Letm1 RBD domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

LETM1 and EF-hand domain-containing protein 1, putative

Species:

Leishmania braziliensis

UniProt:

A4HHA3_LEIBR

TriTrypDb:

LbrM.29.0990 , LBRM2903_290016800

Length:

504

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005743	mitochondrial inner membrane	5	12
GO:0016020	membrane	2	12
GO:0019866	organelle inner membrane	4	12
GO:0031090	organelle membrane	3	12
GO:0031966	mitochondrial membrane	4	12
GO:0110165	cellular anatomical entity	1	12
GO:0005737	cytoplasm	2	2
GO:0005739	mitochondrion	5	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2

Expansion

Sequence features

A4HHA3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HHA3

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	2
GO:0006811	monoatomic ion transport	4	2
GO:0006812	monoatomic cation transport	5	2
GO:0006816	calcium ion transport	7	2
GO:0006851	mitochondrial calcium ion transmembrane transport	4	2
GO:0006873	intracellular monoatomic ion homeostasis	4	1
GO:0006875	obsolete intracellular metal ion homeostasis	6	1
GO:0009987	cellular process	1	2
GO:0019725	cellular homeostasis	2	1
GO:0030001	metal ion transport	6	2
GO:0030003	intracellular monoatomic cation homeostasis	5	1
GO:0034220	monoatomic ion transmembrane transport	3	2
GO:0042592	homeostatic process	3	1
GO:0048878	chemical homeostasis	4	1
GO:0050801	monoatomic ion homeostasis	5	1
GO:0051179	localization	1	2
GO:0051234	establishment of localization	2	2
GO:0055065	obsolete metal ion homeostasis	7	1
GO:0055080	monoatomic cation homeostasis	6	1
GO:0055082	intracellular chemical homeostasis	3	1
GO:0055085	transmembrane transport	2	2
GO:0065007	biological regulation	1	1
GO:0065008	regulation of biological quality	2	1
GO:0070588	calcium ion transmembrane transport	6	2
GO:0098655	monoatomic cation transmembrane transport	4	2
GO:0098660	inorganic ion transmembrane transport	4	2
GO:0098662	inorganic cation transmembrane transport	5	2
GO:0098771	inorganic ion homeostasis	6	1
GO:1990542	mitochondrial transmembrane transport	3	2

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	12
GO:0043021	ribonucleoprotein complex binding	3	12
GO:0043022	ribosome binding	4	12
GO:0044877	protein-containing complex binding	2	12
GO:0005215	transporter activity	1	2
GO:0005432	calcium:sodium antiporter activity	7	2
GO:0005509	calcium ion binding	5	2
GO:0008324	monoatomic cation transmembrane transporter activity	4	2
GO:0015075	monoatomic ion transmembrane transporter activity	3	2
GO:0015081	sodium ion transmembrane transporter activity	6	2
GO:0015085	calcium ion transmembrane transporter activity	6	2
GO:0015291	secondary active transmembrane transporter activity	4	2
GO:0015297	antiporter activity	5	2
GO:0015298	obsolete solute:monoatomic cation antiporter activity	5	2
GO:0015318	inorganic molecular entity transmembrane transporter activity	3	2
GO:0015368	calcium:monoatomic cation antiporter activity	7	2
GO:0022804	active transmembrane transporter activity	3	2
GO:0022853	active monoatomic ion transmembrane transporter activity	4	2
GO:0022857	transmembrane transporter activity	2	2
GO:0022890	inorganic cation transmembrane transporter activity	4	2
GO:0043167	ion binding	2	2
GO:0043169	cation binding	3	2
GO:0046872	metal ion binding	4	2
GO:0046873	metal ion transmembrane transporter activity	5	2
GO:0140828	metal cation:monoatomic cation antiporter activity	6	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	255	259	PF00656	0.352
CLV_C14_Caspase3-7	378	382	PF00656	0.539
CLV_NRD_NRD_1	172	174	PF00675	0.490
CLV_NRD_NRD_1	235	237	PF00675	0.458
CLV_NRD_NRD_1	240	242	PF00675	0.458
CLV_NRD_NRD_1	314	316	PF00675	0.622
CLV_NRD_NRD_1	326	328	PF00675	0.582
CLV_NRD_NRD_1	467	469	PF00675	0.629
CLV_NRD_NRD_1	8	10	PF00675	0.472
CLV_NRD_NRD_1	80	82	PF00675	0.258
CLV_PCSK_KEX2_1	172	174	PF00082	0.490
CLV_PCSK_KEX2_1	235	237	PF00082	0.453
CLV_PCSK_KEX2_1	240	242	PF00082	0.447
CLV_PCSK_KEX2_1	326	328	PF00082	0.631
CLV_PCSK_KEX2_1	403	405	PF00082	0.594
CLV_PCSK_KEX2_1	8	10	PF00082	0.457
CLV_PCSK_KEX2_1	80	82	PF00082	0.262
CLV_PCSK_PC1ET2_1	403	405	PF00082	0.594
CLV_PCSK_PC7_1	236	242	PF00082	0.533
CLV_PCSK_SKI1_1	327	331	PF00082	0.625
CLV_PCSK_SKI1_1	403	407	PF00082	0.550
CLV_PCSK_SKI1_1	453	457	PF00082	0.570
CLV_PCSK_SKI1_1	458	462	PF00082	0.556
CLV_PCSK_SKI1_1	56	60	PF00082	0.348
CLV_PCSK_SKI1_1	70	74	PF00082	0.308
CLV_PCSK_SKI1_1	83	87	PF00082	0.238
CLV_PCSK_SKI1_1	91	95	PF00082	0.258
DEG_APCC_DBOX_1	325	333	PF00400	0.417
DEG_APCC_DBOX_1	339	347	PF00400	0.385
DEG_Nend_Nbox_1	1	3	PF02207	0.613
DEG_SPOP_SBC_1	484	488	PF00917	0.587
DOC_AGCK_PIF_2	443	448	PF00069	0.435
DOC_CKS1_1	474	479	PF01111	0.388
DOC_CYCLIN_RxL_1	80	90	PF00134	0.458
DOC_CYCLIN_yCln2_LP_2	110	116	PF00134	0.315
DOC_MAPK_gen_1	315	323	PF00069	0.432
DOC_MAPK_gen_1	326	332	PF00069	0.377
DOC_MAPK_gen_1	36	43	PF00069	0.622
DOC_MAPK_gen_1	466	473	PF00069	0.296
DOC_MAPK_gen_1	70	78	PF00069	0.535
DOC_MAPK_gen_1	80	86	PF00069	0.458
DOC_MAPK_MEF2A_6	202	211	PF00069	0.293
DOC_PP1_RVXF_1	54	60	PF00149	0.530
DOC_PP1_RVXF_1	61	67	PF00149	0.501
DOC_PP2B_LxvP_1	110	113	PF13499	0.315
DOC_PP2B_LxvP_1	187	190	PF13499	0.279
DOC_PP4_FxxP_1	201	204	PF00568	0.352
DOC_USP7_MATH_1	19	23	PF00917	0.681
DOC_USP7_MATH_1	377	381	PF00917	0.486
DOC_USP7_MATH_1	415	419	PF00917	0.402
DOC_USP7_UBL2_3	32	36	PF12436	0.627
DOC_USP7_UBL2_3	365	369	PF12436	0.476
DOC_USP7_UBL2_3	408	412	PF12436	0.441
DOC_USP7_UBL2_3	485	489	PF12436	0.504
DOC_WW_Pin1_4	228	233	PF00397	0.352
DOC_WW_Pin1_4	473	478	PF00397	0.419
LIG_14-3-3_CanoR_1	275	283	PF00244	0.258
LIG_14-3-3_CanoR_1	3	7	PF00244	0.640
LIG_14-3-3_CanoR_1	315	319	PF00244	0.394
LIG_14-3-3_CanoR_1	340	344	PF00244	0.494
LIG_Actin_WH2_2	34	51	PF00022	0.635
LIG_Actin_WH2_2	57	75	PF00022	0.533
LIG_APCC_ABBA_1	104	109	PF00400	0.315
LIG_APCC_ABBA_1	188	193	PF00400	0.171
LIG_APCC_ABBAyCdc20_2	134	140	PF00400	0.333
LIG_BRCT_BRCA1_1	439	443	PF00533	0.323
LIG_Clathr_ClatBox_1	251	255	PF01394	0.271
LIG_eIF4E_1	52	58	PF01652	0.521
LIG_FHA_1	225	231	PF00498	0.314
LIG_FHA_1	24	30	PF00498	0.725
LIG_FHA_1	278	284	PF00498	0.258
LIG_FHA_1	454	460	PF00498	0.372
LIG_FHA_1	88	94	PF00498	0.458
LIG_FHA_2	343	349	PF00498	0.439
LIG_FHA_2	439	445	PF00498	0.344
LIG_FHA_2	77	83	PF00498	0.458
LIG_LIR_Apic_2	199	204	PF02991	0.307
LIG_LIR_Apic_2	303	309	PF02991	0.247
LIG_LIR_Gen_1	100	110	PF02991	0.315
LIG_LIR_Gen_1	288	294	PF02991	0.249
LIG_LIR_Gen_1	298	309	PF02991	0.257
LIG_LIR_Gen_1	440	450	PF02991	0.348
LIG_LIR_Nem_3	100	105	PF02991	0.299
LIG_LIR_Nem_3	288	293	PF02991	0.251
LIG_LIR_Nem_3	298	304	PF02991	0.257
LIG_LIR_Nem_3	383	389	PF02991	0.450
LIG_LIR_Nem_3	440	446	PF02991	0.335
LIG_MYND_1	120	124	PF01753	0.247
LIG_NRP_CendR_1	503	504	PF00754	0.783
LIG_PCNA_PIPBox_1	390	399	PF02747	0.356
LIG_PCNA_yPIPBox_3	390	404	PF02747	0.358
LIG_Pex14_2	55	59	PF04695	0.530
LIG_SH2_CRK	221	225	PF00017	0.288
LIG_SH2_CRK	40	44	PF00017	0.578
LIG_SH2_STAP1	68	72	PF00017	0.502
LIG_SH2_STAT3	68	71	PF00017	0.508
LIG_SH2_STAT5	154	157	PF00017	0.271
LIG_SH2_STAT5	191	194	PF00017	0.333
LIG_SH2_STAT5	396	399	PF00017	0.341
LIG_SH3_3	226	232	PF00018	0.333
LIG_SH3_3	468	474	PF00018	0.451
LIG_SH3_4	32	39	PF00018	0.594
LIG_Sin3_3	108	115	PF02671	0.334
LIG_TRAF2_1	479	482	PF00917	0.590
LIG_TYR_ITIM	299	304	PF00017	0.247
LIG_TYR_ITIM	43	48	PF00017	0.615
LIG_UBA3_1	405	413	PF00899	0.357
LIG_WRC_WIRS_1	160	165	PF05994	0.258
MOD_CDK_SPK_2	473	478	PF00069	0.379
MOD_CDK_SPxxK_3	228	235	PF00069	0.352
MOD_CK1_1	342	348	PF00069	0.500
MOD_CK1_1	354	360	PF00069	0.522
MOD_CK1_1	495	501	PF00069	0.556
MOD_CK2_1	122	128	PF00069	0.247
MOD_CK2_1	258	264	PF00069	0.173
MOD_CK2_1	342	348	PF00069	0.444
MOD_CK2_1	372	378	PF00069	0.468
MOD_CK2_1	485	491	PF00069	0.561
MOD_CK2_1	76	82	PF00069	0.458
MOD_Cter_Amidation	501	504	PF01082	0.773
MOD_DYRK1A_RPxSP_1	228	232	PF00069	0.352
MOD_GlcNHglycan	155	158	PF01048	0.502
MOD_GlcNHglycan	21	24	PF01048	0.515
MOD_GlcNHglycan	361	364	PF01048	0.692
MOD_GlcNHglycan	375	378	PF01048	0.609
MOD_GSK3_1	122	129	PF00069	0.241
MOD_GSK3_1	15	22	PF00069	0.672
MOD_GSK3_1	155	162	PF00069	0.271
MOD_GSK3_1	220	227	PF00069	0.339
MOD_GSK3_1	310	317	PF00069	0.354
MOD_GSK3_1	335	342	PF00069	0.449
MOD_GSK3_1	373	380	PF00069	0.465
MOD_GSK3_1	415	422	PF00069	0.373
MOD_GSK3_1	429	436	PF00069	0.350
MOD_GSK3_1	449	456	PF00069	0.230
MOD_N-GLC_1	15	20	PF02516	0.369
MOD_N-GLC_1	268	273	PF02516	0.516
MOD_N-GLC_1	433	438	PF02516	0.616
MOD_NEK2_1	1	6	PF00069	0.598
MOD_NEK2_1	155	160	PF00069	0.261
MOD_NEK2_1	176	181	PF00069	0.301
MOD_NEK2_1	211	216	PF00069	0.251
MOD_NEK2_1	234	239	PF00069	0.322
MOD_NEK2_1	59	64	PF00069	0.532
MOD_NEK2_1	85	90	PF00069	0.458
MOD_NEK2_2	141	146	PF00069	0.271
MOD_NEK2_2	279	284	PF00069	0.311
MOD_PIKK_1	128	134	PF00454	0.248
MOD_PIKK_1	23	29	PF00454	0.707
MOD_PKA_2	2	8	PF00069	0.595
MOD_PKA_2	234	240	PF00069	0.345
MOD_PKA_2	274	280	PF00069	0.258
MOD_PKA_2	310	316	PF00069	0.353
MOD_PKA_2	339	345	PF00069	0.463
MOD_Plk_1	415	421	PF00069	0.381
MOD_Plk_1	433	439	PF00069	0.304
MOD_Plk_2-3	492	498	PF00069	0.573
MOD_Plk_4	196	202	PF00069	0.225
MOD_Plk_4	2	8	PF00069	0.645
MOD_Plk_4	220	226	PF00069	0.281
MOD_Plk_4	300	306	PF00069	0.247
MOD_Plk_4	415	421	PF00069	0.444
MOD_Plk_4	438	444	PF00069	0.342
MOD_ProDKin_1	228	234	PF00069	0.352
MOD_ProDKin_1	473	479	PF00069	0.423
MOD_SUMO_rev_2	475	484	PF00179	0.565
MOD_SUMO_rev_2	486	496	PF00179	0.563
TRG_DiLeu_BaEn_1	247	252	PF01217	0.271
TRG_DiLeu_BaLyEn_6	80	85	PF01217	0.471
TRG_DiLeu_LyEn_5	247	252	PF01217	0.271
TRG_ENDOCYTIC_2	221	224	PF00928	0.254
TRG_ENDOCYTIC_2	301	304	PF00928	0.247
TRG_ENDOCYTIC_2	40	43	PF00928	0.559
TRG_ENDOCYTIC_2	45	48	PF00928	0.519
TRG_ENDOCYTIC_2	52	55	PF00928	0.419
TRG_ER_diArg_1	134	137	PF00400	0.286
TRG_ER_diArg_1	145	148	PF00400	0.205
TRG_ER_diArg_1	171	173	PF00400	0.289
TRG_ER_diArg_1	234	236	PF00400	0.258
TRG_ER_diArg_1	239	241	PF00400	0.258
TRG_ER_diArg_1	7	9	PF00400	0.672
TRG_NLS_MonoExtC_3	410	415	PF00514	0.493
TRG_NLS_MonoExtN_4	408	415	PF00514	0.418
TRG_Pf-PMV_PEXEL_1	412	416	PF00026	0.699
TRG_Pf-PMV_PEXEL_1	83	87	PF00026	0.258

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PD73	Leptomonas seymouri	84%	99%
A0A0S4JFV9	Bodo saltans	52%	100%
A0A1X0NZY3	Trypanosomatidae	63%	100%
A0A3S5IR30	Trypanosoma rangeli	62%	100%
A0A3S7X2D5	Leishmania donovani	94%	100%
A4I4E9	Leishmania infantum	94%	100%
C9ZLK0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	60%	100%
E9ADU9	Leishmania major	94%	99%
E9ALY1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	100%
Q5ZK33	Gallus gallus	32%	67%
Q7TNU7	Mus musculus	29%	100%
V5DI32	Trypanosoma cruzi	64%	100%