Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HH97_LEIBR

TriTrypDb:

LbrM.29.0930 , LBRM2903_290015900

Length:

491

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HH97

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HH97

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	30	32	PF00675	0.408
CLV_NRD_NRD_1	38	40	PF00675	0.497
CLV_NRD_NRD_1	398	400	PF00675	0.459
CLV_PCSK_KEX2_1	30	32	PF00082	0.395
CLV_PCSK_KEX2_1	398	400	PF00082	0.540
CLV_PCSK_KEX2_1	97	99	PF00082	0.344
CLV_PCSK_PC1ET2_1	97	99	PF00082	0.338
CLV_PCSK_SKI1_1	16	20	PF00082	0.476
CLV_PCSK_SKI1_1	180	184	PF00082	0.410
CLV_PCSK_SKI1_1	249	253	PF00082	0.505
CLV_PCSK_SKI1_1	304	308	PF00082	0.494
CLV_PCSK_SKI1_1	356	360	PF00082	0.582
CLV_PCSK_SKI1_1	409	413	PF00082	0.363
CLV_PCSK_SKI1_1	450	454	PF00082	0.315
CLV_PCSK_SKI1_1	470	474	PF00082	0.242
DEG_APCC_DBOX_1	66	74	PF00400	0.383
DEG_APCC_DBOX_1	8	16	PF00400	0.607
DEG_Nend_Nbox_1	1	3	PF02207	0.575
DOC_CKS1_1	186	191	PF01111	0.476
DOC_CKS1_1	363	368	PF01111	0.556
DOC_CYCLIN_RxL_1	405	415	PF00134	0.371
DOC_CYCLIN_RxL_1	455	466	PF00134	0.362
DOC_MAPK_gen_1	347	355	PF00069	0.354
DOC_MAPK_gen_1	455	464	PF00069	0.426
DOC_MAPK_gen_1	97	105	PF00069	0.316
DOC_MAPK_MEF2A_6	347	355	PF00069	0.354
DOC_MAPK_MEF2A_6	67	74	PF00069	0.245
DOC_MAPK_MEF2A_6	97	105	PF00069	0.316
DOC_MAPK_NFAT4_5	67	75	PF00069	0.251
DOC_PP2B_LxvP_1	8	11	PF13499	0.536
DOC_SPAK_OSR1_1	98	102	PF12202	0.445
DOC_USP7_MATH_1	128	132	PF00917	0.444
DOC_USP7_MATH_1	295	299	PF00917	0.558
DOC_USP7_MATH_1	361	365	PF00917	0.550
DOC_USP7_MATH_1	377	381	PF00917	0.326
DOC_USP7_MATH_1	384	388	PF00917	0.455
DOC_USP7_MATH_1	45	49	PF00917	0.380
DOC_USP7_UBL2_3	401	405	PF12436	0.481
DOC_WW_Pin1_4	145	150	PF00397	0.390
DOC_WW_Pin1_4	185	190	PF00397	0.409
DOC_WW_Pin1_4	305	310	PF00397	0.561
DOC_WW_Pin1_4	362	367	PF00397	0.623
DOC_WW_Pin1_4	434	439	PF00397	0.478
DOC_WW_Pin1_4	483	488	PF00397	0.652
LIG_14-3-3_CanoR_1	104	112	PF00244	0.481
LIG_14-3-3_CanoR_1	321	327	PF00244	0.571
LIG_14-3-3_CanoR_1	477	483	PF00244	0.522
LIG_Actin_WH2_2	1	18	PF00022	0.536
LIG_AP2alpha_1	277	281	PF02296	0.392
LIG_CaM_NSCaTE_8	152	159	PF13499	0.444
LIG_CtBP_PxDLS_1	366	370	PF00389	0.406
LIG_eIF4E_1	459	465	PF01652	0.471
LIG_FHA_1	23	29	PF00498	0.405
LIG_FHA_1	239	245	PF00498	0.311
LIG_FHA_1	36	42	PF00498	0.439
LIG_FHA_1	435	441	PF00498	0.472
LIG_FHA_1	59	65	PF00498	0.439
LIG_FHA_1	76	82	PF00498	0.472
LIG_FHA_2	124	130	PF00498	0.397
LIG_FHA_2	255	261	PF00498	0.397
LIG_FHA_2	265	271	PF00498	0.335
LIG_FHA_2	281	287	PF00498	0.579
LIG_FHA_2	464	470	PF00498	0.496
LIG_FHA_2	484	490	PF00498	0.432
LIG_FHA_2	51	57	PF00498	0.527
LIG_GBD_Chelix_1	403	411	PF00786	0.462
LIG_LIR_Gen_1	202	212	PF02991	0.419
LIG_LIR_Gen_1	444	453	PF02991	0.304
LIG_LIR_Nem_3	140	144	PF02991	0.356
LIG_LIR_Nem_3	160	164	PF02991	0.202
LIG_LIR_Nem_3	202	208	PF02991	0.416
LIG_LIR_Nem_3	279	284	PF02991	0.340
LIG_LIR_Nem_3	456	462	PF02991	0.396
LIG_LRP6_Inhibitor_1	24	30	PF00058	0.483
LIG_MAD2	181	189	PF02301	0.266
LIG_NRBOX	337	343	PF00104	0.493
LIG_PCNA_yPIPBox_3	26	40	PF02747	0.520
LIG_Pex14_2	277	281	PF04695	0.392
LIG_PTB_Apo_2	325	332	PF02174	0.575
LIG_SH2_CRK	459	463	PF00017	0.487
LIG_SH2_GRB2like	185	188	PF00017	0.270
LIG_SH2_STAT3	413	416	PF00017	0.390
LIG_SH2_STAT5	164	167	PF00017	0.475
LIG_SH2_STAT5	185	188	PF00017	0.406
LIG_SH2_STAT5	445	448	PF00017	0.325
LIG_SH2_STAT5	69	72	PF00017	0.349
LIG_SH3_3	360	366	PF00018	0.538
LIG_SUMO_SIM_par_1	350	357	PF11976	0.347
LIG_SUMO_SIM_par_1	364	371	PF11976	0.378
LIG_TRAF2_1	167	170	PF00917	0.535
LIG_TRAF2_1	257	260	PF00917	0.399
LIG_UBA3_1	111	115	PF00899	0.397
MOD_CDK_SPxxK_3	483	490	PF00069	0.657
MOD_CK1_1	162	168	PF00069	0.479
MOD_CK1_1	22	28	PF00069	0.341
MOD_CK1_1	387	393	PF00069	0.434
MOD_CK2_1	104	110	PF00069	0.455
MOD_CK2_1	123	129	PF00069	0.303
MOD_CK2_1	254	260	PF00069	0.387
MOD_CK2_1	264	270	PF00069	0.336
MOD_CK2_1	351	357	PF00069	0.539
MOD_CK2_1	45	51	PF00069	0.454
MOD_CK2_1	478	484	PF00069	0.611
MOD_GlcNHglycan	121	124	PF01048	0.572
MOD_GlcNHglycan	224	227	PF01048	0.501
MOD_GlcNHglycan	297	300	PF01048	0.531
MOD_GlcNHglycan	343	346	PF01048	0.521
MOD_GlcNHglycan	43	46	PF01048	0.466
MOD_GSK3_1	119	126	PF00069	0.535
MOD_GSK3_1	128	135	PF00069	0.426
MOD_GSK3_1	195	202	PF00069	0.465
MOD_GSK3_1	347	354	PF00069	0.500
MOD_GSK3_1	361	368	PF00069	0.475
MOD_GSK3_1	387	394	PF00069	0.547
MOD_GSK3_1	41	48	PF00069	0.475
MOD_N-GLC_1	119	124	PF02516	0.467
MOD_N-GLC_1	41	46	PF02516	0.501
MOD_NEK2_1	119	124	PF00069	0.507
MOD_NEK2_1	144	149	PF00069	0.470
MOD_NEK2_1	19	24	PF00069	0.378
MOD_NEK2_1	210	215	PF00069	0.398
MOD_NEK2_1	264	269	PF00069	0.526
MOD_NEK2_1	341	346	PF00069	0.447
MOD_NEK2_1	412	417	PF00069	0.309
MOD_NEK2_1	453	458	PF00069	0.448
MOD_NEK2_1	478	483	PF00069	0.548
MOD_NEK2_1	58	63	PF00069	0.400
MOD_NEK2_2	11	16	PF00069	0.583
MOD_NEK2_2	159	164	PF00069	0.439
MOD_NEK2_2	377	382	PF00069	0.653
MOD_PIKK_1	22	28	PF00454	0.474
MOD_PIKK_1	412	418	PF00454	0.364
MOD_PK_1	174	180	PF00069	0.502
MOD_PK_1	347	353	PF00069	0.507
MOD_PKA_2	322	328	PF00069	0.571
MOD_PKA_2	35	41	PF00069	0.339
MOD_Plk_1	159	165	PF00069	0.466
MOD_Plk_1	347	353	PF00069	0.507
MOD_Plk_1	41	47	PF00069	0.503
MOD_Plk_4	159	165	PF00069	0.469
MOD_Plk_4	45	51	PF00069	0.274
MOD_Plk_4	83	89	PF00069	0.266
MOD_ProDKin_1	145	151	PF00069	0.383
MOD_ProDKin_1	185	191	PF00069	0.416
MOD_ProDKin_1	305	311	PF00069	0.565
MOD_ProDKin_1	362	368	PF00069	0.619
MOD_ProDKin_1	434	440	PF00069	0.474
MOD_ProDKin_1	483	489	PF00069	0.654
MOD_SUMO_for_1	314	317	PF00179	0.622
MOD_SUMO_rev_2	107	117	PF00179	0.404
MOD_SUMO_rev_2	135	144	PF00179	0.416
MOD_SUMO_rev_2	177	183	PF00179	0.416
MOD_SUMO_rev_2	469	475	PF00179	0.426
TRG_DiLeu_BaEn_4	259	265	PF01217	0.489
TRG_ENDOCYTIC_2	141	144	PF00928	0.343
TRG_ENDOCYTIC_2	445	448	PF00928	0.325
TRG_ENDOCYTIC_2	459	462	PF00928	0.379
TRG_ENDOCYTIC_2	69	72	PF00928	0.235
TRG_ER_diArg_1	103	106	PF00400	0.329
TRG_ER_diArg_1	214	217	PF00400	0.564
TRG_ER_diArg_1	29	31	PF00400	0.390
TRG_Pf-PMV_PEXEL_1	470	474	PF00026	0.407

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I9E1	Leptomonas seymouri	75%	100%
A0A0S4IX38	Bodo saltans	28%	95%
A0A1X0P156	Trypanosomatidae	43%	100%
A0A3S7X2A6	Leishmania donovani	87%	100%
A0A422NRS1	Trypanosoma rangeli	41%	100%
A4I4E3	Leishmania infantum	87%	100%
C9ZL20	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	42%	100%
E9ADU3	Leishmania major	87%	100%
E9ALY7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%
V5BR79	Trypanosoma cruzi	45%	100%