Putative U-box domain protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

U-box domain protein, putative

Species:

Leishmania braziliensis

UniProt:

A4HH85_LEIBR

TriTrypDb:

LbrM.29.0800 , LBRM2903_290014300 , LBRM2903_290014400

Length:

601

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 3
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 20

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 7

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HH85

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HH85

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	12
GO:0004842	ubiquitin-protein transferase activity	4	12
GO:0016740	transferase activity	2	12
GO:0019787	ubiquitin-like protein transferase activity	3	12
GO:0140096	catalytic activity, acting on a protein	2	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	278	282	PF00656	0.443
CLV_C14_Caspase3-7	514	518	PF00656	0.622
CLV_NRD_NRD_1	428	430	PF00675	0.553
CLV_NRD_NRD_1	50	52	PF00675	0.476
CLV_NRD_NRD_1	72	74	PF00675	0.491
CLV_PCSK_KEX2_1	428	430	PF00082	0.560
CLV_PCSK_KEX2_1	50	52	PF00082	0.423
CLV_PCSK_KEX2_1	72	74	PF00082	0.491
CLV_PCSK_SKI1_1	107	111	PF00082	0.556
CLV_PCSK_SKI1_1	264	268	PF00082	0.307
CLV_PCSK_SKI1_1	428	432	PF00082	0.487
CLV_PCSK_SKI1_1	562	566	PF00082	0.392
DOC_CKS1_1	568	573	PF01111	0.232
DOC_CYCLIN_yClb1_LxF_4	368	374	PF00134	0.476
DOC_MAPK_gen_1	107	117	PF00069	0.535
DOC_MAPK_gen_1	484	493	PF00069	0.616
DOC_MAPK_gen_1	72	81	PF00069	0.361
DOC_MAPK_MEF2A_6	123	132	PF00069	0.346
DOC_MAPK_MEF2A_6	209	218	PF00069	0.351
DOC_PP1_RVXF_1	207	213	PF00149	0.398
DOC_PP1_RVXF_1	89	96	PF00149	0.440
DOC_PP4_FxxP_1	185	188	PF00568	0.356
DOC_USP7_MATH_1	116	120	PF00917	0.600
DOC_USP7_MATH_1	233	237	PF00917	0.546
DOC_USP7_MATH_1	304	308	PF00917	0.373
DOC_USP7_MATH_1	357	361	PF00917	0.547
DOC_USP7_MATH_1	43	47	PF00917	0.610
DOC_USP7_MATH_1	437	441	PF00917	0.556
DOC_USP7_MATH_1	545	549	PF00917	0.232
DOC_USP7_MATH_1	89	93	PF00917	0.545
DOC_USP7_UBL2_3	205	209	PF12436	0.461
DOC_USP7_UBL2_3	260	264	PF12436	0.450
DOC_WW_Pin1_4	305	310	PF00397	0.391
DOC_WW_Pin1_4	428	433	PF00397	0.480
DOC_WW_Pin1_4	502	507	PF00397	0.478
DOC_WW_Pin1_4	532	537	PF00397	0.337
DOC_WW_Pin1_4	567	572	PF00397	0.433
LIG_14-3-3_CanoR_1	123	131	PF00244	0.344
LIG_14-3-3_CanoR_1	336	342	PF00244	0.425
LIG_14-3-3_CanoR_1	351	359	PF00244	0.498
LIG_14-3-3_CanoR_1	401	405	PF00244	0.516
LIG_14-3-3_CanoR_1	51	57	PF00244	0.344
LIG_14-3-3_CanoR_1	562	567	PF00244	0.395
LIG_14-3-3_CanoR_1	585	593	PF00244	0.619
LIG_Actin_WH2_2	125	143	PF00022	0.360
LIG_Actin_WH2_2	385	403	PF00022	0.491
LIG_AP2alpha_1	342	346	PF02296	0.495
LIG_BIR_II_1	1	5	PF00653	0.414
LIG_BIR_III_4	378	382	PF00653	0.404
LIG_BRCT_BRCA1_1	275	279	PF00533	0.315
LIG_BRCT_BRCA1_1	316	320	PF00533	0.393
LIG_BRCT_BRCA1_1	439	443	PF00533	0.476
LIG_BRCT_BRCA1_1	91	95	PF00533	0.555
LIG_deltaCOP1_diTrp_1	421	427	PF00928	0.524
LIG_EH1_1	154	162	PF00400	0.359
LIG_EH1_1	385	393	PF00400	0.627
LIG_eIF4E_1	386	392	PF01652	0.553
LIG_EVH1_2	168	172	PF00568	0.478
LIG_FHA_1	205	211	PF00498	0.379
LIG_FHA_1	275	281	PF00498	0.354
LIG_FHA_1	523	529	PF00498	0.337
LIG_FHA_2	276	282	PF00498	0.350
LIG_GBD_Chelix_1	291	299	PF00786	0.461
LIG_LIR_Gen_1	23	31	PF02991	0.463
LIG_LIR_Gen_1	251	261	PF02991	0.256
LIG_LIR_Gen_1	340	350	PF02991	0.492
LIG_LIR_Gen_1	440	451	PF02991	0.369
LIG_LIR_Gen_1	75	84	PF02991	0.431
LIG_LIR_Gen_1	92	101	PF02991	0.473
LIG_LIR_Nem_3	317	323	PF02991	0.407
LIG_LIR_Nem_3	340	345	PF02991	0.452
LIG_LIR_Nem_3	421	427	PF02991	0.579
LIG_LIR_Nem_3	440	446	PF02991	0.250
LIG_LIR_Nem_3	75	80	PF02991	0.404
LIG_LIR_Nem_3	85	90	PF02991	0.380
LIG_LIR_Nem_3	92	98	PF02991	0.315
LIG_MYND_1	481	485	PF01753	0.725
LIG_NRBOX	160	166	PF00104	0.348
LIG_PDZ_Class_2	596	601	PF00595	0.594
LIG_Pex14_1	423	427	PF04695	0.467
LIG_Pex14_2	338	342	PF04695	0.502
LIG_Pex14_2	419	423	PF04695	0.433
LIG_SH2_CRK	87	91	PF00017	0.433
LIG_SH2_GRB2like	367	370	PF00017	0.477
LIG_SH2_GRB2like	60	63	PF00017	0.368
LIG_SH2_PTP2	367	370	PF00017	0.406
LIG_SH2_STAP1	170	174	PF00017	0.421
LIG_SH2_STAP1	541	545	PF00017	0.466
LIG_SH2_STAT5	10	13	PF00017	0.540
LIG_SH2_STAT5	367	370	PF00017	0.372
LIG_SH2_STAT5	60	63	PF00017	0.383
LIG_SH3_3	303	309	PF00018	0.339
LIG_SH3_3	381	387	PF00018	0.624
LIG_SH3_3	530	536	PF00018	0.322
LIG_SUMO_SIM_anti_2	125	132	PF11976	0.342
LIG_TRAF2_1	331	334	PF00917	0.464
LIG_TYR_ITIM	365	370	PF00017	0.415
LIG_UBA3_1	132	141	PF00899	0.463
LIG_UBA3_1	159	166	PF00899	0.348
LIG_UBA3_1	255	260	PF00899	0.502
LIG_WRC_WIRS_1	338	343	PF05994	0.499
MOD_CDK_SPxxK_3	502	509	PF00069	0.486
MOD_CK1_1	236	242	PF00069	0.509
MOD_CK1_1	29	35	PF00069	0.498
MOD_CK1_1	452	458	PF00069	0.477
MOD_CK2_1	100	106	PF00069	0.453
MOD_CK2_1	259	265	PF00069	0.583
MOD_GlcNHglycan	12	15	PF01048	0.569
MOD_GlcNHglycan	179	182	PF01048	0.442
MOD_GlcNHglycan	245	248	PF01048	0.431
MOD_GlcNHglycan	359	362	PF01048	0.449
MOD_GlcNHglycan	38	41	PF01048	0.431
MOD_GlcNHglycan	396	399	PF01048	0.478
MOD_GlcNHglycan	506	509	PF01048	0.690
MOD_GSK3_1	260	267	PF00069	0.378
MOD_GSK3_1	310	317	PF00069	0.430
MOD_GSK3_1	570	577	PF00069	0.500
MOD_N-GLC_1	248	253	PF02516	0.540
MOD_N-GLC_1	314	319	PF02516	0.443
MOD_N-GLC_1	552	557	PF02516	0.356
MOD_N-GLC_1	82	87	PF02516	0.524
MOD_NEK2_1	105	110	PF00069	0.406
MOD_NEK2_1	183	188	PF00069	0.352
MOD_NEK2_1	243	248	PF00069	0.426
MOD_NEK2_1	259	264	PF00069	0.363
MOD_NEK2_1	274	279	PF00069	0.293
MOD_NEK2_1	280	285	PF00069	0.356
MOD_NEK2_1	314	319	PF00069	0.475
MOD_NEK2_1	346	351	PF00069	0.415
MOD_NEK2_1	520	525	PF00069	0.232
MOD_NEK2_2	100	105	PF00069	0.405
MOD_PIKK_1	150	156	PF00454	0.422
MOD_PIKK_1	183	189	PF00454	0.360
MOD_PIKK_1	264	270	PF00454	0.385
MOD_PIKK_1	329	335	PF00454	0.471
MOD_PIKK_1	452	458	PF00454	0.602
MOD_PIKK_1	587	593	PF00454	0.509
MOD_PK_1	509	515	PF00069	0.674
MOD_PKA_1	50	56	PF00069	0.445
MOD_PKA_1	72	78	PF00069	0.442
MOD_PKA_2	122	128	PF00069	0.354
MOD_PKA_2	357	363	PF00069	0.549
MOD_PKA_2	400	406	PF00069	0.463
MOD_PKA_2	50	56	PF00069	0.454
MOD_PKA_2	584	590	PF00069	0.541
MOD_PKA_2	72	78	PF00069	0.442
MOD_Plk_1	105	111	PF00069	0.386
MOD_Plk_1	248	254	PF00069	0.488
MOD_Plk_1	264	270	PF00069	0.417
MOD_Plk_1	314	320	PF00069	0.382
MOD_Plk_1	438	444	PF00069	0.534
MOD_Plk_1	82	88	PF00069	0.523
MOD_Plk_4	100	106	PF00069	0.517
MOD_Plk_4	248	254	PF00069	0.408
MOD_Plk_4	275	281	PF00069	0.358
MOD_Plk_4	314	320	PF00069	0.499
MOD_Plk_4	337	343	PF00069	0.509
MOD_Plk_4	431	437	PF00069	0.417
MOD_Plk_4	449	455	PF00069	0.316
MOD_Plk_4	545	551	PF00069	0.232
MOD_ProDKin_1	305	311	PF00069	0.381
MOD_ProDKin_1	428	434	PF00069	0.478
MOD_ProDKin_1	502	508	PF00069	0.482
MOD_ProDKin_1	532	538	PF00069	0.337
MOD_ProDKin_1	567	573	PF00069	0.433
MOD_SUMO_for_1	109	112	PF00179	0.468
MOD_SUMO_for_1	408	411	PF00179	0.472
TRG_DiLeu_BaEn_2	207	213	PF01217	0.423
TRG_DiLeu_BaLyEn_6	472	477	PF01217	0.699
TRG_ENDOCYTIC_2	367	370	PF00928	0.358
TRG_ENDOCYTIC_2	424	427	PF00928	0.523
TRG_ENDOCYTIC_2	87	90	PF00928	0.440
TRG_ER_diArg_1	427	429	PF00400	0.536
TRG_ER_diArg_1	49	51	PF00400	0.521
TRG_ER_diArg_1	71	73	PF00400	0.496
TRG_NLS_MonoExtN_4	70	77	PF00514	0.452
TRG_Pf-PMV_PEXEL_1	475	479	PF00026	0.618

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IMG8	Leptomonas seymouri	73%	100%
A0A0S4IVT7	Bodo saltans	47%	98%
A0A1X0NZM7	Trypanosomatidae	44%	96%
A0A3R7MLP4	Trypanosoma rangeli	44%	99%
A0A3S7X270	Leishmania donovani	89%	100%
A4I4D1	Leishmania infantum	89%	100%
C9ZL32	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	41%	96%
E9ADT0	Leishmania major	88%	100%
E9AM00	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%
V5DLG6	Trypanosoma cruzi	44%	99%