Guanine deaminase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Guanine deaminase

Gene product:

guanine deaminase, putative

Species:

Leishmania braziliensis

UniProt:

A4HH95_LEIBR

TriTrypDb:

LbrM.29.0910 , LBRM2903_290015500

Length:

454

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 20

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 8

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

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Cellular components
Term	Name	Level	Count
GO:0005829	cytosol	2	1
GO:0110165	cellular anatomical entity	1	1

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Expansion

Sequence features

A4HH95

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HH95

Function

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Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	11
GO:0006144	purine nucleobase metabolic process	5	11
GO:0006145	purine nucleobase catabolic process	6	11
GO:0006147	guanine catabolic process	7	11
GO:0006725	cellular aromatic compound metabolic process	3	11
GO:0006807	nitrogen compound metabolic process	2	11
GO:0008152	metabolic process	1	11
GO:0009056	catabolic process	2	11
GO:0009112	nucleobase metabolic process	4	11
GO:0009987	cellular process	1	11

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Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	11
GO:0005488	binding	1	11
GO:0008270	zinc ion binding	6	11
GO:0008892	guanine deaminase activity	4	11
GO:0016787	hydrolase activity	2	11
GO:0016810	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds	3	11
GO:0016814	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines	4	11
GO:0019239	deaminase activity	3	11
GO:0043167	ion binding	2	11
GO:0043169	cation binding	3	11

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	271	273	PF00675	0.324
CLV_PCSK_KEX2_1	271	273	PF00082	0.324
CLV_PCSK_SKI1_1	196	200	PF00082	0.355
CLV_PCSK_SKI1_1	272	276	PF00082	0.311
CLV_PCSK_SKI1_1	314	318	PF00082	0.324
CLV_PCSK_SKI1_1	342	346	PF00082	0.390
DEG_APCC_DBOX_1	15	23	PF00400	0.454
DEG_ODPH_VHL_1	396	407	PF01847	0.590
DOC_CKS1_1	11	16	PF01111	0.481
DOC_MAPK_gen_1	254	263	PF00069	0.586

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PG27	Leptomonas seymouri	78%	100%
A0A1X0NZN2	Trypanosomatidae	62%	100%
A0A3Q8IBE4	Leishmania donovani	89%	100%
A0A422NRP3	Trypanosoma rangeli	62%	100%
A0B7V2	Methanothrix thermoacetophila (strain DSM 6194 / JCM 14653 / NBRC 101360 / PT)	26%	100%
A0LMI3	Syntrophobacter fumaroxidans (strain DSM 10017 / MPOB)	27%	100%
A0RCM7	Bacillus thuringiensis (strain Al Hakam)	24%	100%
A1VD37	Desulfovibrio vulgaris subsp. vulgaris (strain DP4)	25%	100%
A3DEQ2	Acetivibrio thermocellus (strain ATCC 27405 / DSM 1237 / JCM 9322 / NBRC 103400 / NCIMB 10682 / NRRL B-4536 / VPI 7372)	24%	100%
A4FW32	Methanococcus maripaludis (strain C5 / ATCC BAA-1333)	24%	100%

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