LeishMANIAdb
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Transmembrane protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Transmembrane protein
Gene product:
hypothetical protein, conserved
Species:
Leishmania braziliensis
UniProt:
A4HHA7_LEIBR
TriTrypDb:
LbrM.29.1030 , LBRM2903_290017200 *
Length:
419

Annotations

LeishMANIAdb annotations

Kinetoplastid-unique proteins with many disordered segments and a hydrophobic C-terminal region.

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 9
NetGPI no yes: 0, no: 9
Cellular components
Term Name Level Count
GO:0016020 membrane 2 8
GO:0110165 cellular anatomical entity 1 8
GO:0005737 cytoplasm 2 1

Expansion

Sequence features

A4HHA7
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HHA7

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 265 267 PF00675 0.477
CLV_NRD_NRD_1 306 308 PF00675 0.365
CLV_PCSK_KEX2_1 265 267 PF00082 0.475
CLV_PCSK_KEX2_1 306 308 PF00082 0.365
CLV_PCSK_KEX2_1 413 415 PF00082 0.413
CLV_PCSK_PC1ET2_1 413 415 PF00082 0.479
CLV_PCSK_PC7_1 409 415 PF00082 0.396
CLV_PCSK_SKI1_1 172 176 PF00082 0.495
CLV_PCSK_SKI1_1 310 314 PF00082 0.425
CLV_PCSK_SKI1_1 378 382 PF00082 0.459
DEG_APCC_DBOX_1 305 313 PF00400 0.585
DEG_APCC_DBOX_1 55 63 PF00400 0.687
DEG_Nend_UBRbox_2 1 3 PF02207 0.588
DEG_SCF_SKP2-CKS1_1 113 120 PF00560 0.584
DEG_SCF_SKP2-CKS1_1 165 172 PF00560 0.575
DEG_SPOP_SBC_1 8 12 PF00917 0.725
DOC_CDC14_PxL_1 370 378 PF14671 0.394
DOC_CKS1_1 148 153 PF01111 0.579
DOC_CYCLIN_yCln2_LP_2 376 382 PF00134 0.242
DOC_PP4_FxxP_1 393 396 PF00568 0.341
DOC_USP7_MATH_1 15 19 PF00917 0.686
DOC_USP7_MATH_1 254 258 PF00917 0.666
DOC_USP7_UBL2_3 116 120 PF12436 0.744
DOC_USP7_UBL2_3 131 135 PF12436 0.677
DOC_USP7_UBL2_3 171 175 PF12436 0.593
DOC_WW_Pin1_4 114 119 PF00397 0.704
DOC_WW_Pin1_4 126 131 PF00397 0.648
DOC_WW_Pin1_4 147 152 PF00397 0.564
DOC_WW_Pin1_4 166 171 PF00397 0.634
DOC_WW_Pin1_4 42 47 PF00397 0.658
LIG_14-3-3_CanoR_1 321 326 PF00244 0.576
LIG_BRCT_BRCA1_1 107 111 PF00533 0.733
LIG_deltaCOP1_diTrp_1 335 340 PF00928 0.300
LIG_FHA_1 233 239 PF00498 0.628
LIG_FHA_1 290 296 PF00498 0.650
LIG_FHA_1 322 328 PF00498 0.673
LIG_FHA_1 332 338 PF00498 0.491
LIG_FHA_1 383 389 PF00498 0.303
LIG_FHA_1 43 49 PF00498 0.614
LIG_FHA_2 312 318 PF00498 0.667
LIG_FXI_DFP_1 313 317 PF00024 0.402
LIG_LIR_Gen_1 108 118 PF02991 0.726
LIG_LIR_Gen_1 150 160 PF02991 0.631
LIG_LIR_Gen_1 279 286 PF02991 0.703
LIG_LIR_Gen_1 323 333 PF02991 0.590
LIG_LIR_Gen_1 334 344 PF02991 0.457
LIG_LIR_Nem_3 108 114 PF02991 0.730
LIG_LIR_Nem_3 150 156 PF02991 0.619
LIG_LIR_Nem_3 334 339 PF02991 0.460
LIG_LIR_Nem_3 360 365 PF02991 0.374
LIG_Pex14_1 336 340 PF04695 0.300
LIG_SH2_CRK 153 157 PF00017 0.639
LIG_SH2_CRK 213 217 PF00017 0.615
LIG_SH2_CRK 230 234 PF00017 0.628
LIG_SH2_CRK 296 300 PF00017 0.676
LIG_SH2_CRK 32 36 PF00017 0.735
LIG_SH2_CRK 341 345 PF00017 0.335
LIG_SH2_GRB2like 31 34 PF00017 0.586
LIG_SH2_NCK_1 213 217 PF00017 0.682
LIG_SH2_STAP1 153 157 PF00017 0.641
LIG_SH2_STAP1 333 337 PF00017 0.459
LIG_SH2_STAP1 362 366 PF00017 0.398
LIG_SH2_STAT3 350 353 PF00017 0.417
LIG_SH2_STAT5 281 284 PF00017 0.732
LIG_SH2_STAT5 333 336 PF00017 0.581
LIG_SH2_STAT5 365 368 PF00017 0.416
LIG_SH3_3 412 418 PF00018 0.602
LIG_SH3_4 131 138 PF00018 0.673
LIG_SUMO_SIM_anti_2 214 220 PF11976 0.592
LIG_SUMO_SIM_anti_2 385 390 PF11976 0.303
LIG_SUMO_SIM_par_1 395 401 PF11976 0.299
LIG_TRAF2_1 40 43 PF00917 0.606
LIG_TYR_ITIM 294 299 PF00017 0.677
LIG_TYR_ITIM 339 344 PF00017 0.335
MOD_CDK_SPK_2 126 131 PF00069 0.635
MOD_CDK_SPK_2 166 171 PF00069 0.578
MOD_CDK_SPxK_1 114 120 PF00069 0.583
MOD_CDK_SPxK_1 166 172 PF00069 0.581
MOD_CK1_1 401 407 PF00069 0.436
MOD_CK1_1 54 60 PF00069 0.716
MOD_CK1_1 94 100 PF00069 0.704
MOD_CK2_1 36 42 PF00069 0.718
MOD_GlcNHglycan 207 210 PF01048 0.456
MOD_GlcNHglycan 22 25 PF01048 0.515
MOD_GlcNHglycan 38 41 PF01048 0.440
MOD_GlcNHglycan 85 88 PF01048 0.556
MOD_GlcNHglycan 89 92 PF01048 0.569
MOD_GlcNHglycan 94 97 PF01048 0.576
MOD_GSK3_1 20 27 PF00069 0.686
MOD_GSK3_1 285 292 PF00069 0.669
MOD_GSK3_1 327 334 PF00069 0.608
MOD_GSK3_1 398 405 PF00069 0.300
MOD_GSK3_1 47 54 PF00069 0.662
MOD_GSK3_1 83 90 PF00069 0.716
MOD_GSK3_1 92 99 PF00069 0.792
MOD_N-GLC_1 321 326 PF02516 0.400
MOD_NEK2_1 20 25 PF00069 0.674
MOD_NEK2_1 295 300 PF00069 0.681
MOD_NEK2_1 398 403 PF00069 0.331
MOD_NEK2_1 51 56 PF00069 0.715
MOD_NEK2_2 15 20 PF00069 0.565
MOD_NEK2_2 9 14 PF00069 0.582
MOD_PKA_2 320 326 PF00069 0.593
MOD_Plk_1 100 106 PF00069 0.735
MOD_Plk_1 289 295 PF00069 0.649
MOD_Plk_1 321 327 PF00069 0.597
MOD_Plk_4 100 106 PF00069 0.611
MOD_Plk_4 15 21 PF00069 0.706
MOD_Plk_4 214 220 PF00069 0.664
MOD_ProDKin_1 114 120 PF00069 0.704
MOD_ProDKin_1 126 132 PF00069 0.645
MOD_ProDKin_1 147 153 PF00069 0.560
MOD_ProDKin_1 166 172 PF00069 0.636
MOD_ProDKin_1 42 48 PF00069 0.660
MOD_SUMO_rev_2 138 144 PF00179 0.620
MOD_SUMO_rev_2 279 288 PF00179 0.680
TRG_DiLeu_BaEn_1 290 295 PF01217 0.709
TRG_DiLeu_BaLyEn_6 393 398 PF01217 0.296
TRG_ENDOCYTIC_2 153 156 PF00928 0.562
TRG_ENDOCYTIC_2 213 216 PF00928 0.619
TRG_ENDOCYTIC_2 281 284 PF00928 0.744
TRG_ENDOCYTIC_2 296 299 PF00928 0.543
TRG_ENDOCYTIC_2 341 344 PF00928 0.311
TRG_ENDOCYTIC_2 365 368 PF00928 0.391
TRG_ER_diArg_1 264 266 PF00400 0.680
TRG_ER_diArg_1 56 59 PF00400 0.720
TRG_Pf-PMV_PEXEL_1 186 191 PF00026 0.410

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1PF35 Leptomonas seymouri 68% 74%
A0A0S4JJG2 Bodo saltans 33% 87%
A0A1X0NZR0 Trypanosomatidae 56% 80%
A0A3Q8IF28 Leishmania donovani 81% 73%
A4I4F3 Leishmania infantum 81% 73%
C9ZLK3 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 55% 84%
E9ADV3 Leishmania major 82% 100%
E9ALX7 Leishmania mexicana (strain MHOM/GT/2001/U1103) 84% 73%

Download

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS