Transmembrane protein

Quick info Annotations Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HH92_LEIBR

TriTrypDb:

LbrM.29.0870 , LBRM2903_290015100

Length:

391

Annotations

LeishMANIAdb annotations

This protein is only found among Kinetoplastds. However, its function is unclear, could be a transporter or channel protein.

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	9
GO:0110165	cellular anatomical entity	1	9
GO:0005635	nuclear envelope	4	1
GO:0005737	cytoplasm	2	1
GO:0005819	spindle	5	1
GO:0031967	organelle envelope	3	1
GO:0031975	envelope	2	1
GO:0043226	organelle	2	1
GO:0043228	non-membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043232	intracellular non-membrane-bounded organelle	4	1

Expansion

Sequence features

A4HH92

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HH92

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	183	185	PF00675	0.429
CLV_PCSK_KEX2_1	183	185	PF00082	0.438
CLV_PCSK_SKI1_1	178	182	PF00082	0.483
CLV_PCSK_SKI1_1	183	187	PF00082	0.333
CLV_PCSK_SKI1_1	276	280	PF00082	0.446
DEG_SCF_FBW7_2	248	253	PF00400	0.357
DOC_MAPK_MEF2A_6	123	132	PF00069	0.474
DOC_MAPK_MEF2A_6	168	176	PF00069	0.376
DOC_MAPK_MEF2A_6	208	216	PF00069	0.556
DOC_MAPK_RevD_3	170	184	PF00069	0.432
DOC_PP2B_LxvP_1	87	90	PF13499	0.444
DOC_PP2B_PxIxI_1	106	112	PF00149	0.410
DOC_PP4_FxxP_1	104	107	PF00568	0.319
DOC_PP4_FxxP_1	11	14	PF00568	0.653
DOC_PP4_FxxP_1	118	121	PF00568	0.505
DOC_PP4_FxxP_1	338	341	PF00568	0.712
DOC_PP4_FxxP_1	51	54	PF00568	0.322
DOC_USP7_MATH_1	311	315	PF00917	0.385
DOC_WW_Pin1_4	10	15	PF00397	0.660
DOC_WW_Pin1_4	246	251	PF00397	0.384
DOC_WW_Pin1_4	27	32	PF00397	0.513
LIG_14-3-3_CanoR_1	123	128	PF00244	0.567
LIG_14-3-3_CanoR_1	45	51	PF00244	0.497
LIG_14-3-3_CanoR_1	82	88	PF00244	0.335
LIG_APCC_ABBA_1	65	70	PF00400	0.565
LIG_APCC_ABBA_1	73	78	PF00400	0.342
LIG_BIR_II_1	1	5	PF00653	0.701
LIG_BIR_III_2	285	289	PF00653	0.269
LIG_BRCT_BRCA1_1	29	33	PF00533	0.543
LIG_CaM_NSCaTE_8	347	354	PF13499	0.355
LIG_CSL_BTD_1	209	212	PF09270	0.651
LIG_DLG_GKlike_1	123	130	PF00625	0.496
LIG_FHA_1	159	165	PF00498	0.480
LIG_FHA_1	216	222	PF00498	0.279
LIG_FHA_1	379	385	PF00498	0.276
LIG_FHA_1	47	53	PF00498	0.342
LIG_LIR_Apic_2	10	14	PF02991	0.654
LIG_LIR_Apic_2	207	213	PF02991	0.559
LIG_LIR_Apic_2	49	54	PF02991	0.322
LIG_LIR_Gen_1	129	140	PF02991	0.313
LIG_LIR_Gen_1	381	389	PF02991	0.197
LIG_LIR_Nem_3	129	135	PF02991	0.364
LIG_LIR_Nem_3	277	282	PF02991	0.364
LIG_LIR_Nem_3	30	36	PF02991	0.538
LIG_LIR_Nem_3	330	336	PF02991	0.656
LIG_LIR_Nem_3	381	385	PF02991	0.382
LIG_LIR_Nem_3	56	61	PF02991	0.373
LIG_PDZ_Class_2	386	391	PF00595	0.410
LIG_Pex14_1	201	205	PF04695	0.616
LIG_Pex14_2	114	118	PF04695	0.535
LIG_Pex14_2	333	337	PF04695	0.615
LIG_Pex14_2	46	50	PF04695	0.355
LIG_Pex14_2	51	55	PF04695	0.448
LIG_Rb_LxCxE_1	20	35	PF01857	0.472
LIG_SH2_CRK	63	67	PF00017	0.201
LIG_SH2_SRC	370	373	PF00017	0.306
LIG_SH2_STAT5	19	22	PF00017	0.557
LIG_SH2_STAT5	309	312	PF00017	0.338
LIG_SH2_STAT5	36	39	PF00017	0.495
LIG_SH2_STAT5	47	50	PF00017	0.328
LIG_SH3_3	107	113	PF00018	0.410
LIG_SH3_3	209	215	PF00018	0.577
LIG_SH3_3	290	296	PF00018	0.381
LIG_SH3_3	338	344	PF00018	0.578
LIG_SH3_3	366	372	PF00018	0.296
LIG_SUMO_SIM_anti_2	171	176	PF11976	0.379
LIG_SUMO_SIM_anti_2	98	104	PF11976	0.357
LIG_SUMO_SIM_par_1	173	179	PF11976	0.344
LIG_TYR_ITIM	60	65	PF00017	0.325
LIG_WRC_WIRS_1	140	145	PF05994	0.311
LIG_WW_2	212	215	PF00397	0.648
MOD_CDK_SPK_2	27	32	PF00069	0.617
MOD_CDK_SPxxK_3	27	34	PF00069	0.624
MOD_CK1_1	126	132	PF00069	0.417
MOD_CK1_1	304	310	PF00069	0.291
MOD_CK1_1	80	86	PF00069	0.476
MOD_GlcNHglycan	225	228	PF01048	0.420
MOD_GlcNHglycan	87	90	PF01048	0.634
MOD_GSK3_1	255	262	PF00069	0.411
MOD_GSK3_1	266	273	PF00069	0.308
MOD_GSK3_1	300	307	PF00069	0.353
MOD_GSK3_1	77	84	PF00069	0.513
MOD_N-GLC_1	136	141	PF02516	0.210
MOD_NEK2_1	153	158	PF00069	0.393
MOD_NEK2_1	163	168	PF00069	0.270
MOD_NEK2_1	200	205	PF00069	0.614
MOD_NEK2_1	255	260	PF00069	0.432
MOD_NEK2_1	270	275	PF00069	0.344
MOD_NEK2_1	351	356	PF00069	0.340
MOD_NEK2_1	46	51	PF00069	0.334
MOD_NEK2_1	77	82	PF00069	0.512
MOD_PKA_2	81	87	PF00069	0.334
MOD_Plk_1	136	142	PF00069	0.389
MOD_Plk_1	206	212	PF00069	0.498
MOD_Plk_4	123	129	PF00069	0.515
MOD_Plk_4	131	137	PF00069	0.327
MOD_Plk_4	201	207	PF00069	0.513
MOD_Plk_4	270	276	PF00069	0.320
MOD_Plk_4	304	310	PF00069	0.250
MOD_Plk_4	313	319	PF00069	0.404
MOD_Plk_4	342	348	PF00069	0.474
MOD_Plk_4	357	363	PF00069	0.242
MOD_Plk_4	46	52	PF00069	0.297
MOD_Plk_4	95	101	PF00069	0.327
MOD_ProDKin_1	10	16	PF00069	0.653
MOD_ProDKin_1	246	252	PF00069	0.382
MOD_ProDKin_1	27	33	PF00069	0.513
TRG_ENDOCYTIC_2	150	153	PF00928	0.456
TRG_ENDOCYTIC_2	62	65	PF00928	0.279
TRG_ER_diArg_1	182	184	PF00400	0.428
TRG_Pf-PMV_PEXEL_1	184	189	PF00026	0.297

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PEY8	Leptomonas seymouri	61%	100%
A0A1X0P088	Trypanosomatidae	33%	100%
A0A3Q8IH62	Leishmania donovani	83%	100%
A0A3R7MU19	Trypanosoma rangeli	37%	92%
A4I4D8	Leishmania infantum	83%	100%
C9ZL26	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	31%	100%
E9ADT7	Leishmania major	84%	100%
E9ALZ3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	84%	100%
V5BH42	Trypanosoma cruzi	31%	100%