5-histidylcysteine sulfoxide synthase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

5-histidylcysteine sulfoxide synthase, putative

Species:

Leishmania braziliensis

UniProt:

A4HHA6_LEIBR

TriTrypDb:

LbrM.29.1020 , LBRM2903_290017100

Length:

754

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 3
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 12

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 6

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 6

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0031974	membrane-enclosed lumen	2	1
GO:0031981	nuclear lumen	5	1
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	1
GO:0043233	organelle lumen	3	1
GO:0070013	intracellular organelle lumen	4	1
GO:0097014	ciliary plasm	5	1
GO:0099568	cytoplasmic region	3	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HHA6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HHA6

Function

Biological processes
Term	Name	Level	Count
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	3
GO:0010035	response to inorganic substance	3	1
GO:0010038	response to metal ion	4	1
GO:0010039	response to iron ion	5	1
GO:0010040	response to iron(II) ion	6	1
GO:0018158	protein oxidation	5	1
GO:0018171	peptidyl-cysteine oxidation	6	1
GO:0018193	peptidyl-amino acid modification	5	1
GO:0018198	peptidyl-cysteine modification	6	1
GO:0019538	protein metabolic process	3	1
GO:0036211	protein modification process	4	1
GO:0042221	response to chemical	2	1
GO:0043170	macromolecule metabolic process	3	1
GO:0043412	macromolecule modification	4	1
GO:0044238	primary metabolic process	2	1
GO:0050896	response to stimulus	1	1
GO:0071704	organic substance metabolic process	2	1
GO:1901564	organonitrogen compound metabolic process	3	1
GO:0032259	methylation	2	2

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	1
GO:0005506	iron ion binding	6	1
GO:0008198	ferrous iron binding	7	1
GO:0043167	ion binding	2	1
GO:0043169	cation binding	3	1
GO:0046872	metal ion binding	4	1
GO:0046914	transition metal ion binding	5	1
GO:0003824	catalytic activity	1	2
GO:0008168	methyltransferase activity	4	2
GO:0016740	transferase activity	2	2
GO:0016741	transferase activity, transferring one-carbon groups	3	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	171	175	PF00656	0.506
CLV_NRD_NRD_1	143	145	PF00675	0.262
CLV_NRD_NRD_1	217	219	PF00675	0.282
CLV_NRD_NRD_1	476	478	PF00675	0.289
CLV_NRD_NRD_1	579	581	PF00675	0.419
CLV_NRD_NRD_1	751	753	PF00675	0.384
CLV_PCSK_KEX2_1	143	145	PF00082	0.262
CLV_PCSK_KEX2_1	217	219	PF00082	0.336
CLV_PCSK_KEX2_1	476	478	PF00082	0.289
CLV_PCSK_KEX2_1	536	538	PF00082	0.402
CLV_PCSK_KEX2_1	579	581	PF00082	0.416
CLV_PCSK_PC1ET2_1	536	538	PF00082	0.379
CLV_PCSK_PC7_1	472	478	PF00082	0.289
CLV_PCSK_SKI1_1	206	210	PF00082	0.375
CLV_PCSK_SKI1_1	24	28	PF00082	0.362
CLV_PCSK_SKI1_1	364	368	PF00082	0.301
CLV_PCSK_SKI1_1	472	476	PF00082	0.274
CLV_PCSK_SKI1_1	477	481	PF00082	0.274
CLV_PCSK_SKI1_1	536	540	PF00082	0.377
CLV_PCSK_SKI1_1	666	670	PF00082	0.456
CLV_PCSK_SKI1_1	744	748	PF00082	0.470
DEG_Nend_UBRbox_1	1	4	PF02207	0.520
DOC_CYCLIN_yClb3_PxF_3	308	316	PF00134	0.289
DOC_CYCLIN_yCln2_LP_2	161	167	PF00134	0.437
DOC_CYCLIN_yCln2_LP_2	581	587	PF00134	0.246
DOC_CYCLIN_yCln2_LP_2	71	74	PF00134	0.463
DOC_CYCLIN_yCln2_LP_2	78	84	PF00134	0.414
DOC_MAPK_FxFP_2	427	430	PF00069	0.193
DOC_MAPK_gen_1	666	675	PF00069	0.364
DOC_MAPK_gen_1	77	84	PF00069	0.437
DOC_MAPK_MEF2A_6	158	167	PF00069	0.439
DOC_PP1_RVXF_1	188	194	PF00149	0.448
DOC_PP1_RVXF_1	22	29	PF00149	0.292
DOC_PP1_RVXF_1	299	306	PF00149	0.334
DOC_PP1_RVXF_1	557	563	PF00149	0.321
DOC_PP2B_LxvP_1	161	164	PF13499	0.437
DOC_PP2B_LxvP_1	20	23	PF13499	0.304
DOC_PP2B_LxvP_1	71	74	PF13499	0.491
DOC_PP4_FxxP_1	427	430	PF00568	0.331
DOC_PP4_FxxP_1	443	446	PF00568	0.258
DOC_PP4_FxxP_1	70	73	PF00568	0.451
DOC_USP7_MATH_1	319	323	PF00917	0.193
DOC_USP7_MATH_1	350	354	PF00917	0.417
DOC_WW_Pin1_4	241	246	PF00397	0.193
LIG_14-3-3_CanoR_1	327	336	PF00244	0.289
LIG_14-3-3_CanoR_1	364	373	PF00244	0.303
LIG_14-3-3_CanoR_1	559	563	PF00244	0.216
LIG_AP2alpha_1	517	521	PF02296	0.480
LIG_BRCT_BRCA1_1	155	159	PF00533	0.504
LIG_BRCT_BRCA1_1	320	324	PF00533	0.193
LIG_BRCT_BRCA1_1	611	615	PF00533	0.429
LIG_deltaCOP1_diTrp_1	296	305	PF00928	0.276
LIG_deltaCOP1_diTrp_1	309	314	PF00928	0.280
LIG_deltaCOP1_diTrp_1	334	339	PF00928	0.274
LIG_deltaCOP1_diTrp_1	368	375	PF00928	0.289
LIG_eIF4E_1	576	582	PF01652	0.483
LIG_eIF4E_1	66	72	PF01652	0.491
LIG_eIF4E_1	695	701	PF01652	0.532
LIG_FHA_1	101	107	PF00498	0.524
LIG_FHA_1	193	199	PF00498	0.461
LIG_FHA_1	328	334	PF00498	0.289
LIG_FHA_1	559	565	PF00498	0.324
LIG_FHA_1	695	701	PF00498	0.566
LIG_FHA_1	738	744	PF00498	0.503
LIG_FHA_2	169	175	PF00498	0.499
LIG_FHA_2	365	371	PF00498	0.274
LIG_FHA_2	599	605	PF00498	0.348
LIG_Integrin_RGD_1	590	592	PF01839	0.440
LIG_LIR_Apic_2	128	134	PF02991	0.430
LIG_LIR_Apic_2	334	340	PF02991	0.274
LIG_LIR_Apic_2	425	430	PF02991	0.213
LIG_LIR_Apic_2	441	446	PF02991	0.374
LIG_LIR_Apic_2	67	73	PF02991	0.451
LIG_LIR_Gen_1	120	131	PF02991	0.437
LIG_LIR_Gen_1	279	289	PF02991	0.274
LIG_LIR_Gen_1	368	379	PF02991	0.274
LIG_LIR_Gen_1	412	420	PF02991	0.368
LIG_LIR_Gen_1	55	65	PF02991	0.448
LIG_LIR_Gen_1	565	576	PF02991	0.337
LIG_LIR_Gen_1	639	645	PF02991	0.297
LIG_LIR_Gen_1	678	687	PF02991	0.529
LIG_LIR_LC3C_4	640	645	PF02991	0.441
LIG_LIR_Nem_3	120	126	PF02991	0.437
LIG_LIR_Nem_3	132	136	PF02991	0.437
LIG_LIR_Nem_3	279	283	PF02991	0.274
LIG_LIR_Nem_3	297	303	PF02991	0.274
LIG_LIR_Nem_3	309	315	PF02991	0.272
LIG_LIR_Nem_3	368	374	PF02991	0.274
LIG_LIR_Nem_3	412	417	PF02991	0.368
LIG_LIR_Nem_3	519	524	PF02991	0.421
LIG_LIR_Nem_3	55	60	PF02991	0.437
LIG_LIR_Nem_3	565	571	PF02991	0.330
LIG_LIR_Nem_3	639	644	PF02991	0.300
LIG_LIR_Nem_3	678	684	PF02991	0.491
LIG_LIR_Nem_3	709	715	PF02991	0.371
LIG_OCRL_FandH_1	447	459	PF00620	0.187
LIG_PCNA_yPIPBox_3	218	232	PF02747	0.495
LIG_PCNA_yPIPBox_3	704	715	PF02747	0.450
LIG_Pex14_1	252	256	PF04695	0.274
LIG_Pex14_1	371	375	PF04695	0.417
LIG_Pex14_2	475	479	PF04695	0.274
LIG_Pex14_2	517	521	PF04695	0.396
LIG_Pex14_2	57	61	PF04695	0.491
LIG_PTB_Apo_2	274	281	PF02174	0.288
LIG_Rb_pABgroove_1	434	442	PF01858	0.193
LIG_REV1ctd_RIR_1	25	31	PF16727	0.273
LIG_SH2_CRK	414	418	PF00017	0.368
LIG_SH2_GRB2like	256	259	PF00017	0.368
LIG_SH2_GRB2like	609	612	PF00017	0.298
LIG_SH2_GRB2like	93	96	PF00017	0.448
LIG_SH2_NCK_1	18	22	PF00017	0.284
LIG_SH2_NCK_1	414	418	PF00017	0.368
LIG_SH2_PTP2	482	485	PF00017	0.308
LIG_SH2_SRC	256	259	PF00017	0.278
LIG_SH2_SRC	487	490	PF00017	0.309
LIG_SH2_SRC	609	612	PF00017	0.298
LIG_SH2_SRC	66	69	PF00017	0.575
LIG_SH2_STAP1	66	70	PF00017	0.485
LIG_SH2_STAT3	142	145	PF00017	0.491
LIG_SH2_STAT3	289	292	PF00017	0.274
LIG_SH2_STAT5	207	210	PF00017	0.398
LIG_SH2_STAT5	273	276	PF00017	0.243
LIG_SH2_STAT5	378	381	PF00017	0.289
LIG_SH2_STAT5	482	485	PF00017	0.281
LIG_SH2_STAT5	487	490	PF00017	0.301
LIG_SH2_STAT5	49	52	PF00017	0.308
LIG_SH2_STAT5	576	579	PF00017	0.438
LIG_SH2_STAT5	609	612	PF00017	0.400
LIG_SH2_STAT5	695	698	PF00017	0.566
LIG_SH2_STAT5	93	96	PF00017	0.448
LIG_SH3_2	616	621	PF14604	0.270
LIG_SH3_3	305	311	PF00018	0.274
LIG_SH3_3	485	491	PF00018	0.417
LIG_SH3_3	613	619	PF00018	0.570
LIG_SH3_3	729	735	PF00018	0.365
LIG_SUMO_SIM_anti_2	508	515	PF11976	0.298
LIG_SxIP_EBH_1	652	665	PF03271	0.400
LIG_TRAF2_1	135	138	PF00917	0.418
LIG_TRAF2_1	65	68	PF00917	0.480
LIG_TRFH_1	503	507	PF08558	0.320
LIG_WRC_WIRS_1	280	285	PF05994	0.349
LIG_WRC_WIRS_1	351	356	PF05994	0.368
LIG_WRC_WIRS_1	445	450	PF05994	0.274
MOD_CDK_SPxxK_3	241	248	PF00069	0.193
MOD_CK1_1	132	138	PF00069	0.504
MOD_CK1_1	170	176	PF00069	0.458
MOD_CK1_1	220	226	PF00069	0.400
MOD_CK1_1	353	359	PF00069	0.343
MOD_CK1_1	444	450	PF00069	0.274
MOD_CK1_1	639	645	PF00069	0.342
MOD_CK2_1	132	138	PF00069	0.441
MOD_CK2_1	273	279	PF00069	0.274
MOD_CK2_1	364	370	PF00069	0.274
MOD_CK2_1	598	604	PF00069	0.428
MOD_CK2_1	7	13	PF00069	0.352
MOD_CMANNOS	302	305	PF00535	0.274
MOD_Cter_Amidation	359	362	PF01082	0.334
MOD_GlcNHglycan	155	158	PF01048	0.246
MOD_GlcNHglycan	321	324	PF01048	0.350
MOD_GlcNHglycan	35	38	PF01048	0.454
MOD_GlcNHglycan	462	465	PF01048	0.247
MOD_GlcNHglycan	656	659	PF01048	0.426
MOD_GlcNHglycan	9	12	PF01048	0.434
MOD_GSK3_1	163	170	PF00069	0.439
MOD_GSK3_1	206	213	PF00069	0.498
MOD_GSK3_1	217	224	PF00069	0.522
MOD_GSK3_1	456	463	PF00069	0.368
MOD_GSK3_1	558	565	PF00069	0.226
MOD_GSK3_1	593	600	PF00069	0.431
MOD_GSK3_1	629	636	PF00069	0.433
MOD_GSK3_1	650	657	PF00069	0.365
MOD_GSK3_1	687	694	PF00069	0.609
MOD_GSK3_1	733	740	PF00069	0.429
MOD_N-GLC_1	168	173	PF02516	0.262
MOD_N-GLC_1	392	397	PF02516	0.217
MOD_N-GLC_1	598	603	PF02516	0.478
MOD_N-GLC_2	112	114	PF02516	0.274
MOD_N-GLC_2	526	528	PF02516	0.319
MOD_NEK2_1	153	158	PF00069	0.445
MOD_NEK2_1	167	172	PF00069	0.418
MOD_NEK2_1	268	273	PF00069	0.274
MOD_NEK2_1	517	522	PF00069	0.385
MOD_NEK2_1	562	567	PF00069	0.329
MOD_NEK2_1	650	655	PF00069	0.359
MOD_NEK2_1	700	705	PF00069	0.467
MOD_NEK2_2	350	355	PF00069	0.368
MOD_PIKK_1	221	227	PF00454	0.371
MOD_PIKK_1	687	693	PF00454	0.518
MOD_PKA_1	217	223	PF00069	0.293
MOD_PKA_1	685	691	PF00069	0.428
MOD_PKA_2	217	223	PF00069	0.455
MOD_PKA_2	319	325	PF00069	0.350
MOD_PKA_2	450	456	PF00069	0.303
MOD_PKA_2	517	523	PF00069	0.366
MOD_PKA_2	558	564	PF00069	0.215
MOD_Plk_1	119	125	PF00069	0.437
MOD_Plk_1	369	375	PF00069	0.394
MOD_Plk_1	392	398	PF00069	0.217
MOD_Plk_1	441	447	PF00069	0.274
MOD_Plk_1	639	645	PF00069	0.310
MOD_Plk_1	650	656	PF00069	0.324
MOD_Plk_1	66	72	PF00069	0.491
MOD_Plk_1	691	697	PF00069	0.548
MOD_Plk_2-3	119	125	PF00069	0.437
MOD_Plk_4	622	628	PF00069	0.414
MOD_Plk_4	66	72	PF00069	0.496
MOD_Plk_4	691	697	PF00069	0.576
MOD_ProDKin_1	241	247	PF00069	0.193
MOD_SUMO_for_1	354	357	PF00179	0.289
MOD_SUMO_for_1	41	44	PF00179	0.506
TRG_DiLeu_BaEn_1	67	72	PF01217	0.491
TRG_DiLeu_BaEn_1	710	715	PF01217	0.356
TRG_DiLeu_BaEn_2	278	284	PF01217	0.274
TRG_DiLeu_BaEn_4	15	21	PF01217	0.438
TRG_DiLeu_LyEn_5	710	715	PF01217	0.284
TRG_ENDOCYTIC_2	414	417	PF00928	0.362
TRG_ENDOCYTIC_2	440	443	PF00928	0.288
TRG_ENDOCYTIC_2	482	485	PF00928	0.308
TRG_ER_diArg_1	142	144	PF00400	0.462
TRG_ER_diArg_1	216	218	PF00400	0.284
TRG_ER_diArg_1	475	477	PF00400	0.289
TRG_ER_diArg_1	579	581	PF00400	0.390
TRG_NES_CRM1_1	44	58	PF08389	0.334
TRG_Pf-PMV_PEXEL_1	24	29	PF00026	0.395
TRG_Pf-PMV_PEXEL_1	364	368	PF00026	0.308

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IMA1	Leptomonas seymouri	78%	100%
A0A0S4JIK4	Bodo saltans	59%	100%
A0A1X0NZP4	Trypanosomatidae	63%	100%
A0A3S7X2D6	Leishmania donovani	86%	100%
A0A422NF05	Trypanosoma rangeli	61%	100%
A4I4F2	Leishmania infantum	86%	100%
C9ZLK2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	61%	100%
E9ADV2	Leishmania major	84%	100%
E9ALX8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	84%	100%
V5BR85	Trypanosoma cruzi	61%	100%