Nucleoporin

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Nucleoporin

Gene product:

Nucleoporin NUP53b

Species:

Leishmania braziliensis

UniProt:

A4HH87_LEIBR

TriTrypDb:

LbrM.29.0820 , LBRM2903_290014600

Length:

652

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005643	nuclear pore	3	1
GO:0032991	protein-containing complex	1	1
GO:0044613	nuclear pore central transport channel	3	1
GO:0140513	nuclear protein-containing complex	2	1

Expansion

Sequence features

A4HH87

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HH87

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	212	216	PF00656	0.468
CLV_NRD_NRD_1	271	273	PF00675	0.594
CLV_NRD_NRD_1	444	446	PF00675	0.643
CLV_NRD_NRD_1	649	651	PF00675	0.565
CLV_PCSK_KEX2_1	271	273	PF00082	0.594
CLV_PCSK_KEX2_1	444	446	PF00082	0.585
CLV_PCSK_KEX2_1	649	651	PF00082	0.570
CLV_PCSK_SKI1_1	239	243	PF00082	0.599
CLV_PCSK_SKI1_1	414	418	PF00082	0.522
DEG_APCC_DBOX_1	238	246	PF00400	0.598
DEG_APCC_DBOX_1	270	278	PF00400	0.575
DEG_SPOP_SBC_1	233	237	PF00917	0.635
DEG_SPOP_SBC_1	469	473	PF00917	0.676
DEG_SPOP_SBC_1	485	489	PF00917	0.511
DOC_CDC14_PxL_1	451	459	PF14671	0.675
DOC_CYCLIN_RxL_1	409	418	PF00134	0.472
DOC_CYCLIN_yCln2_LP_2	353	356	PF00134	0.634
DOC_MAPK_gen_1	202	208	PF00069	0.563
DOC_PP1_RVXF_1	161	168	PF00149	0.503
DOC_PP2B_LxvP_1	353	356	PF13499	0.634
DOC_PP2B_LxvP_1	64	67	PF13499	0.506
DOC_PP4_FxxP_1	452	455	PF00568	0.676
DOC_PP4_FxxP_1	521	524	PF00568	0.598
DOC_PP4_FxxP_1	60	63	PF00568	0.504
DOC_PP4_FxxP_1	70	73	PF00568	0.494
DOC_USP7_MATH_1	115	119	PF00917	0.594
DOC_USP7_MATH_1	225	229	PF00917	0.625
DOC_USP7_MATH_1	231	235	PF00917	0.557
DOC_USP7_MATH_1	27	31	PF00917	0.668
DOC_USP7_MATH_1	318	322	PF00917	0.728
DOC_USP7_MATH_1	356	360	PF00917	0.679
DOC_USP7_MATH_1	446	450	PF00917	0.591
DOC_USP7_MATH_1	458	462	PF00917	0.489
DOC_USP7_MATH_1	465	469	PF00917	0.543
DOC_USP7_MATH_1	586	590	PF00917	0.725
DOC_USP7_MATH_1	635	639	PF00917	0.699
DOC_WW_Pin1_4	227	232	PF00397	0.482
DOC_WW_Pin1_4	25	30	PF00397	0.690
DOC_WW_Pin1_4	323	328	PF00397	0.653
DOC_WW_Pin1_4	34	39	PF00397	0.611
DOC_WW_Pin1_4	444	449	PF00397	0.647
DOC_WW_Pin1_4	460	465	PF00397	0.552
DOC_WW_Pin1_4	559	564	PF00397	0.528
LIG_14-3-3_CanoR_1	437	443	PF00244	0.565
LIG_Actin_WH2_2	346	363	PF00022	0.673
LIG_Actin_WH2_2	382	399	PF00022	0.557
LIG_APCC_ABBAyCdc20_2	191	197	PF00400	0.539
LIG_BIR_II_1	1	5	PF00653	0.653
LIG_BRCT_BRCA1_1	448	452	PF00533	0.660
LIG_FHA_1	114	120	PF00498	0.616
LIG_FHA_1	169	175	PF00498	0.580
LIG_FHA_1	471	477	PF00498	0.606
LIG_FHA_1	486	492	PF00498	0.649
LIG_FHA_2	345	351	PF00498	0.507
LIG_FHA_2	448	454	PF00498	0.650
LIG_GBD_Chelix_1	331	339	PF00786	0.558
LIG_Integrin_isoDGR_2	373	375	PF01839	0.512
LIG_LIR_Apic_2	449	455	PF02991	0.670
LIG_LIR_Apic_2	518	524	PF02991	0.672
LIG_LIR_Gen_1	164	174	PF02991	0.506
LIG_LIR_Gen_1	326	335	PF02991	0.575
LIG_LIR_Nem_3	164	170	PF02991	0.501
LIG_LIR_Nem_3	235	241	PF02991	0.552
LIG_LIR_Nem_3	326	331	PF02991	0.606
LIG_LIR_Nem_3	449	454	PF02991	0.647
LIG_MLH1_MIPbox_1	448	452	PF16413	0.660
LIG_MYND_1	604	608	PF01753	0.529
LIG_NRP_CendR_1	649	652	PF00754	0.719
LIG_SH2_CRK	149	153	PF00017	0.459
LIG_SH2_CRK	238	242	PF00017	0.608
LIG_SH2_GRB2like	207	210	PF00017	0.571
LIG_SH2_STAP1	287	291	PF00017	0.479
LIG_SH2_STAT3	147	150	PF00017	0.492
LIG_SH2_STAT5	205	208	PF00017	0.572
LIG_SH2_STAT5	451	454	PF00017	0.632
LIG_SH3_3	136	142	PF00018	0.699
LIG_SH3_3	288	294	PF00018	0.480
LIG_SH3_3	452	458	PF00018	0.673
LIG_SH3_3	598	604	PF00018	0.769
LIG_SH3_3	605	611	PF00018	0.641
LIG_UBA3_1	241	249	PF00899	0.587
LIG_WRC_WIRS_1	190	195	PF05994	0.574
LIG_WW_2	455	458	PF00397	0.668
MOD_CK1_1	113	119	PF00069	0.609
MOD_CK1_1	168	174	PF00069	0.587
MOD_CK1_1	229	235	PF00069	0.591
MOD_CK1_1	344	350	PF00069	0.575
MOD_CK1_1	447	453	PF00069	0.630
MOD_CK1_1	468	474	PF00069	0.583
MOD_CK1_1	613	619	PF00069	0.549
MOD_CK2_1	344	350	PF00069	0.429
MOD_GlcNHglycan	215	218	PF01048	0.572
MOD_GlcNHglycan	223	226	PF01048	0.669
MOD_GlcNHglycan	306	309	PF01048	0.602
MOD_GlcNHglycan	343	346	PF01048	0.516
MOD_GlcNHglycan	467	470	PF01048	0.798
MOD_GlcNHglycan	488	491	PF01048	0.557
MOD_GlcNHglycan	498	501	PF01048	0.644
MOD_GlcNHglycan	52	55	PF01048	0.619
MOD_GlcNHglycan	521	524	PF01048	0.545
MOD_GlcNHglycan	588	591	PF01048	0.663
MOD_GlcNHglycan	612	615	PF01048	0.541
MOD_GlcNHglycan	637	640	PF01048	0.755
MOD_GlcNHglycan	64	67	PF01048	0.506
MOD_GSK3_1	101	108	PF00069	0.702
MOD_GSK3_1	110	117	PF00069	0.703
MOD_GSK3_1	221	228	PF00069	0.644
MOD_GSK3_1	229	236	PF00069	0.564
MOD_GSK3_1	28	35	PF00069	0.727
MOD_GSK3_1	300	307	PF00069	0.616
MOD_GSK3_1	340	347	PF00069	0.417
MOD_GSK3_1	465	472	PF00069	0.678
MOD_GSK3_1	474	481	PF00069	0.533
MOD_GSK3_1	515	522	PF00069	0.766
MOD_GSK3_1	83	90	PF00069	0.507
MOD_N-GLC_1	156	161	PF02516	0.563
MOD_N-GLC_1	208	213	PF02516	0.576
MOD_N-GLC_2	310	312	PF02516	0.511
MOD_NEK2_1	111	116	PF00069	0.667
MOD_NEK2_1	133	138	PF00069	0.735
MOD_NEK2_1	304	309	PF00069	0.772
MOD_NEK2_1	349	354	PF00069	0.656
MOD_NEK2_1	396	401	PF00069	0.639
MOD_NEK2_1	474	479	PF00069	0.587
MOD_NEK2_1	50	55	PF00069	0.497
MOD_NEK2_1	542	547	PF00069	0.500
MOD_NEK2_2	356	361	PF00069	0.579
MOD_PIKK_1	165	171	PF00454	0.573
MOD_PIKK_1	458	464	PF00454	0.528
MOD_PKA_2	396	402	PF00069	0.491
MOD_PKA_2	645	651	PF00069	0.714
MOD_Plk_1	156	162	PF00069	0.561
MOD_Plk_1	165	171	PF00069	0.453
MOD_Plk_1	349	355	PF00069	0.607
MOD_Plk_1	397	403	PF00069	0.609
MOD_Plk_4	349	355	PF00069	0.662
MOD_Plk_4	438	444	PF00069	0.529
MOD_Plk_4	447	453	PF00069	0.668
MOD_Plk_4	613	619	PF00069	0.528
MOD_ProDKin_1	227	233	PF00069	0.482
MOD_ProDKin_1	25	31	PF00069	0.693
MOD_ProDKin_1	323	329	PF00069	0.649
MOD_ProDKin_1	34	40	PF00069	0.607
MOD_ProDKin_1	444	450	PF00069	0.648
MOD_ProDKin_1	460	466	PF00069	0.555
MOD_ProDKin_1	559	565	PF00069	0.529
TRG_DiLeu_BaEn_2	188	194	PF01217	0.475
TRG_DiLeu_BaLyEn_6	291	296	PF01217	0.568
TRG_ENDOCYTIC_2	149	152	PF00928	0.542
TRG_ENDOCYTIC_2	205	208	PF00928	0.572
TRG_ENDOCYTIC_2	238	241	PF00928	0.540
TRG_ENDOCYTIC_2	451	454	PF00928	0.798
TRG_ER_diArg_1	443	445	PF00400	0.648
TRG_ER_diArg_1	649	652	PF00400	0.570
TRG_Pf-PMV_PEXEL_1	239	244	PF00026	0.597

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3R7L5N2	Trypanosoma rangeli	32%	100%
A0A3S7X2B5	Leishmania donovani	81%	99%
A4I4D3	Leishmania infantum	78%	93%
E9ADT2	Leishmania major	82%	100%
E9ALZ8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	78%	97%