Solute carrier family 35 member F1

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Eukaryotic protein of unknown function (DUF914), putative

Species:

Leishmania braziliensis

UniProt:

A4HHA0_LEIBR

TriTrypDb:

LbrM.29.0960 , LBRM2903_290016500

Length:

451

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	12
GO:0110165	cellular anatomical entity	1	12

Expansion

Sequence features

A4HHA0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HHA0

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005215	transporter activity	1	12
GO:0022857	transmembrane transporter activity	2	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_PCSK_KEX2_1	17	19	PF00082	0.282
CLV_PCSK_PC1ET2_1	17	19	PF00082	0.312
CLV_PCSK_SKI1_1	18	22	PF00082	0.304
CLV_PCSK_SKI1_1	220	224	PF00082	0.599
CLV_PCSK_SKI1_1	285	289	PF00082	0.338
CLV_PCSK_SKI1_1	353	357	PF00082	0.409
DEG_APCC_KENBOX_2	391	395	PF00400	0.536
DEG_MDM2_SWIB_1	84	92	PF02201	0.473
DOC_CKS1_1	201	206	PF01111	0.317
DOC_CYCLIN_yClb1_LxF_4	351	356	PF00134	0.538
DOC_MAPK_gen_1	86	95	PF00069	0.476
DOC_PP1_RVXF_1	351	357	PF00149	0.528
DOC_PP4_FxxP_1	122	125	PF00568	0.320
DOC_PP4_FxxP_1	198	201	PF00568	0.276
DOC_USP7_MATH_1	222	226	PF00917	0.529
DOC_USP7_MATH_1	265	269	PF00917	0.399
DOC_USP7_MATH_1	289	293	PF00917	0.521
DOC_USP7_UBL2_3	13	17	PF12436	0.436
DOC_USP7_UBL2_3	392	396	PF12436	0.363
DOC_WW_Pin1_4	200	205	PF00397	0.446
LIG_14-3-3_CanoR_1	220	228	PF00244	0.539
LIG_14-3-3_CanoR_1	291	295	PF00244	0.538
LIG_AP2alpha_2	389	391	PF02296	0.486
LIG_BIR_III_4	161	165	PF00653	0.252
LIG_BIR_III_4	432	436	PF00653	0.517
LIG_BRCT_BRCA1_1	323	327	PF00533	0.287
LIG_BRCT_BRCA1_1	5	9	PF00533	0.708
LIG_BRCT_BRCA1_1	74	78	PF00533	0.376
LIG_Clathr_ClatBox_1	157	161	PF01394	0.304
LIG_deltaCOP1_diTrp_1	283	287	PF00928	0.463
LIG_deltaCOP1_diTrp_1	298	305	PF00928	0.463
LIG_EH1_1	304	312	PF00400	0.451
LIG_eIF4E_1	62	68	PF01652	0.334
LIG_FHA_1	140	146	PF00498	0.351
LIG_FHA_1	188	194	PF00498	0.292
LIG_FHA_1	222	228	PF00498	0.488
LIG_FHA_1	306	312	PF00498	0.451
LIG_FHA_1	332	338	PF00498	0.389
LIG_FHA_1	34	40	PF00498	0.304
LIG_FHA_1	370	376	PF00498	0.521
LIG_FHA_1	432	438	PF00498	0.559
LIG_FHA_2	236	242	PF00498	0.382
LIG_FHA_2	293	299	PF00498	0.478
LIG_FHA_2	419	425	PF00498	0.522
LIG_FHA_2	9	15	PF00498	0.644
LIG_GBD_Chelix_1	363	371	PF00786	0.333
LIG_LIR_Apic_2	195	201	PF02991	0.278
LIG_LIR_Gen_1	268	277	PF02991	0.374
LIG_LIR_Gen_1	298	309	PF02991	0.486
LIG_LIR_Gen_1	324	335	PF02991	0.263
LIG_LIR_Gen_1	358	367	PF02991	0.339
LIG_LIR_Gen_1	53	63	PF02991	0.310
LIG_LIR_Gen_1	75	84	PF02991	0.510
LIG_LIR_Gen_1	99	110	PF02991	0.360
LIG_LIR_Nem_3	131	135	PF02991	0.327
LIG_LIR_Nem_3	255	260	PF02991	0.377
LIG_LIR_Nem_3	268	273	PF02991	0.339
LIG_LIR_Nem_3	276	282	PF02991	0.291
LIG_LIR_Nem_3	283	287	PF02991	0.392
LIG_LIR_Nem_3	298	304	PF02991	0.452
LIG_LIR_Nem_3	30	34	PF02991	0.290
LIG_LIR_Nem_3	324	330	PF02991	0.252
LIG_LIR_Nem_3	345	350	PF02991	0.351
LIG_LIR_Nem_3	358	362	PF02991	0.300
LIG_LIR_Nem_3	45	49	PF02991	0.257
LIG_LIR_Nem_3	53	58	PF02991	0.306
LIG_LIR_Nem_3	6	12	PF02991	0.684
LIG_LIR_Nem_3	75	81	PF02991	0.492
LIG_LIR_Nem_3	99	105	PF02991	0.240
LIG_LYPXL_yS_3	46	49	PF13949	0.276
LIG_Pex14_2	27	31	PF04695	0.198
LIG_Pex14_2	270	274	PF04695	0.343
LIG_Pex14_2	280	284	PF04695	0.263
LIG_Pex14_2	301	305	PF04695	0.389
LIG_Pex14_2	379	383	PF04695	0.451
LIG_Pex14_2	59	63	PF04695	0.391
LIG_Pex14_2	83	87	PF04695	0.478
LIG_PTB_Apo_2	77	84	PF02174	0.492
LIG_REV1ctd_RIR_1	130	140	PF16727	0.361
LIG_REV1ctd_RIR_1	81	90	PF16727	0.490
LIG_SH2_CRK	359	363	PF00017	0.366
LIG_SH2_CRK	55	59	PF00017	0.328
LIG_SH2_CRK	90	94	PF00017	0.339
LIG_SH2_GRB2like	110	113	PF00017	0.338
LIG_SH2_PTP2	102	105	PF00017	0.389
LIG_SH2_SRC	338	341	PF00017	0.354
LIG_SH2_SRC	359	362	PF00017	0.328
LIG_SH2_STAP1	338	342	PF00017	0.316
LIG_SH2_STAP1	359	363	PF00017	0.333
LIG_SH2_STAP1	55	59	PF00017	0.328
LIG_SH2_STAP1	90	94	PF00017	0.389
LIG_SH2_STAT3	73	76	PF00017	0.446
LIG_SH2_STAT5	102	105	PF00017	0.327
LIG_SH2_STAT5	110	113	PF00017	0.219
LIG_SH2_STAT5	313	316	PF00017	0.304
LIG_SH2_STAT5	62	65	PF00017	0.340
LIG_SH3_3	198	204	PF00018	0.345
LIG_SH3_3	372	378	PF00018	0.471
LIG_SH3_3	58	64	PF00018	0.240
LIG_SUMO_SIM_par_1	126	131	PF11976	0.219
LIG_SUMO_SIM_par_1	156	161	PF11976	0.307
LIG_SUMO_SIM_par_1	308	314	PF11976	0.389
LIG_SUMO_SIM_par_1	91	97	PF11976	0.389
LIG_TYR_ITIM	357	362	PF00017	0.361
LIG_TYR_ITSM	51	58	PF00017	0.304
LIG_UBA3_1	134	138	PF00899	0.501
LIG_UBA3_1	346	353	PF00899	0.405
LIG_UBA3_1	67	72	PF00899	0.424
LIG_WRC_WIRS_1	129	134	PF05994	0.339
LIG_WRC_WIRS_1	267	272	PF05994	0.431
LIG_WRC_WIRS_1	28	33	PF05994	0.283
MOD_CK1_1	216	222	PF00069	0.467
MOD_CK1_1	292	298	PF00069	0.487
MOD_CK1_1	331	337	PF00069	0.331
MOD_CK1_1	422	428	PF00069	0.558
MOD_CK2_1	418	424	PF00069	0.439
MOD_CK2_1	445	451	PF00069	0.539
MOD_CK2_1	8	14	PF00069	0.611
MOD_Cter_Amidation	394	397	PF01082	0.755
MOD_GlcNHglycan	167	170	PF01048	0.406
MOD_GlcNHglycan	224	227	PF01048	0.727
MOD_GlcNHglycan	228	231	PF01048	0.745
MOD_GlcNHglycan	254	257	PF01048	0.590
MOD_GlcNHglycan	323	326	PF01048	0.452
MOD_GlcNHglycan	426	429	PF01048	0.764
MOD_GlcNHglycan	438	441	PF01048	0.718
MOD_GSK3_1	108	115	PF00069	0.243
MOD_GSK3_1	188	195	PF00069	0.302
MOD_GSK3_1	216	223	PF00069	0.435
MOD_GSK3_1	29	36	PF00069	0.309
MOD_GSK3_1	418	425	PF00069	0.563
MOD_GSK3_1	431	438	PF00069	0.541
MOD_GSK3_1	72	79	PF00069	0.476
MOD_N-GLC_1	111	116	PF02516	0.376
MOD_N-GLC_1	213	218	PF02516	0.660
MOD_N-GLC_1	220	225	PF02516	0.625
MOD_N-GLC_1	289	294	PF02516	0.326
MOD_N-GLC_1	328	333	PF02516	0.304
MOD_N-GLC_1	342	347	PF02516	0.320
MOD_N-GLC_1	369	374	PF02516	0.522
MOD_N-GLC_1	42	47	PF02516	0.462
MOD_NEK2_1	128	133	PF00069	0.307
MOD_NEK2_1	139	144	PF00069	0.463
MOD_NEK2_1	165	170	PF00069	0.230
MOD_NEK2_1	182	187	PF00069	0.276
MOD_NEK2_1	206	211	PF00069	0.506
MOD_NEK2_1	252	257	PF00069	0.474
MOD_NEK2_1	266	271	PF00069	0.394
MOD_NEK2_1	27	32	PF00069	0.320
MOD_NEK2_1	272	277	PF00069	0.340
MOD_NEK2_1	305	310	PF00069	0.319
MOD_NEK2_1	311	316	PF00069	0.304
MOD_NEK2_1	320	325	PF00069	0.304
MOD_NEK2_1	355	360	PF00069	0.321
MOD_NEK2_1	445	450	PF00069	0.503
MOD_NEK2_2	342	347	PF00069	0.320
MOD_NEK2_2	8	13	PF00069	0.574
MOD_OFUCOSY	210	217	PF10250	0.542
MOD_PIKK_1	445	451	PF00454	0.515
MOD_PIKK_1	72	78	PF00454	0.376
MOD_PKA_2	290	296	PF00069	0.512
MOD_PKA_2	435	441	PF00069	0.488
MOD_Plk_1	111	117	PF00069	0.273
MOD_Plk_1	289	295	PF00069	0.488
MOD_Plk_1	328	334	PF00069	0.304
MOD_Plk_1	342	348	PF00069	0.320
MOD_Plk_1	42	48	PF00069	0.242
MOD_Plk_2-3	399	405	PF00069	0.475
MOD_Plk_4	128	134	PF00069	0.303
MOD_Plk_4	182	188	PF00069	0.325
MOD_Plk_4	305	311	PF00069	0.311
MOD_Plk_4	342	348	PF00069	0.335
MOD_ProDKin_1	200	206	PF00069	0.453
TRG_ENDOCYTIC_2	102	105	PF00928	0.320
TRG_ENDOCYTIC_2	110	113	PF00928	0.214
TRG_ENDOCYTIC_2	313	316	PF00928	0.347
TRG_ENDOCYTIC_2	338	341	PF00928	0.304
TRG_ENDOCYTIC_2	359	362	PF00928	0.304
TRG_ENDOCYTIC_2	46	49	PF00928	0.256
TRG_ENDOCYTIC_2	55	58	PF00928	0.293
TRG_ENDOCYTIC_2	62	65	PF00928	0.276
TRG_ENDOCYTIC_2	90	93	PF00928	0.343

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P8D2	Leptomonas seymouri	64%	100%
A0A0S4ISV7	Bodo saltans	41%	100%
A0A1X0PAA4	Trypanosomatidae	51%	100%
A0A3S7X2D4	Leishmania donovani	79%	100%
A0A422NJ67	Trypanosoma rangeli	48%	100%
A4I4E6	Leishmania infantum	79%	100%
C9ZLM2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	47%	100%
E9ADU6	Leishmania major	78%	100%
E9ALY4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	78%	100%
O59785	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	24%	89%
Q0V9U2	Xenopus tropicalis	25%	100%
V5BCU4	Trypanosoma cruzi	46%	100%