Transmembrane protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HH91_LEIBR

TriTrypDb:

LbrM.29.0860 , LBRM2903_290015000

Length:

481

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	7
GO:0110165	cellular anatomical entity	1	7
GO:0005737	cytoplasm	2	1
GO:0031974	membrane-enclosed lumen	2	1
GO:0031981	nuclear lumen	5	1
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	1
GO:0043233	organelle lumen	3	1
GO:0070013	intracellular organelle lumen	4	1
GO:0097014	ciliary plasm	5	1
GO:0099568	cytoplasmic region	3	1

Expansion

Sequence features

A4HH91

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HH91

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	35	39	PF00656	0.521
CLV_NRD_NRD_1	243	245	PF00675	0.686
CLV_NRD_NRD_1	359	361	PF00675	0.707
CLV_NRD_NRD_1	471	473	PF00675	0.430
CLV_PCSK_KEX2_1	243	245	PF00082	0.686
CLV_PCSK_KEX2_1	359	361	PF00082	0.735
CLV_PCSK_KEX2_1	471	473	PF00082	0.378
CLV_PCSK_SKI1_1	206	210	PF00082	0.606
CLV_PCSK_SKI1_1	227	231	PF00082	0.570
DEG_Nend_UBRbox_2	1	3	PF02207	0.527
DOC_CDC14_PxL_1	270	278	PF14671	0.411
DOC_CDC14_PxL_1	340	348	PF14671	0.501
DOC_MAPK_gen_1	213	221	PF00069	0.403
DOC_MAPK_gen_1	381	391	PF00069	0.605
DOC_MAPK_MEF2A_6	211	219	PF00069	0.388
DOC_MAPK_RevD_3	456	472	PF00069	0.243
DOC_USP7_MATH_1	13	17	PF00917	0.510
DOC_USP7_MATH_1	135	139	PF00917	0.555
DOC_USP7_MATH_1	233	237	PF00917	0.426
DOC_USP7_MATH_1	248	252	PF00917	0.487
DOC_USP7_MATH_1	257	261	PF00917	0.417
DOC_USP7_MATH_1	409	413	PF00917	0.477
DOC_USP7_MATH_2	22	28	PF00917	0.469
DOC_USP7_UBL2_3	177	181	PF12436	0.443
DOC_WW_Pin1_4	137	142	PF00397	0.418
DOC_WW_Pin1_4	252	257	PF00397	0.352
DOC_WW_Pin1_4	331	336	PF00397	0.427
DOC_WW_Pin1_4	344	349	PF00397	0.518
DOC_WW_Pin1_4	40	45	PF00397	0.566
DOC_WW_Pin1_4	405	410	PF00397	0.452
LIG_14-3-3_CanoR_1	167	172	PF00244	0.376
LIG_14-3-3_CanoR_1	423	429	PF00244	0.417
LIG_Actin_WH2_2	262	279	PF00022	0.356
LIG_Actin_WH2_2	282	297	PF00022	0.278
LIG_Actin_WH2_2	456	473	PF00022	0.219
LIG_deltaCOP1_diTrp_1	296	306	PF00928	0.437
LIG_FHA_2	256	262	PF00498	0.477
LIG_Integrin_RGD_1	325	327	PF01839	0.686
LIG_LIR_Gen_1	212	221	PF02991	0.363
LIG_LIR_Nem_3	212	217	PF02991	0.365
LIG_LIR_Nem_3	267	273	PF02991	0.408
LIG_LIR_Nem_3	317	323	PF02991	0.398
LIG_LIR_Nem_3	446	452	PF02991	0.413
LIG_MYND_1	344	348	PF01753	0.516
LIG_NRBOX	454	460	PF00104	0.374
LIG_PTB_Apo_2	450	457	PF02174	0.247
LIG_SH2_PTP2	399	402	PF00017	0.489
LIG_SH2_SRC	171	174	PF00017	0.410
LIG_SH2_STAT5	110	113	PF00017	0.438
LIG_SH2_STAT5	171	174	PF00017	0.380
LIG_SH2_STAT5	280	283	PF00017	0.381
LIG_SH2_STAT5	329	332	PF00017	0.521
LIG_SH2_STAT5	399	402	PF00017	0.489
LIG_SH3_2	333	338	PF14604	0.514
LIG_SH3_3	218	224	PF00018	0.407
LIG_SH3_3	268	274	PF00018	0.399
LIG_SH3_3	330	336	PF00018	0.478
LIG_SH3_3	345	351	PF00018	0.519
LIG_SH3_3	44	50	PF00018	0.505
LIG_SH3_3	470	476	PF00018	0.524
LIG_SUMO_SIM_par_1	147	152	PF11976	0.414
LIG_TRAF2_1	123	126	PF00917	0.565
LIG_TRAF2_2	351	356	PF00917	0.528
LIG_TYR_ITIM	447	452	PF00017	0.417
LIG_WRC_WIRS_1	1	6	PF05994	0.405
MOD_CDK_SPK_2	142	147	PF00069	0.390
MOD_CDK_SPxK_1	344	350	PF00069	0.519
MOD_CDK_SPxxK_3	331	338	PF00069	0.455
MOD_CK1_1	12	18	PF00069	0.561
MOD_CK1_1	142	148	PF00069	0.481
MOD_CK1_1	255	261	PF00069	0.341
MOD_CK1_1	3	9	PF00069	0.458
MOD_CK1_1	309	315	PF00069	0.347
MOD_CK1_1	37	43	PF00069	0.608
MOD_CK1_1	403	409	PF00069	0.593
MOD_CK1_1	411	417	PF00069	0.534
MOD_CK2_1	120	126	PF00069	0.484
MOD_Cter_Amidation	224	227	PF01082	0.506
MOD_GlcNHglycan	11	14	PF01048	0.630
MOD_GlcNHglycan	160	163	PF01048	0.612
MOD_GlcNHglycan	38	42	PF01048	0.762
MOD_GlcNHglycan	417	420	PF01048	0.670
MOD_GSK3_1	135	142	PF00069	0.536
MOD_GSK3_1	248	255	PF00069	0.551
MOD_GSK3_1	298	305	PF00069	0.465
MOD_GSK3_1	309	316	PF00069	0.461
MOD_GSK3_1	327	334	PF00069	0.575
MOD_GSK3_1	33	40	PF00069	0.547
MOD_GSK3_1	400	407	PF00069	0.559
MOD_GSK3_1	408	415	PF00069	0.486
MOD_GSK3_1	431	438	PF00069	0.434
MOD_GSK3_1	56	63	PF00069	0.612
MOD_GSK3_1	9	16	PF00069	0.510
MOD_N-GLC_1	327	332	PF02516	0.731
MOD_NEK2_1	149	154	PF00069	0.410
MOD_NEK2_1	289	294	PF00069	0.305
MOD_NEK2_1	431	436	PF00069	0.419
MOD_PIKK_1	298	304	PF00454	0.439
MOD_PIKK_1	400	406	PF00454	0.516
MOD_PKA_2	307	313	PF00069	0.407
MOD_Plk_1	135	141	PF00069	0.426
MOD_Plk_1	56	62	PF00069	0.541
MOD_Plk_4	167	173	PF00069	0.416
MOD_Plk_4	191	197	PF00069	0.401
MOD_Plk_4	225	231	PF00069	0.353
MOD_ProDKin_1	137	143	PF00069	0.416
MOD_ProDKin_1	252	258	PF00069	0.351
MOD_ProDKin_1	331	337	PF00069	0.426
MOD_ProDKin_1	344	350	PF00069	0.519
MOD_ProDKin_1	40	46	PF00069	0.565
MOD_ProDKin_1	405	411	PF00069	0.454
MOD_SUMO_rev_2	87	96	PF00179	0.425
TRG_DiLeu_BaLyEn_6	145	150	PF01217	0.421
TRG_ENDOCYTIC_2	449	452	PF00928	0.411
TRG_ER_diArg_1	359	362	PF00400	0.509
TRG_ER_diArg_1	470	472	PF00400	0.568

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P8Q7	Leptomonas seymouri	59%	95%
A0A3S7X2C7	Leishmania donovani	72%	99%
A4I4D7	Leishmania infantum	72%	99%
C9ZL27	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	34%	98%
E9ADT6	Leishmania major	70%	100%
E9ALZ4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	70%	100%