Transmembrane protein

Quick info Annotations Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HH92_LEIBR

TriTrypDb:

LbrM.29.0870 , LBRM2903_290015100

Length:

391

Annotations

LeishMANIAdb annotations

This protein is only found among Kinetoplastds. However, its function is unclear, could be a transporter or channel protein.

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Show entries

Cellular components
Term	Name	Level	Count
GO:0005635	nuclear envelope	4	1
GO:0005737	cytoplasm	2	1
GO:0005819	spindle	5	1
GO:0016020	membrane	2	9
GO:0031967	organelle envelope	3	1
GO:0031975	envelope	2	1
GO:0043226	organelle	2	1
GO:0043228	non-membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043232	intracellular non-membrane-bounded organelle	4	1

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Expansion

Sequence features

A4HH92

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HH92

Putative motif mimicry

Show entries


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	183	185	PF00675	0.429
CLV_PCSK_KEX2_1	183	185	PF00082	0.438
CLV_PCSK_SKI1_1	178	182	PF00082	0.483
CLV_PCSK_SKI1_1	183	187	PF00082	0.333
CLV_PCSK_SKI1_1	276	280	PF00082	0.446
DEG_SCF_FBW7_2	248	253	PF00400	0.357
DOC_MAPK_MEF2A_6	123	132	PF00069	0.474
DOC_MAPK_MEF2A_6	168	176	PF00069	0.376
DOC_MAPK_MEF2A_6	208	216	PF00069	0.556
DOC_MAPK_RevD_3	170	184	PF00069	0.432

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Homologs

Show entries


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PEY8	Leptomonas seymouri	61%	100%
A0A1X0P088	Trypanosomatidae	33%	100%
A0A3Q8IH62	Leishmania donovani	83%	100%
A0A3R7MU19	Trypanosoma rangeli	37%	92%
A4I4D8	Leishmania infantum	83%	100%
C9ZL26	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	31%	100%
E9ADT7	Leishmania major	84%	100%
E9ALZ3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	84%	100%
V5BH42	Trypanosoma cruzi	31%	100%

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