069	0.383
DOC_PP1_RVXF_1	50	57	PF00149	0.567
DOC_PP1_RVXF_1	950	957	PF00149	0.523
DOC_PP2B_LxvP_1	275	278	PF13499	0.518
DOC_PP2B_LxvP_1	856	859	PF13499	0.627
DOC_PP4_FxxP_1	956	959	PF00568	0.533
DOC_USP7_MATH_1	173	177	PF00917	0.556
DOC_USP7_MATH_1	232	236	PF00917	0.684
DOC_USP7_MATH_1	286	290	PF00917	0.667
DOC_USP7_MATH_1	412	416	PF00917	0.553
DOC_USP7_MATH_1	471	475	PF00917	0.570
DOC_USP7_MATH_1	510	514	PF00917	0.735
DOC_USP7_MATH_1	518	522	PF00917	0.777
DOC_USP7_MATH_1	6	10	PF00917	0.660
DOC_USP7_MATH_1	656	660	PF00917	0.545
DOC_USP7_MATH_1	674	678	PF00917	0.629
DOC_USP7_MATH_1	771	775	PF00917	0.554
DOC_USP7_MATH_1	919	923	PF00917	0.642
DOC_USP7_MATH_1	939	943	PF00917	0.705
DOC_USP7_UBL2_3	488	492	PF12436	0.637
DOC_USP7_UBL2_3	531	535	PF12436	0.702
DOC_WW_Pin1_4	167	172	PF00397	0.526
DOC_WW_Pin1_4	382	387	PF00397	0.782
DOC_WW_Pin1_4	390	395	PF00397	0.828
DOC_WW_Pin1_4	4	9	PF00397	0.641
DOC_WW_Pin1_4	467	472	PF00397	0.693
DOC_WW_Pin1_4	480	485	PF00397	0.771
DOC_WW_Pin1_4	514	519	PF00397	0.794
DOC_WW_Pin1_4	669	674	PF00397	0.737
DOC_WW_Pin1_4	718	723	PF00397	0.623
DOC_WW_Pin1_4	775	780	PF00397	0.788
DOC_WW_Pin1_4	841	846	PF00397	0.704
DOC_WW_Pin1_4	930	935	PF00397	0.667
DOC_WW_Pin1_4	955	960	PF00397	0.815
LIG_14-3-3_CanoR_1	122	131	PF00244	0.623
LIG_14-3-3_CanoR_1	217	225	PF00244	0.620
LIG_14-3-3_CanoR_1	443	448	PF00244	0.585
LIG_14-3-3_CanoR_1	511	520	PF00244	0.572
LIG_14-3-3_CanoR_1	565	573	PF00244	0.403
LIG_14-3-3_CanoR_1	732	740	PF00244	0.569
LIG_14-3-3_CanoR_1	773	779	PF00244	0.534
LIG_14-3-3_CanoR_1	84	92	PF00244	0.632
LIG_14-3-3_CanoR_1	894	899	PF00244	0.639
LIG_14-3-3_CanoR_1	928	933	PF00244	0.710
LIG_14-3-3_CanoR_1	945	954	PF00244	0.622
LIG_Actin_WH2_2	671	687	PF00022	0.507
LIG_BIR_III_2	796	800	PF00653	0.655
LIG_CaM_IQ_9	629	645	PF13499	0.438
LIG_FHA_1	102	108	PF00498	0.469
LIG_FHA_1	173	179	PF00498	0.488
LIG_FHA_1	253	259	PF00498	0.634
LIG_FHA_1	327	333	PF00498	0.391
LIG_FHA_1	521	527	PF00498	0.708
LIG_FHA_1	557	563	PF00498	0.500
LIG_FHA_1	670	676	PF00498	0.679
LIG_FHA_1	719	725	PF00498	0.583
LIG_FHA_1	735	741	PF00498	0.704
LIG_FHA_2	247	253	PF00498	0.580
LIG_FHA_2	36	42	PF00498	0.668
LIG_FHA_2	503	509	PF00498	0.627
LIG_LIR_Apic_2	955	959	PF02991	0.529
LIG_LIR_Gen_1	144	154	PF02991	0.530
LIG_LIR_Gen_1	817	827	PF02991	0.607
LIG_LIR_LC3C_4	974	979	PF02991	0.555
LIG_LIR_Nem_3	125	130	PF02991	0.706
LIG_LIR_Nem_3	144	149	PF02991	0.451
LIG_LIR_Nem_3	172	177	PF02991	0.564
LIG_LIR_Nem_3	427	433	PF02991	0.532
LIG_LIR_Nem_3	817	822	PF02991	0.709
LIG_Pex14_2	146	150	PF04695	0.473
LIG_Pex14_2	63	67	PF04695	0.535
LIG_PTAP_UEV_1	753	758	PF05743	0.499
LIG_SH2_CRK	819	823	PF00017	0.607
LIG_SH2_STAP1	174	178	PF00017	0.488
LIG_SH2_STAT5	174	177	PF00017	0.496
LIG_SH2_STAT5	319	322	PF00017	0.514
LIG_SH2_STAT5	80	83	PF00017	0.487
LIG_SH3_1	751	757	PF00018	0.500
LIG_SH3_3	165	171	PF00018	0.584
LIG_SH3_3	176	182	PF00018	0.542
LIG_SH3_3	26	32	PF00018	0.622
LIG_SH3_3	287	293	PF00018	0.753
LIG_SH3_3	389	395	PF00018	0.749
LIG_SH3_3	523	529	PF00018	0.806
LIG_SH3_3	535	541	PF00018	0.524
LIG_SH3_3	660	666	PF00018	0.544
LIG_SH3_3	751	757	PF00018	0.689
LIG_SH3_3	773	779	PF00018	0.613
LIG_SH3_3	856	862	PF00018	0.655
LIG_SH3_3	933	939	PF00018	0.616
LIG_SH3_3	956	962	PF00018	0.655
LIG_SUMO_SIM_anti_2	415	421	PF11976	0.545
LIG_SUMO_SIM_anti_2	737	744	PF11976	0.490
LIG_SUMO_SIM_anti_2	760	767	PF11976	0.681
LIG_TRAF2_1	555	558	PF00917	0.488
LIG_TRAF2_1	579	582	PF00917	0.447
LIG_TRAF2_1	884	887	PF00917	0.477
LIG_UBA3_1	629	637	PF00899	0.494
LIG_UBA3_1	822	829	PF00899	0.481
LIG_UBA3_1	91	97	PF00899	0.429
MOD_CDK_SPK_2	955	960	PF00069	0.532
MOD_CDK_SPxxK_3	958	965	PF00069	0.534
MOD_CK1_1	120	126	PF00069	0.640
MOD_CK1_1	231	237	PF00069	0.651
MOD_CK1_1	288	294	PF00069	0.671
MOD_CK1_1	331	337	PF00069	0.529
MOD_CK1_1	385	391	PF00069	0.619
MOD_CK1_1	470	476	PF00069	0.777
MOD_CK1_1	478	484	PF00069	0.761
MOD_CK1_1	521	527	PF00069	0.755
MOD_CK1_1	595	601	PF00069	0.543
MOD_CK1_1	726	732	PF00069	0.549
MOD_CK1_1	755	761	PF00069	0.685
MOD_CK1_1	774	780	PF00069	0.645
MOD_CK1_1	783	789	PF00069	0.713
MOD_CK1_1	897	903	PF00069	0.636
MOD_CK1_1	9	15	PF00069	0.501
MOD_CK1_1	955	961	PF00069	0.678
MOD_CK2_1	246	252	PF00069	0.576
MOD_CK2_1	35	41	PF00069	0.669
MOD_CK2_1	454	460	PF00069	0.706
MOD_CK2_1	502	508	PF00069	0.657
MOD_CK2_1	564	570	PF00069	0.386
MOD_CK2_1	920	926	PF00069	0.607
MOD_CK2_1	958	964	PF00069	0.530
MOD_GlcNHglycan	196	199	PF01048	0.522
MOD_GlcNHglycan	2	7	PF01048	0.555
MOD_GlcNHglycan	230	233	PF01048	0.711
MOD_GlcNHglycan	297	300	PF01048	0.727
MOD_GlcNHglycan	302	305	PF01048	0.711
MOD_GlcNHglycan	353	356	PF01048	0.626
MOD_GlcNHglycan	367	370	PF01048	0.520
MOD_GlcNHglycan	387	390	PF01048	0.596
MOD_GlcNHglycan	451	454	PF01048	0.718
MOD_GlcNHglycan	485	488	PF01048	0.614
MOD_GlcNHglycan	512	515	PF01048	0.721
MOD_GlcNHglycan	594	597	PF01048	0.573
MOD_GlcNHglycan	647	650	PF01048	0.556
MOD_GlcNHglycan	658	661	PF01048	0.611
MOD_GlcNHglycan	714	717	PF01048	0.452
MOD_GlcNHglycan	725	728	PF01048	0.675
MOD_GlcNHglycan	754	757	PF01048	0.633
MOD_GlcNHglycan	773	776	PF01048	0.538
MOD_GlcNHglycan	779	782	PF01048	0.642
MOD_GlcNHglycan	8	11	PF01048	0.549
MOD_GlcNHglycan	899	902	PF01048	0.735
MOD_GSK3_1	2	9	PF00069	0.640
MOD_GSK3_1	202	209	PF00069	0.494
MOD_GSK3_1	228	235	PF00069	0.641
MOD_GSK3_1	36	43	PF00069	0.556
MOD_GSK3_1	378	385	PF00069	0.713
MOD_GSK3_1	454	461	PF00069	0.647
MOD_GSK3_1	465	472	PF00069	0.686
MOD_GSK3_1	476	483	PF00069	0.767
MOD_GSK3_1	510	517	PF00069	0.809
MOD_GSK3_1	520	527	PF00069	0.680
MOD_GSK3_1	556	563	PF00069	0.502
MOD_GSK3_1	603	610	PF00069	0.572
MOD_GSK3_1	674	681	PF00069	0.659
MOD_GSK3_1	731	738	PF00069	0.626
MOD_GSK3_1	745	752	PF00069	0.785
MOD_GSK3_1	771	778	PF00069	0.592
MOD_GSK3_1	779	786	PF00069	0.655
MOD_GSK3_1	926	933	PF00069	0.675
MOD_GSK3_1	954	961	PF00069	0.624
MOD_GSK3_1	966	973	PF00069	0.675
MOD_N-GLC_1	219	224	PF02516	0.629
MOD_N-GLC_1	666	671	PF02516	0.614
MOD_N-GLC_1	841	846	PF02516	0.513
MOD_N-GLC_1	939	944	PF02516	0.509
MOD_NEK2_1	101	106	PF00069	0.417
MOD_NEK2_1	194	199	PF00069	0.504
MOD_NEK2_1	592	597	PF00069	0.670
MOD_NEK2_1	684	689	PF00069	0.491
MOD_NEK2_1	749	754	PF00069	0.562
MOD_NEK2_1	818	823	PF00069	0.551
MOD_NEK2_2	117	122	PF00069	0.488
MOD_PIKK_1	13	19	PF00454	0.633
MOD_PIKK_1	196	202	PF00454	0.465
MOD_PIKK_1	235	241	PF00454	0.526
MOD_PIKK_1	326	332	PF00454	0.408
MOD_PIKK_1	766	772	PF00454	0.511
MOD_PK_1	139	145	PF00069	0.394
MOD_PK_1	894	900	PF00069	0.647
MOD_PK_1	928	934	PF00069	0.640
MOD_PKA_1	188	194	PF00069	0.537
MOD_PKA_1	218	224	PF00069	0.625
MOD_PKA_1	226	232	PF00069	0.700
MOD_PKA_1	449	455	PF00069	0.509
MOD_PKA_1	849	855	PF00069	0.532
MOD_PKA_1	894	900	PF00069	0.775
MOD_PKA_1	966	972	PF00069	0.501
MOD_PKA_2	188	194	PF00069	0.487
MOD_PKA_2	218	224	PF00069	0.637
MOD_PKA_2	226	232	PF00069	0.670
MOD_PKA_2	449	455	PF00069	0.685
MOD_PKA_2	48	54	PF00069	0.628
MOD_PKA_2	510	516	PF00069	0.575
MOD_PKA_2	527	533	PF00069	0.659
MOD_PKA_2	564	570	PF00069	0.494
MOD_PKA_2	684	690	PF00069	0.564
MOD_PKA_2	731	737	PF00069	0.676
MOD_PKA_2	83	89	PF00069	0.499
MOD_PKA_2	849	855	PF00069	0.662
MOD_PKA_2	894	900	PF00069	0.775
MOD_PKA_2	920	926	PF00069	0.614
MOD_PKA_2	946	952	PF00069	0.682
MOD_PKA_2	966	972	PF00069	0.598
MOD_PKB_1	217	225	PF00069	0.642
MOD_Plk_1	286	292	PF00069	0.664
MOD_Plk_1	422	428	PF00069	0.576
MOD_Plk_1	556	562	PF00069	0.427
MOD_Plk_1	666	672	PF00069	0.613
MOD_Plk_1	878	884	PF00069	0.475
MOD_Plk_2-3	502	508	PF00069	0.548
MOD_Plk_2-3	564	570	PF00069	0.404
MOD_Plk_4	173	179	PF00069	0.535
MOD_Plk_4	328	334	PF00069	0.553
MOD_Plk_4	625	631	PF00069	0.451
MOD_Plk_4	678	684	PF00069	0.524
MOD_Plk_4	73	79	PF00069	0.515
MOD_Plk_4	818	824	PF00069	0.670
MOD_Plk_4	989	995	PF00069	0.478
MOD_ProDKin_1	167	173	PF00069	0.522
MOD_ProDKin_1	382	388	PF00069	0.782
MOD_ProDKin_1	390	396	PF00069	0.825
MOD_ProDKin_1	4	10	PF00069	0.639
MOD_ProDKin_1	467	473	PF00069	0.692
MOD_ProDKin_1	480	486	PF00069	0.771
MOD_ProDKin_1	514	520	PF00069	0.788
MOD_ProDKin_1	669	675	PF00069	0.733
MOD_ProDKin_1	718	724	PF00069	0.628
MOD_ProDKin_1	775	781	PF00069	0.784
MOD_ProDKin_1	841	847	PF00069	0.704
MOD_ProDKin_1	930	936	PF00069	0.664
MOD_ProDKin_1	955	961	PF00069	0.814
MOD_SUMO_for_1	225	228	PF00179	0.535
MOD_SUMO_rev_2	491	499	PF00179	0.695
MOD_SUMO_rev_2	58	63	PF00179	0.536
MOD_SUMO_rev_2	612	621	PF00179	0.481
TRG_AP2beta_CARGO_1	144	153	PF09066	0.530
TRG_DiLeu_BaEn_1	156	161	PF01217	0.422
TRG_DiLeu_BaEn_1	679	684	PF01217	0.464
TRG_DiLeu_BaEn_2	189	195	PF01217	0.566
TRG_DiLeu_BaEn_3	581	587	PF01217	0.459
TRG_DiLeu_BaEn_4	557	563	PF01217	0.482
TRG_DiLeu_BaLyEn_6	541	546	PF01217	0.670
TRG_ENDOCYTIC_2	819	822	PF00928	0.607
TRG_ER_diArg_1	102	105	PF00400	0.503
TRG_ER_diArg_1	217	219	PF00400	0.665
TRG_ER_diArg_1	321	323	PF00400	0.537
TRG_ER_diArg_1	428	430	PF00400	0.536
TRG_ER_diArg_1	52	54	PF00400	0.571
TRG_ER_diArg_1	583	586	PF00400	0.463
TRG_ER_diArg_1	855	858	PF00400	0.645
TRG_ER_diArg_1	894	896	PF00400	0.711
TRG_ER_diArg_1	945	948	PF00400	0.714
TRG_ER_diArg_1	965	967	PF00400	0.555
TRG_ER_FFAT_2	950	961	PF00635	0.526

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P8D5	Leptomonas seymouri	42%	100%
A0A1X0P045	Trypanosomatidae	28%	98%
A0A3Q8IH72	Leishmania donovani	74%	100%
A4I4F7	Leishmania infantum	75%	100%
E9ADV7	Leishmania major	74%	100%
E9ALX3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	74%	100%