Putative signal peptide peptidase

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

signal peptide peptidase, putative

Species:

Leishmania braziliensis

UniProt:

A4HHA2_LEIBR

TriTrypDb:

LbrM.29.0980 , LBRM2903_290016700

Length:

306

Annotations

LeishMANIAdb annotations

Orthologous to animal ER-localized signal peptide peptidases, including minor histocompatibility antigen H13.. Localization: ER (by homology)

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

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Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	10
GO:0110165	cellular anatomical entity	1	10

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Expansion

Sequence features

A4HHA2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HHA2

Function

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Biological processes
Term	Name	Level	Count
GO:0006465	signal peptide processing	5	1
GO:0006508	proteolysis	4	1
GO:0006518	peptide metabolic process	4	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0016485	protein processing	5	1
GO:0019538	protein metabolic process	3	1
GO:0033619	membrane protein proteolysis	5	1
GO:0043170	macromolecule metabolic process	3	1
GO:0043603	amide metabolic process	3	1

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Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	11
GO:0004175	endopeptidase activity	4	11
GO:0004190	aspartic-type endopeptidase activity	5	11
GO:0008233	peptidase activity	3	11
GO:0016787	hydrolase activity	2	11
GO:0042500	aspartic endopeptidase activity, intramembrane cleaving	6	1
GO:0070001	aspartic-type peptidase activity	4	11
GO:0140096	catalytic activity, acting on a protein	2	11

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	139	143	PF00656	0.255
CLV_NRD_NRD_1	295	297	PF00675	0.503
CLV_PCSK_KEX2_1	187	189	PF00082	0.251
CLV_PCSK_PC1ET2_1	187	189	PF00082	0.224
CLV_PCSK_SKI1_1	146	150	PF00082	0.426
CLV_PCSK_SKI1_1	160	164	PF00082	0.311
DEG_Nend_UBRbox_1	1	4	PF02207	0.522
DEG_SPOP_SBC_1	253	257	PF00917	0.525
DOC_CDC14_PxL_1	222	230	PF14671	0.258
DOC_CYCLIN_yClb1_LxF_4	144	149	PF00134	0.275

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I7Y2	Leptomonas seymouri	64%	90%
A0A0S4JJ36	Bodo saltans	50%	81%
A0A1X0P170	Trypanosomatidae	59%	86%
A0A3Q8IDL5	Leishmania donovani	85%	99%
A0A3R7NBZ0	Trypanosoma rangeli	59%	100%
A4I4E8	Leishmania infantum	85%	99%
B9FJ61	Oryza sativa subsp. japonica	38%	89%
C9ZLJ9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	54%	87%
E9ADU8	Leishmania major	85%	100%
E9ALY2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	99%

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