Transmembrane protein

Quick info Annotations Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HH84_LEIBR

TriTrypDb:

LbrM.29.0790 , LBRM2903_290014200

Length:

202

Annotations

LeishMANIAdb annotations

Seems to form a single continuous helix according to predictions. Kinetoplastid-only protein.

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 5

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	9
GO:0110165	cellular anatomical entity	1	9
GO:0005737	cytoplasm	2	1

Expansion

Sequence features

A4HH84

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HH84

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	14	18	PF00656	0.731
CLV_C14_Caspase3-7	160	164	PF00656	0.509
CLV_NRD_NRD_1	108	110	PF00675	0.437
CLV_NRD_NRD_1	143	145	PF00675	0.749
CLV_NRD_NRD_1	37	39	PF00675	0.453
CLV_NRD_NRD_1	53	55	PF00675	0.469
CLV_NRD_NRD_1	58	60	PF00675	0.472
CLV_PCSK_FUR_1	141	145	PF00082	0.681
CLV_PCSK_FUR_1	94	98	PF00082	0.541
CLV_PCSK_KEX2_1	143	145	PF00082	0.737
CLV_PCSK_KEX2_1	37	39	PF00082	0.526
CLV_PCSK_KEX2_1	53	55	PF00082	0.442
CLV_PCSK_KEX2_1	96	98	PF00082	0.501
CLV_PCSK_PC1ET2_1	96	98	PF00082	0.501
DEG_APCC_DBOX_1	101	109	PF00400	0.718
DEG_SPOP_SBC_1	75	79	PF00917	0.705
DOC_MAPK_gen_1	109	117	PF00069	0.558
DOC_MAPK_MEF2A_6	109	117	PF00069	0.558
DOC_PP2B_LxvP_1	44	47	PF13499	0.748
DOC_USP7_MATH_1	152	156	PF00917	0.498
DOC_USP7_MATH_1	167	171	PF00917	0.518
DOC_USP7_MATH_1	18	22	PF00917	0.708
LIG_14-3-3_CanoR_1	102	108	PF00244	0.696
LIG_14-3-3_CanoR_1	11	19	PF00244	0.623
LIG_14-3-3_CanoR_1	151	157	PF00244	0.516
LIG_BRCT_BRCA1_1	69	73	PF00533	0.782
LIG_FHA_1	24	30	PF00498	0.723
LIG_FHA_1	70	76	PF00498	0.672
LIG_LIR_Apic_2	127	133	PF02991	0.397
LIG_Pex14_2	118	122	PF04695	0.330
LIG_SH2_NCK_1	149	153	PF00017	0.462
LIG_SH2_STAT5	130	133	PF00017	0.575
LIG_SH2_STAT5	135	138	PF00017	0.494
LIG_SH3_3	176	182	PF00018	0.557
MOD_CK1_1	103	109	PF00069	0.554
MOD_CK1_1	66	72	PF00069	0.784
MOD_Cter_Amidation	35	38	PF01082	0.382
MOD_GlcNHglycan	13	16	PF01048	0.549
MOD_GlcNHglycan	169	172	PF01048	0.697
MOD_GlcNHglycan	20	23	PF01048	0.479
MOD_GlcNHglycan	5	8	PF01048	0.602
MOD_GSK3_1	18	25	PF00069	0.698
MOD_GSK3_1	63	70	PF00069	0.786
MOD_N-GLC_1	103	108	PF02516	0.506
MOD_N-GLC_1	67	72	PF02516	0.435
MOD_NEK2_1	10	15	PF00069	0.808
MOD_NEK2_1	197	202	PF00069	0.564
MOD_PKA_1	53	59	PF00069	0.593
MOD_PKA_2	10	16	PF00069	0.733
MOD_PKA_2	53	59	PF00069	0.648
MOD_Plk_1	103	109	PF00069	0.705
MOD_Plk_2-3	157	163	PF00069	0.384
MOD_Plk_4	103	109	PF00069	0.705
MOD_SUMO_rev_2	70	78	PF00179	0.729
TRG_ENDOCYTIC_2	135	138	PF00928	0.444
TRG_ER_diArg_1	141	144	PF00400	0.469
TRG_NLS_MonoExtN_4	57	63	PF00514	0.623

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P8C6	Leptomonas seymouri	59%	100%
A0A0S4ISL6	Bodo saltans	41%	100%
A0A1X0NZL1	Trypanosomatidae	48%	100%
A0A3S7X2B4	Leishmania donovani	71%	100%
A4I4D0	Leishmania infantum	72%	100%
C9ZL34	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	44%	100%
E9ADS9	Leishmania major	71%	97%
E9AM01	Leishmania mexicana (strain MHOM/GT/2001/U1103)	76%	100%