Putative signal peptide peptidase

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

signal peptide peptidase, putative

Species:

Leishmania braziliensis

UniProt:

A4HHA2_LEIBR

TriTrypDb:

LbrM.29.0980 , LBRM2903_290016700

Length:

306

Annotations

LeishMANIAdb annotations

Orthologous to animal ER-localized signal peptide peptidases, including minor histocompatibility antigen H13.. Localization: ER (by homology)

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	10
GO:0110165	cellular anatomical entity	1	10

Expansion

Sequence features

A4HHA2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HHA2

Function

Biological processes
Term	Name	Level	Count
GO:0006465	signal peptide processing	5	1
GO:0006508	proteolysis	4	1
GO:0006518	peptide metabolic process	4	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0016485	protein processing	5	1
GO:0019538	protein metabolic process	3	1
GO:0033619	membrane protein proteolysis	5	1
GO:0043170	macromolecule metabolic process	3	1
GO:0043603	amide metabolic process	3	1
GO:0044238	primary metabolic process	2	1
GO:0051604	protein maturation	4	1
GO:0071704	organic substance metabolic process	2	1
GO:1901564	organonitrogen compound metabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	11
GO:0004175	endopeptidase activity	4	11
GO:0004190	aspartic-type endopeptidase activity	5	11
GO:0008233	peptidase activity	3	11
GO:0016787	hydrolase activity	2	11
GO:0070001	aspartic-type peptidase activity	4	11
GO:0140096	catalytic activity, acting on a protein	2	11
GO:0042500	aspartic endopeptidase activity, intramembrane cleaving	6	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	139	143	PF00656	0.255
CLV_NRD_NRD_1	295	297	PF00675	0.503
CLV_PCSK_KEX2_1	187	189	PF00082	0.251
CLV_PCSK_PC1ET2_1	187	189	PF00082	0.224
CLV_PCSK_SKI1_1	146	150	PF00082	0.426
CLV_PCSK_SKI1_1	160	164	PF00082	0.311
DEG_Nend_UBRbox_1	1	4	PF02207	0.522
DEG_SPOP_SBC_1	253	257	PF00917	0.525
DOC_CDC14_PxL_1	222	230	PF14671	0.258
DOC_CYCLIN_yClb1_LxF_4	144	149	PF00134	0.275
DOC_MAPK_gen_1	159	165	PF00069	0.316
DOC_MAPK_gen_1	187	193	PF00069	0.475
DOC_MAPK_gen_1	2	9	PF00069	0.600
DOC_MAPK_MEF2A_6	37	46	PF00069	0.280
DOC_PP1_RVXF_1	144	150	PF00149	0.251
DOC_PP2B_LxvP_1	15	18	PF13499	0.337
DOC_PP4_FxxP_1	223	226	PF00568	0.277
DOC_USP7_UBL2_3	183	187	PF12436	0.490
DOC_USP7_UBL2_3	61	65	PF12436	0.591
LIG_AP2alpha_1	122	126	PF02296	0.277
LIG_BRCT_BRCA1_1	282	286	PF00533	0.466
LIG_BRCT_BRCA1_1	30	34	PF00533	0.343
LIG_deltaCOP1_diTrp_1	103	110	PF00928	0.175
LIG_deltaCOP1_diTrp_1	124	129	PF00928	0.258
LIG_EH1_1	191	199	PF00400	0.490
LIG_eIF4E_1	157	163	PF01652	0.160
LIG_FHA_1	110	116	PF00498	0.475
LIG_FHA_1	193	199	PF00498	0.453
LIG_FHA_1	205	211	PF00498	0.210
LIG_FHA_1	68	74	PF00498	0.413
LIG_FHA_2	137	143	PF00498	0.266
LIG_FHA_2	254	260	PF00498	0.589
LIG_FHA_2	98	104	PF00498	0.388
LIG_LIR_Gen_1	111	122	PF02991	0.434
LIG_LIR_Gen_1	231	238	PF02991	0.401
LIG_LIR_Gen_1	27	36	PF02991	0.287
LIG_LIR_Gen_1	38	48	PF02991	0.203
LIG_LIR_Nem_3	101	107	PF02991	0.299
LIG_LIR_Nem_3	111	117	PF02991	0.421
LIG_LIR_Nem_3	124	129	PF02991	0.229
LIG_LIR_Nem_3	152	157	PF02991	0.160
LIG_LIR_Nem_3	231	235	PF02991	0.401
LIG_LIR_Nem_3	27	32	PF02991	0.287
LIG_LIR_Nem_3	283	289	PF02991	0.513
LIG_LIR_Nem_3	38	43	PF02991	0.203
LIG_PCNA_yPIPBox_3	243	254	PF02747	0.378
LIG_Pex14_2	110	114	PF04695	0.433
LIG_Pex14_2	122	126	PF04695	0.277
LIG_Pex14_2	223	227	PF04695	0.310
LIG_Pex14_2	83	87	PF04695	0.437
LIG_SH2_GRB2like	39	42	PF00017	0.233
LIG_SH2_PTP2	29	32	PF00017	0.258
LIG_SH2_PTP2	63	66	PF00017	0.592
LIG_SH2_STAP1	123	127	PF00017	0.258
LIG_SH2_STAP1	200	204	PF00017	0.302
LIG_SH2_STAT5	185	188	PF00017	0.423
LIG_SH2_STAT5	192	195	PF00017	0.413
LIG_SH2_STAT5	200	203	PF00017	0.238
LIG_SH2_STAT5	29	32	PF00017	0.258
LIG_SH2_STAT5	39	42	PF00017	0.219
LIG_SH2_STAT5	47	50	PF00017	0.258
LIG_SH2_STAT5	63	66	PF00017	0.499
LIG_SUMO_SIM_anti_2	111	119	PF11976	0.434
LIG_SUMO_SIM_anti_2	131	137	PF11976	0.123
LIG_SUMO_SIM_anti_2	201	207	PF11976	0.314
LIG_SUMO_SIM_par_1	131	139	PF11976	0.233
LIG_TRAF2_1	268	271	PF00917	0.670
LIG_WRC_WIRS_1	229	234	PF05994	0.315
LIG_WRC_WIRS_1	43	48	PF05994	0.323
MOD_CK1_1	158	164	PF00069	0.280
MOD_CK1_1	49	55	PF00069	0.334
MOD_CK2_1	253	259	PF00069	0.605
MOD_CK2_1	97	103	PF00069	0.388
MOD_GlcNHglycan	232	235	PF01048	0.343
MOD_GSK3_1	175	182	PF00069	0.277
MOD_GSK3_1	200	207	PF00069	0.279
MOD_GSK3_1	24	31	PF00069	0.424
MOD_GSK3_1	42	49	PF00069	0.143
MOD_GSK3_1	74	81	PF00069	0.352
MOD_GSK3_1	89	96	PF00069	0.229
MOD_NEK2_1	110	115	PF00069	0.365
MOD_NEK2_1	19	24	PF00069	0.277
MOD_NEK2_1	193	198	PF00069	0.462
MOD_NEK2_1	204	209	PF00069	0.216
MOD_NEK2_1	228	233	PF00069	0.266
MOD_NEK2_1	28	33	PF00069	0.266
MOD_NEK2_1	46	51	PF00069	0.190
MOD_NEK2_1	93	98	PF00069	0.308
MOD_NEK2_2	78	83	PF00069	0.343
MOD_Plk_1	270	276	PF00069	0.615
MOD_Plk_4	110	116	PF00069	0.433
MOD_Plk_4	149	155	PF00069	0.248
MOD_Plk_4	158	164	PF00069	0.191
MOD_Plk_4	175	181	PF00069	0.258
MOD_Plk_4	19	25	PF00069	0.277
MOD_Plk_4	193	199	PF00069	0.368
MOD_Plk_4	200	206	PF00069	0.250
MOD_Plk_4	78	84	PF00069	0.462
MOD_SUMO_rev_2	290	299	PF00179	0.635
TRG_DiLeu_BaEn_4	269	275	PF01217	0.495
TRG_ENDOCYTIC_2	123	126	PF00928	0.258
TRG_ENDOCYTIC_2	29	32	PF00928	0.258
TRG_ENDOCYTIC_2	39	42	PF00928	0.219
TRG_ER_diLys_1	303	306	PF00400	0.618
TRG_Pf-PMV_PEXEL_1	276	280	PF00026	0.390

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I7Y2	Leptomonas seymouri	64%	90%
A0A0S4JJ36	Bodo saltans	50%	81%
A0A1X0P170	Trypanosomatidae	59%	86%
A0A3Q8IDL5	Leishmania donovani	85%	99%
A0A3R7NBZ0	Trypanosoma rangeli	59%	100%
A4I4E8	Leishmania infantum	85%	99%
B9FJ61	Oryza sativa subsp. japonica	38%	89%
C9ZLJ9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	54%	87%
E9ADU8	Leishmania major	85%	100%
E9ALY2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	99%
O81062	Arabidopsis thaliana	35%	89%
Q6ZGL9	Oryza sativa subsp. japonica	40%	89%
Q8TCT6	Homo sapiens	27%	80%
Q8TCT9	Homo sapiens	31%	81%
Q93Z32	Arabidopsis thaliana	27%	82%
Q9CUS9	Mus musculus	27%	80%
Q9D8V0	Mus musculus	32%	81%
Q9UTA3	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	32%	100%