Cytochrome b5 heme-binding domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

cytochrome b5-like Heme/Steroid binding domain containing protein, putative

Species:

Leishmania braziliensis

UniProt:

A4HH96_LEIBR

TriTrypDb:

LbrM.29.0920 , LBRM2903_290015600

Length:

168

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0016020	membrane	2	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HH96

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HH96

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	1
GO:0020037	heme binding	4	1
GO:0046906	tetrapyrrole binding	3	1
GO:0097159	organic cyclic compound binding	2	1
GO:1901363	heterocyclic compound binding	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	29	31	PF00675	0.366
CLV_NRD_NRD_1	59	61	PF00675	0.364
CLV_NRD_NRD_1	79	81	PF00675	0.277
CLV_NRD_NRD_1	84	86	PF00675	0.446
CLV_PCSK_KEX2_1	13	15	PF00082	0.594
CLV_PCSK_KEX2_1	29	31	PF00082	0.248
CLV_PCSK_KEX2_1	59	61	PF00082	0.376
CLV_PCSK_KEX2_1	79	81	PF00082	0.277
CLV_PCSK_PC1ET2_1	13	15	PF00082	0.618
CLV_PCSK_SKI1_1	111	115	PF00082	0.684
CLV_PCSK_SKI1_1	3	7	PF00082	0.420
DEG_APCC_DBOX_1	28	36	PF00400	0.430
DEG_Nend_Nbox_1	1	3	PF02207	0.611
DOC_PP2B_LxvP_1	98	101	PF13499	0.628
DOC_WW_Pin1_4	147	152	PF00397	0.701
LIG_14-3-3_CanoR_1	111	120	PF00244	0.639
LIG_14-3-3_CanoR_1	29	33	PF00244	0.374
LIG_EH1_1	40	48	PF00400	0.311
LIG_eIF4E_1	41	47	PF01652	0.249
LIG_FHA_1	136	142	PF00498	0.664
LIG_FHA_1	42	48	PF00498	0.411
LIG_FHA_1	89	95	PF00498	0.522
LIG_LIR_Nem_3	152	158	PF02991	0.516
LIG_NRBOX	1	7	PF00104	0.603
LIG_SH2_SRC	158	161	PF00017	0.494
LIG_SH2_STAT5	71	74	PF00017	0.492
LIG_SUMO_SIM_anti_2	4	9	PF11976	0.416
LIG_SUMO_SIM_par_1	4	9	PF11976	0.483
LIG_TRAF2_1	132	135	PF00917	0.801
LIG_TRAF2_1	19	22	PF00917	0.377
LIG_UBA3_1	5	13	PF00899	0.559
LIG_WW_3	99	103	PF00397	0.671
MOD_CK1_1	36	42	PF00069	0.460
MOD_CK2_1	109	115	PF00069	0.684
MOD_CK2_1	129	135	PF00069	0.788
MOD_CK2_1	16	22	PF00069	0.334
MOD_GlcNHglycan	111	114	PF01048	0.565
MOD_GlcNHglycan	131	134	PF01048	0.790
MOD_GlcNHglycan	35	38	PF01048	0.405
MOD_GlcNHglycan	8	11	PF01048	0.587
MOD_GSK3_1	125	132	PF00069	0.715
MOD_GSK3_1	133	140	PF00069	0.609
MOD_GSK3_1	143	150	PF00069	0.684
MOD_NEK2_1	25	30	PF00069	0.238
MOD_NEK2_1	46	51	PF00069	0.341
MOD_NEK2_1	6	11	PF00069	0.559
MOD_NEK2_2	69	74	PF00069	0.540
MOD_PKA_2	28	34	PF00069	0.374
MOD_Plk_1	69	75	PF00069	0.541
MOD_Plk_4	36	42	PF00069	0.392
MOD_ProDKin_1	147	153	PF00069	0.701
TRG_ER_diArg_1	164	167	PF00400	0.645
TRG_ER_diArg_1	58	60	PF00400	0.376
TRG_NLS_MonoExtC_3	11	16	PF00514	0.633

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IMH0	Leptomonas seymouri	62%	98%
A0A3S7X2B2	Leishmania donovani	85%	100%
A0A422NRL8	Trypanosoma rangeli	45%	97%
A4I4E2	Leishmania infantum	85%	100%
E9ADU2	Leishmania major	84%	100%
E9ALY8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	81%	100%