Cysteine peptidase C (CPC)

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like

Species:

Leishmania braziliensis

UniProt:

A4HH90_LEIBR

TriTrypDb:

LbrM.29.0850 , LBRM2903_290014900

Length:

340

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 25

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 16

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 8, no: 2
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0000323	lytic vacuole	6	1
GO:0005615	extracellular space	2	1
GO:0005764	lysosome	7	1
GO:0005773	vacuole	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HH90

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HH90

Function

Biological processes
Term	Name	Level	Count
GO:0006508	proteolysis	4	11
GO:0006807	nitrogen compound metabolic process	2	11
GO:0008152	metabolic process	1	11
GO:0019538	protein metabolic process	3	11
GO:0043170	macromolecule metabolic process	3	11
GO:0044238	primary metabolic process	2	11
GO:0071704	organic substance metabolic process	2	11
GO:1901564	organonitrogen compound metabolic process	3	11
GO:0008219	cell death	2	1
GO:0009987	cellular process	1	1
GO:0051603	proteolysis involved in protein catabolic process	5	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	11
GO:0008233	peptidase activity	3	11
GO:0008234	cysteine-type peptidase activity	4	11
GO:0016787	hydrolase activity	2	11
GO:0140096	catalytic activity, acting on a protein	2	11
GO:0004175	endopeptidase activity	4	1
GO:0004197	cysteine-type endopeptidase activity	5	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	221	225	PF00656	0.299
CLV_C14_Caspase3-7	310	314	PF00656	0.221
CLV_NRD_NRD_1	320	322	PF00675	0.478
CLV_NRD_NRD_1	70	72	PF00675	0.636
CLV_PCSK_KEX2_1	320	322	PF00082	0.462
CLV_PCSK_SKI1_1	6	10	PF00082	0.325
DEG_Nend_UBRbox_1	1	4	PF02207	0.595
DEG_SCF_FBW7_1	30	37	PF00400	0.322
DOC_CKS1_1	213	218	PF01111	0.270
DOC_MAPK_gen_1	241	250	PF00069	0.325
DOC_MAPK_MEF2A_6	6	15	PF00069	0.455
DOC_PP1_RVXF_1	286	293	PF00149	0.270
DOC_USP7_MATH_1	207	211	PF00917	0.289
DOC_WW_Pin1_4	212	217	PF00397	0.276
DOC_WW_Pin1_4	295	300	PF00397	0.212
DOC_WW_Pin1_4	30	35	PF00397	0.377
DOC_WW_Pin1_4	82	87	PF00397	0.369
LIG_14-3-3_CanoR_1	138	143	PF00244	0.304
LIG_14-3-3_CanoR_1	149	156	PF00244	0.300
LIG_14-3-3_CanoR_1	87	94	PF00244	0.402
LIG_APCC_ABBA_1	260	265	PF00400	0.270
LIG_BRCT_BRCA1_1	156	160	PF00533	0.333
LIG_BRCT_BRCA1_1	36	40	PF00533	0.355
LIG_deltaCOP1_diTrp_1	310	317	PF00928	0.272
LIG_eIF4E_1	4	10	PF01652	0.412
LIG_EVH1_1	191	195	PF00568	0.212
LIG_FHA_1	150	156	PF00498	0.338
LIG_FHA_1	182	188	PF00498	0.305
LIG_FHA_1	23	29	PF00498	0.534
LIG_FHA_1	3	9	PF00498	0.648
LIG_FHA_1	31	37	PF00498	0.383
LIG_FHA_1	79	85	PF00498	0.374
LIG_FHA_2	111	117	PF00498	0.305
LIG_FHA_2	209	215	PF00498	0.326
LIG_FHA_2	219	225	PF00498	0.300
LIG_FHA_2	275	281	PF00498	0.372
LIG_FHA_2	98	104	PF00498	0.273
LIG_GBD_Chelix_1	11	19	PF00786	0.321
LIG_LIR_Apic_2	210	216	PF02991	0.284
LIG_LIR_Apic_2	24	30	PF02991	0.585
LIG_LIR_Gen_1	136	145	PF02991	0.284
LIG_LIR_Gen_1	261	269	PF02991	0.215
LIG_LIR_Gen_1	5	15	PF02991	0.412
LIG_LIR_Nem_3	136	142	PF02991	0.319
LIG_LIR_Nem_3	252	256	PF02991	0.290
LIG_LIR_Nem_3	257	263	PF02991	0.278
LIG_LIR_Nem_3	265	269	PF02991	0.317
LIG_LIR_Nem_3	298	303	PF02991	0.283
LIG_LIR_Nem_3	313	319	PF02991	0.328
LIG_LIR_Nem_3	5	10	PF02991	0.412
LIG_NRBOX	14	20	PF00104	0.226
LIG_Pex14_2	256	260	PF04695	0.208
LIG_SH2_CRK	139	143	PF00017	0.264
LIG_SH2_CRK	213	217	PF00017	0.302
LIG_SH2_NCK_1	213	217	PF00017	0.242
LIG_SH2_PTP2	27	30	PF00017	0.565
LIG_SH2_STAP1	263	267	PF00017	0.284
LIG_SH2_STAP1	4	8	PF00017	0.575
LIG_SH2_STAT5	139	142	PF00017	0.302
LIG_SH2_STAT5	27	30	PF00017	0.441
LIG_SH2_STAT5	316	319	PF00017	0.270
LIG_SH2_STAT5	4	7	PF00017	0.589
LIG_SH3_3	184	190	PF00018	0.373
LIG_SH3_3	203	209	PF00018	0.207
LIG_SUMO_SIM_par_1	15	22	PF11976	0.340
LIG_SUMO_SIM_par_1	245	252	PF11976	0.307
LIG_TRAF2_1	66	69	PF00917	0.369
LIG_TRAF2_1	90	93	PF00917	0.323
LIG_TYR_ITSM	296	303	PF00017	0.212
LIG_Vh1_VBS_1	8	26	PF01044	0.226
MOD_CDK_SPK_2	82	87	PF00069	0.332
MOD_CDK_SPxxK_3	295	302	PF00069	0.212
MOD_CK1_1	101	107	PF00069	0.269
MOD_CK1_1	268	274	PF00069	0.307
MOD_CK1_1	275	281	PF00069	0.255
MOD_CK1_1	306	312	PF00069	0.327
MOD_CK1_1	63	69	PF00069	0.512
MOD_CK2_1	110	116	PF00069	0.321
MOD_CK2_1	274	280	PF00069	0.372
MOD_CK2_1	63	69	PF00069	0.423
MOD_CK2_1	87	93	PF00069	0.327
MOD_CMANNOS	175	178	PF00535	0.527
MOD_GlcNHglycan	270	273	PF01048	0.524
MOD_GlcNHglycan	54	57	PF01048	0.646
MOD_GlcNHglycan	62	65	PF01048	0.690
MOD_GlcNHglycan	89	92	PF01048	0.521
MOD_GSK3_1	118	125	PF00069	0.302
MOD_GSK3_1	18	25	PF00069	0.399
MOD_GSK3_1	208	215	PF00069	0.333
MOD_GSK3_1	218	225	PF00069	0.355
MOD_GSK3_1	268	275	PF00069	0.212
MOD_GSK3_1	30	37	PF00069	0.405
MOD_GSK3_1	78	85	PF00069	0.371
MOD_GSK3_1	97	104	PF00069	0.239
MOD_N-GLC_1	218	223	PF02516	0.547
MOD_N-GLC_1	295	300	PF02516	0.412
MOD_N-GLC_1	77	82	PF02516	0.639
MOD_NEK2_1	148	153	PF00069	0.321
MOD_NEK2_1	18	23	PF00069	0.456
MOD_NEK2_1	77	82	PF00069	0.363
MOD_PKA_1	320	326	PF00069	0.242
MOD_PKA_2	148	154	PF00069	0.302
MOD_PKA_2	320	326	PF00069	0.261
MOD_Plk_1	234	240	PF00069	0.333
MOD_Plk_4	208	214	PF00069	0.364
MOD_Plk_4	22	28	PF00069	0.411
MOD_ProDKin_1	212	218	PF00069	0.276
MOD_ProDKin_1	295	301	PF00069	0.212
MOD_ProDKin_1	30	36	PF00069	0.368
MOD_ProDKin_1	82	88	PF00069	0.373
TRG_DiLeu_BaEn_1	69	74	PF01217	0.382
TRG_DiLeu_BaLyEn_6	31	36	PF01217	0.434
TRG_ENDOCYTIC_2	139	142	PF00928	0.327
TRG_ENDOCYTIC_2	253	256	PF00928	0.307
TRG_ENDOCYTIC_2	263	266	PF00928	0.294
TRG_ENDOCYTIC_2	300	303	PF00928	0.299
TRG_ENDOCYTIC_2	316	319	PF00928	0.270
TRG_ENDOCYTIC_2	4	7	PF00928	0.616
TRG_ER_diArg_1	319	321	PF00400	0.229
TRG_Pf-PMV_PEXEL_1	112	116	PF00026	0.412

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A072UTP9	Medicago truncatula	28%	97%
A0A0N0P293	Leptomonas seymouri	25%	92%
A0A0N0P8D1	Leptomonas seymouri	62%	100%
A0A0N1PA65	Leptomonas seymouri	28%	73%
A0A0S4III3	Bodo saltans	26%	100%
A0A0S4IMD3	Bodo saltans	27%	91%
A0A0S4IN52	Bodo saltans	55%	100%
A0A0S4J328	Bodo saltans	26%	100%
A0A0S4J7T4	Bodo saltans	24%	67%
A0A0S4J918	Bodo saltans	26%	100%
A0A0S4J9K9	Bodo saltans	28%	100%
A0A0S4JIQ4	Bodo saltans	27%	100%
A0A0S4JPQ2	Bodo saltans	25%	92%
A0A0S4JSZ3	Bodo saltans	24%	92%
A0A0S4JV57	Bodo saltans	27%	92%
A0A0S4JXJ3	Bodo saltans	25%	89%
A0A0S4KGP4	Bodo saltans	28%	100%
A0A0S4KI32	Bodo saltans	30%	100%
A0A0S4KJA5	Bodo saltans	28%	73%
A0A1X0NIG8	Trypanosomatidae	29%	78%
A0A1X0NTV4	Trypanosomatidae	56%	100%
A0A1X0NXC8	Trypanosomatidae	28%	90%
A0A3R7N5T7	Trypanosoma rangeli	51%	100%
A0A3S5H682	Leishmania donovani	28%	86%
A0A3S5H683	Leishmania donovani	28%	77%
A0A3S5H684	Leishmania donovani	29%	77%
A0A3S5H685	Leishmania donovani	28%	77%
A0A3S7WQD0	Leishmania donovani	28%	77%
A0A6L0WJ22	Leishmania infantum	29%	77%
A1E295	Sus scrofa	45%	100%
A1KXI0	Blomia tropicalis	29%	100%
A2XQE8	Oryza sativa subsp. indica	29%	100%
A4H5E4	Leishmania braziliensis	28%	77%
A4H5E5	Leishmania braziliensis	28%	77%
A4H5E6	Leishmania braziliensis	28%	77%
A4HA92	Leishmania braziliensis	29%	71%
A4HYH2	Leishmania infantum	27%	96%
A4I4D6	Leishmania infantum	69%	100%
A5HII1	Actinidia deliciosa	25%	89%
B2LSD2	Mucuna pruriens	28%	79%
C9ZQ62	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	52%	100%
D3ZZ07	Rattus norvegicus	25%	100%
E8NHD8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	29%	95%
E8NHH6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	30%	100%
E8NHS3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	30%	91%
E9ADT5	Leishmania major	69%	100%
E9ALZ5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	70%	100%
E9AMH5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	30%	93%
E9AMH6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	30%	77%
E9AMH7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	30%	95%
E9AS96	Leishmania mexicana (strain MHOM/GT/2001/U1103)	25%	96%
F4HVZ1	Arabidopsis thaliana	36%	90%
F4JNL3	Arabidopsis thaliana	30%	96%
G5EGP8	Caenorhabditis elegans	25%	100%
O10364	Orgyia pseudotsugata multicapsid polyhedrosis virus	26%	100%
O23791	Ananas comosus	29%	97%
O35186	Rattus norvegicus	27%	100%
O45734	Caenorhabditis elegans	27%	100%
O46427	Sus scrofa	31%	100%
O60911	Homo sapiens	29%	100%
O65039	Ricinus communis	28%	94%
O65493	Arabidopsis thaliana	27%	96%
O70370	Mus musculus	26%	100%
O91466	Cydia pomonella granulosis virus (isolate Mexico/1963)	29%	100%
O97397	Phaedon cochleariae	26%	100%
O97578	Canis lupus familiaris	33%	78%
P00784	Carica papaya	26%	99%
P00785	Actinidia chinensis var. chinensis	25%	89%
P00786	Rattus norvegicus	31%	100%
P00787	Rattus norvegicus	43%	100%
P04988	Dictyostelium discoideum	21%	99%
P05167	Hordeum vulgare	31%	94%
P05689	Bos taurus	27%	100%
P05994	Carica papaya	25%	98%
P06797	Mus musculus	27%	100%
P07688	Bos taurus	43%	100%
P07711	Homo sapiens	27%	100%
P07858	Homo sapiens	44%	100%
P09668	Homo sapiens	31%	100%
P10056	Carica papaya	26%	98%
P10605	Mus musculus	47%	100%
P12412	Vigna mungo	24%	94%
P13277	Homarus americanus	25%	100%
P14080	Carica papaya	26%	97%
P15242	Rattus norvegicus	25%	100%
P16311	Dermatophagoides farinae	26%	100%
P19092	Haemonchus contortus	43%	99%
P20721	Solanum lycopersicum	27%	98%
P22497	Theileria parva	30%	77%
P22895	Glycine max	27%	90%
P25249	Hordeum vulgare	27%	92%
P25250	Hordeum vulgare	27%	91%
P25251	Brassica napus	28%	100%
P25326	Bos taurus	29%	100%
P25773	Felis catus	28%	100%
P25774	Homo sapiens	28%	100%
P25775	Leishmania mexicana	25%	96%
P25776	Oryza sativa subsp. japonica	28%	74%
P25777	Oryza sativa subsp. japonica	28%	73%
P25778	Oryza sativa subsp. japonica	33%	94%
P25779	Trypanosoma cruzi	26%	73%
P25780	Euroglyphus maynei	26%	100%
P25781	Theileria annulata	31%	77%
P25782	Homarus americanus	25%	100%
P25783	Autographa californica nuclear polyhedrosis virus	27%	100%
P25784	Homarus americanus	27%	100%
P25792	Schistosoma mansoni	44%	100%
P25793	Haemonchus contortus	35%	99%
P25802	Ostertagia ostertagi	39%	100%
P25803	Phaseolus vulgaris	27%	94%
P25804	Pisum sativum	26%	94%
P25807	Caenorhabditis elegans	38%	100%
P25975	Bos taurus	28%	100%
P35591	Leishmania pifanoi	25%	96%
P36185	Entamoeba histolytica	27%	100%
P41715	Choristoneura fumiferana nuclear polyhedrosis virus	29%	100%
P41721	Bombyx mori nuclear polyhedrosis virus	27%	100%
P43156	Hemerocallis sp.	27%	94%
P43157	Schistosoma japonicum	45%	99%
P43233	Gallus gallus	45%	100%
P43234	Homo sapiens	28%	100%
P43235	Homo sapiens	27%	100%
P43236	Oryctolagus cuniculus	26%	100%
P43295	Arabidopsis thaliana	27%	94%
P43296	Arabidopsis thaliana	25%	92%
P43297	Arabidopsis thaliana	26%	74%
P43507	Caenorhabditis elegans	41%	92%
P43508	Caenorhabditis elegans	39%	100%
P43509	Caenorhabditis elegans	44%	99%
P43510	Caenorhabditis elegans	42%	90%
P49935	Mus musculus	31%	100%
P53634	Homo sapiens	32%	73%
P55097	Mus musculus	26%	100%
P56202	Homo sapiens	28%	90%
P56203	Mus musculus	28%	92%
P61276	Macaca fascicularis	26%	100%
P61277	Macaca mulatta	26%	100%
P80067	Rattus norvegicus	30%	74%
P80884	Ananas comosus	26%	99%
P83205	Ovis aries	43%	100%
P90850	Caenorhabditis elegans	34%	75%
P92131	Giardia intestinalis	35%	100%
P92132	Giardia intestinalis	38%	100%
P92133	Giardia intestinalis	38%	100%
P97821	Mus musculus	30%	74%
Q01957	Entamoeba histolytica	26%	100%
Q01958	Entamoeba histolytica	27%	100%
Q02765	Rattus norvegicus	28%	100%
Q06964	Entamoeba histolytica	27%	100%
Q10716	Zea mays	26%	92%
Q10717	Zea mays	31%	94%
Q23894	Dictyostelium discoideum	26%	100%
Q24940	Fasciola hepatica	31%	100%
Q26534	Schistosoma mansoni	27%	100%
Q26563	Schistosoma mansoni	34%	75%
Q26636	Sarcophaga peregrina	28%	100%
Q28944	Sus scrofa	27%	100%
Q3SZI1	Bos taurus	31%	71%
Q3T0I2	Bos taurus	30%	100%
Q3ZCJ8	Bos taurus	35%	73%
Q3ZKN1	Canis lupus familiaris	27%	100%
Q40143	Solanum lycopersicum	33%	96%
Q4QD68	Leishmania major	26%	100%
Q4R5M2	Macaca fascicularis	47%	100%
Q54QD9	Dictyostelium discoideum	37%	100%
Q5E968	Bos taurus	27%	100%
Q5E998	Bos taurus	28%	100%
Q5R6D1	Pongo abelii	47%	100%
Q5RB02	Pongo abelii	31%	73%
Q60HG6	Macaca fascicularis	31%	73%
Q63088	Rattus norvegicus	28%	100%
Q6PN98	Onchocerca volvulus	26%	100%
Q6VTL7	Choristoneura fumiferana defective polyhedrosis virus	29%	100%
Q6YD92	Petrosia ficiformis	25%	100%
Q7F3A8	Oryza sativa subsp. japonica	29%	92%
Q7GDU7	Oryza sativa subsp. japonica	28%	90%
Q7XR52	Oryza sativa subsp. japonica	30%	69%
Q7XWK5	Oryza sativa subsp. japonica	29%	100%
Q80LP4	Adoxophyes honmai nucleopolyhedrovirus	30%	100%
Q80UB0	Mus musculus	26%	100%
Q86GF7	Pandalus borealis	29%	100%
Q8B9D5	Rachiplusia ou multiple nucleopolyhedrovirus (strain R1)	27%	100%
Q8BM88	Mus musculus	28%	100%
Q8H166	Arabidopsis thaliana	32%	95%
Q8HY81	Canis lupus familiaris	29%	100%
Q8HY82	Saimiri boliviensis boliviensis	29%	100%
Q8QLK1	Mamestra configurata nucleopolyhedrovirus	28%	100%
Q8RWQ9	Arabidopsis thaliana	32%	95%
Q8V5U0	Heliothis zea nuclear polyhedrosis virus	30%	93%
Q8VYS0	Arabidopsis thaliana	29%	93%
Q90686	Gallus gallus	28%	100%
Q91BH1	Spodoptera litura multicapsid nucleopolyhedrovirus	34%	100%
Q91CL9	Antheraea pernyi nuclear polyhedrosis virus	28%	100%
Q91GE3	Epiphyas postvittana nucleopolyhedrovirus	27%	100%
Q91ZF2	Mus musculus	27%	100%
Q93VC9	Arabidopsis thaliana	41%	94%
Q94B08	Arabidopsis thaliana	28%	90%
Q94K85	Arabidopsis thaliana	40%	95%
Q95029	Drosophila melanogaster	27%	92%
Q99JR5	Mus musculus	32%	73%
Q9BIE1	Leishmania donovani	27%	96%
Q9EQT5	Rattus norvegicus	32%	73%
Q9FGR9	Arabidopsis thaliana	28%	94%
Q9FJ47	Arabidopsis thaliana	29%	98%
Q9FMH8	Arabidopsis thaliana	27%	73%
Q9GKL8	Chlorocebus aethiops	27%	100%
Q9GL24	Canis lupus familiaris	27%	100%
Q9GLE3	Sus scrofa	27%	100%
Q9GQM5	Leishmania donovani	69%	100%
Q9GZM7	Homo sapiens	33%	73%
Q9J8B9	Spodoptera exigua nuclear polyhedrosis virus (strain US)	32%	100%
Q9JI81	Mus musculus	27%	100%
Q9JL96	Mus musculus	26%	100%
Q9LM66	Arabidopsis thaliana	27%	96%
Q9LT77	Arabidopsis thaliana	31%	94%
Q9LT78	Arabidopsis thaliana	27%	75%
Q9LXW3	Arabidopsis thaliana	27%	90%
Q9PYY5	Xestia c-nigrum granulosis virus	30%	98%
Q9R013	Mus musculus	27%	74%
Q9R014	Mus musculus	28%	100%
Q9STL4	Arabidopsis thaliana	29%	94%
Q9STL5	Arabidopsis thaliana	29%	93%
Q9SUL1	Arabidopsis thaliana	25%	91%
Q9SUS9	Arabidopsis thaliana	27%	92%
Q9UBX1	Homo sapiens	24%	70%
Q9UJW2	Homo sapiens	30%	71%
Q9WGE0	Hyphantria cunea nuclear polyhedrosis virus	25%	100%
Q9YMP9	Lymantria dispar multicapsid nuclear polyhedrosis virus	31%	96%
Q9YWK4	Buzura suppressaria nuclear polyhedrosis virus	27%	100%