Putative A-1 protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

A-1 protein, putative

Species:

Leishmania braziliensis

UniProt:

A4HHA5_LEIBR

TriTrypDb:

LbrM.29.1010 , LBRM2903_290017000

Length:

174

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HHA5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HHA5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	4	6	PF00675	0.697
CLV_PCSK_KEX2_1	6	8	PF00082	0.667
CLV_PCSK_KEX2_1	64	66	PF00082	0.580
CLV_PCSK_PC1ET2_1	6	8	PF00082	0.667
CLV_PCSK_PC1ET2_1	64	66	PF00082	0.580
CLV_PCSK_SKI1_1	156	160	PF00082	0.665
CLV_PCSK_SKI1_1	76	80	PF00082	0.606
CLV_PCSK_SKI1_1	92	96	PF00082	0.521
DEG_Nend_UBRbox_2	1	3	PF02207	0.690
DOC_CYCLIN_RxL_1	153	162	PF00134	0.579
DOC_PP2B_LxvP_1	121	124	PF13499	0.610
DOC_USP7_MATH_1	128	132	PF00917	0.696
LIG_14-3-3_CanoR_1	65	73	PF00244	0.577
LIG_Dynein_DLC8_1	140	146	PF01221	0.685
LIG_FHA_1	109	115	PF00498	0.503
LIG_FHA_1	132	138	PF00498	0.611
LIG_FHA_2	142	148	PF00498	0.675
LIG_FHA_2	50	56	PF00498	0.751
LIG_FHA_2	88	94	PF00498	0.667
LIG_LIR_Gen_1	164	174	PF02991	0.618
LIG_LIR_Gen_1	56	63	PF02991	0.603
LIG_LIR_Nem_3	164	170	PF02991	0.605
LIG_LIR_Nem_3	56	62	PF02991	0.607
LIG_NRBOX	165	171	PF00104	0.565
LIG_PDZ_Class_2	169	174	PF00595	0.446
LIG_SH2_CRK	167	171	PF00017	0.568
LIG_SH2_CRK	59	63	PF00017	0.592
LIG_SH2_NCK_1	22	26	PF00017	0.507
LIG_SH2_STAP1	22	26	PF00017	0.507
LIG_SH2_STAP1	59	63	PF00017	0.634
LIG_SH2_STAT5	167	170	PF00017	0.707
LIG_SH3_3	130	136	PF00018	0.529
LIG_TRAF2_1	83	86	PF00917	0.656
MOD_CK1_1	10	16	PF00069	0.521
MOD_CK1_1	117	123	PF00069	0.588
MOD_CK1_1	131	137	PF00069	0.536
MOD_CK1_1	140	146	PF00069	0.523
MOD_CK1_1	148	154	PF00069	0.619
MOD_CK1_1	38	44	PF00069	0.638
MOD_CK1_1	49	55	PF00069	0.558
MOD_CK2_1	141	147	PF00069	0.680
MOD_CK2_1	44	50	PF00069	0.662
MOD_CK2_1	8	14	PF00069	0.546
MOD_CK2_1	87	93	PF00069	0.669
MOD_GlcNHglycan	10	13	PF01048	0.603
MOD_GlcNHglycan	116	119	PF01048	0.600
MOD_GlcNHglycan	23	26	PF01048	0.586
MOD_GlcNHglycan	40	43	PF01048	0.752
MOD_GlcNHglycan	46	49	PF01048	0.691
MOD_GlcNHglycan	66	69	PF01048	0.435
MOD_GSK3_1	108	115	PF00069	0.475
MOD_GSK3_1	124	131	PF00069	0.536
MOD_GSK3_1	137	144	PF00069	0.607
MOD_GSK3_1	161	168	PF00069	0.499
MOD_GSK3_1	46	53	PF00069	0.614
MOD_GSK3_1	64	71	PF00069	0.529
MOD_GSK3_1	92	99	PF00069	0.694
MOD_NEK2_1	36	41	PF00069	0.533
MOD_NEK2_1	98	103	PF00069	0.502
MOD_PIKK_1	141	147	PF00454	0.680
MOD_PIKK_1	81	87	PF00454	0.625
MOD_PIKK_1	92	98	PF00454	0.576
MOD_PKA_1	64	70	PF00069	0.574
MOD_PKA_2	64	70	PF00069	0.574
MOD_PKA_2	8	14	PF00069	0.546
MOD_PKB_1	5	13	PF00069	0.522
MOD_Plk_2-3	50	56	PF00069	0.524
MOD_Plk_4	117	123	PF00069	0.610
MOD_Plk_4	165	171	PF00069	0.679
TRG_DiLeu_BaEn_1	165	170	PF01217	0.562
TRG_ENDOCYTIC_2	167	170	PF00928	0.565
TRG_ENDOCYTIC_2	59	62	PF00928	0.596
TRG_NLS_MonoExtC_3	4	9	PF00514	0.665
TRG_NLS_MonoExtN_4	5	10	PF00514	0.664

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S7X2A2	Leishmania donovani	75%	99%
A4I4F1	Leishmania infantum	75%	99%
E9ADV1	Leishmania major	74%	100%
E9ALX9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	74%	99%