Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania braziliensis

UniProt:

A4HHA8_LEIBR

TriTrypDb:

LbrM.29.1040 , LBRM2903_290017300

Length:

435

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HHA8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HHA8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	13	17	PF00656	0.681
CLV_C14_Caspase3-7	264	268	PF00656	0.739
CLV_PCSK_KEX2_1	122	124	PF00082	0.671
CLV_PCSK_PC1ET2_1	122	124	PF00082	0.727
CLV_PCSK_SKI1_1	123	127	PF00082	0.705
CLV_PCSK_SKI1_1	404	408	PF00082	0.818
CLV_PCSK_SKI1_1	50	54	PF00082	0.728
DEG_SPOP_SBC_1	154	158	PF00917	0.564
DEG_SPOP_SBC_1	345	349	PF00917	0.578
DOC_CKS1_1	163	168	PF01111	0.561
DOC_CKS1_1	316	321	PF01111	0.744
DOC_CKS1_1	405	410	PF01111	0.684
DOC_CKS1_1	413	418	PF01111	0.737
DOC_MAPK_gen_1	180	188	PF00069	0.539
DOC_MAPK_gen_1	36	46	PF00069	0.699
DOC_MAPK_MEF2A_6	180	188	PF00069	0.539
DOC_PP1_RVXF_1	40	47	PF00149	0.700
DOC_PP2B_LxvP_1	240	243	PF13499	0.580
DOC_PP4_FxxP_1	350	353	PF00568	0.577
DOC_PP4_FxxP_1	405	408	PF00568	0.569
DOC_SPAK_OSR1_1	363	367	PF12202	0.557
DOC_USP7_MATH_1	154	158	PF00917	0.817
DOC_USP7_MATH_1	178	182	PF00917	0.629
DOC_USP7_MATH_1	21	25	PF00917	0.800
DOC_USP7_MATH_1	274	278	PF00917	0.702
DOC_USP7_MATH_1	283	287	PF00917	0.786
DOC_WW_Pin1_4	113	118	PF00397	0.780
DOC_WW_Pin1_4	162	167	PF00397	0.724
DOC_WW_Pin1_4	213	218	PF00397	0.686
DOC_WW_Pin1_4	279	284	PF00397	0.679
DOC_WW_Pin1_4	315	320	PF00397	0.828
DOC_WW_Pin1_4	325	330	PF00397	0.666
DOC_WW_Pin1_4	404	409	PF00397	0.681
DOC_WW_Pin1_4	412	417	PF00397	0.744
LIG_14-3-3_CanoR_1	199	204	PF00244	0.677
LIG_14-3-3_CanoR_1	313	319	PF00244	0.584
LIG_14-3-3_CanoR_1	419	427	PF00244	0.590
LIG_14-3-3_CanoR_1	428	434	PF00244	0.746
LIG_Actin_WH2_2	40	55	PF00022	0.744
LIG_BRCT_BRCA1_1	356	360	PF00533	0.801
LIG_deltaCOP1_diTrp_1	260	265	PF00928	0.536
LIG_FHA_1	116	122	PF00498	0.712
LIG_FHA_1	310	316	PF00498	0.693
LIG_FHA_1	373	379	PF00498	0.676
LIG_FHA_1	382	388	PF00498	0.636
LIG_FHA_1	408	414	PF00498	0.700
LIG_FHA_1	53	59	PF00498	0.770
LIG_FHA_2	419	425	PF00498	0.655
LIG_GBD_Chelix_1	44	52	PF00786	0.804
LIG_LIR_Apic_2	250	256	PF02991	0.562
LIG_LIR_Apic_2	347	353	PF02991	0.579
LIG_LIR_Apic_2	403	408	PF02991	0.572
LIG_LIR_Gen_1	260	270	PF02991	0.576
LIG_LIR_Gen_1	308	319	PF02991	0.587
LIG_LIR_Gen_1	99	108	PF02991	0.719
LIG_LIR_Nem_3	260	265	PF02991	0.569
LIG_LIR_Nem_3	308	314	PF02991	0.586
LIG_LIR_Nem_3	423	429	PF02991	0.544
LIG_LIR_Nem_3	99	104	PF02991	0.718
LIG_MYND_1	213	217	PF01753	0.712
LIG_Pex14_2	360	364	PF04695	0.554
LIG_SH2_CRK	253	257	PF00017	0.728
LIG_SH2_CRK	311	315	PF00017	0.587
LIG_SH2_NCK_1	110	114	PF00017	0.651
LIG_SH2_STAP1	311	315	PF00017	0.587
LIG_SH2_STAT5	311	314	PF00017	0.633
LIG_SH3_2	319	324	PF14604	0.591
LIG_SH3_3	132	138	PF00018	0.737
LIG_SH3_3	172	178	PF00018	0.709
LIG_SH3_3	211	217	PF00018	0.713
LIG_SH3_3	316	322	PF00018	0.824
LIG_SUMO_SIM_par_1	131	136	PF11976	0.587
LIG_SUMO_SIM_par_1	365	372	PF11976	0.549
LIG_SUMO_SIM_par_1	409	415	PF11976	0.549
LIG_TRAF2_1	20	23	PF00917	0.556
LIG_TYR_ITIM	108	113	PF00017	0.648
LIG_TYR_ITIM	309	314	PF00017	0.586
MOD_CDK_SPxK_1	318	324	PF00069	0.793
MOD_CDK_SPxxK_3	412	419	PF00069	0.807
MOD_CK1_1	155	161	PF00069	0.707
MOD_CK1_1	195	201	PF00069	0.599
MOD_CK1_1	202	208	PF00069	0.660
MOD_CK1_1	286	292	PF00069	0.815
MOD_CK1_1	31	37	PF00069	0.611
MOD_CK1_1	317	323	PF00069	0.710
MOD_CK1_1	328	334	PF00069	0.787
MOD_CK1_1	372	378	PF00069	0.705
MOD_CK1_1	381	387	PF00069	0.718
MOD_CK1_1	398	404	PF00069	0.721
MOD_CK2_1	23	29	PF00069	0.814
MOD_CK2_1	269	275	PF00069	0.727
MOD_CK2_1	418	424	PF00069	0.709
MOD_GlcNHglycan	105	108	PF01048	0.600
MOD_GlcNHglycan	16	19	PF01048	0.665
MOD_GlcNHglycan	166	169	PF01048	0.627
MOD_GlcNHglycan	25	28	PF01048	0.711
MOD_GlcNHglycan	271	274	PF01048	0.573
MOD_GlcNHglycan	275	279	PF01048	0.565
MOD_GlcNHglycan	330	333	PF01048	0.615
MOD_GlcNHglycan	81	84	PF01048	0.775
MOD_GSK3_1	10	17	PF00069	0.676
MOD_GSK3_1	111	118	PF00069	0.525
MOD_GSK3_1	149	156	PF00069	0.725
MOD_GSK3_1	164	171	PF00069	0.797
MOD_GSK3_1	194	201	PF00069	0.674
MOD_GSK3_1	21	28	PF00069	0.612
MOD_GSK3_1	243	250	PF00069	0.639
MOD_GSK3_1	261	268	PF00069	0.764
MOD_GSK3_1	279	286	PF00069	0.629
MOD_GSK3_1	305	312	PF00069	0.652
MOD_GSK3_1	314	321	PF00069	0.673
MOD_GSK3_1	334	341	PF00069	0.756
MOD_GSK3_1	368	375	PF00069	0.694
MOD_GSK3_1	377	384	PF00069	0.718
MOD_N-GLC_1	309	314	PF02516	0.781
MOD_N-GLC_1	378	383	PF02516	0.728
MOD_NEK2_1	125	130	PF00069	0.569
MOD_NEK2_1	265	270	PF00069	0.717
MOD_NEK2_1	334	339	PF00069	0.570
MOD_NEK2_1	367	372	PF00069	0.789
MOD_NEK2_1	392	397	PF00069	0.648
MOD_PIKK_1	395	401	PF00454	0.725
MOD_PKA_2	198	204	PF00069	0.716
MOD_PKA_2	243	249	PF00069	0.640
MOD_PKA_2	362	368	PF00069	0.752
MOD_PKA_2	372	378	PF00069	0.649
MOD_PKA_2	418	424	PF00069	0.678
MOD_PKA_2	427	433	PF00069	0.803
MOD_Plk_1	21	27	PF00069	0.697
MOD_Plk_1	231	237	PF00069	0.732
MOD_Plk_1	28	34	PF00069	0.571
MOD_Plk_1	309	315	PF00069	0.633
MOD_Plk_1	378	384	PF00069	0.726
MOD_Plk_4	168	174	PF00069	0.757
MOD_Plk_4	265	271	PF00069	0.549
MOD_Plk_4	346	352	PF00069	0.728
MOD_ProDKin_1	113	119	PF00069	0.784
MOD_ProDKin_1	162	168	PF00069	0.723
MOD_ProDKin_1	213	219	PF00069	0.685
MOD_ProDKin_1	279	285	PF00069	0.682
MOD_ProDKin_1	315	321	PF00069	0.827
MOD_ProDKin_1	325	331	PF00069	0.665
MOD_ProDKin_1	404	410	PF00069	0.676
MOD_ProDKin_1	412	418	PF00069	0.744
MOD_SUMO_for_1	121	124	PF00179	0.577
MOD_SUMO_rev_2	49	55	PF00179	0.797
TRG_DiLeu_BaEn_3	206	212	PF01217	0.557
TRG_DiLeu_BaLyEn_6	214	219	PF01217	0.713
TRG_ENDOCYTIC_2	110	113	PF00928	0.646
TRG_ENDOCYTIC_2	311	314	PF00928	0.586
TRG_ER_diArg_1	179	182	PF00400	0.545
TRG_ER_diArg_1	90	93	PF00400	0.626
TRG_Pf-PMV_PEXEL_1	236	241	PF00026	0.745
TRG_Pf-PMV_PEXEL_1	50	54	PF00026	0.799

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P8D7	Leptomonas seymouri	41%	100%
A0A3Q8IFA6	Leishmania donovani	70%	100%
A4I4F4	Leishmania infantum	70%	100%
E9ADV4	Leishmania major	70%	100%
E9ALX6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	69%	99%