RRM domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain), putative

Species:

Leishmania braziliensis

UniProt:

A4HH94_LEIBR

TriTrypDb:

LbrM.29.0900 , LBRM2903_290015400

Length:

114

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

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Cellular components
Term	Name	Level	Count
GO:0005654	nucleoplasm	2	1
GO:0032991	protein-containing complex	1	4
GO:0110165	cellular anatomical entity	1	1
GO:1990904	ribonucleoprotein complex	2	4

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Expansion

Sequence features

A4HH94

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HH94

Function

Could not find GO biological_process term for this entry.

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Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	11
GO:0003723	RNA binding	4	11
GO:0005488	binding	1	11
GO:0097159	organic cyclic compound binding	2	11
GO:1901363	heterocyclic compound binding	2	11

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	23	25	PF00675	0.237
CLV_NRD_NRD_1	65	67	PF00675	0.211
CLV_NRD_NRD_1	97	99	PF00675	0.425
CLV_PCSK_FUR_1	95	99	PF00082	0.431
CLV_PCSK_KEX2_1	105	107	PF00082	0.443
CLV_PCSK_KEX2_1	23	25	PF00082	0.237
CLV_PCSK_KEX2_1	65	67	PF00082	0.211
CLV_PCSK_KEX2_1	95	97	PF00082	0.464
CLV_PCSK_PC1ET2_1	105	107	PF00082	0.564
CLV_PCSK_SKI1_1	23	27	PF00082	0.283

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IM99	Leptomonas seymouri	87%	100%
A0A0S4J2L5	Bodo saltans	53%	79%
A0A1X0NZM5	Trypanosomatidae	71%	100%
A0A3S7X280	Leishmania donovani	96%	100%
A0A422NRL3	Trypanosoma rangeli	71%	100%
A4I4E0	Leishmania infantum	96%	100%
C9ZL22	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	78%	97%
E9ADU0	Leishmania major	96%	100%
E9ALZ0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	96%	100%
Q7LL14	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	34%	100%

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