Putative high mobility group protein homolog tdp-1

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

High mobility group protein TDP1

Species:

Leishmania braziliensis

UniProt:

A4HH93_LEIBR

TriTrypDb:

LbrM.29.0880 , LBRM2903_290015200

Length:

299

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 18

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	12
GO:0043226	organelle	2	12
GO:0043227	membrane-bounded organelle	3	12
GO:0043229	intracellular organelle	3	12
GO:0043231	intracellular membrane-bounded organelle	4	12
GO:0110165	cellular anatomical entity	1	12
GO:0005730	nucleolus	5	1
GO:0043228	non-membrane-bounded organelle	3	1
GO:0043232	intracellular non-membrane-bounded organelle	4	1

Expansion

Sequence features

A4HH93

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HH93

Function

Biological processes
Term	Name	Level	Count
GO:0010468	regulation of gene expression	5	1
GO:0010608	post-transcriptional regulation of gene expression	6	1
GO:0019222	regulation of metabolic process	3	1
GO:0050789	regulation of biological process	2	1
GO:0060255	regulation of macromolecule metabolic process	4	1
GO:0065007	biological regulation	1	1

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	12
GO:0003677	DNA binding	4	12
GO:0005488	binding	1	12
GO:0097159	organic cyclic compound binding	2	12
GO:1901363	heterocyclic compound binding	2	12
GO:0000182	rDNA binding	7	1
GO:0000217	DNA secondary structure binding	5	1
GO:0000400	four-way junction DNA binding	6	1
GO:0000402	crossed form four-way junction DNA binding	7	1
GO:0003690	double-stranded DNA binding	5	1
GO:0008301	DNA binding, bending	5	1
GO:0043565	sequence-specific DNA binding	5	1
GO:1990837	sequence-specific double-stranded DNA binding	6	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	286	290	PF00656	0.698
CLV_C14_Caspase3-7	291	295	PF00656	0.702
CLV_NRD_NRD_1	36	38	PF00675	0.301
CLV_NRD_NRD_1	83	85	PF00675	0.597
CLV_PCSK_FUR_1	84	88	PF00082	0.703
CLV_PCSK_KEX2_1	103	105	PF00082	0.525
CLV_PCSK_KEX2_1	190	192	PF00082	0.574
CLV_PCSK_KEX2_1	208	210	PF00082	0.216
CLV_PCSK_KEX2_1	261	263	PF00082	0.303
CLV_PCSK_KEX2_1	35	37	PF00082	0.300
CLV_PCSK_KEX2_1	83	85	PF00082	0.539
CLV_PCSK_KEX2_1	86	88	PF00082	0.552
CLV_PCSK_PC1ET2_1	103	105	PF00082	0.525
CLV_PCSK_PC1ET2_1	190	192	PF00082	0.559
CLV_PCSK_PC1ET2_1	208	210	PF00082	0.216
CLV_PCSK_PC1ET2_1	261	263	PF00082	0.303
CLV_PCSK_PC1ET2_1	86	88	PF00082	0.569
CLV_PCSK_SKI1_1	115	119	PF00082	0.295
CLV_PCSK_SKI1_1	15	19	PF00082	0.355
CLV_PCSK_SKI1_1	194	198	PF00082	0.655
CLV_PCSK_SKI1_1	208	212	PF00082	0.196
CLV_PCSK_SKI1_1	59	63	PF00082	0.462
DEG_SPOP_SBC_1	283	287	PF00917	0.733
DEG_SPOP_SBC_1	288	292	PF00917	0.741
DOC_CKS1_1	61	66	PF01111	0.555
DOC_MAPK_MEF2A_6	115	124	PF00069	0.498
DOC_USP7_MATH_1	158	162	PF00917	0.407
DOC_USP7_MATH_1	269	273	PF00917	0.586
DOC_USP7_MATH_1	283	287	PF00917	0.642
DOC_USP7_MATH_1	288	292	PF00917	0.751
DOC_USP7_MATH_1	82	86	PF00917	0.461
DOC_USP7_MATH_1	94	98	PF00917	0.622
DOC_USP7_UBL2_3	103	107	PF12436	0.547
DOC_USP7_UBL2_3	190	194	PF12436	0.533
DOC_USP7_UBL2_3	96	100	PF12436	0.677
DOC_WW_Pin1_4	116	121	PF00397	0.498
DOC_WW_Pin1_4	44	49	PF00397	0.585
DOC_WW_Pin1_4	60	65	PF00397	0.458
LIG_14-3-3_CanoR_1	209	217	PF00244	0.431
LIG_BIR_II_1	1	5	PF00653	0.554
LIG_FHA_1	140	146	PF00498	0.442
LIG_FHA_1	48	54	PF00498	0.559
LIG_FHA_1	61	67	PF00498	0.514
LIG_FHA_2	60	66	PF00498	0.582
LIG_LIR_Gen_1	119	125	PF02991	0.442
LIG_LIR_Gen_1	161	170	PF02991	0.535
LIG_LIR_Nem_3	119	124	PF02991	0.431
LIG_LIR_Nem_3	161	166	PF02991	0.498
LIG_LIR_Nem_3	212	217	PF02991	0.432
LIG_LIR_Nem_3	45	49	PF02991	0.578
LIG_RPA_C_Fungi	179	191	PF08784	0.466
LIG_SH2_CRK	163	167	PF00017	0.300
LIG_SH2_STAP1	174	178	PF00017	0.331
LIG_SH2_STAP1	252	256	PF00017	0.266
LIG_SH2_STAT5	121	124	PF00017	0.281
LIG_SH2_STAT5	181	184	PF00017	0.529
LIG_SH2_STAT5	214	217	PF00017	0.281
LIG_SH3_2	204	209	PF14604	0.578
LIG_SH3_3	201	207	PF00018	0.579
LIG_SH3_3	271	277	PF00018	0.577
LIG_SUMO_SIM_anti_2	16	23	PF11976	0.418
LIG_TRAF2_1	251	254	PF00917	0.417
LIG_UBA3_1	144	153	PF00899	0.300
MOD_CK1_1	27	33	PF00069	0.325
MOD_CK1_1	272	278	PF00069	0.631
MOD_CK1_1	282	288	PF00069	0.731
MOD_CK1_1	290	296	PF00069	0.658
MOD_CK1_1	90	96	PF00069	0.633
MOD_CK2_1	13	19	PF00069	0.341
MOD_CK2_1	153	159	PF00069	0.411
MOD_CK2_1	242	248	PF00069	0.369
MOD_CK2_1	59	65	PF00069	0.535
MOD_Cter_Amidation	192	195	PF01082	0.574
MOD_GlcNHglycan	1	4	PF01048	0.622
MOD_GlcNHglycan	244	247	PF01048	0.489
MOD_GlcNHglycan	281	284	PF01048	0.808
MOD_GlcNHglycan	286	289	PF01048	0.725
MOD_GlcNHglycan	78	83	PF01048	0.522
MOD_GlcNHglycan	89	92	PF01048	0.510
MOD_GSK3_1	216	223	PF00069	0.257
MOD_GSK3_1	272	279	PF00069	0.685
MOD_GSK3_1	283	290	PF00069	0.648
MOD_GSK3_1	78	85	PF00069	0.533
MOD_GSK3_1	90	97	PF00069	0.624
MOD_N-GLC_1	5	10	PF02516	0.537
MOD_NEK2_1	13	18	PF00069	0.411
MOD_PKA_1	153	159	PF00069	0.331
MOD_PKA_2	269	275	PF00069	0.530
MOD_PKA_2	82	88	PF00069	0.538
MOD_PKB_1	87	95	PF00069	0.698
MOD_Plk_1	13	19	PF00069	0.348
MOD_Plk_1	158	164	PF00069	0.331
MOD_Plk_4	13	19	PF00069	0.352
MOD_ProDKin_1	116	122	PF00069	0.360
MOD_ProDKin_1	44	50	PF00069	0.481
MOD_ProDKin_1	60	66	PF00069	0.451
MOD_SUMO_rev_2	167	172	PF00179	0.260
MOD_SUMO_rev_2	201	207	PF00179	0.472
MOD_SUMO_rev_2	245	251	PF00179	0.331
TRG_DiLeu_BaEn_1	52	57	PF01217	0.331
TRG_ENDOCYTIC_2	121	124	PF00928	0.281
TRG_ENDOCYTIC_2	163	166	PF00928	0.281
TRG_ENDOCYTIC_2	214	217	PF00928	0.281
TRG_ENDOCYTIC_2	252	255	PF00928	0.281
TRG_ER_diArg_1	34	37	PF00400	0.281
TRG_NLS_MonoExtN_4	191	198	PF00514	0.671
TRG_NLS_MonoExtN_4	83	90	PF00514	0.493

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P8C9	Leptomonas seymouri	64%	99%
A0A0S4KNH5	Bodo saltans	37%	77%
A0A1X0NZM0	Trypanosomatidae	45%	100%
A0A3Q8IEB8	Leishmania donovani	86%	99%
A0A3R7KR63	Trypanosoma rangeli	46%	100%
A4I4D9	Leishmania infantum	86%	99%
C9ZL24	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	43%	100%
E9ADT8	Leishmania major	87%	100%
E9ALZ2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	100%
P26586	Trypanosoma brucei rhodesiense	43%	100%
V5B1M8	Trypanosoma cruzi	49%	100%