tRNA isopentenyltransferase 1

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

IPP transferase, putative

Species:

Leishmania braziliensis

UniProt:

A4HHA1_LEIBR

TriTrypDb:

LbrM.29.0970 , LBRM2903_290016600

Length:

215

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005739	mitochondrion	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HHA1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HHA1

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	1
GO:0006396	RNA processing	6	1
GO:0006399	tRNA metabolic process	7	1
GO:0006400	tRNA modification	6	1
GO:0006725	cellular aromatic compound metabolic process	3	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008033	tRNA processing	8	1
GO:0008152	metabolic process	1	1
GO:0009451	RNA modification	5	1
GO:0009987	cellular process	1	1
GO:0016070	RNA metabolic process	5	1
GO:0034470	ncRNA processing	7	1
GO:0034641	cellular nitrogen compound metabolic process	3	1
GO:0034660	ncRNA metabolic process	6	1
GO:0043170	macromolecule metabolic process	3	1
GO:0043412	macromolecule modification	4	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0046483	heterocycle metabolic process	3	1
GO:0071704	organic substance metabolic process	2	1
GO:0090304	nucleic acid metabolic process	4	1
GO:1901360	organic cyclic compound metabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	2
GO:0016740	transferase activity	2	2
GO:0016765	transferase activity, transferring alkyl or aryl (other than methyl) groups	3	1
GO:0052381	tRNA dimethylallyltransferase activity	4	1
GO:0140098	catalytic activity, acting on RNA	3	1
GO:0140101	catalytic activity, acting on a tRNA	4	1
GO:0140640	catalytic activity, acting on a nucleic acid	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	12	14	PF00675	0.338
CLV_NRD_NRD_1	190	192	PF00675	0.489
CLV_NRD_NRD_1	210	212	PF00675	0.445
CLV_NRD_NRD_1	80	82	PF00675	0.302
CLV_PCSK_KEX2_1	12	14	PF00082	0.328
CLV_PCSK_KEX2_1	183	185	PF00082	0.299
CLV_PCSK_KEX2_1	190	192	PF00082	0.506
CLV_PCSK_KEX2_1	2	4	PF00082	0.420
CLV_PCSK_KEX2_1	210	212	PF00082	0.446
CLV_PCSK_KEX2_1	80	82	PF00082	0.302
CLV_PCSK_PC1ET2_1	183	185	PF00082	0.293
CLV_PCSK_PC1ET2_1	2	4	PF00082	0.222
CLV_PCSK_PC1ET2_1	210	212	PF00082	0.558
CLV_PCSK_PC7_1	186	192	PF00082	0.488
CLV_PCSK_PC7_1	76	82	PF00082	0.222
CLV_PCSK_SKI1_1	191	195	PF00082	0.473
CLV_PCSK_SKI1_1	20	24	PF00082	0.209
CLV_PCSK_SKI1_1	3	7	PF00082	0.454
DEG_APCC_DBOX_1	185	193	PF00400	0.434
DEG_APCC_DBOX_1	19	27	PF00400	0.290
DEG_Nend_UBRbox_1	1	4	PF02207	0.223
DOC_CYCLIN_RxL_1	88	101	PF00134	0.483
DOC_CYCLIN_yCln2_LP_2	141	147	PF00134	0.442
DOC_MAPK_gen_1	12	18	PF00069	0.364
DOC_PP2B_LxvP_1	206	209	PF13499	0.480
DOC_PP4_FxxP_1	204	207	PF00568	0.404
DOC_USP7_MATH_1	38	42	PF00917	0.302
DOC_USP7_UBL2_3	32	36	PF12436	0.454
DOC_WW_Pin1_4	98	103	PF00397	0.350
LIG_14-3-3_CanoR_1	39	43	PF00244	0.316
LIG_Actin_WH2_2	118	136	PF00022	0.389
LIG_Actin_WH2_2	19	34	PF00022	0.338
LIG_BRCT_BRCA1_1	51	55	PF00533	0.364
LIG_FHA_1	106	112	PF00498	0.486
LIG_FHA_2	62	68	PF00498	0.328
LIG_LIR_Gen_1	108	115	PF02991	0.490
LIG_LIR_Gen_1	4	14	PF02991	0.222
LIG_LIR_Gen_1	50	55	PF02991	0.364
LIG_LIR_Nem_3	108	113	PF02991	0.487
LIG_LIR_Nem_3	4	10	PF02991	0.222
LIG_LIR_Nem_3	50	54	PF02991	0.302
LIG_MLH1_MIPbox_1	51	55	PF16413	0.364
LIG_NRBOX	128	134	PF00104	0.535
LIG_PCNA_yPIPBox_3	126	139	PF02747	0.415
LIG_Pex14_2	110	114	PF04695	0.540
LIG_Pex14_2	51	55	PF04695	0.302
LIG_Rb_LxCxE_1	41	64	PF01857	0.302
LIG_SH2_CRK	7	11	PF00017	0.222
LIG_SH2_STAT3	82	85	PF00017	0.302
LIG_SH3_2	144	149	PF14604	0.423
LIG_SH3_3	141	147	PF00018	0.485
LIG_SUMO_SIM_par_1	56	67	PF11976	0.222
LIG_TRFH_1	204	208	PF08558	0.410
LIG_TYR_ITIM	5	10	PF00017	0.222
LIG_UBA3_1	145	149	PF00899	0.564
LIG_WRC_WIRS_1	6	11	PF05994	0.261
MOD_CDC14_SPxK_1	101	104	PF00782	0.369
MOD_CDK_SPxK_1	98	104	PF00069	0.354
MOD_CK2_1	194	200	PF00069	0.493
MOD_CK2_1	38	44	PF00069	0.276
MOD_CK2_1	63	69	PF00069	0.326
MOD_GlcNHglycan	135	138	PF01048	0.622
MOD_GlcNHglycan	32	35	PF01048	0.261
MOD_GSK3_1	121	128	PF00069	0.508
MOD_GSK3_1	49	56	PF00069	0.370
MOD_NEK2_1	194	199	PF00069	0.348
MOD_NEK2_1	54	59	PF00069	0.258
MOD_NEK2_1	61	66	PF00069	0.236
MOD_NEK2_1	97	102	PF00069	0.465
MOD_PIKK_1	156	162	PF00454	0.500
MOD_PIKK_1	49	55	PF00454	0.364
MOD_PKA_2	133	139	PF00069	0.442
MOD_PKA_2	185	191	PF00069	0.493
MOD_PKA_2	38	44	PF00069	0.308
MOD_Plk_1	49	55	PF00069	0.370
MOD_Plk_4	5	11	PF00069	0.279
MOD_ProDKin_1	98	104	PF00069	0.354
MOD_SUMO_rev_2	24	29	PF00179	0.222
TRG_DiLeu_BaLyEn_6	57	62	PF01217	0.222
TRG_DiLeu_BaLyEn_6	90	95	PF01217	0.307
TRG_ENDOCYTIC_2	7	10	PF00928	0.222
TRG_ER_diArg_1	12	14	PF00400	0.332
TRG_ER_diArg_1	189	191	PF00400	0.490
TRG_ER_diArg_1	80	82	PF00400	0.347
TRG_ER_diLys_1	210	215	PF00400	0.638
TRG_NLS_MonoCore_2	209	214	PF00514	0.558
TRG_NLS_MonoExtN_4	181	187	PF00514	0.471
TRG_NLS_MonoExtN_4	207	214	PF00514	0.590
TRG_Pf-PMV_PEXEL_1	139	143	PF00026	0.460
TRG_Pf-PMV_PEXEL_1	190	195	PF00026	0.448

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PDI4	Leptomonas seymouri	54%	100%
A0A3Q8IIN6	Leishmania donovani	80%	100%
A4I4E7	Leishmania infantum	80%	100%
E9ADU7	Leishmania major	82%	100%
E9ALY3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	79%	100%