Phytanoyl-CoA dioxygenase family protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

phytanoyl-CoA dioxygenase (PhyH), putative

Species:

Leishmania braziliensis

UniProt:

A4HH99_LEIBR

TriTrypDb:

LbrM.29.0950 , LBRM2903_290016100

Length:

350

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005654	nucleoplasm	2	1
GO:0005730	nucleolus	5	1
GO:0005737	cytoplasm	2	1
GO:0043226	organelle	2	1
GO:0043228	non-membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043232	intracellular non-membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HH99

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HH99

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	2
GO:0043167	ion binding	2	2
GO:0043169	cation binding	3	2
GO:0046872	metal ion binding	4	2
GO:0003824	catalytic activity	1	1
GO:0016491	oxidoreductase activity	2	1
GO:0051213	dioxygenase activity	3	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	132	136	PF00656	0.330
CLV_NRD_NRD_1	259	261	PF00675	0.507
CLV_NRD_NRD_1	311	313	PF00675	0.571
CLV_NRD_NRD_1	337	339	PF00675	0.403
CLV_PCSK_FUR_1	314	318	PF00082	0.415
CLV_PCSK_KEX2_1	258	260	PF00082	0.585
CLV_PCSK_KEX2_1	313	315	PF00082	0.539
CLV_PCSK_KEX2_1	316	318	PF00082	0.487
CLV_PCSK_KEX2_1	336	338	PF00082	0.407
CLV_PCSK_KEX2_1	98	100	PF00082	0.382
CLV_PCSK_PC1ET2_1	313	315	PF00082	0.564
CLV_PCSK_PC1ET2_1	316	318	PF00082	0.550
CLV_PCSK_PC1ET2_1	336	338	PF00082	0.404
CLV_PCSK_PC1ET2_1	98	100	PF00082	0.278
CLV_PCSK_PC7_1	312	318	PF00082	0.476
CLV_PCSK_PC7_1	332	338	PF00082	0.423
CLV_PCSK_SKI1_1	20	24	PF00082	0.378
CLV_PCSK_SKI1_1	285	289	PF00082	0.521
CLV_PCSK_SKI1_1	332	336	PF00082	0.643
CLV_PCSK_SKI1_1	80	84	PF00082	0.459
DEG_APCC_DBOX_1	98	106	PF00400	0.256
DEG_MDM2_SWIB_1	299	307	PF02201	0.238
DEG_Nend_UBRbox_1	1	4	PF02207	0.471
DOC_ANK_TNKS_1	336	343	PF00023	0.410
DOC_MAPK_gen_1	312	321	PF00069	0.423
DOC_MAPK_gen_1	32	42	PF00069	0.361
DOC_MAPK_MEF2A_6	260	269	PF00069	0.354
DOC_PP2B_PxIxI_1	234	240	PF00149	0.359
DOC_SPAK_OSR1_1	154	158	PF12202	0.436
DOC_WW_Pin1_4	261	266	PF00397	0.456
LIG_Actin_WH2_2	272	287	PF00022	0.446
LIG_BIR_III_2	135	139	PF00653	0.308
LIG_BRCT_BRCA1_1	197	201	PF00533	0.441
LIG_Clathr_ClatBox_1	236	240	PF01394	0.340
LIG_FHA_1	44	50	PF00498	0.394
LIG_FHA_2	64	70	PF00498	0.246
LIG_LIR_Gen_1	141	152	PF02991	0.365
LIG_LIR_Gen_1	198	205	PF02991	0.458
LIG_LIR_Gen_1	302	310	PF02991	0.419
LIG_LIR_Gen_1	55	63	PF02991	0.265
LIG_LIR_Gen_1	87	96	PF02991	0.291
LIG_LIR_Nem_3	141	147	PF02991	0.372
LIG_LIR_Nem_3	198	204	PF02991	0.361
LIG_LIR_Nem_3	276	280	PF02991	0.306
LIG_LIR_Nem_3	302	307	PF02991	0.346
LIG_LIR_Nem_3	55	60	PF02991	0.282
LIG_LIR_Nem_3	87	93	PF02991	0.293
LIG_MYND_3	137	141	PF01753	0.434
LIG_NRBOX	179	185	PF00104	0.319
LIG_PCNA_yPIPBox_3	113	125	PF02747	0.349
LIG_PCNA_yPIPBox_3	172	184	PF02747	0.225
LIG_Pex14_2	299	303	PF04695	0.349
LIG_SH2_CRK	277	281	PF00017	0.309
LIG_SH2_CRK	57	61	PF00017	0.236
LIG_SH2_GRB2like	119	122	PF00017	0.275
LIG_SH2_GRB2like	144	147	PF00017	0.416
LIG_SH2_NCK_1	81	85	PF00017	0.222
LIG_SH2_SRC	304	307	PF00017	0.265
LIG_SH2_STAP1	228	232	PF00017	0.287
LIG_SH2_STAP1	81	85	PF00017	0.401
LIG_SH2_STAT3	127	130	PF00017	0.428
LIG_SH2_STAT3	315	318	PF00017	0.313
LIG_SH2_STAT5	119	122	PF00017	0.329
LIG_SH2_STAT5	296	299	PF00017	0.375
LIG_SH3_1	259	265	PF00018	0.347
LIG_SH3_3	229	235	PF00018	0.288
LIG_SH3_3	259	265	PF00018	0.402
LIG_SUMO_SIM_par_1	235	241	PF11976	0.403
LIG_SUMO_SIM_par_1	3	8	PF11976	0.389
LIG_TRAF2_1	328	331	PF00917	0.581
LIG_TRAF2_1	66	69	PF00917	0.255
LIG_TYR_ITSM	53	60	PF00017	0.296
LIG_Vh1_VBS_1	169	187	PF01044	0.232
LIG_WRC_WIRS_1	296	301	PF05994	0.328
MOD_CK1_1	142	148	PF00069	0.362
MOD_CK1_1	238	244	PF00069	0.480
MOD_CK2_1	321	327	PF00069	0.554
MOD_CK2_1	63	69	PF00069	0.242
MOD_GlcNHglycan	141	144	PF01048	0.407
MOD_GlcNHglycan	197	200	PF01048	0.382
MOD_GlcNHglycan	338	341	PF01048	0.496
MOD_GlcNHglycan	63	66	PF01048	0.278
MOD_GSK3_1	20	27	PF00069	0.308
MOD_GSK3_1	200	207	PF00069	0.308
MOD_GSK3_1	238	245	PF00069	0.455
MOD_GSK3_1	295	302	PF00069	0.304
MOD_GSK3_1	321	328	PF00069	0.405
MOD_N-GLC_1	242	247	PF02516	0.312
MOD_N-GLC_1	308	313	PF02516	0.419
MOD_NEK2_1	123	128	PF00069	0.274
MOD_NEK2_1	161	166	PF00069	0.480
MOD_NEK2_1	24	29	PF00069	0.398
MOD_NEK2_1	299	304	PF00069	0.355
MOD_NEK2_1	43	48	PF00069	0.341
MOD_PIKK_1	170	176	PF00454	0.252
MOD_PIKK_1	206	212	PF00454	0.477
MOD_PIKK_1	297	303	PF00454	0.256
MOD_PKA_1	336	342	PF00069	0.407
MOD_PKA_2	336	342	PF00069	0.553
MOD_Plk_1	107	113	PF00069	0.486
MOD_Plk_1	20	26	PF00069	0.374
MOD_Plk_4	179	185	PF00069	0.268
MOD_Plk_4	200	206	PF00069	0.460
MOD_Plk_4	299	305	PF00069	0.273
MOD_Plk_4	321	327	PF00069	0.423
MOD_Plk_4	342	348	PF00069	0.442
MOD_ProDKin_1	261	267	PF00069	0.446
MOD_SUMO_rev_2	45	54	PF00179	0.443
MOD_SUMO_rev_2	64	71	PF00179	0.424
TRG_DiLeu_BaLyEn_6	232	237	PF01217	0.342
TRG_ENDOCYTIC_2	144	147	PF00928	0.384
TRG_ENDOCYTIC_2	277	280	PF00928	0.309
TRG_ENDOCYTIC_2	296	299	PF00928	0.201
TRG_ENDOCYTIC_2	304	307	PF00928	0.373
TRG_ENDOCYTIC_2	37	40	PF00928	0.253
TRG_ENDOCYTIC_2	57	60	PF00928	0.240
TRG_ER_diArg_1	147	150	PF00400	0.415
TRG_ER_diArg_1	258	260	PF00400	0.416
TRG_ER_diArg_1	312	315	PF00400	0.641
TRG_NLS_MonoCore_2	334	339	PF00514	0.429
TRG_NLS_MonoExtC_3	311	316	PF00514	0.344
TRG_NLS_MonoExtC_3	335	341	PF00514	0.496
TRG_NLS_MonoExtN_4	312	317	PF00514	0.342
TRG_NLS_MonoExtN_4	332	339	PF00514	0.564
TRG_Pf-PMV_PEXEL_1	17	21	PF00026	0.523
TRG_Pf-PMV_PEXEL_1	317	322	PF00026	0.291

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P8R0	Leptomonas seymouri	61%	100%
A0A0S4IX88	Bodo saltans	34%	71%
A0A1X0NZP8	Trypanosomatidae	47%	100%
A0A3S7X2B0	Leishmania donovani	78%	100%
A0A422NRL2	Trypanosoma rangeli	45%	100%
A4I4E5	Leishmania infantum	79%	100%
C9ZL18	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	44%	100%
E9ADU5	Leishmania major	80%	100%
E9ALY5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	78%	100%
V5BH47	Trypanosoma cruzi	45%	100%