Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HH88_LEIBR

TriTrypDb:

LbrM.29.0830 , LBRM2903_290014700

Length:

602

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HH88

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HH88

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	138	142	PF00656	0.818
CLV_C14_Caspase3-7	20	24	PF00656	0.444
CLV_C14_Caspase3-7	350	354	PF00656	0.657
CLV_C14_Caspase3-7	388	392	PF00656	0.574
CLV_C14_Caspase3-7	92	96	PF00656	0.581
CLV_NRD_NRD_1	135	137	PF00675	0.585
CLV_NRD_NRD_1	199	201	PF00675	0.548
CLV_NRD_NRD_1	277	279	PF00675	0.677
CLV_NRD_NRD_1	346	348	PF00675	0.832
CLV_NRD_NRD_1	430	432	PF00675	0.853
CLV_NRD_NRD_1	525	527	PF00675	0.589
CLV_NRD_NRD_1	577	579	PF00675	0.725
CLV_NRD_NRD_1	76	78	PF00675	0.572
CLV_PCSK_KEX2_1	135	137	PF00082	0.788
CLV_PCSK_KEX2_1	199	201	PF00082	0.578
CLV_PCSK_KEX2_1	277	279	PF00082	0.677
CLV_PCSK_KEX2_1	430	432	PF00082	0.693
CLV_PCSK_KEX2_1	525	527	PF00082	0.589
CLV_PCSK_KEX2_1	577	579	PF00082	0.725
CLV_PCSK_KEX2_1	76	78	PF00082	0.572
CLV_PCSK_SKI1_1	101	105	PF00082	0.828
CLV_PCSK_SKI1_1	451	455	PF00082	0.712
CLV_PCSK_SKI1_1	591	595	PF00082	0.603
CLV_Separin_Metazoa	383	387	PF03568	0.604
DEG_APCC_DBOX_1	27	35	PF00400	0.659
DEG_COP1_1	280	289	PF00400	0.541
DEG_Nend_Nbox_1	1	3	PF02207	0.779
DEG_SCF_FBW7_1	102	109	PF00400	0.709
DEG_SCF_FBW7_1	122	129	PF00400	0.479
DEG_SPOP_SBC_1	161	165	PF00917	0.783
DEG_SPOP_SBC_1	166	170	PF00917	0.774
DEG_SPOP_SBC_1	61	65	PF00917	0.733
DOC_CKS1_1	103	108	PF01111	0.711
DOC_CKS1_1	123	128	PF01111	0.594
DOC_MAPK_gen_1	221	228	PF00069	0.559
DOC_MAPK_gen_1	556	564	PF00069	0.676
DOC_MAPK_MEF2A_6	548	557	PF00069	0.506
DOC_MAPK_RevD_3	122	136	PF00069	0.571
DOC_SPAK_OSR1_1	460	464	PF12202	0.498
DOC_USP7_MATH_1	106	110	PF00917	0.714
DOC_USP7_MATH_1	126	130	PF00917	0.596
DOC_USP7_MATH_1	162	166	PF00917	0.793
DOC_USP7_MATH_1	204	208	PF00917	0.675
DOC_USP7_MATH_1	279	283	PF00917	0.633
DOC_USP7_MATH_1	306	310	PF00917	0.654
DOC_USP7_MATH_1	362	366	PF00917	0.603
DOC_WW_Pin1_4	102	107	PF00397	0.507
DOC_WW_Pin1_4	122	127	PF00397	0.523
DOC_WW_Pin1_4	293	298	PF00397	0.740
DOC_WW_Pin1_4	375	380	PF00397	0.545
DOC_WW_Pin1_4	435	440	PF00397	0.566
DOC_WW_Pin1_4	83	88	PF00397	0.824
LIG_14-3-3_CanoR_1	101	106	PF00244	0.709
LIG_14-3-3_CanoR_1	135	145	PF00244	0.651
LIG_14-3-3_CanoR_1	223	229	PF00244	0.561
LIG_14-3-3_CanoR_1	231	237	PF00244	0.519
LIG_14-3-3_CanoR_1	256	260	PF00244	0.645
LIG_14-3-3_CanoR_1	278	287	PF00244	0.540
LIG_14-3-3_CanoR_1	28	32	PF00244	0.552
LIG_14-3-3_CanoR_1	337	345	PF00244	0.624
LIG_14-3-3_CanoR_1	407	417	PF00244	0.805
LIG_14-3-3_CanoR_1	480	486	PF00244	0.804
LIG_14-3-3_CanoR_1	548	554	PF00244	0.771
LIG_14-3-3_CanoR_1	76	82	PF00244	0.561
LIG_AP_GAE_1	298	304	PF02883	0.556
LIG_BRCT_BRCA1_1	437	441	PF00533	0.808
LIG_BRCT_BRCA1_1	51	55	PF00533	0.630
LIG_FHA_1	289	295	PF00498	0.803
LIG_FHA_1	379	385	PF00498	0.573
LIG_FHA_1	442	448	PF00498	0.752
LIG_FHA_1	452	458	PF00498	0.592
LIG_FHA_1	48	54	PF00498	0.634
LIG_FHA_1	548	554	PF00498	0.701
LIG_FHA_1	557	563	PF00498	0.591
LIG_FHA_1	63	69	PF00498	0.579
LIG_FHA_1	8	14	PF00498	0.709
LIG_FHA_2	1	7	PF00498	0.749
LIG_FHA_2	103	109	PF00498	0.742
LIG_FHA_2	250	256	PF00498	0.464
LIG_FHA_2	315	321	PF00498	0.697
LIG_LIR_Apic_2	206	211	PF02991	0.539
LIG_LIR_Apic_2	48	54	PF02991	0.770
LIG_LIR_Gen_1	147	156	PF02991	0.555
LIG_LIR_Gen_1	265	274	PF02991	0.715
LIG_LIR_Gen_1	298	308	PF02991	0.805
LIG_LIR_Nem_3	147	151	PF02991	0.551
LIG_LIR_Nem_3	265	269	PF02991	0.693
LIG_LIR_Nem_3	298	304	PF02991	0.809
LIG_LIR_Nem_3	374	380	PF02991	0.719
LIG_LIR_Nem_3	6	12	PF02991	0.718
LIG_Pex14_1	262	266	PF04695	0.678
LIG_Pex14_1	588	592	PF04695	0.707
LIG_PTAP_UEV_1	86	91	PF05743	0.825
LIG_SH2_CRK	266	270	PF00017	0.701
LIG_SH2_CRK	51	55	PF00017	0.791
LIG_SH2_NCK_1	51	55	PF00017	0.791
LIG_SH2_PTP2	592	595	PF00017	0.470
LIG_SH2_SRC	12	15	PF00017	0.460
LIG_SH2_STAP1	9	13	PF00017	0.705
LIG_SH2_STAT3	568	571	PF00017	0.705
LIG_SH2_STAT5	146	149	PF00017	0.592
LIG_SH2_STAT5	380	383	PF00017	0.792
LIG_SH2_STAT5	592	595	PF00017	0.586
LIG_SH2_STAT5	9	12	PF00017	0.710
LIG_SH3_3	120	126	PF00018	0.657
LIG_SH3_3	302	308	PF00018	0.761
LIG_SH3_3	84	90	PF00018	0.829
LIG_SUMO_SIM_par_1	495	500	PF11976	0.489
LIG_TRAF2_1	296	299	PF00917	0.549
LIG_TRAF2_1	4	7	PF00917	0.726
LIG_UBA3_1	68	74	PF00899	0.569
MOD_CK1_1	164	170	PF00069	0.651
MOD_CK1_1	177	183	PF00069	0.597
MOD_CK1_1	206	212	PF00069	0.796
MOD_CK1_1	230	236	PF00069	0.806
MOD_CK1_1	238	244	PF00069	0.664
MOD_CK1_1	288	294	PF00069	0.800
MOD_CK1_1	352	358	PF00069	0.708
MOD_CK1_1	365	371	PF00069	0.627
MOD_CK1_1	378	384	PF00069	0.554
MOD_CK1_1	49	55	PF00069	0.704
MOD_CK1_1	56	62	PF00069	0.708
MOD_CK1_1	579	585	PF00069	0.474
MOD_CK1_1	63	69	PF00069	0.618
MOD_CK1_1	79	85	PF00069	0.805
MOD_CK1_1	88	94	PF00069	0.626
MOD_CK2_1	1	7	PF00069	0.749
MOD_CK2_1	102	108	PF00069	0.788
MOD_CK2_1	206	212	PF00069	0.680
MOD_CK2_1	233	239	PF00069	0.799
MOD_CK2_1	249	255	PF00069	0.401
MOD_CK2_1	293	299	PF00069	0.553
MOD_Cter_Amidation	523	526	PF01082	0.589
MOD_GlcNHglycan	164	167	PF01048	0.643
MOD_GlcNHglycan	176	179	PF01048	0.557
MOD_GlcNHglycan	200	203	PF01048	0.646
MOD_GlcNHglycan	243	246	PF01048	0.614
MOD_GlcNHglycan	272	275	PF01048	0.613
MOD_GlcNHglycan	308	311	PF01048	0.804
MOD_GlcNHglycan	320	325	PF01048	0.618
MOD_GlcNHglycan	410	413	PF01048	0.715
MOD_GlcNHglycan	522	525	PF01048	0.815
MOD_GlcNHglycan	545	548	PF01048	0.786
MOD_GlcNHglycan	579	582	PF01048	0.735
MOD_GlcNHglycan	584	587	PF01048	0.633
MOD_GlcNHglycan	59	62	PF01048	0.673
MOD_GlcNHglycan	81	84	PF01048	0.805
MOD_GlcNHglycan	87	90	PF01048	0.665
MOD_GSK3_1	102	109	PF00069	0.812
MOD_GSK3_1	122	129	PF00069	0.479
MOD_GSK3_1	136	143	PF00069	0.670
MOD_GSK3_1	146	153	PF00069	0.696
MOD_GSK3_1	160	167	PF00069	0.594
MOD_GSK3_1	169	176	PF00069	0.690
MOD_GSK3_1	211	218	PF00069	0.738
MOD_GSK3_1	227	234	PF00069	0.749
MOD_GSK3_1	352	359	PF00069	0.687
MOD_GSK3_1	361	368	PF00069	0.724
MOD_GSK3_1	45	52	PF00069	0.613
MOD_GSK3_1	53	60	PF00069	0.612
MOD_GSK3_1	543	550	PF00069	0.588
MOD_GSK3_1	63	70	PF00069	0.778
MOD_GSK3_1	77	84	PF00069	0.713
MOD_LATS_1	133	139	PF00433	0.584
MOD_N-GLC_1	365	370	PF02516	0.719
MOD_N-GLC_1	57	62	PF02516	0.556
MOD_NEK2_1	179	184	PF00069	0.610
MOD_NEK2_1	229	234	PF00069	0.559
MOD_NEK2_1	269	274	PF00069	0.695
MOD_NEK2_1	45	50	PF00069	0.594
MOD_NEK2_1	68	73	PF00069	0.569
MOD_NEK2_1	81	86	PF00069	0.678
MOD_PIKK_1	393	399	PF00454	0.579
MOD_PIKK_1	510	516	PF00454	0.544
MOD_PKA_1	135	141	PF00069	0.666
MOD_PKA_1	277	283	PF00069	0.639
MOD_PKA_1	577	583	PF00069	0.732
MOD_PKA_1	76	82	PF00069	0.581
MOD_PKA_2	135	141	PF00069	0.666
MOD_PKA_2	198	204	PF00069	0.646
MOD_PKA_2	230	236	PF00069	0.564
MOD_PKA_2	255	261	PF00069	0.645
MOD_PKA_2	27	33	PF00069	0.554
MOD_PKA_2	277	283	PF00069	0.756
MOD_PKA_2	336	342	PF00069	0.685
MOD_PKA_2	343	349	PF00069	0.629
MOD_PKA_2	479	485	PF00069	0.637
MOD_PKA_2	547	553	PF00069	0.530
MOD_PKA_2	576	582	PF00069	0.734
MOD_PKA_2	76	82	PF00069	0.833
MOD_Plk_1	211	217	PF00069	0.800
MOD_Plk_1	238	244	PF00069	0.544
MOD_Plk_1	352	358	PF00069	0.610
MOD_Plk_1	365	371	PF00069	0.509
MOD_Plk_1	37	43	PF00069	0.593
MOD_Plk_1	46	52	PF00069	0.520
MOD_Plk_4	127	133	PF00069	0.824
MOD_Plk_4	224	230	PF00069	0.560
MOD_Plk_4	366	372	PF00069	0.543
MOD_Plk_4	64	70	PF00069	0.568
MOD_ProDKin_1	102	108	PF00069	0.509
MOD_ProDKin_1	122	128	PF00069	0.523
MOD_ProDKin_1	293	299	PF00069	0.743
MOD_ProDKin_1	375	381	PF00069	0.548
MOD_ProDKin_1	435	441	PF00069	0.565
MOD_ProDKin_1	83	89	PF00069	0.822
TRG_DiLeu_BaEn_1	265	270	PF01217	0.697
TRG_ENDOCYTIC_2	266	269	PF00928	0.697
TRG_ENDOCYTIC_2	592	595	PF00928	0.722
TRG_ER_diArg_1	276	278	PF00400	0.675
TRG_ER_diArg_1	457	460	PF00400	0.480
TRG_ER_diArg_1	525	527	PF00400	0.589
TRG_ER_diArg_1	561	564	PF00400	0.672
TRG_ER_diArg_1	75	77	PF00400	0.571
TRG_NLS_MonoCore_2	72	77	PF00514	0.567
TRG_NLS_MonoExtC_3	72	77	PF00514	0.567

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3Q8IIM2	Leishmania donovani	69%	100%
A4I4D4	Leishmania infantum	69%	100%
E9ADT3	Leishmania major	70%	99%
E9ALZ7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	67%	100%