Pribosyltran domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HH89_LEIBR

TriTrypDb:

LbrM.29.0840 , LBRM2903_290014800

Length:

616

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

A4HH89

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HH89

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	141	145	PF00656	0.618
CLV_C14_Caspase3-7	203	207	PF00656	0.685
CLV_C14_Caspase3-7	209	213	PF00656	0.675
CLV_C14_Caspase3-7	304	308	PF00656	0.666
CLV_C14_Caspase3-7	552	556	PF00656	0.529
CLV_NRD_NRD_1	289	291	PF00675	0.382
CLV_NRD_NRD_1	467	469	PF00675	0.416
CLV_NRD_NRD_1	470	472	PF00675	0.425
CLV_NRD_NRD_1	530	532	PF00675	0.449
CLV_NRD_NRD_1	567	569	PF00675	0.408
CLV_NRD_NRD_1	572	574	PF00675	0.418
CLV_NRD_NRD_1	576	578	PF00675	0.429
CLV_NRD_NRD_1	84	86	PF00675	0.473
CLV_PCSK_FUR_1	287	291	PF00082	0.375
CLV_PCSK_FUR_1	468	472	PF00082	0.476
CLV_PCSK_FUR_1	531	535	PF00082	0.427
CLV_PCSK_KEX2_1	289	291	PF00082	0.382
CLV_PCSK_KEX2_1	467	469	PF00082	0.416
CLV_PCSK_KEX2_1	470	472	PF00082	0.425
CLV_PCSK_KEX2_1	530	532	PF00082	0.448
CLV_PCSK_KEX2_1	533	535	PF00082	0.391
CLV_PCSK_KEX2_1	576	578	PF00082	0.400
CLV_PCSK_KEX2_1	84	86	PF00082	0.473
CLV_PCSK_PC1ET2_1	533	535	PF00082	0.414
CLV_PCSK_PC7_1	463	469	PF00082	0.471
CLV_PCSK_SKI1_1	190	194	PF00082	0.333
CLV_PCSK_SKI1_1	538	542	PF00082	0.401
CLV_PCSK_SKI1_1	560	564	PF00082	0.342
DEG_Nend_Nbox_1	1	3	PF02207	0.658
DOC_ANK_TNKS_1	398	405	PF00023	0.699
DOC_CYCLIN_RxL_1	184	196	PF00134	0.578
DOC_CYCLIN_RxL_1	533	542	PF00134	0.599
DOC_CYCLIN_RxL_1	81	90	PF00134	0.596
DOC_CYCLIN_yClb1_LxF_4	455	461	PF00134	0.568
DOC_MAPK_gen_1	180	188	PF00069	0.626
DOC_PP1_RVXF_1	82	89	PF00149	0.596
DOC_USP7_MATH_1	30	34	PF00917	0.440
DOC_USP7_MATH_1	302	306	PF00917	0.663
DOC_USP7_MATH_1	99	103	PF00917	0.621
DOC_USP7_UBL2_3	112	116	PF12436	0.684
DOC_WW_Pin1_4	258	263	PF00397	0.559
DOC_WW_Pin1_4	298	303	PF00397	0.645
DOC_WW_Pin1_4	523	528	PF00397	0.585
DOC_WW_Pin1_4	72	77	PF00397	0.663
LIG_14-3-3_CanoR_1	131	139	PF00244	0.649
LIG_14-3-3_CanoR_1	371	376	PF00244	0.714
LIG_APCC_ABBA_1	291	296	PF00400	0.597
LIG_APCC_ABBAyCdc20_2	290	296	PF00400	0.593
LIG_BIR_III_4	144	148	PF00653	0.619
LIG_BRCT_BRCA1_1	158	162	PF00533	0.576
LIG_BRCT_BRCA1_1	49	53	PF00533	0.231
LIG_deltaCOP1_diTrp_1	605	613	PF00928	0.745
LIG_EVH1_1	6	10	PF00568	0.219
LIG_FHA_1	22	28	PF00498	0.589
LIG_FHA_1	286	292	PF00498	0.554
LIG_FHA_1	35	41	PF00498	0.240
LIG_FHA_2	102	108	PF00498	0.619
LIG_FHA_2	207	213	PF00498	0.664
LIG_FHA_2	222	228	PF00498	0.614
LIG_FHA_2	506	512	PF00498	0.744
LIG_LIR_Apic_2	3	9	PF02991	0.495
LIG_LIR_Apic_2	358	364	PF02991	0.622
LIG_LIR_Apic_2	418	424	PF02991	0.623
LIG_LIR_Gen_1	183	193	PF02991	0.676
LIG_LIR_Gen_1	247	257	PF02991	0.625
LIG_LIR_Gen_1	273	282	PF02991	0.535
LIG_LIR_Gen_1	539	548	PF02991	0.600
LIG_LIR_Gen_1	56	65	PF02991	0.388
LIG_LIR_Gen_1	77	86	PF02991	0.691
LIG_LIR_Nem_3	183	188	PF02991	0.683
LIG_LIR_Nem_3	239	244	PF02991	0.687
LIG_LIR_Nem_3	247	253	PF02991	0.673
LIG_LIR_Nem_3	539	544	PF02991	0.540
LIG_LIR_Nem_3	56	62	PF02991	0.388
LIG_LIR_Nem_3	77	82	PF02991	0.685
LIG_PDZ_Class_3	611	616	PF00595	0.689
LIG_SH2_CRK	241	245	PF00017	0.528
LIG_SH2_CRK	250	254	PF00017	0.597
LIG_SH2_CRK	59	63	PF00017	0.291
LIG_SH2_PTP2	185	188	PF00017	0.591
LIG_SH2_STAP1	17	21	PF00017	0.388
LIG_SH2_STAT3	450	453	PF00017	0.645
LIG_SH2_STAT5	185	188	PF00017	0.591
LIG_SH2_STAT5	276	279	PF00017	0.535
LIG_SH2_STAT5	450	453	PF00017	0.631
LIG_SH3_3	4	10	PF00018	0.521
LIG_TRAF2_1	166	169	PF00917	0.555
LIG_TRAF2_1	462	465	PF00917	0.681
LIG_TRAF2_1	508	511	PF00917	0.757
LIG_TYR_ITIM	57	62	PF00017	0.388
LIG_UBA3_1	540	549	PF00899	0.468
MOD_CDK_SPxxK_3	523	530	PF00069	0.451
MOD_CK1_1	207	213	PF00069	0.614
MOD_CK1_1	245	251	PF00069	0.459
MOD_CK1_1	581	587	PF00069	0.504
MOD_CK1_1	61	67	PF00069	0.580
MOD_CK1_1	70	76	PF00069	0.663
MOD_CK1_1	77	83	PF00069	0.618
MOD_CK2_1	101	107	PF00069	0.532
MOD_CK2_1	221	227	PF00069	0.447
MOD_CK2_1	459	465	PF00069	0.529
MOD_CK2_1	491	497	PF00069	0.696
MOD_CK2_1	505	511	PF00069	0.522
MOD_Cter_Amidation	566	569	PF01082	0.412
MOD_GlcNHglycan	101	104	PF01048	0.608
MOD_GlcNHglycan	135	138	PF01048	0.726
MOD_GlcNHglycan	140	143	PF01048	0.677
MOD_GlcNHglycan	149	152	PF01048	0.583
MOD_GlcNHglycan	158	161	PF01048	0.538
MOD_GlcNHglycan	2	5	PF01048	0.696
MOD_GlcNHglycan	244	247	PF01048	0.650
MOD_GlcNHglycan	413	416	PF01048	0.578
MOD_GlcNHglycan	49	52	PF01048	0.458
MOD_GlcNHglycan	63	66	PF01048	0.634
MOD_GlcNHglycan	69	72	PF01048	0.760
MOD_GSK3_1	127	134	PF00069	0.679
MOD_GSK3_1	204	211	PF00069	0.632
MOD_GSK3_1	22	29	PF00069	0.658
MOD_GSK3_1	245	252	PF00069	0.475
MOD_GSK3_1	294	301	PF00069	0.530
MOD_GSK3_1	30	37	PF00069	0.538
MOD_GSK3_1	411	418	PF00069	0.554
MOD_GSK3_1	547	554	PF00069	0.444
MOD_GSK3_1	578	585	PF00069	0.464
MOD_GSK3_1	67	74	PF00069	0.667
MOD_N-GLC_1	204	209	PF02516	0.494
MOD_N-GLC_1	242	247	PF02516	0.421
MOD_NEK2_1	156	161	PF00069	0.547
MOD_NEK2_1	2	7	PF00069	0.591
MOD_NEK2_1	236	241	PF00069	0.487
MOD_NEK2_1	47	52	PF00069	0.388
MOD_NEK2_1	53	58	PF00069	0.345
MOD_NEK2_1	547	552	PF00069	0.444
MOD_PIKK_1	129	135	PF00454	0.556
MOD_PKA_2	294	300	PF00069	0.442
MOD_PKB_1	85	93	PF00069	0.635
MOD_Plk_1	214	220	PF00069	0.474
MOD_Plk_1	392	398	PF00069	0.520
MOD_Plk_2-3	491	497	PF00069	0.696
MOD_Plk_4	245	251	PF00069	0.459
MOD_Plk_4	371	377	PF00069	0.633
MOD_Plk_4	392	398	PF00069	0.520
MOD_Plk_4	53	59	PF00069	0.430
MOD_Plk_4	74	80	PF00069	0.549
MOD_ProDKin_1	258	264	PF00069	0.425
MOD_ProDKin_1	298	304	PF00069	0.549
MOD_ProDKin_1	523	529	PF00069	0.458
MOD_ProDKin_1	72	78	PF00069	0.572
MOD_SUMO_for_1	166	169	PF00179	0.411
TRG_DiLeu_BaEn_1	443	448	PF01217	0.616
TRG_DiLeu_BaEn_4	168	174	PF01217	0.417
TRG_ENDOCYTIC_2	185	188	PF00928	0.589
TRG_ENDOCYTIC_2	241	244	PF00928	0.537
TRG_ENDOCYTIC_2	250	253	PF00928	0.567
TRG_ENDOCYTIC_2	276	279	PF00928	0.395
TRG_ENDOCYTIC_2	59	62	PF00928	0.388
TRG_ER_diArg_1	286	289	PF00400	0.443
TRG_ER_diArg_1	466	468	PF00400	0.585
TRG_ER_diArg_1	83	85	PF00400	0.537
TRG_NES_CRM1_1	542	555	PF08389	0.360
TRG_NLS_MonoExtC_3	572	577	PF00514	0.440
TRG_Pf-PMV_PEXEL_1	190	194	PF00026	0.469
TRG_Pf-PMV_PEXEL_1	399	403	PF00026	0.541
TRG_Pf-PMV_PEXEL_1	538	542	PF00026	0.328

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I7X5	Leptomonas seymouri	44%	100%
A0A3S7X291	Leishmania donovani	73%	100%
A4I4D5	Leishmania infantum	72%	100%
E9ADT4	Leishmania major	72%	100%
E9ALZ6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	70%	100%